Details of a Researcher - Oya, Mototsugu

Papers - Oya, Mototsugu

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A Multi-Institutional Validation of the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio for Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy

Tanaka Nobuyuki, Kikuchi Eiji, Kanao Kent, Matsumoto Kazuhiro, Shirotake Suguru, Miyazaki Yasumasa, Kobayashi Hiroaki, Kaneko Gou, Hagiwara Masayuki, Ide Hiroki, Obata Jun, Hoshino Katsura, Hayakawa Nozomi, Kosaka Takeo, Hara Satoshi, Oyama Masafumi, Momma Tetsuo, Nakajima Yosuke, Jinzaki Masahiro, Oya Mototsugu

Annals of Surgical Oncology 21 ( 12 ) 4041 - 4048 2014.10

ISSN 1068-9265

Background: To externally validate the prognostic impact of preoperative neutrophil–lymphocyte ratio (pre-NLR) in patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU).Methods: A total of 665 patients from 12 institutions were included. The median follow-up was 28 months. Associations between pre-NLR level and outcome were assessed using multivariate analysis. A pre-NLR level of >3.0 was defined as elevated.Results: Pre-NLR levels were elevated in 184 patients (27.7 %), and pre-NLR elevation was significantly associated with worse pathological features such as tumor grade 3, advanced pT stage, positive lymphovascular invasion (LVI), and lymph node involvement in RNU specimens. The 5-year recurrence-free and cancer-specific survival rates were 57.0 % (p < 0.001) and 60.2 % (p < 0.001), respectively, in patients with elevated pre-NLR, and 69.2 and 77.3 %, respectively, in their counterparts. Multivariate analysis showed that elevated pre-NLR was an independent risk factor for predicting subsequent disease recurrence (p = 0.037; hazard ratio (HR) 1.38) and cancer-specific mortality (p = 0.036;, HR 1.47), although the addition of pre-NLR slightly improved the accuracies of the base model for predicting both disease recurrence and cancer-specific mortality to 79.8 % (p = 0.041) and 83.0 % (p = 0.039), respectively (gain in predictive accuracy: 0.2 and 0.1 %, respectively).Conclusion: This multi-institutional study revealed that elevated pre-NLR was significantly associated with worse pathological features such as tumor grade 3, advanced pT stage, positive LVI, and lymph node involvement in RNU specimens, and elevated pre-NLR was an independent risk factor of disease recurrence and cancer-specific mortality in UTUC patients treated with RNU.

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Recent trends in the initial therapy for newly diagnosed prostate cancer in Japan

Onozawa Mizuki, Hinotsu Shiro, Tsukamoto Taiji, Oya Mototsugu, Ogawa Osamu, Kitamura Tadaichi, Suzuki Kazuhiro, Naito Seiji, Namiki Mikio, Nishimura Kazuo, Hirao Yoshihiko, Akaza Hideyuki

Japanese Journal of Clinical Oncology 44 ( 10 ) 969 - 981 2014.10

ISSN 0368-2811

OBJECTIVE: The objective of the present study was to investigate the trends over time in the initial treatment of prostate cancer in Japan.METHODS: A total of 8291 patients with newly diagnosed prostate cancer whose treatment started in 2010 were registered in a multi-institutional observational study undertaken nationwide across Japan by the Japan Prostate Cancer Study Group. Each patient's background characteristics and initial treatment were recorded.RESULTS: The median age at diagnosis was 71 years. The proportion of T1c disease was 40.5% and that of M1 disease was 10.4%. The prostate-specific antigen level was <10 ng/ml in 52.0% of the patients. High-, intermediate- and low-risk patients as determined by D'Amico's classification system made up 19.3, 29.8 and 25.9% of the cases, respectively. The initial treatment was androgen depletion therapy in 40.2%, radical prostatectomy in 32.0% (17.3% of these involved laparoscopic prostatectomy), radiation in 21.0% (46.4% of these involved brachytherapy). In cases of organ-confined disease, radical prostatectomy was selected in 39.5%, androgen depletion therapy in 28.0% and radiation in 23.9%. In D'Amico's low-risk group, the proportion treated with radiation was nearly equal to that treated with radical prostatectomy (30.2 and 32.7%, respectively); 73.2% of the radiation treatments involved brachytherapy.CONCLUSION: Compared with previous Japanese studies, radiation use was increased by ∼10%. This increased proportion of radiation use was a typical trend in initial therapy for newly diagnosed prostate cancer cases in Japan. Although androgen depletion therapy use was decreased, it was selected in a high proportion of the patients irrespective of the disease stage.

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Clinical pearls in treatment for the patients of adrenal tumor

Hattori Seiya, Kikuchi Eiji, Oya Mototsugu

Japanese Journal of Clinical Urology 68 ( 11 ) 822 - 825 2014.10

ISSN 0385-2393

Erratum

Togo Yoshikazu, Kubo Tatsuhiko, Taoka Rikiya, Hiyama Yoshiki, Uehara Teruhisa, Hashimoto Jiroh, Kurimura Yuichiro, Takahashi Satoshi, Tsukamoto Taiji, Miyazaki Jun, Nishiyama Hiroyuki, Kira Shinichiro, Kiyota Hiroshi, Yazawa Satoshi, Niwa Naoya, Hongo Hiroshi, Oya Mototsugu, Kato Taku, Yasuda Mitsuru, Deguchi Takashi, Ishikawa Kiyohito, Hoshinaga Kiyotaka, Matsumoto Minori, Shigemura Katsumi, Tanaka Kazushi, Arakawa Soichi, Fujisawa Masato, Wada Koichiro, Uehara Shinya, Watanabe Toyohiko, Kumon Hiromi, Kobayashi Kanao, Matsubara Akio, Matsumoto Masahiro, Sho Takehiko, Hamasuna Ryoichi, Matsumoto Tetsuro, Hayami Hiroshi, Nakagawa Masayuki, Yamamoto Shingo

Journal of Infection and Chemotherapy 20 ( 10 ) 660 2014.10

ISSN 1341-321X

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Expression level of dihydropyrimidine dehydrogenase is associated with clinical outcome in patients with T1G3 bladder cancer treated with Bacillus Calmette-Guerin

Ide Hiroki, Kikuchi Eiji, Mikami Shuji, Miyajima Akira, Oya Mototsugu

BMC Research Notes 7 ( 1 ) 2014.09

Background: Recently, it has been shown that 5-fluorouracil (5-FU) with a strong dihydropyrimidine dehydrogenase (DPD) inhibitor elicits a significant response in bladder cancer with a high level of DPD. However, only a few studies investigated the association between the level of the enzyme that regulates the metabolism of 5-FU and prognosis in bladder cancer. Furthermore, to our knowledge, there has also been no such report in T1G3 bladder tumors treated with BCG. Therefore, we evaluated enzymes that regulate the metabolism of 5-FU in T1G3 tumors treated with BCG immunotherapy using the Danenberg tumor profile (DTP) method, a highly accurate measurement of RNA from paraffin-embedded specimens. Methods. This study included 28 patients with T1G3 bladder cancer, each of whom underwent complete transurethral tumor resection and BCG intravesical instillation at our institution. The median follow-up period was 39 months (range, 3 to 159 months). The DTP method was used to analyze the mRNA expression of 3 enzymes related to 5-FU: DPD, orotate phosphoribosyltransferase (OPRT), and thymidylate synthase (TS). Results: Among the 28 patients, 13 developed recurrences (46.4%) and 5 experienced disease progression (17.9%). An elevated DPD mRNA level was significantly associated with recurrence (p = 0.048) and progression (p = 0.045). However, TS and OPRT mRNA levels were not significantly associated with any other clinical features or outcomes. Furthermore, the high DPD group had a significantly lower recurrence-free survival rate than the low DPD group (p = 0.047). Among patients with low DPD, the 2- and 5-year recurrence-free survival rates were 88.9% and 74.1%, respectively; while among patients with high DPD, the corresponding rates were 61.3% and 36.8%, respectively. TS and OPRT were not significantly associated with recurrence-free survival rates. Conclusion: DPD is significantly associated with recurrence and progression among T1G3 bladder cancer patients treated with BCG.

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Unidirectional barbed suture for vesicourethral anastomosis during laparoscopic radical prostatectomy

Takeda Toshikazu, Miyajima Akira, Kaneko Gou, Hasegawa Masanori, Kikuchi Eiji, Oya Mototsugu

Asian journal of endoscopic surgery 7 ( 3 ) 241 - 245 2014.08

INTRODUCTION: We investigated the impact of unidirectional barbed suture (UBS) for vesicourethral anastomosis (VUA) during laparoscopic radical prostatectomy.METHODS: The polyglyconate UBS V-Loc 180 was used for VUA during laparoscopic radical prostatectomy in 30 consecutive patients who were diagnosed with organ-confined prostate cancer between January and October 2012. The operative and postoperative parameters were then compared with those of 30 consecutive patients who had previously undergone the same procedure but with the monofilament poliglecaprone suture Monocryl. All procedures were performed by the same experienced surgeon.RESULTS: VUA time was significantly shorter in the V-Loc group (13.2 ± 2.3 min) than in the Monocryl group (19.1 ± 3.3 min) (P < 0.001). The V-Loc group required significantly more stitches than the Monocryl group (11.4 ± 1.3 vs 10.6 ± 1.6 stitches; P = 0.031). The percentage of patients who required no more than one pad per day at 3 months postoperatively was significantly higher in the V-Loc group (63.3%) than in the Monocryl group (23.3%) (P = 0.020). No significant differences in other perioperative parameters were observed between the two groups.CONCLUSION: Using UBS prevents suture slippage and enables tieless anastomosis. VUA using a UBS may relieve surgeon stress because a rapid and secure anastomosis is achievable.

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Activity of axitinib in patients with metastatic renal cell carcinoma previously treated with both vascular endothelial growth factor receptor tyrosine-kinase inhibitor and mammalian target of rapamycin inhibitor

Mizuno Ryuichi, Miyajima Akira, Oya Mototsugu

INTERNATIONAL JOURNAL OF UROLOGY 21 ( 7 ) 740 - 740 2014.07

Research paper (scientific journal), Joint Work, ISSN 0919-8172

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Surgical outcome of laparoscopic surgery, including laparoendoscopic single-site surgery, for retroperitoneal paraganglioma compared with adrenal pheochromocytoma

Hattori Seiya, Miyajima Akira, Hirasawa Yousuke, Kikuchi Eiji, Kurihara Isao, Miyashita Kazutoshi, Shibata Hirotaka, Nakagawa Ken, Oya Mototsugu

Journal of Endourology 28 ( 6 ) 686 - 692 2014.06

ISSN 0892-7790

Objective: Paraganglioma (PGL) is a rare type of tumor that arises from the extra-adrenal paraganglia. A PGL tumor hypersecretes catecholamines and causes symptoms identical to those in patients with hyper-functioning adrenal pheochromocytoma (PCC). In this study, we compared the surgical outcome of laparoscopic surgery, including laparoendoscopic single-site (LESS) surgery, in patients with PCC and patients with retroperitoneal solitary PGL. Methods: The records of 49 patients with PCC and 9 patients with unilateral retroperitoneal PGL at our institution from January 2001 to March 2013 were retrospectively reviewed. Multiple tumors, tumors suspected of being malignant preoperatively, and tumors operated on using a retroperitoneal approach were excluded from the study. Results: Each group was equivalent with respect to patient background, hemodynamic variables, and preoperative biochemical assessments, including plasma catecholamine levels and catecholamine levels in 24-hour urine samples. The mean operative time was significantly longer in the PGL group (149.4±56.5 minutes v 189.8±44.9 minutes, P=0.019). In univariate and multivariate analyses, tumor size ≥50 mm and PGL were statistically significant factors that predicted prolonged operative time. Intraoperative hypotension occurred in 15 patients in the PCC group and in 8 patients in the PGL group, and the difference was statistically significant (P=0.002). One postoperative complication in the PCC group and two postoperative complications (Clavien-Dindo grade II or higher) in the PGL group were observed, and the difference was statistically significant (P=0.012). Twenty-two patients in this series underwent LESS surgery (PCC: n=19; PGL: n=3), and there was no statistically significant difference in the perioperative outcomes between the two groups. Conclusions: The present results demonstrate that the operation for solitary extraperitoneal PGL required a longer operative time and had more hypotensive episodes and higher postoperative morbidity than the PCC group. Though the perioperative outcome of LESS surgery for PGL is comparable to that of PCC, we should treat the patients with PGL accordingly.

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Surgical Outcome of Laparoscopic Surgery, Including Laparoendoscopic Single-Site Surgery, for Retroperitoneal Paraganglioma Compared with Adrenal Pheochromocytoma

Hattori Seiya, Miyajima Akira, Hirasawa Yousuke, Kikuchi Eiji, Kurihara Isao, Miyashita Kazutoshi, Shibata Hirotaka, Nakagawa Ken, Oya Mototsugu

JOURNAL OF ENDOUROLOGY 28 ( 6 ) 686 - 692 2014.06

Research paper (scientific journal), Joint Work, ISSN 0892-7790

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Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management

Jinzaki Masahiro, Silverman Stuart G., Akita Hirotaka, Nagashima Yoji, Mikami Shuji, Oya Mototsugu

ABDOMINAL IMAGING 39 ( 3 ) 588 - 604 2014.06

Research paper (scientific journal), Joint Work, ISSN 0942-8925

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Androgen deprivation therapy improves pneumoperitoneum time during laparoscopic radical prostatectomy in Japanese patients with enlarged prostates

Takeda Toshikazu, Miyajima Akira, Kaneko Gou, Kikuchi Eiji, Nakagawa Ken, Oya Mototsugu

Asian journal of endoscopic surgery 7 ( 2 ) 145 - 151 2014.05

INTRODUCTION: The aim of this study was to investigate if neoadjuvant hormone therapy (NHT) is associated with surgical outcomes of laparoscopic radical prostatectomy.METHODS: A total of 286 patients with organ-confined prostate cancer and a preoperative prostate volume that could be estimated by transrectal ultrasound underwent laparoscopic radical prostatectomy between 2006 and 2011 at our institution. We examined whether NHT was associated with pneumoperitoneum time (PT) or estimated blood loss during laparoscopic radical prostatectomy.RESULTS: NHT was performed in 80 patients; the mean duration of NHT was 5.2 ± 0.2 months. Multivariate analysis demonstrated that history of NHT and no NHT were not independent predictors of prolonged PT or higher estimated blood loss. Next, we evaluated 57 patients whose estimated preoperative baseline prostate volume was over 50 mL. Multivariate analysis demonstrated that no history of NHT (P = 0.011) was an independent predictor of prolonged PT. PT was significantly shorter in the NHT group (164.5 ± 39.0 min, n = 26) than in the non-NHT group (184.0 ± 36.7 min, n = 31) (P = 0.048). In the NHT group, mean prostate volume was reduced from 63.7 ± 16.0 mL to 42.1 ± 18.6 mL (33.9% reduction) by NHT.CONCLUSION: NHT shortened the PT of the patients whose preoperative baseline prostate volume was over 50 mL. This suggests NHT downsized prostate volume, resulting in greater working space and shorter PT.

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Erythrocyte protein bond 4.1-like5 expression in patients with upper urinary tract urothelial carcinoma correlates with tumor recurrence

Daimon Tatsuaki, Kosaka Takeo, Mikami Shuji, Miyazaki Yasumasa, Mizuno Ryuichi, Kikuchi Eiji, Miyajima Akira, Nakagawa Ken, Sabe Hisataka, Oya Mototsugu

JOURNAL OF CLINICAL ONCOLOGY 32 ( 15 ) E264 - E264 2014.05

Research paper (scientific journal), Joint Work, ISSN 0732-183X

METABOLIC SHIFT UNDER HYPOXIC ENVIRONMENT CAUSES RESISTANCE TO MTOR INHIBITOR IN HUMAN CASTRATION RESISTANT PROSTATE CANCER.

Yasumizu Yota, Kosaka Takeo, Miyazaki Yasumasa, Kikuchi Eiji, Miyajima Akira, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E264 - E264 2014.04

Research paper (scientific journal), Joint Work, ISSN 0022-5347

THERAPEUTIC EFFECT BY TARGETING BCL-XL PROTEIN IN UROTHELIAL CARCINOMA CELLS

Yoshimine Shunsuke, Kikuchi Eiji, Kosaka Takeo, Miyajima Akira, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E230 - E230 2014.04

Research paper (scientific journal), Joint Work, ISSN 0022-5347

METFORMIN IS A NEW THERAPEUTIC STRATEGY FOR TARGETING CD44 VARIANT IN BLADDER CANCER

Hagiwara Masayuki, Kikuchi Eiji, Kosaka Takeo, Yuge Kazuhiro, Yasumizu Yota, Saya Hideyuki, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E431 - E431 2014.04

Research paper (scientific journal), Joint Work, ISSN 0022-5347

ERECTILE FUNCTION IS HIGHLY ASSOCIATED WITH PROSTATE-SPECIFIC ANTIGEN BOUNCE IN LOCALIZED PROSTATE CANCER PATIENTS TREATED WITH PERMANENT PROSTATE BRACHYTHERAPY

Matsushima Masashi, Kikuchi Eiji, Maeda Takahiro, Ando Toshiyuki, Nagata Hirohiko, Miyajima Akira, Nakagawa Ken, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E334 - E334 2014.04

Research paper (scientific journal), Joint Work, ISSN 0022-5347

DEVELOPMENT OF AN ALGORITHM FOR PREDICTING SEVERE ACUTE EPIDIDYMITIS

Hongo Hiroshi, Shinojima Toshiaki, Yazawa Satoshi, Kanao Kent, Morita Shinya, Kosaka Takeo, Kono Hidaka, Mizuno Ryuichi, Kikuchi Eiji, Nagata Hirohiko, Asanuma Hiroshi, Miyajima Akira, Nakagawa Ken, Saito Shiro, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E160 - E160 2014.04

Research paper (scientific journal), ISSN 0022-5347

INCREASED EXPRESSION OF ARYL HYDROCARBON RECEPTOR IN CLEAR CELL RENAL CELL CARCINOMA AND INFILTRATING LYMPHOCYTES: IMPLICATIONS FOR CANCER INVASION, PROGNOSIS AND TUMOR IMMUNITY

Ishida Masaru, Mikami Shuji, Kosaka Takeo, Mizuno Ryuichi, Kikuchi Eiji, Miyajima Akira, Nakagawa Ken, Okada Yasunori, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E304 - E305 2014.04

Research paper (scientific journal), Joint Work, ISSN 0022-5347

AXL IS A NOVEL PROGNOSTIC MARKER IN UPPER URINARY TRACT UROTHELIAL CARCINOM

Hattori Seiya, Kikuchi Eiji, Kosaka Takeo, Miyajima Akira, Mikami Shuji, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E297 - E297 2014.04

Research paper (scientific journal), Joint Work, ISSN 0022-5347

PROSPECTIVE EVALUATION OF EFFICACY AND SAFETY OF SOLIFENACIN AND MIRABEGRON TREATMENT IN BPH PATIENTS TREATED WITH DUTASTERIDE BUT HAVING OAB SYMPTOMS

Ishioka Katsura, Kikuchi Eiji, Maeda Takahiro, Hasegawa Masanori, Kosaka Takeo, Shinojima Toshiaki, Nagata Hirohiko, Miyajima Akira, Nakagawa Ken, Oya Mototsugu

JOURNAL OF UROLOGY 191 ( 4 ) E670 - E671 2014.04

Research paper (scientific journal), Joint Work, ISSN 0022-5347

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