田中　伸之 (タナカ　ノブユキ)

Tanaka, Nobuyuki

写真a

所属（所属キャンパス）

医学部 泌尿器科学教室 （信濃町）

職名

専任講師（有期）

外部リンク
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学歴 【 表示 ／ 非表示 】

  • 1996年04月
    -
    2003年03月

    慶應義塾大学, 医学部

    卒業

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  • 医学博士, 慶應義塾大学, 2015年02月

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  • Predictors of renal function after adrenalectomy in patients with Cushing or subclinical Cushing syndrome.

    Kufukihara R, Takeda T, Hakozaki K, Yasumizu Y, Tanaka N, Matsumoto K, Morita S, Kosaka T, Mizuno R, Asanuma H, Miyashita K, Kurihara I, Oya M

    International journal of urology : official journal of the Japanese Urological Association （International Journal of Urology)  2022年08月

    ISSN  0919-8172

    　概要を見る

    Purpose: The postoperative course of renal function remains unclear in Cushing syndrome. We examined changes in renal function after adrenalectomy in patients with Cushing syndrome and attempted to identify predictors of renal impairment. Methods: The study population comprised 76 patients who underwent adrenalectomy for Cushing and subclinical Cushing syndrome between 2001 and 2018. Renal function and other factors were evaluated pre-operation, at 1 postoperative month, and 1 postoperative year. We defined a ≥10% decrease in the estimated glomerular filtration rate at 1 postoperative year as renal impairment, and predictors associated with this reduction were investigated. The relationship between renal function and steroid replacement after surgery was also examined. Results: Mean pre-operative estimated glomerular filtration rate was 82.2 ml/min/1.73 m2. While mean estimated glomerular filtration rate was significantly lower at 1 postoperative month than the pre-operative value (71.7 ml/min/1.73 m2 [89.1%], p < 0.001), no significant differences were observed between 1 postoperative year and pre-operation (79.5 ml/min/1.73 m2 [97.6%], p = 0.108). Twenty-six patients (34.2%) developed renal impairment. A multivariate analysis identified a low pre-operative adrenocorticotropic hormone level as an independent predictor of renal impairment (odds ratio 6.30, p = 0.031). Among 43 patients with available records of steroid replacement history, 18 (41.9%) developed renal impairment. The ratio of patients with a reduced steroid replacement dose at 1 postoperative month was significantly lower among patients with renal impairment than those without (22.2% vs. 56.0%, p = 0.027). Conclusions: The pre-operative adrenocorticotropic hormone level was a predictor of renal function after adrenalectomy in patients with Cushing or subclinical Cushing syndrome.

  • Site-Specific Differences in PD-1 Blockade Success and Biomarkers in Urothelial Carcinoma Treated with Pembrolizumab.

    Umeda K, Tanaka N, Yasumizu Y, Takeda T, Matsumoto K, Morita S, Kosaka T, Mizuno R, Oya M

    Clinical genitourinary cancer 2022年08月

    ISSN  1558-7673

  • Principal component analysis of early immune cell dynamics during pembrolizumab treatment of advanced urothelial carcinoma

    Teshima T., Kobayashi Y., Kawai T., Kushihara Y., Nagaoka K., Miyakawa J., Akiyama Y., Yamada Y., Sato Y., Yamada D., Tanaka N., Tsunoda T., Kume H., Kakimi K.

    Oncology Letters （Oncology Letters)  24 （ 2 ） 265 2022年08月

    ISSN  17921074

    　概要を見る

    Immune checkpoint inhibitors have been approved as second-line therapy for patients with advanced urothelial carcinoma (UC). However, which patients will obtain clinical benefit remains to be determined. To identify predictive biomarkers for the pembrolizumab (PEM) response early during treatment, the present study investigated 31 patients with chemotherapy-resistant recurrent or metastatic UC who received 200 mg PEM intravenously every 3 weeks. Blood was taken just before the first dose and again before the second dose, and the peripheral blood mononuclear cells of all 31 pairs of blood samples were immune phenotyped by flow cytometry. Data were assessed by principal component analysis (PCA), correlation analysis and Cox proportional hazards modeling in order to comprehensively determine the effects of PEM on peripheral mononuclear immune cells. Absolute counts of CD45RA+CD27-CCR7- terminally differentiated CD8+ T cells and KLRG1+CD57+ senescent CD8+ T cells were significantly increased after PEM administration (P=0.042 and P=0.043, respectively). Senescent and exhausted CD4+ and CD8+ T cell dynamics were strongly associated with each other. By contrast, counts of monocytic myeloid-derived suppressor cells (mMDSCs) were not associated with other immune cell phenotypes. The results of PCA and non-hierarchical clus-tering of patients suggested that excessive T cell senescence and differentiation early during treatment were not neces-sarily associated with a survival benefit. However, decreased mMDSC counts after PEM were associated with improved overall survival. In conclusion, early on-treatment peripheral T cell status was associated with response to PEM; however, it was not associated with clinical benefit. By contrast, decreased peripheral mMDSC counts did predict improved overall survival.

  • A low subcutaneous fat mass is a risk factor for the development of inguinal hernia after radical prostatectomy.

    Umeda K, Takeda T, Hakozaki K, Yasumizu Y, Tanaka N, Matsumoto K, Morita S, Kosaka T, Mizuno R, Asanuma H, Oya M

    Langenbeck's archives of surgery （Langenbeck's Archives of Surgery)  2022年06月

    ISSN  1435-2443

    　概要を見る

    Purpose: Inguinal hernia (IH) after radical prostatectomy (RP) is a complication that impairs quality of life; however, the factors contributing to IH after RP remain unclear. Therefore, we herein attempted to identify the factors responsible for the development of IH after RP. Methods: We reviewed 622 patients who underwent laparoscopic or robot-assisted laparoscopic RP at our hospital between December 2011 and April 2020. The total fat area and visceral fat area were calculated at the level of the umbilicus using computed tomography, and the subcutaneous fat area (SFA) was calculated by subtracting the visceral fat area from the total fat area. The psoas muscle area was measured at the third lumbar vertebrae level using computed tomography to calculate the psoas muscle mass index, which is used in sarcopenia as an index of muscle mass. We investigated the risk factors for IH after laparoscopic or robot-assisted laparoscopic RP. Results: IH developed in 88 patients (16.7%). Fifty-seven of these patients underwent hernia repair at our hospital, and 56 (98.2%) had indirect hernias. A multivariate analysis identified SFA (odds ratios: 0.383, p < 0.001) as an independent predictor for the development of IH. Two-year IH-free survival rates were 77.3% in the small SFA group (SFA < 123 cm2) and 88.7% in the large SFA group (SFA ≥ 123 cm2) (p < 0.001). Conclusion: Subcutaneous fat was associated with the development of IH, particularly indirect IH, after laparoscopic or robot-assisted laparoscopic RP. An indirect IH prevention technique needs to be considered, particularly for patients with less subcutaneous fat.

  • Profiling the Biological Characteristics and Transitions through Upper Tract Tumor Origin, Bladder Recurrence and Muscle-Invasive Bladder Progression in Upper Tract Urothelial Carcinoma

    Shigeta K., Matsumoto K., Tanaka N., Mikami S., Kosaka T., Yasumizu Y., Takeda T., Mizuno R., Kikuchi E., Oya M.

    International Journal of Molecular Sciences （International Journal of Molecular Sciences)  23 （ 9 ）  2022年05月

    ISSN  16616596

    　概要を見る

    To evaluate biological characteristics and transitions of upper tract urothelial carcinoma (UTUC) through metachronous bladder tumors after radical nephroureterectomy (RNU), we con-ducted immunohistochemical (IHC) staining of tumor specimens of UTUC tumor origin, non-mus-cle-invasive bladder cancer (NMIBC) and MIBC progressed after intravesical recurrence (IVR), and bladder primary MIBC. Fibroblast growth factor receptor 3 (FGFR3), p53, cytokeratin 5/6 (CK5/6), and CK20 were stained to examine expression rates. After expression assessment with heatmap clustering, the overexpression of four biomarkers from UTUC origin to metachronous MIBC progression was analyzed with clinicopathological variables. We found that high CK20 and low CK5/6 expression were both observed in UTUC tumor origin and subsequent NMIBC after RNU. By in-vestigating molecular expression in the IVR specimen, we observed that low pT stage bladder recurrence occupied the majority of CK20 high CK5/6 low expression, but would change to CK20 low CK5/6 high expression as it progressed to MIBC. UTUC metachronous MIBC has different characteristics compared with bladder primary MIBC, which comprises favorable biological features such as high FGFR3 expression, and follows favorable prognosis compared to those without FGFR3 ex-pression. The present study demonstrated that the biological characteristics of UTUC tumor origin shifts from luminal to basal-like features with progression to MIBC, but FGFR3 expression taken over from UTUC origin may comprise a favorable entity compared to primary MIBC.

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総説・解説等 【 表示 ／ 非表示 】

  • バイオインフォマティクスを用いたカバジタキセル耐性前立腺癌リプログラミング薬剤のスクリーニング

    本郷 周, 小坂 威雄, 安水 洋太, 田中 伸之, 武田 利和, 森田 伸也, 松本 一宏, 水野 隆一, 大家 基嗣

    泌尿器外科 (医学図書出版(株))  35 ( 8 ) 866 - 866 2022年08月

    ISSN  0914-6180

  • 全身撮影可能な立位CTを用いた骨盤臓器脱評価の初期経験

    横山 陽一, 寺西 悠, 山田 祥岳, 山田 稔, 田中 伸之, 篠島 利明, 朝倉 博孝, 大家 基嗣, 陣崎 雅弘

    日本女性骨盤底医学会プログラム・抄録集 (日本女性骨盤底医学会)  24回   53 - 53 2022年07月

  • 膀胱メラノーシスの1例

    渡邊 雅斗, 田中 伸之, 岩澤 智裕, 安水 洋太, 武田 利和, 森田 伸也, 松本 一宏, 小坂 威雄, 秋田 大宇, 上野 彰久, 新井 恵吏, 水野 隆一, 浅沼 宏, 陣崎 雅弘, 大家 基嗣

    泌尿器外科 (医学図書出版(株))  35 ( 7 ) 640 - 640 2022年07月

    ISSN  0914-6180

  • 副腎性クッシング症候群における術後腎機能推移の検討

    久冨木原 良平, 武田 利和, 箱崎 恭平, 安水 洋太, 田中 伸之, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 栗原 勲, 浅沼 宏, 伊藤 裕, 大家 基嗣

    泌尿器外科 (医学図書出版(株))  35 ( 臨増 ) 821 - 821 2022年07月

    ISSN  0914-6180

  • カテーテル管理下の前立腺肥大症患者に施行した経尿道的前立腺レーザー蒸散術(CVP)の治療成績

    三條 丹星, 田中 伸之, 安水 洋太, 武田 利和, 松本 一宏, 森田 伸也, 小坂 威雄, 水野 隆一, 浅沼 宏, 大家 基嗣

    泌尿器外科 (医学図書出版(株))  35 ( 臨増 ) 838 - 838 2022年07月

    ISSN  0914-6180

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研究発表 【 表示 ／ 非表示 】

  • 接触式レーザー前立腺蒸散術の治療成績：後出血を来した症例の検討

    第29回日本排尿機能学会, 

    2022年09月

  • 微小環境から考える泌尿器がんの異質性：複合がん免疫療法の最適化

    田中 伸之

    第26回日本がん免疫学会総会, 

    2022年07月
    , 

    シンポジウム・ワークショップ パネル（指名）

  • がん免疫療法時代における腎細胞癌バイオマーカー：がん免疫ゲノミクスの視点から

    第37回腎移植・血管外科研究会, 

    2022年06月
    , 

    シンポジウム・ワークショップ パネル（指名）

  • 多様化する前立腺肥大症患者への射精機能温存の試み

    田中 伸之

    第28回日本排尿機能学会, 

    2021年09月

  • Single-cell RNA-seq analysis of intra-tumor heterogeneity dynamics reveals the novel platinum resistance gene COX7B in patients with urinary bladder cancer

    第108回日本泌尿器科学会総会, 

    2020年12月

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 尿路上皮がんにおけるAXL/GAS6発現と腫瘍免疫微小環境の統合的理解

    2022年04月
    -
    2025年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 箱崎 恭平, 基盤研究(C), 補助金,  研究分担者

  • In situな尿路上皮がん免疫ゲノミクス多様性解析とリキッドバイオプシーの確立

    2022年04月
    -
    2025年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 田中 伸之, 基盤研究(B), 研究代表者

  • In situな尿路上皮がん免疫ゲノミクス多様性解析とリキッドバイオプシーの確立

    2022年04月
    -
    2025年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 田中 伸之, 基盤研究(B), 補助金,  研究代表者

  • がん多様性をin situで見える化する解析プラットフォーム構築と臨床応用

    2021年07月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 田中 伸之, 挑戦的研究(萌芽), 補助金,  研究代表者

  • 酸化ストレス応答に着目した間質性膀胱炎の発症メカニズム解明と治療法の開発

    2021年04月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 松本 一宏, 基盤研究(C), 補助金,  研究分担者

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受賞 【 表示 ／ 非表示 】

  • 第53回高松宮妃癌研究基金研究助成金

    2022年

  • 公益財団法人武田科学振興財団医学系研究助成

    2022年

  • 鈴木泌尿器医学振興財団令和３年度助成金

    2022年

  • 第30回日本泌尿器科学会研究助成金

    2021年

  • 公益財団法人SGH財団SGHがん研究助成

    2020年

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担当授業科目 【 表示 ／ 非表示 】

  • 泌尿器科学講義

    2022年度

  • 泌尿器科学講義

    2021年度

  • 泌尿器科学講義

    2020年度

  • 泌尿器科学講義

    2019年度

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