論文 - 田中　伸之

Congenital Intrathoracic Kidney

Niwa, Naoya, Tanaka, Nobuyuki, Ueda, Soichiro, Masuda, Takeshi

INTERNAL MEDICINE 53 （ 17 ） 2019 - 2020 2014年

研究論文（学術雑誌）,  ISSN  0918-2918

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Third-line Hormonal Therapy to Treat Prostate Cancer Relapse after Initial and Second-line Hormonal Therapy: Report of 52 Cases and Literature Review

Matsumoto, Kazuhiro, Hagiwara, Masayuki, Hayakawa, Nozomi, Tanaka, Nobuyuki, Ito, Yujiro, Maeda, Takahiro, Ninomiya, Akiharu, Nagata, Hirohiko, Nakamura, So

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15 （ 8 ） 3645 - 3649 2014年

研究論文（学術雑誌）,  ISSN  1513-7368

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Independent predictors for bladder outcomes after treatment of intravesical recurrence following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma

Tanaka Nobuyuki, Kikuchi Eiji, Kanao Kent, Matsumoto Kazuhiro, Shirotake Suguru, Kobayashi Hiroaki, Miyazaki Yasumasa, Ide Hiroki, Obata Jun, Hoshino Katsura, Hayakawa Nozomi, Hagiwara Masayuki, Kosaka Takeo, Oyama Masafumi, Miyajima Akira, Momma Tetsuo, Nakagawa Ken, Jinzaki Masahiro, Hasegawa Shintaro, Nakajima Yosuke, Oya Mototsugu

Annals of Surgical Oncology 21 （ 9 ） 3151 - 3158 2014年

研究論文（学術雑誌）,  ISSN  1068-9265

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<p>Background. Few studies have described the clinical courses and outcomes in the bladder after treatment of intravesical recurrence after radical nephroureterectomy (RNU) in patients with primary upper tract urothelial carcinoma (UTUC). We investigated the indicators for predicting subsequent bladder outcomes after treatment of intravesical recurrence after RNU. Methods. A total of 241 patients with primary UTUC (pTa-4N0M0) who experienced intravesical recurrence after RNU were included. Of these patients, 101 (41.9 %) underwent Bacillus Calmette-Guérin treatments, whereas 49 (20.3 %) underwent intravesical chemotherapy. The median follow-up period after initial transurethral resection of the bladder tumor was 33 months. Relationships with bladder outcomes were analyzed by using multivariable analysis. Results. Ninety-six patients experienced intravesical recurrence, and bladder progression was observed in 13. Cumulative incidence rates of intravesical recurrence at 1 and 5 years after treatment of the first intravesical recurrence were 31.0 and 48.4 %, whereas those of bladder progression at 1 and 5 years thereafter were 2.4 and 8.0 %. Multivariate analysis showed that the number of recurrent tumors and pT1 tumors at the time of the first intravesical relapse were independent risk factors for subsequent intravesical recurrence. With respect to bladder progression, multivariate analysis showed that pT1 tumors, the appearance of concomitant carcinoma-in situ at the time of the first intravesical relapse, and the absence of the Bacillus Calmette-Guérin treatment were independent risk factors. Conclusions. This retrospective study presents a detailed picture of further bladder outcomes after intravesical recurrence after RNU in primary UTUC patients. The results may assist physicians to develop a more rational protocol in bladder surveillance.</p>

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Mucosa-associated lymphoid tissue lymphoma arising from the kidney

Niwa Naoya, Tanaka Nobuyuki, Horinaga Minoru, Hongo Hiroshi, Ito Yujiro, Watanabe Takuro, Masuda Takeshi

Journal of the Canadian Urological Association 8 （ 1-2 FEB ）  2014年

研究論文（学術雑誌）,  ISSN  1911-6470

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<p>Primary renal lymphoma is rare, and most are intermediate- and high-grade lymphomas of B-cell lineage, such as diffuse large B-cell or Burkitt lymphoma. We report a case of low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) arising from the kidney. Only a few cases of primary renal MALT lymphoma have been published.</p>

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Efficacy of estramustine phosphate sodium hydrate (EMP) monotherapy in castration-resistant prostate cancer patients: report of 102 cases and review of literature

Matsumoto, Kazuhiro, Tanaka, Nobuyuki, Hayakawa, Nozomi, Ezaki, Taisuke, Suzuki, Kenjiro, Maeda, Takahiro, Ninomiya, Akiharu, Nakamura, So

MEDICAL ONCOLOGY 30 （ 4 ） 32 - 39 2013年12月

研究論文（学術雑誌）,  ISSN  1357-0560

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C-reactive protein: A biomarker of survival in patients with localized upper tract urothelial carcinoma treated with radical nephroureterectomy

Obata, Jun, Kikuchi, Eiji, Tanaka, Nobuyuki, Matsumoto, Kazuhiro, Hayakawa, Nozomi, Ide, Hiroki, Miyajima, Akira, Nakagawa, Ken, Oya, Mototsugu

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 31 （ 8 ） 1725 - 1730 2013年11月

研究論文（学術雑誌）,  ISSN  1078-1439

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The type of patients who would benefit from anti-androgen withdrawal therapy: could it be performed safely for aggressive prostate cancer?

田中 伸之

MEDICAL ONCOLOGY 30 （ 3 ） E161 - E161 2013年09月

研究論文（学術雑誌）,  ISSN  1357-0560

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Patient characteristics and outcomes in metastatic upper tract urothelial carcinoma after radical nephroureterectomy: the experience of Japanese multi-institutions

Tanaka, Nobuyuki, Kikuchi, Eiji, Kanao, Kent, Matsumoto, Kazuhiro, Kobayashi, Hiroaki, Miyazaki, Yasumasa, Ide, Hiroki, Obata, Jun, Hoshino, Katsura, Shirotake, Suguru, Hayakawa, Nozomi, Kosaka, Takeo, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Hasegawa, Shintaro, Nakajima, Yosuke, Oya, Mototsugu

BJU INTERNATIONAL 112 （ 2 ） E28 - E34 2013年07月

研究論文（学術雑誌）,  ISSN  1464-4096

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Impact of Smoking Status on Bladder Tumor Recurrence After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Hagiwara, Masayuki, Kikuchi, Eiji, Tanaka, Nobuyuki, Matsumoto, Kazuhiro, Ide, Hiroki, Miyajima, Akira, Masuda, Takeshi, Nakamura, So, Oya, Mototsugu

JOURNAL OF UROLOGY 189 （ 6 ） 2062 - 2068 2013年06月

研究論文（学術雑誌）,  ISSN  0022-5347

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The prognostic significance of vasohibin-1 expression in patients with prostate cancer

Kosaka T., Miyazaki Y., Miyajima A., Mikami S., Hayashi Y., Tanaka N., Nagata H., Kikuchi E., Nakagawa K., Okada Y., Sato Y., Oya M.

British Journal of Cancer 108 （ 10 ） 2123 - 2129 2013年05月

研究論文（学術雑誌）,  ISSN  0007-0920

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<p>Background:We recently isolated vasohibin-1 (VASH1), a novel angiogenic molecule that is specifically expressed in activated vascular endothelial cells (ECs), and the status of VASH1 expression has been documented in various cancer angiogenesis. The aim of this study was to assess the prognostic value of VASH1 expression in prostate cancer (PCa).Methods:In this study, we retrospectively analysed the clinical records and evaluated the VASH1 expression of tumour microvessels in 167 patients with PCa who underwent radical prostatectomy. We immunohistochemically examined the microvessels positive for anti-CD34 as microvessel density (MVD) and the microvessels with activated ECs positive for VASH1 density.Results:We found that the VASH1 expression was restricted to ECs in the tumour stroma. VASH1 density was significantly associated with pathological T stage, Gleason score and MVD. The 5-year PSA recurrence-free survival rate was 58.8% in patients with higher VASH1 density (≧12 per mm 2) and 89.1% in patients with lower VASH1 density (&lt;12 per mm 2), respectively (P&lt;0.001). Microvessel density was not an independent predictor of PSA recurrence. Multivariate analysis revealed that high VASH1 density was an independent prognostic indicator of PSA recurrence (P=0.007, HR=2.950).Conclusion:VASH1 density represents a clinically relevant predictor of patient prognosis and can be a new biomarker that would provide additional prognostic information in PCa.</p>

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Prognostic value of plasma fibrinogen levels in patients with localized upper tract urothelial carcinoma

Tanaka, Nobuyuki, Kikuchi, Eiji, Matsumoto, Kazuhiro, Hayakawa, Nozomi, Ide, Hiroki, Miyajima, Akira, Nakamura, So, Oya, Mototsugu

BJU INTERNATIONAL 111 （ 6 ） 857 - 864 2013年05月

研究論文（学術雑誌）,  ISSN  1464-4096

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Bisebromoamide, an extract from Lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells

Suzuki, Kenjiro, Mizuno, Ryuichi, Suenaga, Kiyotake, Teruya, Toshiaki, Tanaka, Nobuyuki, Kosaka, Takeo, Oya, Mototsugu

CANCER MEDICINE 2 （ 1 ） 32 - 39 2013年02月

研究論文（学術雑誌）,  ISSN  2045-7634

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Risk of subsequent tumour recurrence and stage progression in bacille Calmette-Guérin relapsing non-muscle-invasive bladder cancer

Matsumoto Kazuhiro, Kikuchi Eiji, Shirakawa Hiroshi, Hayakawa Nozomi, Tanaka Nobuyuki, Ninomiya Akiharu, Miyajima Akira, Nakamura So, Oya Mototsugu

BJU International 110 （ 11 B ）  2012年12月

研究論文（学術雑誌）,  ISSN  1464-4096

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<p>OBJECTIVE • To investigate the risk of subsequent tumour recurrence and stage progression in bacillus Calmette-Guérin (BCG)-relapsing non-muscle-invasive bladder cancer, defined as recurrence after achieving a disease-free status for 6 months. PATIENTS AND METHODS • A total of 183 patients with BCGrelapsing tumours were treated with conservative therapy between 1985 and 2008 at our three institutions. • We analysed the association between their clinicopathological parameters and subsequent tumour recurrence or stage progression. RESULTS • Additional induction courses of BCG or anticancer drug (mitomycin C or epirubicin) instillations were performed in 119 patients and 24 patients, respectively. The remaining 40 patients did not undergo any adjuvant therapy. • Multivariate analysis showed that a relapsing tumour with a pathologically high risk (defined as tumours with G3 and/or pT1 and/or concomitant carcinoma in situ ) was a significant risk factor for subsequent tumour recurrence ( P = 0.002; hazard ratio [ HR ] 2.15). Additional BCG instillation significantly decreased the subsequent tumour recurrence rate ( P &lt; 0.001; HR 0.41). • Multivariate analysis also showed that a relapsing tumour with a pathologically high risk was also significantly associated with stage progression ( P &lt; 0.001; HR 8.05). CONCLUSIONS • An additional course of BCG instillation might be effective in patients with BCG-relapsing tumours with pathologically intermediate risk. • Nevertheless, some patients with high-risk pathological features developed subsequent stage progression. Such patients should be followed up closely and counselled on the need for aggressive therapeutic options, such as radical cystectomy.</p>

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Prognostic Value of Renin-Angiotensin System Blockade in Non-muscle-invasive Bladder Cancer

Yuge, Kazuyuki, Miyajima, Akira, Tanaka, Nobuyuki, Shirotake, Suguru, Kosaka, Takeo, Kikuchi, Eiji, Oya, Mototsugu

ANNALS OF SURGICAL ONCOLOGY 19 （ 12 ） 3987 - 3993 2012年11月

研究論文（学術雑誌）,  ISSN  1068-9265

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Prognostic significance of high nuclear grade in patients with pathologic t1a renal cell carcinoma

Suzuki Kenjiro, Mizuno Ryuichi, Mikami Shuji, Tanaka Nobuyuki, Kanao Kent, Kikuchi Eiji, Miyajima Akira, Nakagawa Ken, Oya Mototsugu

Japanese Journal of Clinical Oncology 42 （ 9 ） 831 - 835 2012年09月

研究論文（学術雑誌）,  ISSN  0368-2811

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<p>Objective: A reliable prognostic indicator in patients with pathologic T1a renal cell carcinoma has not yet been fully elucidated. The aim of this study was to investigate the prognosis of pathologic T1a renal cell carcinoma cases with a special focus on pathological factors. Methods: The study population consisted of 338 patients diagnosed with solitary renal cell carcinoma at our hospital between 1996 and 2009. The relationship between disease progression and clinicopathologic features was analyzed retrospectively to determine if it affected recurrence and distant metastasis. Results: The Fuhrman nuclear grade distribution between the tumors was 1, 2, 3 and 4 in 68 (20.1%), 242 (71.6%), 21 (6.2%) and 7 cases (2.1%), respectively. A total of 11 subjects were identified as having recurrent tumors (3.3%), 9 of whom had metastatic lesions. Multivariate analysis showed that the appearance of tumor Grade 3 and 4 (hazard ratio: 13.0, 95% confidence interval: 3.90-43.0, P &lt; 0.001) was an independent risk factor for tumor recurrence, while no significant correlation was found between tumor recurrence and age, gender, tumor side, tumor size, surgical methods, histology, microvascular invasion or surgical margin status. The 5-year recurrence-free survival rate was 67.8% in patients with a high nuclear grade tumor, and 96.8% in their counterparts. Conclusions: High nuclear grade is possibly one of the most important prognostic factors for predicting tumor recurrence and metastasis after surgery in pathologic T1a renal cell carcinoma. Thus, careful follow-up may be required in patients with pathologic T1a renal cell carcinoma of a high nuclear grade.</p>

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Prognostic significance of Bacillus Calmette-Guerin failure classification in non-muscle-invasive bladder cancer

Shirakawa, Hiroshi, Kikuchi, Eiji, Tanaka, Nobuyuki, Matsumoto, Kazuhiro, Miyajima, Akira, Nakamura, So, Oya, Mototsugu

BJU INTERNATIONAL 110 （ 6B ） E216 - E221 2012年09月

研究論文（学術雑誌）,  ISSN  1464-4096

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Prognostic Significance of High Nuclear Grade in Patients with Pathologic T1a Renal Cell Carcinoma

Suzuki, Kenjiro, Mizuno, Ryuichi, Mikami, Shuji, Tanaka, Nobuyuki, Kanao, Kent, Kikuchi, Eiji, Miyajima, Akira, Nakagawa, Ken, Oya, Mototsugu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42 （ 9 ） 831 - 835 2012年09月

研究論文（学術雑誌）,  ISSN  0368-2811

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Prognostic significance of Bacillus Calmette-Guérin failure classification in non-muscle-invasive bladder cancer

Shirakawa Hiroshi, Kikuchi Eiji, Tanaka Nobuyuki, Matsumoto Kazuhiro, Miyajima Akira, Nakamura So, Oya Mototsugu

BJU International 110 （ 6B ）  2012年09月

研究論文（学術雑誌）,  ISSN  1464-4096

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<p>Objective To investigate the differences in the clinical features and subsequent stage progression and disease-specific survival among patients with Bacillus Calmette-Guérin (BCG) failure, after dividing these patients into BCG-refractory, -resistant, -relapsing, and -intolerant groups. Patients and Methods We identified 173 patients with initial BCG failure from 521 patients who had undergone induction BCG therapy for non-muscle-invasive bladder cancer, excluding CIS, between 1987 and 2009. Patients were stratified into four BCG-failure groups, and each prognostic outcome was evaluated. Results Median follow-up period from initial BCG failure was 4.7 years. A total of 42 patients (24.3%) were stratified into the BCG-refractory, three (1.7%) into the BCG-resistant, 106 (61.3%) into the BCG-relapsing, and 22 (12.7%) into the BCG-intolerant group. Twenty-four patients (13.9%) experienced stage progression during follow-up. Multivariate analysis showed that pathological G3 at BCG failure (P= 0.014; risk ratio 2.84) and BCG-refractory (P &lt; 0.001; risk ratio 4.68) were independent predictors for stage progression. The 10-year progression-free survival rates were 53.2%, 91.1% and 93.8% in the BCG-refractory, BCG-relapsing and BCG-intolerant groups, respectively. The stage progression rate was higher in the BCG-refractory than in the BCG-relapsing (P &lt; 0.001) and BCG-intolerant (P= 0.007) groups. Similarly, the 10-year disease-specific survival rate in the BCG-refractory group was significantly worse than those in the other BCG failure groups (P &lt; 0.001). Conclusions Stratification of BCG failure into the above-mentioned four groups can identify patients with BCG-failure in terms of their prognosis. The potential risk for critical adverse events was higher in the BCG-refractory group than in the other BCG-failure groups, despite the fact that patients in each group all underwent induction BCG therapy, therefore, treatment decisions, protocols and recommendations should be established based on each individual BCG-failure pattern.</p>

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Transumbilical laparoendoscopic single-site varicocelectomy

Takeda Toshikazu, Miyajima Akira, Tanaka Nobuyuki, Kikuchi Eiji, Oya Mototsugu

Japanese Journal of Clinical Urology 66 （ 9 ） 675 - 678 2012年08月

ISSN  0385-2393

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<p>We performed transumbilical laparoendoscopioc singlesite varicocelectomy (LESS-V) for three patients with left painful varicocele. Their average age was 34.7 years old (23-46 years old) and their varicocele grades were grade III in all cases. The operation was performed by the same laparoscopic surgeon. The average operative time was 65 minutes (49-96 minutes) and the estimated blood loss was little. Postoperative pain was tolerant and analgesics was not used in all cases. There were no remarkable complications and the patients were discharged 2 or 3 days after surgery. All cases had complete resolution of pain within 5 months (2-5 months) and hydrocele, testicular atrophy, or recurrence was not seen. LESS-V is safe and feasible for laparoscopic surgeons.</p>

Renal cell carcinoma arising from a horseshoe kidney in a chronic hemodialysis patient

Miyazaki, Yasumasa, Miyajima, Akira, Maeda, Takahiro, Ito, Yujiro, Tanaka, Nobuyuki, Kosaka, Takeo, Masuda, Aya, Mizuno, Ryuichi, Kikuchi, Eiji, Nakagawa, Ken, Oya, Mototsugu

CLINICAL AND EXPERIMENTAL NEPHROLOGY 16 （ 4 ） 647 - 651 2012年08月

研究論文（学術雑誌）,  ISSN  1342-1751

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