Details of a Researcher - Oya, Mototsugu

Papers - Oya, Mototsugu

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Oya Mototsugu

International Journal of Urology 20 ( 7 ) 648 2013.07

ISSN 0919-8172

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A questionnaire survey of antimicrobial prophylaxis to prevent perioperative infection in urological field in Japan

Togo Yoshikazu, Taoka Rikiya, Yamamoto Shingo, Hiyama Yoshiki, Uehara Teruhisa, Hashimoto Jiroh, Kurimura Yuichiro, Takahashi Satoshi, Tsukamoto Taiji, Miyazaki Jun, Nishiyama Hiroyuki, Kiyota Hiroshi, Yazawa Satoshi, Oya Mototsugu, Yasuda Mitsuru, Deguchi Takashi, Ishikawa Kiyohito, Hoshinaga Kiyotaka, Matsumoto Minori, Shigemura Katsumi, Tanaka Kazushi, Arakawa Soichi, Fujisawa Masato, Wada Koichiro, Uehara Shinya, Watanabe Toyohiko, Kumon Hiromi, Kobayashi Kanao, Matsubara Akio, Matsumoto Masahiro, Sho Takehiko, Hamasuna Ryoichi, Matsumoto Tetsuro, Hayami Hiroshi, Yamane Takashi, Nakagawa Masayuki

Japanese Journal of Urology 104 ( 4 ) 579 - 588 2013.07

ISSN 0021-5287

(Purpose): To survey the present condition of administration method of the antimicrobial prophylactic (AMP) agents for the perioperative infection in Japan on revising "The Japanese guidelines for prevention of perioperative infections in urologic field (2006)". (Patients and methods): With the approval of the Japanese Urological Association (JUA) in 2011, all of the principal urological training institutions certified by JUA (n = 836) were encouraged to participate to survey their adherence to the JUA guidelines (published in 2006) for AMP to prevent perioperative infection in urological field, and 446 (53.3%) institutions responded to the questionnaire. (Results): The rates of following the JUA guidelines of, "completely", "mainly", "not too much", and "not at all" were 6.5%, 69.7%, 22.0% and 1.6%, respectively. The guidelines were followed for open clean operations in 48.5%, open clean-contaminated operations in 66.4%, open contaminated operations in 61.8%, laparoscopic clean operations in 54.1%, laparoscopic clean-contaminated operations in 61.2%, transurethral resection of bladder tumor in 71.5%, transurethral resection of prostate in 68.9%, ureteroscopy and transurethral ureterolithotomy in 68.2%, prostate biopsy in 43.2%, and cystoscopy were in 42.2%, respectively. However, in terms of duration of AMP administration, the longer duration than those recommended by the guidelines were observed for clean surgery, transurethral resection of bladder tumor, ureteroscopy and transurethral ureterolithotomy, prostate biopsy, and cystoscopy. (Conclusions): In terms of kinds of AMP, the guidelines were almostly followed in all operative procedures. However, the duration of AMP administration were longer than those recommended by the guidelines. On revision of "Japanese guidelines for prevention of perioperative infections in urologie field (2006)", these data would be taken into consideration to avoid dissociation between the guidelines and the practical side in the urologists.

Three cases of IgG4-related disease associated with urinary tract obstruction

Yazawa Satoshi, Ohara Rei, Maeda Takahiro, Kanao Kent, Hattori Seiya, Nakajima Yosuke, Oya Mototsugu

Japanese Journal of Urology 104 ( 4 ) 620 - 625 2013.07

ISSN 0021-5287

IgG4-related disease (IgG4RD) is a novel clinical entity characterized by tissue infiltration of IgG4-positive plasma cells. We report here 3 cases of IgG4RD associated with urinary tract obstruction. Patient 1 was a 59-year-old male who complained of difficulty on urination. A CT scan showed bilateral ureteral wall thickness, hydronephrosis, and an enlarged prostate. His serum IgG4 was 817 mg/dl. We made a diagnosis of IgG4RD and performed bilateral ureteral stenting and steroid therapy. A significant reduction in the size of the lesion was detected, and IgG4 was decreased to 272 mg/dl. He was doing well after removal of the ureteral stent. Patient 2 was a 51-year-old female who complained of bilateral swelling of the submaxillary gland. A CT scan showed left ureteral wall thickness and hydronephrosis. Her serum IgG4 was 1, 020 mg/dl. We made a diagnosis of IgG4RD and performed left ureteral stenting and steroid therapy. A significant reduction in the size of the lesion was detected, and IgG4 was decreased to 337 mg/dl. She was doing well after removal of the ureteral stent. Patient 3 was a 64-year-old male who underwent evaluation for autoimmune pancreatitis. He complained of back pain and bilateral hydronephrosis was detected. His serum IgG4 level was 649 mg/dl. Bilateral ureteral stenting was performed based on a diagnosis of IgG4RD. He did not receive steroid therapy because of poorly-controlled diabetes mellitus. After insertion of the ureteral stent, hydronephrosis and back pain were relieved. We could only find a few case reports in the literature on IgG4RD associated with urinary tract obstruction. It is important for clinicians to bear in mind that IgG4RD sometimes causes urinary tract obstruction.

Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma

Yoshimine S., Kikuchi E., Kosaka T., Mikami S., Miyajima A., Okada Y., Oya M.

British Journal of Cancer 108 ( 11 ) 2312 - 2320 2013.06

ISSN 0007-0920

Background: Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcinoma (UC) cells. Methods: We evaluated the immunohistochemical expression of Bcl-xL in 175 UTUC patients to determine the clinical role of BclxL expression in clinical outcome. We used bafilomycin A1 (BMA) as a specific inhibitor of Bcl-xL to examine the biological effects in UC cells in vitro and in vivo. Results: Immunohistochemical analysis of Bcl-xL expression revealed that patients with a high Bcl-xL score had a significantly lower 5-year cancer-specific survival (CSS) rate (53.2%) than those with a low Bcl-xL score (77.2%) (P = 0.0011). Multivariate analysis indicated that a high Bcl-xL score was an independent prognostic factor of CSS (P = 0.023). BMA inhibited UMUC-3 cell proliferation in vitro by induction of apoptosis. Treatment with BMA significantly inhibited tumour growth in UMUC-3 tumours in this mouse xenograft model accompanied by an elevated apoptosis induction. Conclusion: Bcl-xL appears to be a significant molecular marker for the prognosis of UTUCs. Targeting Bcl-xL may be a promising therapeutic strategy for patients with UC.

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Impact of smoking status on bladder tumor recurrence after radical nephroureterectomy for upper tract urothelial carcinoma

Hagiwara Masayuki, Kikuchi Eiji, Tanaka Nobuyuki, Matsumoto Kazuhiro, Ide Hiroki, Miyajima Akira, Masuda Takeshi, Nakamura So, Oya Mototsugu

Journal of Urology 189 ( 6 ) 2062 - 2068 2013.06

ISSN 0022-5347

Purpose: Although smoking status has a significant association with clinical features in patients with bladder cancer, there are few reports of the impact of smoking on the clinical outcome of upper tract urothelial cancer. We investigated the possible influence of smoking status on bladder tumor recurrence after radical nephroureterectomy. Materials and Methods: We identified a study population of 245 consecutive patients treated surgically for upper tract urothelial cancer at our 3 institutions between 1994 and 2010. We analyzed associations between subsequent bladder tumor recurrence and patient clinicopathological parameters, including smoking status. Results: The 3-year bladder tumor recurrence-free survival rate was 32.6% in current smokers, 37.6% in former smokers and 61.7% in nonsmokers. Multivariate analysis revealed that male gender (HR 1.90, 95% CI 1.15-3.16, p = 0.013) and smoking status (former vs none HR 1.77, 95% CI 1.07-2.93, p = 0.027 and current vs none HR 1.58, 95% CI 1.03-2.42, p = 0.035) were independent risk factors for subsequent bladder tumor recurrence. Also, of patients with a positive smoking history those with 50 pack-years or greater showed a significantly higher incidence of bladder tumor recurrence after radical nephroureterectomy (HR 2.00, p = 0.003). Conclusions: Positive smoking history and male gender were independent risk factors for bladder tumor recurrence after radical nephroureterectomy. A larger number of cigarettes smoked may increase the incidence of bladder tumor recurrence in patients with upper tract urothelial cancer.

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CLINICAL FEATURES OF LONG-TERM USE OF PDE-5 INHIBITORS IN PATIENTS WITH ED

Daimon Tatsuaki, Kikuchi Eiji, Matsushima Masashi, Ando Toshiyuki, Miyajima Akira, Marumo Ken, Oya Mototsugu

JOURNAL OF SEXUAL MEDICINE 10 216 - 216 2013.06

Research paper (scientific journal), Joint Work, ISSN 1743-6095

A PROSPECTIVE LONGITUDINAL SURVEY OF ERECTILE FUNCTION FOLLOWING TREATMENT FOR LOCALIZED PROSTATE CANCER WITH PROSTATE BRACHYTHERAPY

Matsushima Masashi, Kikuchi Eiji, Maeda Takahiro, Sugawara Akitomo, Ando Toshiyuki, Nagata Hirohiko, Miyajima Akira, Nakagawa Ken, Oya Mototsugu

JOURNAL OF SEXUAL MEDICINE 10 243 - 244 2013.06

Research paper (scientific journal), Joint Work, ISSN 1743-6095

The prognostic significance of vasohibin-1 expression in patients with prostate cancer

Kosaka T., Miyazaki Y., Miyajima A., Mikami S., Hayashi Y., Tanaka N., Nagata H., Kikuchi E., Nakagawa K., Okada Y., Sato Y., Oya M.

British Journal of Cancer 108 ( 10 ) 2123 - 2129 2013.05

ISSN 0007-0920

Background:We recently isolated vasohibin-1 (VASH1), a novel angiogenic molecule that is specifically expressed in activated vascular endothelial cells (ECs), and the status of VASH1 expression has been documented in various cancer angiogenesis. The aim of this study was to assess the prognostic value of VASH1 expression in prostate cancer (PCa).Methods:In this study, we retrospectively analysed the clinical records and evaluated the VASH1 expression of tumour microvessels in 167 patients with PCa who underwent radical prostatectomy. We immunohistochemically examined the microvessels positive for anti-CD34 as microvessel density (MVD) and the microvessels with activated ECs positive for VASH1 density.Results:We found that the VASH1 expression was restricted to ECs in the tumour stroma. VASH1 density was significantly associated with pathological T stage, Gleason score and MVD. The 5-year PSA recurrence-free survival rate was 58.8% in patients with higher VASH1 density (≧12 per mm 2) and 89.1% in patients with lower VASH1 density (<12 per mm 2), respectively (P<0.001). Microvessel density was not an independent predictor of PSA recurrence. Multivariate analysis revealed that high VASH1 density was an independent prognostic indicator of PSA recurrence (P=0.007, HR=2.950).Conclusion:VASH1 density represents a clinically relevant predictor of patient prognosis and can be a new biomarker that would provide additional prognostic information in PCa.

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Prognostic value of plasma fibrinogen levels in patients with localized upper tract urothelial carcinoma

Tanaka Nobuyuki, Kikuchi Eiji, Matsumoto Kazuhiro, Hayakawa Nozomi, Ide Hiroki, Miyajima Akira, Nakamura So, Oya Mototsugu

BJU INTERNATIONAL 111 ( 6 ) 857 - 864 2013.05

Research paper (scientific journal), Joint Work, ISSN 1464-4096

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Efficacy and safety of docetaxel-based chemotherapy in Japanese men over 80 years old with castration-resistant prostate cancer.

Kosaka Takeo, Yasumizu Yota, Mizuno Ryuichi, Miyajima, Akira, Kikuchi Eiji, Shinya Morita, Kono Hidaka, Nakagawa Ken, Oya Mototsugu

JOURNAL OF CLINICAL ONCOLOGY 31 ( 15 ) 619 - 624 2013.05

Research paper (scientific journal), Joint Work, ISSN 0732-183X

How can lymphocele development be prevented after laparoscopic radical prostatectomy?

Yasumizu Yota, Miyajima Akira, Maeda Takahiro, Takeda Toshikazu, Hasegawa Masanori, Kosaka Takeo, Kikuchi Eiji, Oya Mototsugu

Journal of Endourology 27 ( 4 ) 447 - 451 2013.04

ISSN 0892-7790

Objectives: Lymphocele development is the most frequently reported postoperative complication of pelvic lymph node dissection (PLND) performed with laparoscopic radical prostatectomy (LRP). This study evaluated the efficacy of a vessel-sealing device (VSD) for the prevention of lymphocele development. Methods: A total of 120 patients who underwent LRP with PLND were prospectively enrolled. The patients were randomly assigned to one of the two groups: PLND using a conventional technique (group 1), and PLND performed with VSD (group 2). All patients underwent computed tomography (CT) scanning 1 month postoperatively to evaluate the maximum sectional area of the lymphoceles. Results: Lymphoceles developed in 63 cases (52.5%). One case (0.8%) was symptomatic with infection, and drainage tube placement was required. In the other 62 patients, the lymphoceles developed asymptomatically and were detected by CT scanning. There was no significant difference in the lymphocele development ratio between the two groups. However, when we defined a lymphocele over 1500 mm² as being a significant size, lymphoceles were present in 16 of 60 patients in group 1 and 4 of 60 patients in group 2. The incidence of significant lymphoceles over 1500 mm² in the group using VSD was much lower than that of the group without VSD (p<0.01). Multivariate analysis demonstrated that VSD was the only independent factor that had an effect on preventing the development of lymphoceles over 1500 mm² (p<0.01, odds ratio=4.96). Conclusion: The results indicate that the development of large lymphoceles can be prevented by using VSD in LRP with PLND.

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PREDICTIVE VALUE OF POSITIVE URINE CYTOLOGY FOR PROGNOSIS IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA FOLLOWING RADICAL NEPHROURETERECTOMY

Tanaka Nobuyuki, Kikuchi Eiji, Miyazaki Yasumasa, Shirotake Suguru, Kobayashi Hiroaki, Matsumoto Kazuhiro, Ide Hiroki, Obata Jun, Hoshino Katsura, Kosaka Takeo, Kanao Kent, Oyama Masafumi, Miyajima Akira, Momma Tetsuo, Nakagawa Ken, Nakajima Yosuke, Oya Mototsugu

JOURNAL OF UROLOGY 189 ( 4 ) E162 - E162 2013.04