Maeda, Takaki

写真a

Affiliation

School of Medicine, Department of Neuropsychiatry (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor
Page Top ▲

Profile Summary 【 Display / hide 】

  • 慶應義塾大学医学部精神神経科　精神病理学研究室（http://psy.keiomed.jp/byouri.html）
    慶應義塾大学医学部精神神経科　計算論的精神医学研究室（http://psy.keiomed.jp/computation.html）

Page Top ▲

Other Affiliation 【 Display / hide 】

  • 桜ヶ丘記念病院精神科, 非常勤医師

  • 早稲田大学大学院文学研究科, 非常勤講師

  • 駒木野病院精神医学行動科学研究所, 客員研究員

Page Top ▲

Academic Background 【 Display / hide 】

  • 1984.04
    -
    1987.03

    都立白鷗高等学校

    Other

  • 1989.04
    -
    1995.03

    Keio University, 医学部

    University

  • 2006.04
    -
    2010.03

    Keio University, 大学院医学研究科

    Doctoral course

Page Top ▲

Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, 2012.03

Page Top ▲

Licenses and Qualifications 【 Display / hide 】

  • 医師免許（厚生労働省）, 1995.05

  • 精神保健指定医（厚生労働省）, 2000.12

  • 精神科専門医（日本精神神経学会）, 2009.10

  • 精神科専門医制度指導医（日本精神神経学会）, 2006.04

  • 柔道初段（講道館）, 1986.03

display all >>

Page Top ▲
 

Books 【 Display / hide 】

  • 精神医学領域の論文を読みこなすキーワード100！

    新興医学出版社, 2023

    Scope: 前頭前野

  • 学術会議叢書26・社会脳から心を探る－自己と他者をつなぐ社会適応の脳内メカニズム

    今水寛・大木紫・前田貴記・村田哲, 日本学術協力財団, 2020.02

    Scope: 社会脳から見た自己と身体意識,  Contact page： 147-166

  • 身体性システムとリハビリテーションの科学２ 身体認知

    ''Maeda,'' Takaki, 東京大学出版会, 2018.12

    Scope: 精神疾患における身体意識の異常

  • 「精神科レジデントマニュアル」

    ''Maeda,'' Takaki, 医学書院, 2017.03

    Scope: 統合失調症

  • 「精神科レジデントマニュアル」

    ''Maeda,'' Takaki, 医学書院, 2017.03

    Scope: 幻覚・妄想

display all >>

Page Top ▲

Papers 【 Display / hide 】

  • Sense of Agency研究による精神病理学と生物学の連繋 ：統合失調症の病態理解と治療方法確立を目指して

    前田貴記、大井博貴

    日本生物学的精神医学会誌 36 ( 3 ) in press 2025.09

  • 妄想知覚において現れる“他者”とは誰れか？：「異質性（Fremdheit）」の浸潤

    前田貴記

    精神神経学雑誌 in press 2025

    Accepted

  • Hierarchical Analysis of the Sense of Agency in Schizophrenia: Motor Control, Control Detection, and Self-attribution.

    Hiroki Oi, Wen Wen, Acer Chang, Hiroyuki Uchida, Takaki Maeda

    Schizophrenia 10 ( 1 ) 79 2024.09

    Accepted

    　View Summary

    The sense of agency refers to the feeling of initiating and controlling one’s actions and their resulting effects on the external environment. Previous studies have uncovered behavioral evidence of excessive self-attribution and, conversely, a reduction in the sense of agency in patients with schizophrenia. We hypothesize that this apparent paradox is likely to result from impairment in lower-level processes underlying the sense of agency, combined with a higher-level compensational bias. The present study employed three behavioral tasks utilizing the same stimuli and experimental design to systematically evaluate multiple factors that influence the sense of agency, including motor control, sensorimotor processing, and self-attribution. Participants’ real-time mouse movements were combined with prerecorded motions of others in ratios of 30/70, 55/45, or 80/20, with an additional angular bias of either 0° or 90°. Twenty-six patients with schizophrenia and 27 health control volunteers participated in the three tasks. Patients with schizophrenia performed significantly worse in the reaching and control detection tasks than healthy controls. However, their self-attribution in the control judgment task was comparable to that of the healthy controls. Patients with schizophrenia were impaired in motor control components and in the detection of control using sensorimotor information, but their evaluation of agency remained relatively less affected. This underscores the importance of distinguishing between different subcomponents when addressing the abnormal sense of agency in patients with schizophrenia. Subsequent cluster analysis revealed that the combined task performance accurately distinguished between the patients and healthy control participants.

  • Developmental changes in the time window for the explicit sense of agency experienced across the lifespan.

    Satoshi Nobusako, Yusaku Takamura, Kyohei Koge, Michihiro Osumi, Takaki Maeda, Shu Morioka

    Cognitive Development 72   101503 2024

    Accepted,  ISSN  08852014

    　View Summary

    Sense of agency (SoA) is the subjective experience of individuals that they are initiators and controllers of their own actions, but it is not known how the time window for SoA changes developmentally over the lifetime. The present study examined developmental changes in the time window for SoA in school-age children (6–12 years), adolescents (16–18 years), young adults (20–25 years), adults (28–64 years), and older adults (65–83 years). The current results show that the time window for SoA is longer in young adults than in school-age children, adolescents, adults, and older adults, suggesting that young adulthood may be an important period of developmental change in the time window for SoA across the lifespan.

  • Aberrant sense of agency induced by delayed prediction signals in schizophrenia: a computational modeling study

    Okimura T., Maeda T., Mimura M., Yamashita Y.

    Schizophrenia (Schizophrenia)  9 ( 1 ) 72 2023.12

    　View Summary

    Aberrant sense of agency (SoA, a feeling of control over one’s own actions and their subsequent events) has been considered key to understanding the pathology of schizophrenia. Behavioral studies have demonstrated that a bidirectional (i.e., excessive and diminished) SoA is observed in schizophrenia. Several neurophysiological and theoretical studies have suggested that aberrancy may be due to temporal delays (TDs) in sensory-motor prediction signals. Here, we examined this hypothesis via computational modeling using a recurrent neural network (RNN) expressing the sensory-motor prediction process. The proposed model successfully reproduced the behavioral features of SoA in healthy controls. In addition, simulation of delayed prediction signals reproduced the bidirectional schizophrenia-pattern SoA, whereas three control experiments (random noise addition, TDs in outputs, and TDs in inputs) demonstrated no schizophrenia-pattern SoA. These results support the TD hypothesis and provide a mechanistic understanding of the pathology underlying aberrant SoA in schizophrenia.

display all >>

Page Top ▲

Presentations 【 Display / hide 】

  • Aberrant sense of agency in schizophrenia: toward understanding pathophysiology and establishing therapeutic methodology

    Takaki Maeda, Hiroki Oi

    Neuro2024 (Hakata) , 

    2024.07
    , 

    Symposium, workshop panel (nominated)

    　View Summary

    We have studied psychopathology of schizophrenia from the standpoint of abnormal sense of agency(SoA). We developed originl experimental settings where temporal or spatial biases were introduced in order to evaluate the SoA. Moreover, we evaluated hierarchical levelof SoA emergence (bottom-up～top-down process) , and have shown that pathophysiology of schizophrenia would be in the level of bottom up process. Several neurophysiological and theoretical studies have suggested that aberrancy may be due to temporal delays in sensory-motor prediction signals. We have established methodology to intervene learning (updating) mechanisms of the internal prediction model under the delayed prediction signals using original digital device as a cognitive rehabilitation for schizophrenia.

  • 統合失調症における自我障害から考える基本病態仮説 ：sense of agency研究によるdelayed prediction signal仮説

    前田貴記

    第42回日本精神科診断学会, 

    2023.09
    , 

    Symposium, workshop panel (nominated)

  • 妄想知覚の今日的意義

    前田貴記

    第119回日本精神神経学会学術総会 (横浜) , 

    2023.06
    , 

    Symposium, workshop panel (nominated)

  • 自我障害に現れる“他者”の問題：“他者”とは誰れか？

    前田貴記

    日本精神病理学会　第45回大会, 

    2022.09
    , 

    Symposium, workshop panel (nominated)

  • 統合失調症に合併する肥満・糖尿病予防ガイドを使用した経験から

    前田貴記

    第118回日本精神神経学会学術総会, 

    2022.06
    , 

    Symposium, workshop panel (public)

display all >>

Page Top ▲

Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 超適応 Hyper-Adaptability

    2022.04
    -
    2024.03

    文部科学省, 新学術領域研究（研究領域提案型）, Research grant, Principal investigator

  • 主体感の精度向上のための認知リハビリテーションの開発と臨床応用

    2022.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 新学術領域研究（研究領域提案型）, Principal investigator

  • 主体感の探索と利用：その行動メカニズム、神経基盤、および数理モデル

    2021.04
    -
    2024.03

    文部科学省, 基盤研究(B), Research grant, Coinvestigator(s)

  • 超適応 Hyper-Adaptability

    2020.04
    -
    2022.03

    文部科学省, 新学術領域研究（研究領域提案型）, Research grant, Principal investigator

  • 機械学習によるスマートフォンログからストレス状態を推定する技術の開発

    2016
    -
    2022.03

    NTTdocomo株式会社, Principal investigator

display all >>

Page Top ▲

Works 【 Display / hide 】

display all >>

Page Top ▲

Intellectual Property Rights, etc. 【 Display / hide 】

  • 統合失調症を診断するためのデータを取得する方法、装置、プログラム及び記録媒体

    Date issued： 第6560765号 

    Date registered： 2019.07

    Patent, Single

  • 心身状態評価のための方法、プログラム、及びデバイス

    Date issued： 第7355909号 

    Date registered： 2023.09

    Patent, Single

  • サーバ装置

    Date issued： 第6876295号 

    Date registered： 2021.04

    Patent, Joint

  • 教師データ生成装置

    Date issued： 第6935863号 

    Date registered： 2021.08

    Patent, Joint

  • 推定処理装置及び推定モデル構築装置

    Date issued： 第7297236号 

    Date registered： 2023.06

    Patent, Joint

display all >>

Page Top ▲
 

Courses Taught 【 Display / hide 】

  • EEP:early exposure program （慶應医学部第１学年）

    2025, Laboratory work/practical work/exercise

  • 精神病理学（早稲田大学大学院文学研究科）

    2025, Full academic year

  • 精神医学臨床実習「精神科診断学」講義（慶應医学部第５・６学年）

    2025, Full academic year, Laboratory work/practical work/exercise

  • LECTURE SERIES, PSYCHIATRY

    2025

  • LECTURE SERIES, PSYCHIATRY

    2025

display all >>

Page Top ▲