論文 - 平野　仁一

Thalamic volume, resting-state activity, and their association with the efficacy of electroconvulsive therapy

Takamiya A., Kishimoto T., Liang K.c., Terasawa Y., Nishikata S., Tarumi R., Sawada K., Kurokawa S., Hirano J., Yamagata B., Mimura M.

Journal of Psychiatric Research （Journal of Psychiatric Research）  117   135 - 141 2019年10月

ISSN  00223956

　概要を見る

Electroconvulsive therapy (ECT) is the most effective antidepressant treatment. Biological predictors of clinical outcome to ECT are valuable. We aimed to examine multimodal magnetic resonance imaging (MRI) data that correlates to the efficacy of ECT. Structural and resting-state functional MRI data were acquired from 46 individuals (25 depressed individuals who received ECT, and 21 healthy controls). Whole-brain grey matter volume (GMV) and fractional amplitude of low frequency fluctuations (fALFF) were investigated to identify brain regions associated with post-ECT Hamilton Depression Rating Scale (HAM-D) total scores. GMV and fALFF values were compared with those in healthy controls using analysis of covariance (ANCOVA). Remission was defined by HAM-D ≤7. A multiple regression analysis revealed that pretreatment smaller GMV in the left thalamus was associated with worse response to ECT (i.e. higher post-ECT HAM-D). Pretreatment higher fALFF in the right anterior insula, and lower fALFF in the left thalamus and the cerebellum were associated with worse outcomes. The left thalamus was identified in both GMV and fALFF analyses. Nonremitters showed significantly smaller thalamic GMV compared to remitters and controls. We found that pretreatment thalamic volume and resting-state activity were associated with the efficacy of ECT. Our results highlight the importance of the thalamus as a possible biological predictor and its role in the underlying mechanisms of ECT action.

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Prolonged Post-Electroconvulsive Therapy Delirium Controlled With Donepezil.

Takamiya A, Sawada K, Hirano J, Mimura M, Kishimoto T

The journal of ECT 35 （ 3 ） e29 - e30 2019年09月

ISSN  1095-0680

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Brain functional alterations observed 4-weekly in major depressive disorder following antidepressant treatment

Yamagata B., Yamanaka K., Takei Y., Hotta S., Hirano J., Tabuchi H., Mimura M.

Journal of Affective Disorders （Journal of Affective Disorders）  252   25 - 31 2019年06月

ISSN  01650327

　概要を見る

Background: Major depressive disorder (MDD) is a heterogeneous condition. Identifying the brain responses to antidepressant treatment is of particular interest as these may represent potential neural networks related to treatment response, forming one aspect of the biological markers of MDD. Near-infrared spectroscopy (NIRS) is suitable for repeated measurements with short intervals because of its noninvasiveness, and can provide detailed time courses of functional alterations in prefrontal regions. Methods: We conducted a 12-week longitudinal study to explore prefrontal hemodynamic changes at 4-week intervals following sertraline treatment in 11 medication-naïve participants with MDD using 52-channel NIRS. Results: While all participants achieved remission after treatment, intra-class correlation coefficient of oxygenated hemoglobin [oxy-Hb] values throughout the 12-week observation was moderate at the spatially and temporally contiguous cluster located in the left inferior frontal and temporal gyri. There was a significant negative correlation between mean [oxy-Hb] values in the significant cluster at 4 weeks and changes in Hamilton Rating Scale for Depression total score from 4 to 8 weeks (r = −0.73, P = 0.011) and from 4 to 12 weeks (r = −0.63, P = 0.039). Limitations: Without healthy controls for comparison, we were unable to fully evaluate whether improvement of [oxy-Hb] activations after treatment in MDD reached normal levels or not. Conclusion: Our NIRS findings of detailed prefrontal hemodynamic alterations over short interval observations such as 4 weeks may have revealed potential trait marker for MDD and biological maker for predicting clinical response to sertraline treatment in MDD.

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Structural Magnetic Resonance Imaging for Individual Predictions for Electroconvulsive Therapy Remission Utilizing Machine Learning

Takamiya Akihiro, Liang Kuo-ching, Nishikata Shiro, Kurokawa Shunya, Sawada Kyosuke, Hirano Jinichi, Yamagata Bun, Mimura Masaru, Kishimoto Taishiro

BIOLOGICAL PSYCHIATRY 85 （ 10 ） S263 - S263 2019年05月

ISSN  0006-3223

Electroconvulsive therapy modulates resting-state EEG oscillatory pattern and phase synchronization in nodes of the default mode network in patients with depressive disorder

Takamiya A., Hirano J., Yamagata B., Takei S., Kishimoto T., Mimura M.

Frontiers in Human Neuroscience （Frontiers in Human Neuroscience）  13   1 2019年02月

ISSN  1662-5161

　概要を見る

Introduction: Electroconvulsive therapy (ECT) has antidepressant effects, but it also has possible cognitive side effects. The effects of ECT on neuronal oscillatory pattern and phase synchronization, and the relationship between clinical response or cognitive change and electroencephalogram (EEG) measurements remain elusive. Methods: Individuals with unipolar depressive disorder receiving bilateral ECT were recruited. Five minutes of resting, eyes-closed, 19-lead EEG recordings were obtained before and after a course of ECT. Non-overlapping 60 artifact-free epocs of 2-s duration were used for the analyses. We used exact low resolution electromagnetic tomography (eLORETA) to compute the whole-brain three-dimensional intracortical distribution of current source density (CSD) and phase synchronization among 28 regions-of-interest (ROIs). Paired t-tests were used to identify cortical voxels and connectivities showing changes after ECT. Montgomery Asberg Depression Rating Scale (MADRS) and Mini-Mental State Examination (MMSE) were used to evaluate the severity of depression and the global cognitive function. Correlation analyses were conducted to identify the relationship between changes in the EEG measurements and changes in MADRS or MMSE. Results: Thirteen depressed patients (five females, mean age: 58.4 years old) were included. ECT increased theta CSD in the anterior cingulate cortex (ACC), and decreased beta CSD in the frontal pole (FP), and gamma CSD in the inferior parietal lobule (IPL). ECT increased theta phase synchronization between the posterior cingulate cortex (PCC) and the anterior frontal cortex, and decreased beta phase synchronization between the PCC and temporal regions. A decline in beta synchronization in the left hemisphere was associated with cognitive changes after ECT. Conclusion: ECT modulated resting-state EEG oscillatory patterns and phase synchronization in central nodes of the default mode network (DMN). Changes in beta synchronization in the left hemisphere might explain the ECT-related cognitive side effects.

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Electroconvulsive Therapy Induces Age-Dependent Volume Increase in the Human Dentate Gyrus

Takamiya Akihiro, Chung Jun Ku, Plitman Eric, Chakravarty Mallar, Sawada Kyosuke, Hirano Jinichi, Yamagata Bun, Graff-Guerrero Ariel, Kishimoto Taishiro, Mimura Masaru

BIOLOGICAL PSYCHIATRY 83 （ 9 ） S188 - S188 2018年05月

ISSN  0006-3223

Frontal and temporal cortical functional recovery after electroconvulsive therapy for depression: A longitudinal functional near-infrared spectroscopy study.

Hirano J, Takamiya A, Yamagata B, Hotta S, Miyasaka Y, Pu S, Iwanami A, Uchida H, Mimura M

Journal of psychiatric research 91   26 - 35 2017年08月

ISSN  0022-3956

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Resilience and spirituality in patients with depression and their family members: A cross-sectional study.

Ozawa C, Suzuki T, Mizuno Y, Tarumi R, Yoshida K, Fujii K, Hirano J, Tani H, Rubinstein EB, Mimura M, Uchida H

Comprehensive psychiatry 77   53 - 59 2017年08月

ISSN  0010-440X

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Aberrant Spatial and Temporal Prefrontal Activation Patterns in Medication-Naïve Adults with ADHD.

Yamagata B, Takei Y, Itahashi T, Pu S, Hirano J, Mimura M, Iwanami A

Frontiers in psychiatry 8   274 2017年

ISSN  1664-0640

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Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study.

Kitahata R, Nakajima S, Uchida H, Hayashida T, Takahashi M, Nio S, Hirano J, Nagaoka M, Suzuki T, Jinno H, Kitagawa Y, Mimura M

Neuropsychiatric disease and treatment 13   2489 - 2496 2017年

ISSN  1176-6328

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High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study.

Takamiya A, Hirano J, Ebuchi Y, Ogino S, Shimegi K, Emura H, Yonemori K, Shimazawa A, Miura G, Hyodo A, Hyodo S, Nagai T, Funaki M, Sugihara M, Kita M, Yamagata B, Mimura M

NeuroImage. Clinical 14   648 - 655 2017年

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A longitudinal functional neuroimaging study in medication-naïve depression after antidepressant treatment.

Tomioka H, Yamagata B, Kawasaki S, Pu S, Iwanami A, Hirano J, Nakagome K, Mimura M

PloS one 10 （ 3 ） e0120828 2015年

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A review on schizophrenia and relapse--a quest for user-friendly psychopharmacotherapy.

Suzuki T, Uchida H, Takeuchi H, Tsuboi T, Hirano J, Mimura M

Human psychopharmacology 29 （ 5 ） 414 - 26 2014年09月

ISSN  0885-6222

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The impact of prolactin-raising antipsychotics on bone mineral density in patients with schizophrenia: findings from a longitudinal observational cohort.

Takahashi T, Uchida H, John M, Hirano J, Watanabe K, Mimura M, Correll CU, Kishimoto T

Schizophrenia research 147 （ 2-3 ） 383 - 6 2013年07月

ISSN  0920-9964

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An open-label study of algorithm-based treatment versus treatment-as-usual for patients with schizophrenia.

Hirano J, Watanabe K, Suzuki T, Uchida H, Den R, Kishimoto T, Nagasawa T, Tomita Y, Hara K, Ochi H, Kobayashi Y, Ishii M, Fujita A, Kanai Y, Goto M, Hayashi H, Inamura K, Ooshima F, Sumida M, Ozawa T, Sekigawa K, Nagaoka M, Yoshimura K, Konishi M, Inagaki A, Saito T, Motohashi N, Mimura M, Okubo Y, Kato M

Neuropsychiatric disease and treatment 9   1553 - 64 2013年

ISSN  1176-6328

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Dental conditions in inpatients with schizophrenia: a large-scale multi-site survey.

Tani H, Uchida H, Suzuki T, Shibuya Y, Shimanuki H, Watanabe K, Den R, Nishimoto M, Hirano J, Takeuchi H, Nio S, Nakajima S, Kitahata R, Tsuboi T, Tsunoda K, Kikuchi T, Mimura M

BMC oral health 12   32 2012年08月

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A cross-sectional study of plasma risperidone levels with risperidone long-acting injectable: implications for dopamine D2 receptor occupancy during maintenance treatment in schizophrenia.

Ikai S, Remington G, Suzuki T, Takeuchi H, Tsuboi T, Den R, Hirano J, Tsunoda K, Nishimoto M, Watanabe K, Mimura M, Mamo D, Uchida H

The Journal of clinical psychiatry 73 （ 8 ） 1147 - 52 2012年08月

ISSN  0160-6689

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Electroconvulsive therapy and meningioma: a brief review.

Teraishi T, Nakatake M, Hirano J, Ide M, Kuwahara T, Nomura S

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 32 （ 2 ） 57 - 61 2012年04月

ISSN  1340-2544

Is switching antidepressants following early nonresponse more beneficial in acute-phase treatment of depression?: a randomized open-label trial.

Nakajima S, Uchida H, Suzuki T, Watanabe K, Hirano J, Yagihashi T, Takeuchi H, Abe T, Kashima H, Mimura M

Progress in neuro-psychopharmacology & biological psychiatry 35 （ 8 ） 1983 - 9 2011年12月

ISSN  0278-5846

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Clinical and demographic characteristics associated with postural instability in patients with schizophrenia.

Koreki A, Tsunoda K, Suzuki T, Hirano J, Watanabe K, Kashima H, Uchida H

Journal of clinical psychopharmacology 31 （ 1 ） 16 - 21 2011年02月

ISSN  0271-0749

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