論文 - 田中　伸之

The Prognostic Significance of Vasohibin-1 Expression in Patients with Upper Urinary Tract Urothelial Carcinoma

Miyazaki, Yasumasa, Kosaka, Takeo, Mikami, Shuji, Kikuchi, Eiji, Tanaka, Nobuyuki, Maeda, Takahiro, Ishida, Masaru, Miyajima, Akira, Nakagawa, Ken, Okada, Yasunori, Sato, Yasufumi, Oya, Mototsugu

CLINICAL CANCER RESEARCH 18 （ 15 ） 4145 - 4153 2012年08月

研究論文（学術雑誌）,  ISSN  1078-0432

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Three cases of granulocyte colony-stimulating factor-producing urinary upper tract carcinomas

Shirakawa, Hiroshi, Kikuchi, Eiji, Mikami, Shuji, Fukamachi, Shigeru, Miyazaki, Yasumasa, Tanaka, Nobuyuki, Miyajima, Akira, Oya, Mototsugu

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 46 （ 2 ） 136 - 141 2012年04月

研究論文（学術雑誌）,  ISSN  0036-5599

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Pelvic congenital arteriovenous malformation diagnosed by transrectal ultrasonography: A case report

Suzuki, Kenjiro, Tanaka, Nobuyuki, Ebine, Takashi, Momma, Tetsuo

CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL 6 （ 2 ） E61 - E63 2012年04月

研究論文（学術雑誌）,  ISSN  1911-6470

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Regulation of Monocyte Chemoattractant Protein-1 Through Angiotensin II Type 1 Receptor in Prostate Cancer

Shirotake, Suguru, Miyajima, Akira, Kosaka, Takeo, Tanaka, Nobuyuki, Kikuchi, Eiji, Mikami, Shuji, Okada, Yasunori, Oya, Mototsugu

AMERICAN JOURNAL OF PATHOLOGY 180 （ 3 ） 1008 - 1016 2012年03月

研究論文（学術雑誌）,  ISSN  0002-9440

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Preoperative Hydronephrosis: Independent Predictor for Changes in Renal Function Following Nephroureterectomy

Hoshino, Katsura, Kikuchi, Eiji, Tanaka, Nobuyuki, Akita, Hirotaka, Ito, Yujiro, Miyajima, Akira, Jinzaki, Masahiro, Oya, Mototsugu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42 （ 3 ） 202 - 207 2012年03月

研究論文（学術雑誌）,  ISSN  0368-2811

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Prognonstic impact of renin-angiotensin system blockade in localised upper-tract urothelial carcinoma

Tanaka N., Miyajima A., Kikuchi E., Matsumoto K., Hagiwara M., Ide H., Kosaka T., Masuda T., Nakamura S., Oya M.

British Journal of Cancer 106 （ 2 ） 290 - 296 2012年01月

ISSN  0007-0920

　概要を見る

<p>Background: The potential role of the renin-angiotensin system (RAS) in the promotion of tumour growth has been investigated, and the administration of RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), may improve disease control in malignancy. We investigated the prognostic impact of RAS inhibitors by analysing data from patients with upper-tract urothelial carcinoma (UTUC). Methods: A total of 279 patients who underwent nephroureterectomy for localised UTUC (pTa-3N0M0) were identified at our three institutions. We retrospectively investigated the prognostic outcomes following nephroureterectomy in patients administered or not administered ACEIs or ARBs. Results: The median follow-up period was 3.4 years. RAS inhibitors were administered to 48 patients (17.2%). Multivariate analysis showed that the appearance of pathological T3, positive lymphovascular invasion, and no RAS inhibitor administration (P=0.027 HR=3.14) were independent risk factors for a decrease in subsequent metastasis-free survival. The 5-year metastasis-free survival rate was 93.0% in patients who administered RAS inhibitors, and 72.8% in their counterparts who did not (P=0.008). Conclusion: The absence of RAS inhibitor administration was an independent risk factor for subsequent tumour metastasis in patients with localised UTUC. We propose RAS inhibitors may be a potent choice as an effective treatment following nephroureterectomy.</p>

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Low-dose docetaxel enhances the sensitivity of S-1 in a xenograft model of human castration resistant prostate cancer

Hasegawa, Masanori, Miyajima, Akira, Kosaka, Takeo, Yasumizu, Yota, Tanaka, Nobuyuki, Maeda, Takahiro, Shirotake, Suguru, Ide, Hiroki, Kikuchi, Eiji, Oya, Mototsugu

INTERNATIONAL JOURNAL OF CANCER 130 （ 2 ） 431 - 442 2012年01月

研究論文（学術雑誌）,  ISSN  0020-7136

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Acquired platinum resistance enhances tumour angiogenesis through angiotensin II type 1 receptor in bladder cancer

Tanaka N., Miyajima A., Kosaka T., Miyazaki Y., Shirotake S., Shirakawa H., Kikuchi E., Oya M.

British Journal of Cancer 105 （ 9 ） 1331 - 1337 2011年10月

研究論文（学術雑誌）,  ISSN  0007-0920

　概要を見る

<p>Background: We investigated the changes in reactive oxygen species (ROS) and angiogenesis through angiotensin II (Ang II) type 1 receptor (AT1R) after the development of acquired platinum resistance in bladder cancer. Methods: Four invasive human bladder cancer cell lines, T24, 5637, T24PR, and 5637PR, were used in vitro, whereas in vivo, T24 and T24PR cells were used. T24PR and 5637PR cells were newly established at our institution as acquired platinum-resistant sublines by culturing in cisplatin (CDDP)-containing conditioned medium for 6 months. Results: Ang II induced significantly higher vascular endothelial growth factor (VEGF) production in T24PR and 5637PR cells than in their corresponding parent cells in vitro, whereas Ang II induced a further increase in VEGF production. These platinum-resistant cells also showed significantly higher AT1R expression than their corresponding parent cells. ROS was also significantly upregulated in T24PR and 5637PR cells, whereas increased AT1R expression was significantly downregulated by scavenging free radicals. We also demonstrated the efficacy of AT1R blockade at suppressing the growth of platinum-resistant xenograft model. Conclusion: Our findings indicate a new molecular mechanism for upregulated AT1R signalling through increased ROS when tumours progressed after the CDDP-based regimens, and shed light on the importance of AT1R blockade for platinum-resistant bladder cancers.</p>

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Preoperative Hydronephrosis Grade Independently Predicts Worse Pathological Outcomes in Patients Undergoing Nephroureterectomy for Upper Tract Urothelial Carcinoma

Ito, Yujiro, Kikuchi, Eiji, Tanaka, Nobuyuki, Miyajima, Akira, Mikami, Shuji, Jinzaki, Masahiro, Oya, Mototsugu

JOURNAL OF UROLOGY 185 （ 5 ） 1621 - 1626 2011年05月

研究論文（学術雑誌）,  ISSN  0022-5347

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Angiotensin II Type 1 Receptor Expression and Microvessel Density in Human Bladder Cancer

Shirotake, Suguru, Miyajima, Akira, Kosaka, Takeo, Tanaka, Nobuyuki, Maeda, Takahiro, Kikuchi, Eiji, Oya, Mototsugu

UROLOGY 77 （ 4 ） 431 - 442 2011年04月

研究論文（学術雑誌）,  ISSN  0090-4295

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Frequency of Tumor Recurrence: A Strong Predictor of Stage Progression in Initially Diagnosed Nonmuscle Invasive Bladder Cancer

Tanaka, Nobuyuki, Kikuchi, Eiji, Matsumoto, Kazuhiro, Miyajima, Akira, Nakagawa, Ken, Oya, Mototsugu

JOURNAL OF UROLOGY 185 （ 2 ） 450 - 455 2011年02月

研究論文（学術雑誌）,  ISSN  0022-5347

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Cis-dichlorodiammineplatinum Upregulates Angiotensin II Type 1 Receptors through Reactive Oxygen Species Generation and Enhances VEGF Production in Bladder Cancer

Tanaka, Nobuyuki, Miyajima, Akira, Kosaka, Takeo, Shirotake, Suguru, Hasegawa, Masanori, Kikuchi, Eiji, Oya, Mototsugu

MOLECULAR CANCER THERAPEUTICS 9 （ 11 ） 2982 - 2992 2010年11月

研究論文（学術雑誌）,  ISSN  1535-7163

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Regulation of human dendritic cells by a novel specific nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin

Shinoda Kazunobu, Nakagawa Ken, Kosaka Takeo, Tanaka Nobuyuki, Maeda Takahiro, Kono Hidaka, Mizuno Ryuichi, Kikuchi Eiji, Miyajima Akira, Umezawa Kazuo, Oya Mototsugu

Human Immunology 71 （ 8 ） 763 - 770 2010年08月

研究論文（学術雑誌）,  ISSN  0198-8859

　概要を見る

<p>Regulation of antigen-presenting cells (APC) is crucial in controlling allograft rejection. Dendritic cells (DC) are the most potent APC and must mature to present antigens to T-cell receptors. During DC maturation, nuclear factor-κB (NF-κB) is a key transcriptional factor. We synthesized dehydroxymethylepoxyquinomicin (DHMEQ), which specifically inhibits the final step of nuclear translocation of activated NF-κB proteins and examined its immunoregulatory effects on human monocyte-derived DC (Mo-DC). Regulatory Mo-DC were generated by pretreatment with DHMEQ before LPS stimulation, which were termed dl-DC. DHMEQ pretreatment (5 μg/ml) completely inhibited nuclear translocation of activated NF-κB. DHMEQ significantly inhibited DC production of κproinflammatory cytokines (IL-6, TNF-α, and IL-12 p70) in a dose-dependent manner. IL-12 was most potently inhibited. However, IL-10 production by dl-DC was only moderately affected by DHMEQ. Although CD40 and the expression of HLA-DR (HLA-DR) expression on dl-DC was downregulated, CD80 and CD86 expression was moderately upregulated. Induction of T helper 1 cell responses was efficiently impaired by dl-DC. This confirmed that DHMEQ-treated Mo-DC exhibited immunoregulatory effects. These findings suggest that DHMEQ has potential as an immunosuppressive drug for human immune cells.</p>

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Late Recurrence and Progression in Non-muscle-invasive Bladder Cancers After 5-year Tumor-free Periods

Matsumoto, Kazuhiro, Kikuchi, Eiji, Horiguchi, Yutaka, Tanaka, Nobuyuki, Miyajima, Akira, Nakagawa, Ken, Nakashima, Jun, Oya, Mototsugu

UROLOGY 75 （ 6 ） 1385 - 1390 2010年06月

研究論文（学術雑誌）,  ISSN  0090-4295

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