Nakahara, Takehiro

写真a

Affiliation

School of Medicine, Department of Radiology (Diagnostic Radiology) （Shinanomachi）

Position

Project Senior Assistant Professor (Non-tenured)/Project Assistant Professor (Non-tenured)/Project Lecturer (Non-tenured)

External Links
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Career 【 Display / hide 】

  • 2003.04
    -
    2004.09

    群馬大学医学部付属病院

  • 2004.10
    -
    2008.03

    独立行政法人国立病院機構　高崎病院

  • 2006.04
    -
    2010.03

    群馬大学大学院

  • 2010.04
    -
    2013.03

    群馬大学医学部付属病院　循環器内科

  • 2013.04
    -
    2014.08

    群馬大学医学部付属病院　循環器内科

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Academic Background 【 Display / hide 】

  • 1997.04
    -
    2003.03

    Gunma University, 医学部, 医学科

    University, Graduated, Master's course

  • 2007.04
    -
    2010.03

    Gunma University, 医学系研究科

    Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Doctor (Medicine）, Gunma University, Coursework, 2010.03

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Licenses and Qualifications 【 Display / hide 】

  • medical doctor, 2003.04

  • Board Certified Member of the Japanese Society of Internal Medicine, 2006

  • Board Certified Member of the Japanese Circulation Society, 2010

  • MD-PhD, 2010.03

  • The Japanese Board of Nuclear Medicine, 2013

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Matters concerning Career Achievements 【 Display / hide 】

  • 2020.09
    -
    Present

    ＲＩ運営委員会

    　View Details

    ＲＩ運営に関して、各科の意見を調整する。

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Research Areas 【 Display / hide 】

  • Life Science / Cardiology

  • Life Science / Molecular biology

  • Life Science / Radiological sciences

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Research Keywords 【 Display / hide 】

  • 動脈硬化

  • cardiovascular imaging

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Research Themes 【 Display / hide 】

  • 動脈硬化, 

    2006
    -
    Present

  • molecular imaging, 

    2014
    -
    Present

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Proposed Theme of Joint Research 【 Display / hide 】

  • RIカテーテルについて

    Interested in joint research with other research organizations (including universities, etc.),  Desired form： Cooperative Research

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Books 【 Display / hide 】

  • 内科学書　改訂第9版：Ｘ線ＣＴ

    中原健裕、奥田茂男、陣崎雅弘, 中山書店, 2019,  Page： Vol 3,p65-69

  • Rat model of cardiotoxic drug-induced cardiomyopathy

    Nakahara T., Tanimoto T., Petrov A., Ishikawa K., Strauss H., Narula J., Methods in Molecular Biology, 2018

    　View Summary

    Cardiotoxicity from cancer drugs remains a clinical problem. To find reliable markers of cardiotoxicity, animal models were proposed and potential new diagnostic, markers have been actively investigated using these models. Here we describe our protocols, using male Sprague-Dawley rats, for inducing cardiomyopathy by single injection of high-dose doxorubicin (5–10, mg/kg) or multiple injections (2–4 times) of low-dose doxorubicin (2.5, mg/kg) with combined single injection of trastuzumab (10, mg/kg). The cardiotoxicity is evaluated by imaging modalities (echocardiography and nuclear imaging), serum troponin levels, and histopathological analyses.

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Papers 【 Display / hide 】

  • Effect of gravity on brain structure as indicated on upright computed tomography

    Yokoyama Y., Yamada Y., Kosugi K., Yamada M., Narita K., Nakahara T., Fujiwara H., Toda M., Jinzaki M.

    Scientific Reports （Scientific Reports)  11 （ 1 ） 392 2021.12

    ISSN  2045-2322

    　View Summary

    We aimed to use upright computed tomography (CT) to depict posture-related changes in the brain tissue under normal gravity. Thirty-two asymptomatic volunteers underwent upright CT in the sitting position and conventional CT in the supine position on the same day. We compared the shift of the pineal body, cerebellar tonsil, the length of pituitary stalk, optic nerve sheath area and perimeter (ONSA and ONSP, respectively), and lateral ventricular volume between the supine and sitting positions. We also compared shape changes of the cerebrospinal fluid (CSF) spaces at different sites between both positions. In the sitting position, the pineal body shifted 0.68 ± 0.27 mm in the ventral direction and 0.76 ± 0.24 mm in the caudal direction, the length of pituitary stalk decreased by 1.23 ± 0.71 mm, the cerebellar tonsil descended by 2.10 ± 0.86 mm, the right ONSA decreased by 15.21 ± 6.54%, the left ONSA decreased by 15.30 ± 7.37%, the right ONSP decreased by 8.52 ± 3.91%, the left ONSP decreased by 8.20 ± 4.38%, and the lateral ventricular volume decreased by 5.07 ± 3.24% (all P < 0.001). We also observed changes in the shape of CSF spaces with changes in posture. We concluded that the intracranial structure of healthy subjects and volume of ventricles changed according to posture on Earth.

  • Three-dimensional evaluation of the coccyx movement between supine and standing positions using conventional and upright computed tomography imaging

    Yagi F., Yamada Y., Yamada M., Yokoyama Y., Mukai K., Nakahara T., Narita K., Jinzaki M.

    Scientific Reports （Scientific Reports)  11 （ 1 ） 6886 2021.12

    ISSN  2045-2322

    　View Summary

    Currently, no three-dimensional reference data exist for the normal coccyx in the standing position on computed tomography (CT); however, this information could have utility for evaluating patients with coccydynia and pelvic floor dysfunction. Thus, we aimed to compare coccygeal parameters in the standing versus supine positions using upright and supine CT and evaluate the effects of sex, age, and body mass index (BMI) on coccygeal movement. Thirty-two healthy volunteers underwent both upright (standing position) and conventional (supine position) CT examinations. In the standing position, the coccyx became significantly longer and straighter, with the tip of the coccyx moving backward and downward (all p < 0.001). Additionally, the coccygeal straight length (standing/supine, 37.8 ± 7.1/35.7 ± 7.0 mm) and sacrococcygeal straight length (standing/supine, 131.7 ± 11.2/125.0 ± 10.7 mm) were significantly longer in the standing position. The sacrococcygeal angle (standing/supine, 115.0 ± 10.6/105.0 ± 12.5°) was significantly larger, while the lumbosacral angle (standing/supine, 21.1 ± 5.9/25.0 ± 4.9°) was significantly smaller. The migration length of the tip of the coccyx (mean, 7.9 mm) exhibited a moderate correlation with BMI (r = 0.42, p = 0.0163). Our results may provide important clues regarding the pathogenesis of coccydynia and pelvic floor dysfunction.

  • Saphenous vein valve assessment utilizing upright CT to potentially improve graft assessment for bypass surgery

    Nakahara T., Yamada M., Yokoyama Y., Yamada Y., Narita K., Imanishi N., Yamazaki M., Shimizu H., Narula J., Jinzaki M.

    Scientific Reports （Scientific Reports)  11 （ 1 ） 11602 2021.12

    ISSN  2045-2322

    　View Summary

    Saphenous veins (SVs) are frequently employed as bypass grafts. The SV graft failure is predominantly seen at the valve site. Avoiding valves during vein harvest would help reduce graft failure. We endeavored to detect SV valves, tributaries, and vessel size employing upright computed tomography (CT) for the raw cadaver venous samples and in healthy volunteers. Five cadaver legs were scanned. Anatomical analysis showed 3.0 (IQR: 2.0–3.0) valves and 13.50 (IQR: 10.00–16.25) tributaries. The upright CT completely detected, compared to 2.0 (IQR: 1.5–2.5, p = 0.06) valves and 9.5 (IQR: 7.5–13.0, p = 0.13) tributaries by supine CT. From a total of 190 volunteers, 138 (men:75, women:63) were included. The number of valves from the SF junction to 35 cm were significantly higher in upright CT than in supine CT bilaterally [upright vs. supine, Right: 4 (IQR: 3–5) vs. 2 (IQR:1–2), p < 0.0001, Left: 4 (IQR: 3–5) vs. 2 (IQR: 1–2), p < 0.0001]. The number of tributaries and vessel areas per leg were also higher for upright compared with supine CT. Upright CT enables non-invasive detection of SV valves, tributaries, and vessel size. Although not tested here, it is expected that upright CT may potentially improve graft assessment for bypass surgery.

  • JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases

    Yamagishi M., Tamaki N., Akasaka T., Ikeda T., Ueshima K., Uemura S., Otsuji Y., Kihara Y., Kimura K., Kimura T., Kusama Y., Kumita S., Sakuma H., Jinzaki M., Daida H., Takeishi Y., Tada H., Chikamori T., Tsujita K., Teraoka K., Nakajima K., Nakata T., Nakatani S., Nogami A., Node K., Nohara A., Hirayama A., Funabashi N., Miura M., Mochizuki T., Yokoi H., Yoshioka K., Watanabe M., Asanuma T., Ishikawa Y., Ohara T., Kaikita K., Kasai T., Kato E., Kamiyama H., Kawashiri M., Kiso K., Kitagawa K., Kido T., Kinoshita T., Kiriyama T., Kume T., Kurata A., Kurisu S., Kosuge M., Kodani E., Sato A., Shiono Y., Shiomi H., Taki J., Takeuchi M., Tanaka A., Tanaka N., Tanaka R., Nakahashi T., Nakahara T., Nomura A., Hashimoto A., Hayashi K., Higashi M., Hiro T., Fukamachi D., Matsuo H., Matsumoto N., Miyauchi K., Miyagawa M., Yamada Y., Yoshinaga K., Wada H., Watanabe T., Ozaki Y., Kohsaka S., Shimizu W., Yasuda S., Yoshino H.

    Circulation journal : official journal of the Japanese Circulation Society （Circulation journal : official journal of the Japanese Circulation Society)  85 （ 4 ） 402 - 572 2021.03

    ISSN  13469843

  • Accuracy of ultra-high–resolution computed tomography with a 0.3-mm detector for quantitative assessment of coronary artery stenosis grading in comparison with conventional computed tomography: A phantom study

    Yamada M., Yamada Y., Nakahara T., Okuda S., Abe T., Kuribayashi S., Jinzaki M.

    Journal of Cardiovascular Computed Tomography （Journal of Cardiovascular Computed Tomography)   2021

    ISSN  19345925

    　View Summary

    Background: The development of ultra-high–resolution CT (U-HRCT) is expected to improve the accuracy of coronary stenosis evaluation. This study aimed to evaluate the accuracy of the stenosis severities of coronary artery phantoms estimated using U-HRCT by comparing them to those estimated with conventional CT. Methods: Coronary artery phantoms with non-calcified and calcified lesions were scanned with conventional CT (64-row ​× ​0.625 ​mm) and U-HRCT (32-row ​× ​0.3125 ​mm). The coronary artery phantoms had lumen diameters of 2.0, 3.0, and 4.0 ​mm with non-calcified lesions representing 0%, 25%, 50%, and 75% stenosis and 3.0 and 4.0 ​mm with calcified lesions representing 0%, 25%, 50%, and 75% stenosis. The lumen diameters at the stenotic and non-stenotic regions were measured, and the stenosis severities were compared with the true values. Results: For non-calcified lesions, conventional CT significantly underestimated the stenosis severity in the phantom showing 75% stenosis with lumen diameters of 2.0 and 3.0 ​mm (p ​< ​0.05), while the estimated stenosis severities were not significantly different from the true values at all settings with U-HRCT. For the calcified lesions, conventional CT overestimated the stenosis severities at all settings (p ​< ​0.05), while U-HRCT yielded estimations closer to the true values, although still with some overestimation (p ​< ​0.05). Conclusion: By using U-HRCT, the estimated stenosis severities of the coronary artery with non-calcified lesion become almost equal to the true value, while those with calcified lesion are still overestimated although they become closer to the true value.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 画像をリファレンスとした循環器臨床診断における機械学習

    中原健裕、奥田茂男、陣崎雅弘

    画像診断 (学研メディカル秀潤社)   2021.07

    Joint Work, Lead author, Corresponding author

  • 動脈硬化におけるNaF-PET/CTの意義

    中原健裕、岩淵雄、宮澤雷太、藤林靖久、陣崎　雅弘

    Innervation (インナービジョン)   2021.03

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Lead author, Corresponding author

  • 【Precision Medicine時代のCardiac Imaging 2021　技術革新が切り開く循環器画像診断の未来(前編)CT/血管撮影装置/核医学装置】核医学装置　循環器領域における臨床の最前線と技術の到達点　核医学装置の技術革新が広げる循環器画像診断の可能性　動脈硬化におけるNaF-PET/CTの意義

    中原 健裕, 岩淵 雄, 宮澤 雷太, 藤林 靖久, 陣崎 雅弘

    INNERVISION ((株)インナービジョン)  36 ( 4 ) 65 - 67 2021.03

    ISSN  0913-8919

  • 新型コロナウイルス感染症（COVID-19）における心筋イメージング

    中原健裕、奥田茂男、陣崎雅弘

    画像診断 (学研メディカル秀潤社)   2021.01

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Lead author, Corresponding author

  • 腹部大動脈における18F-NaF集積と血管石灰化の経時的変化における関係性

    中原 健裕, 岩渕 雄, 宮澤 雷太, 冨田 快, Narula Jagat, Fox Josef J., 陣崎 雅弘, Strauss H. William

    核医学 ((一社)日本核医学会)  58 ( Suppl. ) S210 - S210 2021

    ISSN  0022-7854

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Presentations 【 Display / hide 】

  • Temporal relationship between 18F-sodium fluoride uptake and evolution of CT-verified vascular calcification in Abdominal Aorta

    Takehiro Nakahara, Jagat Narula, Josef J. Fox, Masahiro Jinzaki, H. William Strauss,

    2021.03
    , 

    Oral presentation (general)

  • Temporal relationship between 18F-sodium fluoride uptake and evolution of CT-verified vascular calcification in Abdominal Aorta

    Takehiro Nakahara, Jagat Narula, Josef J. Fox, Masahiro Jinzaki, H. William Strauss,

    日本循環器学会第85回学術集会, 

    2021.03
    , 

    Oral presentation (general)

  • 陰茎動脈における18F-Fluoride PET画像はErectile Dysfunctionと相関する。

    Takehiro Nakahara, Jagat Narula, Sunil Agarwal, Mohammed M. Chowdhury, Patrick A. Coughlin, Marc Dweck, James Rudd, Masahiro Jinzaki, John Mulhall,, H. William Strauss,

    第60回　日本核医学会学術総会, 

    2020.11
    , 

    Oral presentation (general)

  • 心不全のマルチモダリティイメージング: opening

    中原健裕

    日本循環器学会第84回学術集会, 

    2020.07
    , 

    Oral presentation (keynote)

  • 心不全のマルチモダリティイメージング: Multimodality Imaging in Ischemic Cardiomyopathy

    中原健裕

    日本循環器学会第84回学術集会, 

    2020.07
    , 

    Oral presentation (invited, special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • A time course of atherosclerosis by PET

    2021.04
    -
    2025.03

    Research grant, Principal investigator

  • PETによる炎症から石灰化に至る変化の観察：プラーク破綻予測・新規治療標的の検索

    2021.04
    -
    Present

    日本学術振興会, Research grant, Principal investigator

  • 新しい脆弱プラーク評価法の確立に向けた血管内放射線検出カテーテルの開発

    2019.04
    -
    Present

    日本学術振興会, Research grant, Coinvestigator(s)

  • 先進医療研究振興財団　平成30年度循環医学分野　若手研究助成

    2018.12
    -
    2019.11

    Research grant, Principal investigator

  • ＭＳＤ生命科学財団研究助成2018　‐生活習慣病領域‐

    2018.11
    -
    2020.10

    Research grant, Principal investigator

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Awards 【 Display / hide 】

  • 2015-2017 SNMMI Wagner-Torizuka fellowship

    2015.03

    Type of Award： Award from publisher, newspaper, foundation, etc.

  • 上原記念生命科学財団 ポストドクトラルフェローシップ

    2014.01

    Type of Award： Award from publisher, newspaper, foundation, etc.

  • 第16回心世代核医学研究会　最優秀賞

    2013.11

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Best Young Investigator Award Finalist in the 6th Congress of Asian Society of Cardiovascular Imaging (ASCI). (2012, Bangkok, Thailand)

    2012.06

    Type of Award： Award from international society, conference, symposium, etc.

  • Young Investigator Award Finalist in the SCCT (Society of Cardiovascular Computed Tomography)’s 6th Annual Scientific Meeting. （2011, Denver, CO,USA)

    2011.07

    Type of Award： Award from international society, conference, symposium, etc.

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Educational Activities and Special Notes 【 Display / hide 】

  • Molecular imaging for vulnerable plaque

    2021.09

    , Special Affairs

    　View Details

    PCI Optimization by Physiology And Imaging 2020におけるvulnerable plaqueに関する教育的講演（招待講演）

  • Molecular imaging for vulnerable plaque

    2019.11

    , Special Affairs

    　View Details

    PCI Optimization by Physiology And Imaging 2019におけるvulnerable plaqueに関する教育的講演（招待講演）

  • 分子イメージングによる不安定プラークの検出 ：基礎から臨床へ

    2019.07

    , Special Affairs

    　View Details

    第29回日本心臓核医学会総会・学術大会における分子イメージングによる不安定プラークの検出に関しての、基礎から臨床へわたる教育的講演（招待講演）

  • Molecular imaging for vulnerable plaque

    2018.10

    , Special Affairs

    　View Details

    PCI Optimization by Physiology And Imaging2018における、vulnerable plaqueに関する教育的講演（招待講演）

  • 画像から見る動脈硬化の基礎的研究

    2018.09

    , Special Affairs about A person who has work experience

    　View Details

    第9回 MCVI Multi-modality Cardio Vascular Imagingでの教育的講演（招待講演）

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Academic Activities 【 Display / hide 】

  • 心不全のマルチモダリティイメージング

    日本循環器学会第84回学術集会, 

    2020.07
    -
    2020.08

  • 日本循環器学会 / 循環器病の診断と治療に関するガイドライン「慢性冠動脈疾患診断ガイドライン(2018年度改訂版)

    2018
    -
    2019.03

    　View Summary

    日本循環器学会 / 循環器病の診断と治療に関するガイドライン「慢性冠動脈疾患診断ガイドライン(2018年度改訂版)」
    日本循環器学会　2019年3月29日発行
    に協力員として協力した。

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Memberships in Academic Societies 【 Display / hide 】

  • American College of Cardiology, 

    2014
    -
    Present

  • Society of Nuclear Medicine and Molecular Imaging (SNMMI), 

    2014
    -
    Present

  • 日本核医学学会, 

    2011
    -
    Present

  • 日本医学放射線学会, 

    2010
    -
    Present

  • 日本循環器学会, 

    2004
    -
    Present

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