Details of a Researcher - Tanaka, Nobuyuki

Papers - Tanaka, Nobuyuki

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Risk of subsequent tumour recurrence and stage progression in bacille Calmette-Guérin relapsing non-muscle-invasive bladder cancer

Matsumoto Kazuhiro, Kikuchi Eiji, Shirakawa Hiroshi, Hayakawa Nozomi, Tanaka Nobuyuki, Ninomiya Akiharu, Miyajima Akira, Nakamura So, Oya Mototsugu

BJU International 110 ( 11 B ) 2012.12

Research paper (scientific journal), ISSN 1464-4096

OBJECTIVE • To investigate the risk of subsequent tumour recurrence and stage progression in bacillus Calmette-Guérin (BCG)-relapsing non-muscle-invasive bladder cancer, defined as recurrence after achieving a disease-free status for 6 months. PATIENTS AND METHODS • A total of 183 patients with BCGrelapsing tumours were treated with conservative therapy between 1985 and 2008 at our three institutions. • We analysed the association between their clinicopathological parameters and subsequent tumour recurrence or stage progression. RESULTS • Additional induction courses of BCG or anticancer drug (mitomycin C or epirubicin) instillations were performed in 119 patients and 24 patients, respectively. The remaining 40 patients did not undergo any adjuvant therapy. • Multivariate analysis showed that a relapsing tumour with a pathologically high risk (defined as tumours with G3 and/or pT1 and/or concomitant carcinoma in situ ) was a significant risk factor for subsequent tumour recurrence ( P = 0.002; hazard ratio [ HR ] 2.15). Additional BCG instillation significantly decreased the subsequent tumour recurrence rate ( P < 0.001; HR 0.41). • Multivariate analysis also showed that a relapsing tumour with a pathologically high risk was also significantly associated with stage progression ( P < 0.001; HR 8.05). CONCLUSIONS • An additional course of BCG instillation might be effective in patients with BCG-relapsing tumours with pathologically intermediate risk. • Nevertheless, some patients with high-risk pathological features developed subsequent stage progression. Such patients should be followed up closely and counselled on the need for aggressive therapeutic options, such as radical cystectomy.

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Prognostic Value of Renin-Angiotensin System Blockade in Non-muscle-invasive Bladder Cancer

Yuge, Kazuyuki, Miyajima, Akira, Tanaka, Nobuyuki, Shirotake, Suguru, Kosaka, Takeo, Kikuchi, Eiji, Oya, Mototsugu

ANNALS OF SURGICAL ONCOLOGY 19 ( 12 ) 3987 - 3993 2012.11

Research paper (scientific journal), ISSN 1068-9265

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Prognostic significance of high nuclear grade in patients with pathologic t1a renal cell carcinoma

Suzuki Kenjiro, Mizuno Ryuichi, Mikami Shuji, Tanaka Nobuyuki, Kanao Kent, Kikuchi Eiji, Miyajima Akira, Nakagawa Ken, Oya Mototsugu

Japanese Journal of Clinical Oncology 42 ( 9 ) 831 - 835 2012.09

Research paper (scientific journal), ISSN 0368-2811

Objective: A reliable prognostic indicator in patients with pathologic T1a renal cell carcinoma has not yet been fully elucidated. The aim of this study was to investigate the prognosis of pathologic T1a renal cell carcinoma cases with a special focus on pathological factors. Methods: The study population consisted of 338 patients diagnosed with solitary renal cell carcinoma at our hospital between 1996 and 2009. The relationship between disease progression and clinicopathologic features was analyzed retrospectively to determine if it affected recurrence and distant metastasis. Results: The Fuhrman nuclear grade distribution between the tumors was 1, 2, 3 and 4 in 68 (20.1%), 242 (71.6%), 21 (6.2%) and 7 cases (2.1%), respectively. A total of 11 subjects were identified as having recurrent tumors (3.3%), 9 of whom had metastatic lesions. Multivariate analysis showed that the appearance of tumor Grade 3 and 4 (hazard ratio: 13.0, 95% confidence interval: 3.90-43.0, P < 0.001) was an independent risk factor for tumor recurrence, while no significant correlation was found between tumor recurrence and age, gender, tumor side, tumor size, surgical methods, histology, microvascular invasion or surgical margin status. The 5-year recurrence-free survival rate was 67.8% in patients with a high nuclear grade tumor, and 96.8% in their counterparts. Conclusions: High nuclear grade is possibly one of the most important prognostic factors for predicting tumor recurrence and metastasis after surgery in pathologic T1a renal cell carcinoma. Thus, careful follow-up may be required in patients with pathologic T1a renal cell carcinoma of a high nuclear grade.

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Prognostic significance of Bacillus Calmette-Guerin failure classification in non-muscle-invasive bladder cancer

Shirakawa, Hiroshi, Kikuchi, Eiji, Tanaka, Nobuyuki, Matsumoto, Kazuhiro, Miyajima, Akira, Nakamura, So, Oya, Mototsugu

BJU INTERNATIONAL 110 ( 6B ) E216 - E221 2012.09

Research paper (scientific journal), ISSN 1464-4096

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Prognostic Significance of High Nuclear Grade in Patients with Pathologic T1a Renal Cell Carcinoma

Suzuki, Kenjiro, Mizuno, Ryuichi, Mikami, Shuji, Tanaka, Nobuyuki, Kanao, Kent, Kikuchi, Eiji, Miyajima, Akira, Nakagawa, Ken, Oya, Mototsugu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42 ( 9 ) 831 - 835 2012.09

Research paper (scientific journal), ISSN 0368-2811

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Prognostic significance of Bacillus Calmette-Guérin failure classification in non-muscle-invasive bladder cancer

Shirakawa Hiroshi, Kikuchi Eiji, Tanaka Nobuyuki, Matsumoto Kazuhiro, Miyajima Akira, Nakamura So, Oya Mototsugu

BJU International 110 ( 6B ) 2012.09

Research paper (scientific journal), ISSN 1464-4096

Objective To investigate the differences in the clinical features and subsequent stage progression and disease-specific survival among patients with Bacillus Calmette-Guérin (BCG) failure, after dividing these patients into BCG-refractory, -resistant, -relapsing, and -intolerant groups. Patients and Methods We identified 173 patients with initial BCG failure from 521 patients who had undergone induction BCG therapy for non-muscle-invasive bladder cancer, excluding CIS, between 1987 and 2009. Patients were stratified into four BCG-failure groups, and each prognostic outcome was evaluated. Results Median follow-up period from initial BCG failure was 4.7 years. A total of 42 patients (24.3%) were stratified into the BCG-refractory, three (1.7%) into the BCG-resistant, 106 (61.3%) into the BCG-relapsing, and 22 (12.7%) into the BCG-intolerant group. Twenty-four patients (13.9%) experienced stage progression during follow-up. Multivariate analysis showed that pathological G3 at BCG failure (P= 0.014; risk ratio 2.84) and BCG-refractory (P < 0.001; risk ratio 4.68) were independent predictors for stage progression. The 10-year progression-free survival rates were 53.2%, 91.1% and 93.8% in the BCG-refractory, BCG-relapsing and BCG-intolerant groups, respectively. The stage progression rate was higher in the BCG-refractory than in the BCG-relapsing (P < 0.001) and BCG-intolerant (P= 0.007) groups. Similarly, the 10-year disease-specific survival rate in the BCG-refractory group was significantly worse than those in the other BCG failure groups (P < 0.001). Conclusions Stratification of BCG failure into the above-mentioned four groups can identify patients with BCG-failure in terms of their prognosis. The potential risk for critical adverse events was higher in the BCG-refractory group than in the other BCG-failure groups, despite the fact that patients in each group all underwent induction BCG therapy, therefore, treatment decisions, protocols and recommendations should be established based on each individual BCG-failure pattern.

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Transumbilical laparoendoscopic single-site varicocelectomy

Takeda Toshikazu, Miyajima Akira, Tanaka Nobuyuki, Kikuchi Eiji, Oya Mototsugu

Japanese Journal of Clinical Urology 66 ( 9 ) 675 - 678 2012.08

ISSN 0385-2393

We performed transumbilical laparoendoscopioc singlesite varicocelectomy (LESS-V) for three patients with left painful varicocele. Their average age was 34.7 years old (23-46 years old) and their varicocele grades were grade III in all cases. The operation was performed by the same laparoscopic surgeon. The average operative time was 65 minutes (49-96 minutes) and the estimated blood loss was little. Postoperative pain was tolerant and analgesics was not used in all cases. There were no remarkable complications and the patients were discharged 2 or 3 days after surgery. All cases had complete resolution of pain within 5 months (2-5 months) and hydrocele, testicular atrophy, or recurrence was not seen. LESS-V is safe and feasible for laparoscopic surgeons.

Renal cell carcinoma arising from a horseshoe kidney in a chronic hemodialysis patient

Miyazaki, Yasumasa, Miyajima, Akira, Maeda, Takahiro, Ito, Yujiro, Tanaka, Nobuyuki, Kosaka, Takeo, Masuda, Aya, Mizuno, Ryuichi, Kikuchi, Eiji, Nakagawa, Ken, Oya, Mototsugu

CLINICAL AND EXPERIMENTAL NEPHROLOGY 16 ( 4 ) 647 - 651 2012.08

Research paper (scientific journal), ISSN 1342-1751

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The Prognostic Significance of Vasohibin-1 Expression in Patients with Upper Urinary Tract Urothelial Carcinoma

Miyazaki, Yasumasa, Kosaka, Takeo, Mikami, Shuji, Kikuchi, Eiji, Tanaka, Nobuyuki, Maeda, Takahiro, Ishida, Masaru, Miyajima, Akira, Nakagawa, Ken, Okada, Yasunori, Sato, Yasufumi, Oya, Mototsugu

CLINICAL CANCER RESEARCH 18 ( 15 ) 4145 - 4153 2012.08

Research paper (scientific journal), ISSN 1078-0432

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Pelvic congenital arteriovenous malformation diagnosed by transrectal ultrasonography: A case report

Suzuki, Kenjiro, Tanaka, Nobuyuki, Ebine, Takashi, Momma, Tetsuo

CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL 6 ( 2 ) E61 - E63 2012.04

Research paper (scientific journal), ISSN 1911-6470

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Three cases of granulocyte colony-stimulating factor-producing urinary upper tract carcinomas

Shirakawa, Hiroshi, Kikuchi, Eiji, Mikami, Shuji, Fukamachi, Shigeru, Miyazaki, Yasumasa, Tanaka, Nobuyuki, Miyajima, Akira, Oya, Mototsugu

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 46 ( 2 ) 136 - 141 2012.04

Research paper (scientific journal), ISSN 0036-5599

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Regulation of Monocyte Chemoattractant Protein-1 Through Angiotensin II Type 1 Receptor in Prostate Cancer

Shirotake, Suguru, Miyajima, Akira, Kosaka, Takeo, Tanaka, Nobuyuki, Kikuchi, Eiji, Mikami, Shuji, Okada, Yasunori, Oya, Mototsugu

AMERICAN JOURNAL OF PATHOLOGY 180 ( 3 ) 1008 - 1016 2012.03

Research paper (scientific journal), ISSN 0002-9440

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Preoperative Hydronephrosis: Independent Predictor for Changes in Renal Function Following Nephroureterectomy

Hoshino, Katsura, Kikuchi, Eiji, Tanaka, Nobuyuki, Akita, Hirotaka, Ito, Yujiro, Miyajima, Akira, Jinzaki, Masahiro, Oya, Mototsugu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42 ( 3 ) 202 - 207 2012.03

Research paper (scientific journal), ISSN 0368-2811

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Prognonstic impact of renin-angiotensin system blockade in localised upper-tract urothelial carcinoma

Tanaka N., Miyajima A., Kikuchi E., Matsumoto K., Hagiwara M., Ide H., Kosaka T., Masuda T., Nakamura S., Oya M.

British Journal of Cancer 106 ( 2 ) 290 - 296 2012.01

ISSN 0007-0920

Background: The potential role of the renin-angiotensin system (RAS) in the promotion of tumour growth has been investigated, and the administration of RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), may improve disease control in malignancy. We investigated the prognostic impact of RAS inhibitors by analysing data from patients with upper-tract urothelial carcinoma (UTUC). Methods: A total of 279 patients who underwent nephroureterectomy for localised UTUC (pTa-3N0M0) were identified at our three institutions. We retrospectively investigated the prognostic outcomes following nephroureterectomy in patients administered or not administered ACEIs or ARBs. Results: The median follow-up period was 3.4 years. RAS inhibitors were administered to 48 patients (17.2%). Multivariate analysis showed that the appearance of pathological T3, positive lymphovascular invasion, and no RAS inhibitor administration (P=0.027 HR=3.14) were independent risk factors for a decrease in subsequent metastasis-free survival. The 5-year metastasis-free survival rate was 93.0% in patients who administered RAS inhibitors, and 72.8% in their counterparts who did not (P=0.008). Conclusion: The absence of RAS inhibitor administration was an independent risk factor for subsequent tumour metastasis in patients with localised UTUC. We propose RAS inhibitors may be a potent choice as an effective treatment following nephroureterectomy.

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Low-dose docetaxel enhances the sensitivity of S-1 in a xenograft model of human castration resistant prostate cancer

Hasegawa, Masanori, Miyajima, Akira, Kosaka, Takeo, Yasumizu, Yota, Tanaka, Nobuyuki, Maeda, Takahiro, Shirotake, Suguru, Ide, Hiroki, Kikuchi, Eiji, Oya, Mototsugu

INTERNATIONAL JOURNAL OF CANCER 130 ( 2 ) 431 - 442 2012.01

Research paper (scientific journal), ISSN 0020-7136

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Acquired platinum resistance enhances tumour angiogenesis through angiotensin II type 1 receptor in bladder cancer

Tanaka N., Miyajima A., Kosaka T., Miyazaki Y., Shirotake S., Shirakawa H., Kikuchi E., Oya M.

British Journal of Cancer 105 ( 9 ) 1331 - 1337 2011.10

Research paper (scientific journal), ISSN 0007-0920

Background: We investigated the changes in reactive oxygen species (ROS) and angiogenesis through angiotensin II (Ang II) type 1 receptor (AT1R) after the development of acquired platinum resistance in bladder cancer. Methods: Four invasive human bladder cancer cell lines, T24, 5637, T24PR, and 5637PR, were used in vitro, whereas in vivo, T24 and T24PR cells were used. T24PR and 5637PR cells were newly established at our institution as acquired platinum-resistant sublines by culturing in cisplatin (CDDP)-containing conditioned medium for 6 months. Results: Ang II induced significantly higher vascular endothelial growth factor (VEGF) production in T24PR and 5637PR cells than in their corresponding parent cells in vitro, whereas Ang II induced a further increase in VEGF production. These platinum-resistant cells also showed significantly higher AT1R expression than their corresponding parent cells. ROS was also significantly upregulated in T24PR and 5637PR cells, whereas increased AT1R expression was significantly downregulated by scavenging free radicals. We also demonstrated the efficacy of AT1R blockade at suppressing the growth of platinum-resistant xenograft model. Conclusion: Our findings indicate a new molecular mechanism for upregulated AT1R signalling through increased ROS when tumours progressed after the CDDP-based regimens, and shed light on the importance of AT1R blockade for platinum-resistant bladder cancers.

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Preoperative Hydronephrosis Grade Independently Predicts Worse Pathological Outcomes in Patients Undergoing Nephroureterectomy for Upper Tract Urothelial Carcinoma

Ito, Yujiro, Kikuchi, Eiji, Tanaka, Nobuyuki, Miyajima, Akira, Mikami, Shuji, Jinzaki, Masahiro, Oya, Mototsugu

JOURNAL OF UROLOGY 185 ( 5 ) 1621 - 1626 2011.05

Research paper (scientific journal), ISSN 0022-5347

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Angiotensin II Type 1 Receptor Expression and Microvessel Density in Human Bladder Cancer

Shirotake, Suguru, Miyajima, Akira, Kosaka, Takeo, Tanaka, Nobuyuki, Maeda, Takahiro, Kikuchi, Eiji, Oya, Mototsugu

UROLOGY 77 ( 4 ) 431 - 442 2011.04

Research paper (scientific journal), ISSN 0090-4295

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Frequency of Tumor Recurrence: A Strong Predictor of Stage Progression in Initially Diagnosed Nonmuscle Invasive Bladder Cancer

Tanaka, Nobuyuki, Kikuchi, Eiji, Matsumoto, Kazuhiro, Miyajima, Akira, Nakagawa, Ken, Oya, Mototsugu

JOURNAL OF UROLOGY 185 ( 2 ) 450 - 455 2011.02

Research paper (scientific journal), ISSN 0022-5347

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Cis-dichlorodiammineplatinum Upregulates Angiotensin II Type 1 Receptors through Reactive Oxygen Species Generation and Enhances VEGF Production in Bladder Cancer

Tanaka, Nobuyuki, Miyajima, Akira, Kosaka, Takeo, Shirotake, Suguru, Hasegawa, Masanori, Kikuchi, Eiji, Oya, Mototsugu

MOLECULAR CANCER THERAPEUTICS 9 ( 11 ) 2982 - 2992 2010.11

Research paper (scientific journal), ISSN 1535-7163

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