Papers - Negishi, Kazuno

Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms.

Ayaki M, Negishi K, Kawashima M, Uchino M, Kaido M, Tsubota K.

Diagnostics(Basel) (MDPI)  10 ( 4 ) pii:E193 2020.03

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Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population.

Ayaki M, Negishi K, Yuki K, Kawashima M, Uchino M, Tsubota K.

Diagnostics(Basel) (MDPI)  10 ( 2 ) 124 2020.02

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Five-year Outcomes of Corneal Cross-Linking for Keratoconus: Comparison Between Conventional and Accelerated Procedures.

Kato N, Negishi K, Sakai C, Toda I, Ide T, Torii H, Tsubota K.

Cornea (Wolters Kluwer)  39 ( 1 ) e1 - e2 2020.01

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Subjective Happiness and Sleep in University Students with High Myopia.

Iehisa I, Negishi K, Sakamoto R, Torii H, Ayaki M, Tsubota K.

Psych (MDPI)  2 ( 4 ) 279 - 286 2020

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Nationwide Prospective Cohort Study on Cataract Surgery with Multifocal Intraocular Lens Implantation in Japan.

Negishi K, Hayashi K, Kamiya K, Sato M, Bissen-Miyajima H; Survey Working Group Of The Japanese Society Of Cataract And Refractive Surgery.

Am J Ophthalmol. 208   133 - 144 2019.12

Kinetic visual acuity is correlated with functional visual acuity at higher speeds.

Iehisa I, Negishi K, Ayaki M, Tsubota K.

BMJ Open Ophthalmol. 4 ( 1 ) e000383 2019.11

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Survey of the effects of internet usage on the happiness of Japanese university students.

Kitazawa M, Yoshimura M, Hitokoto H, Sato-Fujimoto Y, Murata M, Negishi K, Mimura M, Tsubota K, Kishimoto T.

Health Qual Life Outcomes. 17 ( 1 ) 151 2019.10

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Shortened Measurement Time of Functional Visual Acuity for Screening Visual Function.

Hidaka Y, Masui S, Nishi Y, Ayaki M, Kaido M, Mimura M, Tsubota K, Negishi K.

Journal of Ophthalmology.    8950418 2019.09

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Suppression of blue light at night ameliorates metabolic abnormalities by controlling circadian rhythms.

Nagai N, Ayaki M, Yanagawa T, Hattori A, Negishi K, Mori T, Nakamura TJ, Tsubota K.

INv Ophth Vis Sci. 60 ( 12 ) 3786 - 3793 2019.09

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Current Prevalence of Myopia and Association of Myopia With Environmental Factors Among Schoolchildren in Japan.

Yotsukura E, Torii H, Inokuchi M, Tokumura M, Uchino M, Nakamura K, Hyodo M, Mori K, Jiang X, Ikeda SI, Kondo S, Negishi K, Kurihara T, Tsubota K.

JAMA Ophthalmol. 137 ( 11 ) 1233 - 1239 2019.08

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Survey Working Group Of The Japanese Society Of Cataract And Refractive Surgery. Nationwide Prospective Cohort Study on Cataract Surgery with Multifocal Intraocular Lens Implantation in Japan.

Negishi K, Hayashi K, Kamiya K, Sato M, Bissen-Miyajima H

Am J Ophthalmol  2019.08

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Protective effects of blue light-blocking shades on phototoxicity in human ocular surface cells.

Niwano Y, Iwasawa A, Tsubota K, Ayaki M, Negishi K.

BMJ Open Ophthalmol. 4 ( 1 ) e000217 2019.05

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Comparison of the Accuracy of Newer Intraocular Lens Power Calculation Methods in Eyes That Underwent Previous Phototherapeutic Keratectomy

Yagi-Yaguchi Y., Negishi K., Saiki M., Torii H., Tsubota K.

Journal of refractive surgery (Thorofare, N.J. : 1995) (Journal of refractive surgery (Thorofare, N.J. : 1995))  35 ( 5 ) 310 - 316 2019.05

ISSN  1081597X

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Copyright 2019, SLACK Incorporated. PURPOSE: To evaluate the accuracy of intraocular lens (IOL) power calculations using ray tracing software in patients who had undergone phototherapeutic keratectomy (PTK). METHODS: In this retrospective case series, 37 eyes of 22 patients (mean age: 69.4 years; range: 56 to 85 years) who underwent cataract surgery after PTK were reviewed. The prediction error, defined as the difference between the estimated postoperative spherical equivalent and the postoperative manifest refraction at the spectacle plane, was calculated using the following formulas: OKULIX (Tedics, Dortmund, Germany), PhacoOptics (IOL Innovations ApS, Aarhus, Denmark), Barrett True K No History (NH), and Camellin-Calossi. The PhacoOptics formula was used in three different ways: historical method (H), no history method (NH), and C-constant method (C). The median values of the arithmetic and absolute prediction errors among these six IOL calculation methods were compared. RESULTS: The median arithmetic errors (in diopters [D]) and percentages of eyes within ±0.50 D of the absolute errors were as follows: OKULIX (0.33, range: -2.20 to 2.50, 30.6%), PhacoOptics (H) (-0.12, range: -3.28 to 4.85, 22.2%), PhacoOptics (NH) (-0.25, range: -2.08 to 1.70, 48.4%), PhacoOptics (C) (0.04, range: -1.40 to 2.18, 48.5%), Barrett True K (NH) (-0.35, range: -1.90 to 1.89, 48.6%), and Camellin-Calossi (-0.19, range: -1.78 to 1.47, 59.5%). CONCLUSIONS: The PhacoOptics, especially the C-constant method (C), and Camellin-Calossi formulas were good options for calculating IOL powers in eyes that underwent PTK. [J Refract Surg. 2019;35(5):310-316.].

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Ocular biometry and refractive outcomes using two swept-source optical coherence tomography-based biometers with segmental or equivalent refractive indices

Omoto M., Torii H., Masui S., Ayaki M., Tsubota K., Negishi K.

Sci Rep. (Scientific Reports)  9 ( 1 ) 6557 2019.04

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© 2019, The Author(s). This study compared the axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), mean anterior corneal radius of curvature (Rm), and postoperative refractive outcomes obtained from two different swept-source optical coherence biometers, the ARGOS (Movu, Nagoya, Japan), which uses the segmental refractive index for each segment, and the IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany), which uses an equivalent refractive index for the entire eye. One hundred and six eyes of 106 patients with cataracts were included. The refractive outcomes using the Barrett Universal II, Haigis, Hoffer Q, and SRK/T formulas were evaluated. The mean AL, CCT, ACD, and Rm differed significantly (P < 0.001) with the IOLMaster 700 (25.22 mm, 559 µm, 3.23 mm, and 7.69 mm) compared with the ARGOS (25.14 mm, 533 µm, 3.33 mm, and 7.66 mm). The mean LTs did not differ significantly. The percentages of eyes within ±0.50 and ±1.00 diopter of the predicted refraction did not differ significantly (P > 0.05). The accuracy of the intraocular lens power calculations was clinically acceptable with both biometers, although the ocular biometry using these two biometers exhibited certain differences.

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Diurnal variation of human tear meniscus volume measured with tear strip meniscometry self-examination

Ayaki M., Tachi N., Hashimoto Y., Kawashima M., Tsubota K., Negishi K.

PLoS ONE (PLoS ONE)  14 ( 4 ) e0215922 2019.04

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© 2019 Ayaki et al. Purpose Tear secretion is critical for maintenance of healthy ocular surface and vision. Most of normal subjects and dry eye patients feel worsening of ocular dryness in the afternoon, however, diurnal variation of tear meniscus volume has not been directly measured because there was no appropriate method. We used a simple, non-invasive technique, tear strip meniscometry (SM) by self-examination. Previous investigations indicated the values of SM correlated strongly with those of the Schirmer test, tests of tear break up time, and tear meniscus height measurement by anterior optical coherence tomography. The purpose of this study was to capture diurnal variation of aqueous availability at the tear meniscus by measuring wetted length using SM through self-examination. Methods Thirty-six medical personnel (mean age; 35.7 years) participated and SM self-examination was performed using a mirror seven times a day. The strip is applied for 5 seconds to the lateral side of the lower lid tear meniscus without touching the ocular surface. Results The measured SM value was the highest upon awakening (4.44 ± 3.14 mm) and gradually decreased in the evening; 3.81 ± 3.12 at 9:00, 3.31 ± 2.72∗ at 12:00, 2.89 ± 1.88∗ at 15:00, 2.92 ± 1.87∗ at 18:00, 2.78 ± 1.85∗ at 21:00, and 2.89 ± 1.75∗ at bedtime with statistical significance compared to the value upon awakening (∗P < 0.05, Dunnett's multiple comparison test). Proportion of number of subjects with low SM value (< 4 mm) to total number of subjects was 52.8% upon awakening and 83.3% at 21:00, and gradually increased toward evening. Conclusion Our results could identify diurnal variation of tear meniscus volume in the general population.

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Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients.

Hanyuda A, Ayaki M, Tsubota K, Negishi K

Journal of clinical medicine 8 ( 2 ) pii:E211 2019.02

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Latanoprost could exacerbate the progression of presbyopia

Ayaki M., Tsuneyoshi Y., Yuki K., Tsubota K., Negishi K.

PLoS ONE (PLoS ONE)  14 ( 1 ) e0211631 2019.01

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© 2019 Ayaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Purpose Prostaglandin analogues (PG) reduce intra-ocular pressure by enhancing uveoscleral flow at the ciliary body, which controls accommodation via the ciliary muscle. We investigated the effect of PG on accommodation and presbyopia progression in glaucoma patients. Methods We conducted a clinic-based, retrospective, cross-sectional study. Inclusion criteria were bilateral phakic patients aged 40–69 years with best corrected visual acuity better than 20/ 30. Exclusion criteria were any disease affecting vision other than glaucoma and history of ocular surgery. Subjects with no prescription or vision-affecting disease served as controls (n = 260). The glaucoma patients were prescribed eye drops containing 0.005% latanoprost for more than six months (n = 23). We measured the binocular near add power at a distance of 30 cm in both groups and compared the results using Kaplan-Meier analysis. Results The mean age (± SD) of the control subjects was 51.5 ± 5.2 years and 39% were male. Similarly, the glaucoma patients had a mean age of 51.0 ± 7.2 years and 39% were male. There were no significant differences in age, gender, intra-ocular pressure, spherical equivalent, astigmatism, or anisometropia between groups. Survival analysis indicated that the glaucoma patients in this study reached the endpoint (near add power of +3.00 D) significantly earlier than control patients (P = 0.0001; generalized Wilcoxon test). Conclusions Exacerbation of presbyopia progression in glaucoma patients is a potential side effect of latanoprost eyedrops.

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Association between retinal nerve fiber layer thickness and eye fatigue

Ayaki M., Kuze M., Kondo M., Tsubota K., Negishi K.

BioMed Research International (BioMed Research International)  2019   3014567 2019.01

ISSN  23146133

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© 2019 Masahiko Ayaki et al. Eye fatigue is a common health problem across all age groups. Herein, we explored the correlation between eye fatigue and thickness of the retinal nerve fiber layer (NFL). Included in the NFL are intrinsically photosensitive retinal ganglion cells (ipRGCs), which are associated with trigeminal pain. This retrospective cross-sectional study included outpatients with best-corrected visual acuity above 20/30 in both eyes and without dry eye, glaucoma, or retinal disease. A total of 1981 patients were initially enrolled and 377 patients were declared as eligible for the study analysis. We tested subjects for the presence of major ocular symptoms and measured thickness of ganglion cell complex (GCC) using optical coherence tomography. A total of 377 outpatients (46.4% men, mean age of 57.1 years) were enrolled for analysis, based on the interview-reported prevalence of six eye symptom, as follows: 31.5% for eye fatigue, 19.2% for blurring, 18.6% for dryness, 15.7% for photophobia, 13.5% for irritation, and 4.6% for pain. The macular GCC was significantly thicker in subjects with eye fatigue compared to the group not reporting eye fatigue (103.8 μm versus 100.3 μm, P = 0.014). Regression analysis identified eye fatigue (P = 0.026, β=0.122, adjusted for age and sex) and dryness (P =0.024, β=0.130) as significantly correlated with the macular GCC thickness, while the full macular thickness showed no significant correlation. In conclusions, eye fatigue and dryness were positively associated with thickness of the macular GCC. Nonvisual symptoms might therefore play a role in the development of eye fatigue.

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The Relationship of Dry Eye Disease with Depression and Anxiety:A Naturalistic Observational Study

Kitazawa M., Sakamoto C., Yoshimura M., Kawashima M., Inoue S.,Mimura M., Tsubota K., Negishi K.

Transl Vis Sci Technol. 7 ( 6 ) 35 2018.12

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Sleep disorders are a prevalent and serious comorbidity in dry eye

Ayaki M., Tsubota K., Kawashima M., Kishimoto T., Mimura M., Negishi K.

Investigative Ophthalmology and Visual Science (Investigative Ophthalmology and Visual Science)  59 ( 14 Special Issue ) DES143 - DES150 2018.11

ISSN  01460404

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© 2018 The Authors. PURPOSE. Sleep is an essential life habit and closely associated with lifespan, diabetes, hypertension, and mental health. Sleep disorders are a prominent, but overlooked problem in patients with dry eye disease (DED), characterized by a poor sleep index, short sleep duration, long sleep latency, and poor subjective sleep. DED and sleep disorders are more prevalent in women than men. Moreover, sleep quality in DED is worse than in other eye diseases, including glaucoma, retinal diseases, cataract, and allergic and chronic conjunctivitis. METHODS. We reviewed the literature for studies investigating sleep and health, eyes and sleep, and DED and sleep, in terms of systemic and eye health, especially in women. RESULTS. Two studies reported that approximately half of patients with DED suffer from poor sleep. The severity of mood disorders, including anxiety and depression, is correlated strongly with sleep disorders in DED, and the symptoms and signs of DED, especially pain, also are correlated with sleep quality. Sleep disorders are documented in primary Sjögren’s syndrome and an association with sleep apnea and depression is suggested. Primary Sjögren’s syndrome includes arthritis and other rheumatic disease causing pain and fatigue; however, how sicca contributes to sleep disorders is not known. CONCLUSIONS. Possible explanations for sleep disorders in DED may be depression, pain, and eye exposure at night. Reciprocal effects may be expected and consultation-liaison psychiatry is recommended for the management of sleep disorders in DED. Topical medication and lid heating also may be advantageous for sleep quality in DED.

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