Details of a Researcher - Tanaka, Nobuyuki

Tanaka, Nobuyuki

写真a

Affiliation: School of Medicine, Department of Urology (Shinanomachi)

Position: Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links

Page Top ▲

Academic Background 【 Display / hide 】

1996.04

-

2003.03

慶應義塾大学, 医学部

Graduated

Page Top ▲

Academic Degrees 【 Display / hide 】

医学博士, Keio University, 2015.02

Page Top ▲

Papers 【 Display / hide 】

Prognostic impact and landscape of cellular CXCR5 chemokine receptor expression in clear-cell renal cell carcinoma.

Arai M, Tanaka N, Takamatsu K, Murakami T, Mikami S, Imamura T, Nakamura K, Nishihara H, Oya M

Cancer immunology, immunotherapy : CII 74 ( 5 ) 166 2025.04

ISSN 0340-7004
- Access to Document (DOI)
Genomic characterization of metastatic patterns in prostate cancer using circulating tumor DNA data from the SCRUM-Japan MONSTAR SCREEN project.

Shiota M, Matsubara N, Kato T, Eto M, Osawa T, Abe T, Shinohara N, Nishimoto K, Yasumizu Y, Tanaka N, Oya M, Fujisawa T, Horasawa S, Nakamura Y, Yoshino T, Nonomura N

The journal of liquid biopsy 7 100282 2025.03
- Access to Document (DOI)
Prediction of pathological up-staging after radical nephroureterectomy in patients with upper tract urothelial carcinoma

Shojo K., Takeda T., Akita H., Suzuki T., Mikami S., Shigeta K., Yasumizu Y., Tanaka N., Matsumoto K., Morita S., Kosaka T., Mizuno R., Asanuma H., Jinzaki M., Oya M.

World Journal of Urology (World Journal of Urology) 42 ( 1 ) 192 2024.12

ISSN 07244983

　View Summary

Purpose: The diagnostic accuracy of computed tomography urography for upper tract urothelial carcinoma is high; however, difficulties are associated with precisely assessing the T stage. Preoperative tumor staging has an impact on treatment options for upper tract urothelial carcinoma. We herein attempted to identify preoperative factors that predict pathological tumor up-staging, which will facilitate the selection of treatment strategies. Materials and methods: We retrospectively identified 148 patients with upper tract urothelial carcinoma who underwent computed tomography urography preoperatively followed by radical nephroureterectomy without preoperative chemotherapy at our institution between 2000 and 2021. Preoperative factors associated with cT2 or lower to pT3 up-staging were examined using a multivariate logistic regression analysis. Results: Ninety out of 148 patients were diagnosed with cT2 or lower, and 22 (24%) were up-staged to pT3. A multivariate analysis identified a positive voided urine cytology (HR 4.69, p = 0.023) and tumor length ≥ 3 cm (HR 6.33, p = 0.003) as independent predictors of pathological tumor up-staging. Conclusions: Patients diagnosed with cT2 or lower, but with preoperative positive voided urine cytology and/or tumor diameter ≥ 3 cm need to be considered for treatment as cT3.
- Access to Document (DOI)
Prediction of undetectable circulating tumor DNA by comprehensive genomic profiling assay in metastatic prostate cancer: the SCRUM-Japan MONSTAR SCREEN project

Shiota M., Matsubara N., Kato T., Eto M., Osawa T., Abe T., Shinohara N., Nishimoto K., Yasumizu Y., Tanaka N., Oya M., Fujisawa T., Horasawa S., Nakamura Y., Yoshino T., Nonomura N.

World Journal of Urology 42 ( 1 ) 526 2024.12

ISSN 07244983

　View Summary

Background: Undetectable circulating tumor DNA (ctDNA) is an obstacle to performing comprehensive genomic profiling in daily practice to identify genomic alterations. We investigated the associations between clinicopathological factors and undetectable ctDNA using a commercially available comprehensive genomic profiling assay in metastatic prostate cancer. Patients and methods: Patients treated with systemic treatment for metastatic prostate cancer were included. ctDNA was analyzed by FoundationOne®Liquid CDx at enrollment. The associations between clinicopathological characteristics and ctDNA detection were analyzed. Results: The number of bone metastasis was associated with ctDNA detection (odds ratio [95% confidence interval], 13.6 [1.71–108], P = 0.014). An algorithm predicting ctDNA detection using clinicopathological parameters was created. If ≥ 4 bone metastases were observed, ctDNA detection was estimated to be 98.9%. Among the patients with < 4 bone metastases, if two or three features among ISUP grade group 5, PSA level ≥ 10 ng/ml, and castration resistance were present, the ctDNA detection rate was 96.7% while the ctDNA detection rate was 86.3% if no or only one feature was present. Conclusions: An algorithm created in this study is helpful in determining when to undertake comprehensive genomic profiling assay using blood.
- Access to Document (DOI)
Tumor immune microenvironment dynamics and outcomes of prognosis in non-muscle-invasive bladder cancer.

Kamitani R, Tanaka N, Anno T, Murakami T, Masuda T, Yasumizu Y, Takeda T, Morita S, Kosaka T, Mikami S, Matsumoto K, Oya M

Cancer science 115 ( 12 ) 3963 - 3972 2024.10

ISSN 1347-9032

　View Summary

Agents that target PD-1 and PD-L1 have been developed in the treatment of bladder cancer (BC). However, the diversity of immune cell infiltration in non-muscle-invasive BC (NMIBC) and the dynamics of the microenvironment as it progresses to muscle-invasive/metastatic disease remains unknown. To assess tumor immune activity, hierarchical clustering was applied to 159 BC samples based on cellular positivity for the defined immune cellular markers (CD3/CD4/CD8/FOXP3/CD20/PD-1/PD-L1/LAG3/TIGIT), divided into two clusters. There was a “hot cluster” (25%) consisting of patients with a high expression of these markers and a “cold cluster” (75%) comprising those without. The expression of CD39, CD44, CD68, CD163, IDO1, and Ki67 was significantly higher in tumors in the hot cluster. Immunologically, high-grade T1 tumors were significantly hotter, whereas tumors that had progressed to muscle invasion turned cold. However, a certain number of high-grade NMIBC patients were in the cold cluster, and these patients had a significantly higher risk of disease progression. Using an externally available TCGA dataset, RB1 and TP53 alterations were more frequently observed in TCGA hot cluster; rather FGFR3, KDM6A, and KMT2A alterations were common in TCGA cold/intermediate cluster. Analyses of recurrent tumors after BCG therapy revealed that tumor immune activity was widely maintained before and after treatment, and high FGFR3 expression was detected after recurrence in tumors initially classified into the cold cluster. Collectively, we revealed the dynamics of the tumor microenvironment in BC as a whole and identified candidate molecules as therapeutic targets for recurrent NMIBC, e.g., after BCG therapy.
- Access to Document (DOI)

display all >>

Page Top ▲

Papers, etc., Registered in KOARA 【 Display / hide 】

Single-cell RNA-seq reveals details of BCG-refractory bladder cancer

Tanaka, Nobuyuki

科学研究費補助金研究成果報告書 2022
Integrated analysis of ITH in drug resistant prostate cancer by single cell analysis

Tanaka, Nobuyuki

科学研究費補助金研究成果報告書 2022
Establishment of new single-cell analysis platform for in-situ-visualizing genitourinary cancer.

Tanaka, Nobuyuki

学事振興資金研究成果実績報告書 (慶應義塾大学) 2022
Targeting cancer stem cells and spatial niches in kidney cancer : unravelling intratumoral heterogeneity

Tanaka, Nobuyuki

科学研究費補助金研究成果報告書 2021
Establishment of new single-cell analysis platform for in-situ-visualizing genitourinary cancer

Tanaka, Nobuyuki

学事振興資金研究成果実績報告書 (慶應義塾大学) 2021

display all >>

Page Top ▲

Reviews, Commentaries, etc. 【 Display / hide 】

【臨床腎・泌尿器癌(中)-基礎・臨床研究の進歩-】膀胱癌の特徴　膀胱癌の発症・進展メカニズム

田中伸之

日本臨床 ((株)日本臨床社) 82 ( 増刊9 臨床腎・泌尿器癌(中) ) 23 - 27 2024.11

ISSN 0047-1852
画像診断と病理　肉腫様腎癌(淡明細胞型腎細胞癌由来)

池田織人, 秋田大宇, 陣崎雅弘, 大家基嗣, 田中伸之, 新井恵吏

画像診断 ((株)Gakken) 44 ( 8 ) 748 - 749 2024.06

ISSN 0285-0524
【薬の使い方がすぐわかる　泌尿器科処方ガイド】腫瘍　抗がん薬の副作用対策　急性過敏性反応

水野隆一, 田中伸之, 大家基嗣

臨床泌尿器科 ((株)医学書院) 78 ( 4 ) 208 - 211 2024.04

ISSN 0385-2393

　View Summary

＜文献概要＞処方のポイント　●アナフィラキシー治療の要はアドレナリンである.●アドレナリン投与時に注意すべき症例がある.●注入時反応(IRR)予防目的に前投薬が用いられる.
【前立腺肥大症:近年の治療の進歩】接触式レーザー蒸散術(Contact laser Vaporization of the Prostate:CVP)の現状と展望

田中伸之, 大家基嗣

Prostate Journal (医学図書出版(株)) 10 ( 2 ) 145 - 150 2023.10

ISSN 2188-4978

　View Summary

前立腺肥大症への接触レーザー蒸散術(CVP)は,光ファイバーを通して980nmダイオードレーザーを照射し,肥大した前立腺組織を気化させる。本邦では人口の高齢化に伴い,抗血栓療法を受ける患者数は増加傾向にある。ダイオードレーザーの有する蒸散力・止血能によって,抗血栓療法の休薬が難しい症例でも,安全な手術が可能となった。われわれは,抗血栓療法下のCVP安全性と有効性を評価した前向き観察研究を中心に,CVP治療の現状と展望について述べる。(著者抄録)
【どこまで変わるの?　腎細胞癌診療の進歩】診断　腎細胞癌の免疫微小環境

田中伸之, 大家基嗣

臨床泌尿器科 ((株)医学書院) 77 ( 5 ) 322 - 326 2023.04

ISSN 0385-2393

　View Summary

＜文献概要＞ポイント　・「複合がん免疫療法」の成功に免疫微小環境の理解は欠かせない.・腎細胞癌の免疫微小環境は,ほかの免疫感受性腫瘍と異なり,「腫瘍内のCD8+T細胞密度の高いほうが予後が悪い」という点で異質性が際立つ.・腎細胞癌の遺伝子変異は挿入・欠失が多いため,ネオアンチゲン増加と関連するTMBが,通常は低く推定される.

display all >>

Page Top ▲

Presentations 【 Display / hide 】

新規分子イメージングによる腎がんPathomicsの実現:組織透明化とナノレゾリューション

田中伸之

第112回日本泌尿器科学会総会,

2025.04
Novel Diagnostic of Prostate Cancer Using Urine-Derived Exosomes: Prospective Pilot Study

田中伸之

The 13rd European Congress of Andrology,

2024.09
組織透明化：がんの可視化、基礎と実践

田中伸之

第49回組織細胞化学講習会,

2024.08
Whole-body analysis of clonal trajectories and spatial transcriptomics reveals inter- and intra-organ heterogeneity in urothelial carcinoma under immunotherapy

田中伸之

第111回日本泌尿器科学会総会,

2024.04
尿由来エクソソームを用いた尿路上皮癌の新しい体外診断

田中伸之

第61回日本癌治療学会学術集会,

2023.10
,
Symposium, workshop panel (nominated)

display all >>

Page Top ▲

Research Projects of Competitive Funds, etc. 【 Display / hide 】

がん免疫治療下における間質軌跡地図の空間解析と新しい間質リプログラミング法の確立

2024.07

-

2028.03

文部科学省・日本学術振興会, 科学研究費助成事業, 挑戦的研究(開拓), Principal investigator
透析患者に発生する腎細胞癌のOmics解析と腫瘍免疫微小環境の統合的理解

2024.04

-

2028.03

文部科学省・日本学術振興会, 科学研究費助成事業, 基盤研究(C), Coinvestigator(s)
泌尿器がんのクローン進化と腫瘍間質の空間解析による免疫治療耐性メカニズムの解明

2024.04

-

2028.03

文部科学省・日本学術振興会, 科学研究費助成事業, 基盤研究(A) , Coinvestigator(s)
膀胱癌における次世代免疫チェックポイント分子B7ファミリーの機能解明

2024.04

-

2027.03

文部科学省・日本学術振興会, 科学研究費助成事業, 基盤研究(C), Coinvestigator(s)
新規3次元イメージングによる腎がんの微小脈管および3次リンパ様構造(TLS)の解析

2024.04

-

2027.03

文部科学省・日本学術振興会, 科学研究費助成事業, 基盤研究(C), Coinvestigator(s)