Maeda, Takaki



School of Medicine, Department of Neuropsychiatry (Shinanomachi)


Assistant Professor/Senior Assistant Professor

Profile Summary 【 Display / hide

  • 慶應義塾大学医学部精神神経科 精神病理学研究室(
    慶應義塾大学医学部精神神経科 計算論的精神医学研究室(

Other Affiliation 【 Display / hide

  • 桜ヶ丘記念病院精神科, 非常勤医師

  • 東京大学大学院工学系研究科精密工学専攻, 客員研究員

  • 早稲田大学大学院(文学研究科), 非常勤講師

  • 駒木野病院精神医学行動科学研究所, 客員研究員

Academic Background 【 Display / hide

  • 1984.04



  • 1989.04

    Keio University, 医学部


  • 2006.04

    Keio University, 大学院医学研究科

    Doctoral course

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, 2012.03

Licenses and Qualifications 【 Display / hide

  • 医師免許(厚生労働省), 1995.05

  • 精神保健指定医(厚生労働省), 2000.12

  • 精神科専門医(日本精神神経学会), 2009.10

  • 精神科専門医制度指導医(日本精神神経学会), 2006.04

  • 柔道初段(講道館), 1986.03

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Books 【 Display / hide

  • 学術会議叢書26・社会脳から心を探る-自己と他者をつなぐ社会適応の脳内メカニズム

    今水寛・大木紫・前田貴記・村田哲, 日本学術協力財団, 2020.02

    Scope: 社会脳から見た自己と身体意識,  Contact page: 147-166

  • 身体性システムとリハビリテーションの科学2 身体認知

    ''Maeda,'' Takaki, 東京大学出版会, 2018.12

    Scope: 精神疾患における身体意識の異常

  • 「精神科レジデントマニュアル」

    ''Maeda,'' Takaki, 医学書院, 2017.03

    Scope: 統合失調症

  • 「精神科レジデントマニュアル」

    ''Maeda,'' Takaki, 医学書院, 2017.03

    Scope: 幻覚・妄想

  • 「精神科レジデントマニュアル」

    ''Maeda,'' Takaki, 医学書院, 2017.03

    Scope: 希死念慮を伴う妄想―微小妄想など

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Papers 【 Display / hide

  • 時空間的なスマートフォンログ分析に基づく利用者のストレス推定手法

    濱谷尚志, 落合桂一, 山本直樹, 深澤佑介, 木本勝敏, 上西康平, 太田順, 寺澤悠理, 沖村宰, 前田貴記

    情報処理学会論文誌 62 ( 4 ) 1 - 15 2021.04


  • Influence of Stochastic Resonance on Manual Dexterity in Children With Developmental Coordination Disorder: A Double-Blind Interventional Study

    Satoshi Nobusako, Michihiro Osumi, Atsushi Matsuo, Emi Furukawa, Takaki Maeda, Sotaro Shimada, Akio Nakai, Shu Morioka

    Frontiers in Neurology (Frontiers in Neurology)  12   626608 2021.03


     View Summary

    Background: There is increasing evidence that the stochastic resonance (SR) phenomenon provided by subthreshold mechanical noise stimulation improves the sensory-motor system. However, the effect of SR on children with developmental coordination disorder (DCD) is unclear. The purpose of this study was to assess whether SR activated by subthreshold vibrotactile noise stimulation of the wrist influences manual dexterity in children with DCD. Methods: A double-blind interventional study was conducted. Participants were 30 children (age: 9.3 ± 1.44 years, range 6–11 years; 27 male, three female; 25 right-handed, five left-handed) meeting DCD diagnostic criteria in DSM-5. The manual dexterity test was administered the day before SR intervention (baseline-data). SR was elicited using subthreshold vibrotactile noise stimulation at 60% of the vibrotactile threshold measured at the wrist. SR was delivered two times and the manual dexterity test was administered during each SR stimulation block (SR-on condition) and after each SR stimulation block (SR-off), for a total of four measurements. Target outcomes were the component score, the standard score, and the percentile score of the manual dexterity test. Results: The manual dexterity test scores in the SR-on condition were significantly improved compared to scores at the baseline and in the SR-off condition (p < 0.001). Conclusions: The present study showed that subthreshold noise stimulation eliciting SR significantly improved manual dexterity outcomes in children with DCD during stimulation but not after stimulation. Future studies will need to investigate the carry-over effects of SR stimulation.

  • Increased visual bias in children with developmental coordination disorder: Evidence from a visual-tactile temporal order judgment task

    Satoshi Nobusako, Michihiro Osumi, Emi Furukawa, Akio Nakai, Takaki Maeda, Shu Morioka

    Human Movement Science (Human Movement Science)  75   102743 2020.12

    Accepted,  ISSN  0167-9457

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    © 2020 Elsevier B.V. Background: Previous studies have suggested that children with developmental coordination disorder (DCD) rely heavily on vision to perform movements, which may contribute to their clumsy movements. However, few studies have objectively and quantitatively investigated the perceptual biases of children with DCD. Methods: A visual-tactile temporal order judgment (TOJ) task was used to measure and compare the perceptual biases of 19 children with DCD and 19 age- and sex-matched typically developing children. The point of subjective equality, which demonstrates when “visual first” and “tactile first” judgment probabilities are equal (50%), obtained by analyzing the results of the visual-tactile TOJ task, was used as an indicator of perceptual biases. Further, variables (age and manual dexterity in all participants; motor function, autism spectrum disorder and attention-deficit hyperactivity disorder traits, and depressive symptoms in children with DCD) associated with perceptual biases were examined with correlation analysis. Results: Children with DCD had significantly stronger visual bias than typically developing children. Overall correlation analysis showed that increased visual bias was significantly correlated with poor manual dexterity. Conclusion: Children with DCD had a strong visual bias, which was associated with poor manual dexterity.

  • Altered sense of agency in children with developmental coordination disorder

    Satoshi Nobusako, Michihiro Osumi, Emi Furukawa, Akio Nakai, Takaki Maeda, Shu Morioka

    Research in Developmental Disabilities (Research in Developmental Disabilities)  107   103794 2020.10

    Accepted,  ISSN  08914222

     View Summary

    © 2020 Elsevier Ltd Background: There is increasing evidence that children with developmental coordination disorder (DCD) have deficits in sensory-motor integration, but it is unclear whether the sense of agency (SoA) generated by sensory-motor integration is altered. Aims: To investigate whether there is a difference in the time window for SoA between children with DCD and typically developing (TD) children. Methods and Procedures: An agency attribution task was used to quantitatively measure and compare the time window for SoA in 15 children with DCD and 46 children in the TD group. Variables that correlated with the time window for SoA were also examined in both groups of children. Outcomes and Results: The time window for SoA was significantly extended in children with DCD compared to TD children. The time window for SoA in TD children was significantly associated with manual dexterity, whereas the time window for SoA in children with DCD was significantly associated with depressive tendency. Conclusions and Implications: The time window for SoA is altered in children with DCD. The present results suggest that there may be a bidirectional relationship between an internal model deficit and depressive tendency and SoA in children with DCD.

  • Statistical Learning model of the Sense of Agency

    Shiro Yano,Yoshikatsu Hayashi,Yuki Murata,Hiroshi Imamizu,Takaki Maeda,Toshiyuki Kondo

    Frontiers in Psychology (Frontiers in Psychology)  11   539957 2020.10


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    © Copyright © 2020 Yano, Hayashi, Murata, Imamizu, Maeda and Kondo. A sense of agency (SoA) is the experience of subjective awareness regarding the control of one's actions. Humans have a natural tendency to generate prediction models of the environment and adapt their models according to changes in the environment. The SoA is associated with the degree of the adaptation of the prediction models, e.g., insufficient adaptation causes low predictability and lowers the SoA over the environment. Thus, identifying the mechanisms behind the adaptation process of a prediction model related to the SoA is essential for understanding the generative process of the SoA. In the first half of the current study, we constructed a mathematical model in which the SoA represents a likelihood value for a given observation (sensory feedback) in a prediction model of the environment and in which the prediction model is updated according to the likelihood value. From our mathematical model, we theoretically derived a testable hypothesis that the prediction model is updated according to a Bayesian rule or a stochastic gradient. In the second half of our study, we focused on the experimental examination of this hypothesis. In our experiment, human subjects were repeatedly asked to observe a moving square on a computer screen and press a button after a beep sound. The button press resulted in an abrupt jump of the moving square on the screen. Experiencing the various stochastic time intervals between the action execution (button-press) and the consequent event (square jumping) caused gradual changes in the subjects' degree of their SoA. By comparing the above theoretical hypothesis with the experimental results, we concluded that the update (adaptation) rule of the prediction model based on the SoA is better described by a Bayesian update than by a stochastic gradient descent.

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Presentations 【 Display / hide

  • 自己意識の神経科学:sense of agency研究から挑む統合失調症の病態論および治療回復論


    第15回日本統合失調症学会 (WEB開催) , 2021.04, Symposium, Workshop, Panelist (nomination)

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     自己意識は主観的体験であるため実証的に扱うことは方法論的に困難であったが、近年、Sense of Agency:SoA(主体感)というパラダイムで、自己意識の神経科学が発展してきている。SoAとは、自己が行為の「主体(agent)」であるという意識のことである。SoAが重要であるのは、“行為”に伴う体験ということで、こころ(主観)と身体(客観)とが重なる現象と言え、精神病理学と生物学との連繋が可能となるからである。
     統合失調症の診断基準において、自我障害はDSM5では特別視されなくなってしまったものの、ICD11では引き続き採用されているだけでなく、disturbances in self-experienceという表現を用いて、むしろ強調されるようになっている。このように両診断基準で自我障害についての見解が分かれる事態となっていたり、またRDoCにおいてはSelfに関するディメンジョンにおいてAgencyが採用されていることからも、自我障害についての議論は統合失調症の症状論・病態論のためには避けて通れないテーマといえよう。  
     我々は、ヒトのSoAの神経基盤である“Agency Network”として、島皮質、頭頂葉下部領域(縁上回および角回)、皮質正中内側部構造(後部帯状回および楔前部)などの皮質領域に加え、尾状核頭の重要性について明らかにしてきたが、統合失調症では、この“Agency Network”のconnectivityに何らかの異常を来しているとの仮説のもと、connectivityを回復させようという治療方略がありうるものと考えている。具体的な方略として、我々が考案したSoA task(Keio method)を改変し、「Self vs. Non-Self」というSoA判断について正解・不正解のフィードバックを行うことで、“SoAの精度”を向上させようという認知リハビリテーションを進めている。“SoAの精度”を向上させるということは、SoA成立のための予測モデルとしてのフォワードモデルの精度を高めることであり、“Agency Network”の機能再編成を目指すものである。言うなれば、体験から脳へと介入しようとする試みである。SoAの認知リハビリテーションによって、“Agency Network”のconnectivityがどのように再編成されるかについて、今後、resting state f-MRIによるconnectivity解析によって検証していきたい。

  • 神経疾患・精神疾患の治療回復論:主体性(agency)の”超適応”という観点から


    第50回日本臨床神経生理学会学術大会 (WEB開催) , 2020.11, Symposium, Workshop, Panelist (nomination)

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  • 精神科臨床における成人の自閉症スペクトラム障害、ADHD、 学習障害、発達性協調運動障害などの発達障害


    「小児の成長期における脳機能と運動の発達に関する多領域共同研究」 (自然科学研究機構・生理学研究所) , 2020.11, Symposium, Workshop, Panelist (nomination)

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  • 人間と人工物とのありうべき関係~「主体性」を護り、かつ創造していくために~(精神医学の立場から)


    第3回人工物工学コロキウム「⼈・もの・社会の共存を⽬指す⼈⼯物工学」 (WEB開催) , 2020.11, Symposium, Workshop, Panelist (nomination), 東京大学大学院工学系研究科・人工物工学研究センター

  • 精神医学におけるこころと身体 :自然科学と精神病理学の連繋のための方法論とは?


    第43回日本精神病理学会総会 (WEB開催) , 2020.10, Oral Presentation(general)

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    ・前田貴記:精神病理学と生物学の連繋.精神科治療学 34(6):613-619, 2019.

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 主体感の探索と利用:その行動メカニズム、神経基盤、および数理モデル


    文部科学省, 基盤研究(B), Research grant, Co-investigator

  • 超適応 Hyper-Adaptability


    文部科学省, 新学術領域研究(研究領域提案型), Research grant, Principal Investigator

  • 機械学習によるスマートフォンログからストレス状態を推定する技術の開発


    NTTdocomo株式会社, Principal Investigator

  • 脳内身体表現の変容機構の理解と制御


    文部科学省, 新学術領域研究(研究領域提案型), Research grant, Co-investigator

Works 【 Display / hide



    Artistic Activity

  • AGENCY TUNER for Researchers (JPN)


    Artistic Activity

  • AGENCY TUNER for Researchers (US)


    Artistic Activity



    Artistic Activity

Intellectual Property Rights, etc. 【 Display / hide

  • 統合失調症を診断するためのデータを取得する方法、装置、プログラム及び記録媒体

    Registration No.: 第6560765号  2019.07

    Patent, Single, National application

  • サーバ装置

    Registration No.: 第6876295号  2021.04

    Patent, Joint, National application

  • 教師データ生成装置

    Registration No.: 第6935863号  2021.08

    Patent, Joint, National application

  • 端末ロック・アプリロック解除に基づいた記憶力の推定システム

    Application No.: 2021-038546  2021.03 

    Patent, Joint, National application

  • 直感的操作を誘発するユーザインターフェース(UI)を伴うタスクに基づいたタスク実行抑制機能の推定システム

    Application No.: 2021-038571  2021.03 

    Patent, Joint, National application

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Courses Taught 【 Display / hide

  • EEP:early exposure program (慶應医学部第1学年)

    2021, Laboratory work/practical work/exercise

  • 神経科学特殊研究-神経科学と精神医学の接点(慶應文学部大学院)


  • 精神医学臨床実習「精神科診断学」講義(慶應医学部第5・6学年)

    2021, Full academic year, Laboratory work/practical work/exercise

  • 精神病理学(早稲田大学大学院文学研究科)

    2021, Full academic year