Papers - Tanaka, Nobuyuki

Independent Predictors for Bladder Outcomes after Treatment of Intravesical Recurrence following Radical Nephroureterectomy in Patients with Primary Upper Tract Urothelial Carcinoma

Tanaka, Nobuyuki, Kikuchi, Eiji, Kanao, Kent, Matsumoto, Kazuhiro, Shirotake, Suguru, Kobayashi, Hiroaki, Miyazaki, Yasumasa, Ide, Hiroki, Obata, Jun, Hoshino, Katsura, Hayakawa, Nozomi, Hagiwara, Masayuki, Kosaka, Takeo, Oyama, Masafumi, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Jinzaki, Masahiro, Hasegawa, Shintaro, Nakajima, Yosuke, Oya, Mototsugu

ANNALS OF SURGICAL ONCOLOGY 21 ( 9 ) 3151 - 3158 2014.09

Research paper (scientific journal),  ISSN  1068-9265

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Optimal timing of hormonal therapy for prostate-specific antigen recurrence after radical prostatectomy

Matsumoto, Kazuhiro, Mizuno, Ryuichi, Tanaka, Nobuyuki, Ide, Hiroki, Hasegawa, Masanori, Ishida, Masaru, Hayakawa, Nozomi, Yasumizu, Yota, Hagiwara, Masayuki, Hara, Satoshi, Kikuchi, Eiji, Miyajima, Akira, Nakagawa, Ken, Nakajima, Yosuke, Nakamura, So, Nakashima, Jun, Oya, Mototsugu

MEDICAL ONCOLOGY 31 ( 7 ) 2019 - 2020 2014.07

Research paper (scientific journal),  ISSN  1357-0560

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Survival following primary androgen deprivation therapy for localized intermediate- or high-risk prostate cancer: comparison with the life expectancy of the age-matched normal population

Matsumoto, Kazuhiro, Hagiwara, Masayuki, Tanaka, Nobuyuki, Hayakawa, Nozomi, Ishida, Masaru, Ninomiya, Akiharu, Nakajima, Yosuke, Nakamura, So

MEDICAL ONCOLOGY 31 ( 6 ) 3645 - 3649 2014.06

Research paper (scientific journal),  ISSN  1357-0560

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Metastatic Behavior of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy: Association with Primary Tumor Location

Tanaka, Nobuyuki, Kikuchi, Eiji, Kanao, Kent, Matsumoto, Kazuhiro, Kobayashi, Hiroaki, Ide, Hiroki, Miyazaki, Yasumasa, Obata, Jun, Hoshino, Katsura, Shirotake, Suguru, Akita, Hirotaka, Kosaka, Takeo, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Hasegawa, Shintaro, Nakajima, Yosuke, Jinzaki, Masahiro, Oya, Mototsugu

ANNALS OF SURGICAL ONCOLOGY 21 ( 3 ) 1038 - 1045 2014.03

Research paper (scientific journal),  ISSN  1068-9265

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Long term follow-up in patients with initially diagnosed low grade Ta non-muscle invasive bladder tumors

Kobayashi Hiroaki, Kikuchi Eiji, Mikami Shuji, Maeda Takahiro, Tanaka Nobuyuki, Miyajima Akira, Nakagawa Ken, Oya Mototsugu

BMC Urology 14 ( 1 )  2014.01

Research paper (scientific journal)

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<p>Background: We evaluated the clinical outcome of low grade Ta bladder cancer followed-up for a long period using the 2004 WHO grading system. Methods. We retrospectively reviewed 190 patients with primary, low grade Ta bladder cancer. We defined worsening progression (WP) as confirmed high grade Ta, all T1 or Tis/concomitant CIS of bladder recurrence, upper urinary tract recurrence (UTR), or progression to equal to or more than T2. The associations between clinicopathological factors and tumor recurrence as well as WP pattern were analyzed. We also evaluated the late recurrence of 76 patients who were tumor-free for more than 5 years. Results: Tumor recurrence and WP occurred in 82 (43.2%) and 21 (11.1%) patients during follow-up (median follow-up: 101.5 months), respectively. WP to high grade Ta, all T1 or Tis/concomitant CIS was seen in 17 patients, and UTR and progression to equal to or more than T2 were seen in 2 and 2 patients, respectively. Multivariate analyses demonstrated that multiple tumor (p &lt; 0.001, HR: 2.97) and absence of intravesical instillation (IVI) (p &lt; 0.001, HR: 2.88) were significant risk factors for tumor recurrence while multiple tumor was the only risk factor for WP (p = 0.001, HR: 5.26). After a 5-year tumor-free period, 9 patients experienced late recurrence in years 5 and 10 and were diagnosed at a follow-up cystoscopy, however, only 2 patients recurred beyond 10 years and were found by gross hematuria. There were no significant risk factors of late recurrence. Conclusions: Multiple tumor was a risk factor for both tumor recurrence and WP while IVI did not affect the occurrence of WP. Our results suggest that routine follow-up of patients with low grade Ta bladder cancer is needed up to 10 years from the initial diagnosis.</p>

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The Predictive Value of C-reactive Protein for Prognosis in Patients with Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy: A Multi-institutional Study

Tanaka, Nobuyuki, Kikuchi, Eiji, Shirotake, Suguru, Kanao, Kent, Matsumoto, Kazuhiro, Kobayashi, Hiroaki, Miyazaki, Yasumasa, Ide, Hiroki, Obata, Jun, Hoshino, Katsura, Hayakawa, Nozomi, Ito, Yujiro, Kosaka, Takeo, Kodaira, Kiichiro, Oyama, Masafumi, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Ueno, Munehisa, Oya, Mototsugu

EUROPEAN UROLOGY 65 ( 1 ) 227 - 234 2014.01

Research paper (scientific journal),  ISSN  0302-2838

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The predictive value of positive urine cytology for outcomes following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma: A multi-institutional study

Tanaka, Nobuyuki, Kikuchi, Eiji, Kanao, Kent, Matsumoto, Kazuhiro, Shirotake, Suguru, Kobayashi, Hiroaki, Miyazaki, Yasumasa, Ide, Hiroki, Obata, Jun, Hoshino, Katsura, Hayakawa, Nozomi, Kosaka, Takeo, Oyama, Masafumi, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Jinzaki, Masahiro, Nakajima, Yosuke, Oya, Mototsugu

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32 ( 1 ) E229 - E230 2014.01

Research paper (scientific journal),  ISSN  1078-1439

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Survival following primary androgen deprivation therapy for localized intermediate- Or high-risk prostate cancer

Matsumoto Kazuhiro, Hagiwara Masayuki, Tanaka Nobuyuki, Hayakawa Nozomi, Ishida Masaru, Ninomiya Akiharu, Nakajima Yosuke, Nakamura So

Medical Oncology 31 ( 6 )  2014

Research paper (scientific journal),  ISSN  1357-0560

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<p>The representative guidelines do not recommend androgen deprivation therapy (ADT) as a primary treatment for localized prostate cancer. However, in clinical practice, the use of primary ADT for localized prostate cancer has been widespread, especially among older patients. We performed a retrospective review of the efficacy of primary ADT for localized prostate cancer and compared their outcomes with the life expectancy of the normal population. The study cohort consisted of 410 men diagnosed with localized intermediate- or high-risk prostate cancer over the period 1992-2012 at five institutions. All patients underwent ADT as a primary cancer therapy, and mean follow-up was 6.0 years. Their progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS) rates were calculated. Patients' expected survival rates were estimated by the Hakulinen method. Multivariate analysis demonstrated that Gleason score ≥8 and cT3a were independent risk factors for all of PFS, CSS, and OS. In patients who have none or one of these risk factors, minimum OS rates were not inferior to the expected survival curves of the normal population. Meanwhile, in patients with both risk factors, the OS curve fell below the expected survival rates, especially after 6 years of follow-up. We conclude that primary ADT might be one of the therapeutic options for localized intermediate- and high-risk prostate cancer. However, for high-risk cases with Gleason score ≥8 and cT3a, the choice of primary ADT should be deliberated carefully because the OS of these cases was inferior to the expected survival, especially at a late time point.</p>

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Congenital Intrathoracic Kidney

Niwa, Naoya, Tanaka, Nobuyuki, Ueda, Soichiro, Masuda, Takeshi

INTERNAL MEDICINE 53 ( 17 ) 2019 - 2020 2014

Research paper (scientific journal),  ISSN  0918-2918

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Third-line Hormonal Therapy to Treat Prostate Cancer Relapse after Initial and Second-line Hormonal Therapy: Report of 52 Cases and Literature Review

Matsumoto, Kazuhiro, Hagiwara, Masayuki, Hayakawa, Nozomi, Tanaka, Nobuyuki, Ito, Yujiro, Maeda, Takahiro, Ninomiya, Akiharu, Nagata, Hirohiko, Nakamura, So

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15 ( 8 ) 3645 - 3649 2014

Research paper (scientific journal),  ISSN  1513-7368

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Independent predictors for bladder outcomes after treatment of intravesical recurrence following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma

Tanaka Nobuyuki, Kikuchi Eiji, Kanao Kent, Matsumoto Kazuhiro, Shirotake Suguru, Kobayashi Hiroaki, Miyazaki Yasumasa, Ide Hiroki, Obata Jun, Hoshino Katsura, Hayakawa Nozomi, Hagiwara Masayuki, Kosaka Takeo, Oyama Masafumi, Miyajima Akira, Momma Tetsuo, Nakagawa Ken, Jinzaki Masahiro, Hasegawa Shintaro, Nakajima Yosuke, Oya Mototsugu

Annals of Surgical Oncology 21 ( 9 ) 3151 - 3158 2014

Research paper (scientific journal),  ISSN  1068-9265

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<p>Background. Few studies have described the clinical courses and outcomes in the bladder after treatment of intravesical recurrence after radical nephroureterectomy (RNU) in patients with primary upper tract urothelial carcinoma (UTUC). We investigated the indicators for predicting subsequent bladder outcomes after treatment of intravesical recurrence after RNU. Methods. A total of 241 patients with primary UTUC (pTa-4N0M0) who experienced intravesical recurrence after RNU were included. Of these patients, 101 (41.9 %) underwent Bacillus Calmette-Guérin treatments, whereas 49 (20.3 %) underwent intravesical chemotherapy. The median follow-up period after initial transurethral resection of the bladder tumor was 33 months. Relationships with bladder outcomes were analyzed by using multivariable analysis. Results. Ninety-six patients experienced intravesical recurrence, and bladder progression was observed in 13. Cumulative incidence rates of intravesical recurrence at 1 and 5 years after treatment of the first intravesical recurrence were 31.0 and 48.4 %, whereas those of bladder progression at 1 and 5 years thereafter were 2.4 and 8.0 %. Multivariate analysis showed that the number of recurrent tumors and pT1 tumors at the time of the first intravesical relapse were independent risk factors for subsequent intravesical recurrence. With respect to bladder progression, multivariate analysis showed that pT1 tumors, the appearance of concomitant carcinoma-in situ at the time of the first intravesical relapse, and the absence of the Bacillus Calmette-Guérin treatment were independent risk factors. Conclusions. This retrospective study presents a detailed picture of further bladder outcomes after intravesical recurrence after RNU in primary UTUC patients. The results may assist physicians to develop a more rational protocol in bladder surveillance.</p>

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Mucosa-associated lymphoid tissue lymphoma arising from the kidney

Niwa Naoya, Tanaka Nobuyuki, Horinaga Minoru, Hongo Hiroshi, Ito Yujiro, Watanabe Takuro, Masuda Takeshi

Journal of the Canadian Urological Association 8 ( 1-2 FEB )  2014

Research paper (scientific journal),  ISSN  1911-6470

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<p>Primary renal lymphoma is rare, and most are intermediate- and high-grade lymphomas of B-cell lineage, such as diffuse large B-cell or Burkitt lymphoma. We report a case of low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) arising from the kidney. Only a few cases of primary renal MALT lymphoma have been published.</p>

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Efficacy of estramustine phosphate sodium hydrate (EMP) monotherapy in castration-resistant prostate cancer patients: report of 102 cases and review of literature

Matsumoto, Kazuhiro, Tanaka, Nobuyuki, Hayakawa, Nozomi, Ezaki, Taisuke, Suzuki, Kenjiro, Maeda, Takahiro, Ninomiya, Akiharu, Nakamura, So

MEDICAL ONCOLOGY 30 ( 4 ) 32 - 39 2013.12

Research paper (scientific journal),  ISSN  1357-0560

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C-reactive protein: A biomarker of survival in patients with localized upper tract urothelial carcinoma treated with radical nephroureterectomy

Obata, Jun, Kikuchi, Eiji, Tanaka, Nobuyuki, Matsumoto, Kazuhiro, Hayakawa, Nozomi, Ide, Hiroki, Miyajima, Akira, Nakagawa, Ken, Oya, Mototsugu

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 31 ( 8 ) 1725 - 1730 2013.11

Research paper (scientific journal),  ISSN  1078-1439

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The type of patients who would benefit from anti-androgen withdrawal therapy: could it be performed safely for aggressive prostate cancer?

Matsumoto, Kazuhiro, Tanaka, Nobuyuki, Hayakawa, Nozomi, Ezaki, Taisuke, Suzuki, Kenjiro, Maeda, Takahiro, Ninomiya, Akiharu, Nakamura, So

MEDICAL ONCOLOGY 30 ( 3 ) E161 - E161 2013.09

Research paper (scientific journal),  ISSN  1357-0560

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Patient characteristics and outcomes in metastatic upper tract urothelial carcinoma after radical nephroureterectomy: the experience of Japanese multi-institutions

Tanaka, Nobuyuki, Kikuchi, Eiji, Kanao, Kent, Matsumoto, Kazuhiro, Kobayashi, Hiroaki, Miyazaki, Yasumasa, Ide, Hiroki, Obata, Jun, Hoshino, Katsura, Shirotake, Suguru, Hayakawa, Nozomi, Kosaka, Takeo, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Hasegawa, Shintaro, Nakajima, Yosuke, Oya, Mototsugu

BJU INTERNATIONAL 112 ( 2 ) E28 - E34 2013.07

Research paper (scientific journal),  ISSN  1464-4096

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Impact of Smoking Status on Bladder Tumor Recurrence After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Hagiwara, Masayuki, Kikuchi, Eiji, Tanaka, Nobuyuki, Matsumoto, Kazuhiro, Ide, Hiroki, Miyajima, Akira, Masuda, Takeshi, Nakamura, So, Oya, Mototsugu

JOURNAL OF UROLOGY 189 ( 6 ) 2062 - 2068 2013.06

Research paper (scientific journal),  ISSN  0022-5347

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The prognostic significance of vasohibin-1 expression in patients with prostate cancer

Kosaka T., Miyazaki Y., Miyajima A., Mikami S., Hayashi Y., Tanaka N., Nagata H., Kikuchi E., Nakagawa K., Okada Y., Sato Y., Oya M.

British Journal of Cancer 108 ( 10 ) 2123 - 2129 2013.05

Research paper (scientific journal),  ISSN  0007-0920

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<p>Background:We recently isolated vasohibin-1 (VASH1), a novel angiogenic molecule that is specifically expressed in activated vascular endothelial cells (ECs), and the status of VASH1 expression has been documented in various cancer angiogenesis. The aim of this study was to assess the prognostic value of VASH1 expression in prostate cancer (PCa).Methods:In this study, we retrospectively analysed the clinical records and evaluated the VASH1 expression of tumour microvessels in 167 patients with PCa who underwent radical prostatectomy. We immunohistochemically examined the microvessels positive for anti-CD34 as microvessel density (MVD) and the microvessels with activated ECs positive for VASH1 density.Results:We found that the VASH1 expression was restricted to ECs in the tumour stroma. VASH1 density was significantly associated with pathological T stage, Gleason score and MVD. The 5-year PSA recurrence-free survival rate was 58.8% in patients with higher VASH1 density (≧12 per mm 2) and 89.1% in patients with lower VASH1 density (&lt;12 per mm 2), respectively (P&lt;0.001). Microvessel density was not an independent predictor of PSA recurrence. Multivariate analysis revealed that high VASH1 density was an independent prognostic indicator of PSA recurrence (P=0.007, HR=2.950).Conclusion:VASH1 density represents a clinically relevant predictor of patient prognosis and can be a new biomarker that would provide additional prognostic information in PCa.</p>

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Prognostic value of plasma fibrinogen levels in patients with localized upper tract urothelial carcinoma

Tanaka, Nobuyuki, Kikuchi, Eiji, Matsumoto, Kazuhiro, Hayakawa, Nozomi, Ide, Hiroki, Miyajima, Akira, Nakamura, So, Oya, Mototsugu

BJU INTERNATIONAL 111 ( 6 ) 857 - 864 2013.05

Research paper (scientific journal),  ISSN  1464-4096

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Bisebromoamide, an extract from Lyngbya species, induces apoptosis through ERK and mTOR inhibitions in renal cancer cells

Suzuki, Kenjiro, Mizuno, Ryuichi, Suenaga, Kiyotake, Teruya, Toshiaki, Tanaka, Nobuyuki, Kosaka, Takeo, Oya, Mototsugu

CANCER MEDICINE 2 ( 1 ) 32 - 39 2013.02

Research paper (scientific journal),  ISSN  2045-7634

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