坪田　一男 （ ツボタ　カズオ ）

Tsubota, Kazuo

写真a

所属（所属キャンパス）

医学部 （ 三田 ）

職名

名誉教授

HP
Scopus 論文情報  
総論文数: 1369 総引用数: 61139 h-index: 115

Click to view the Scopus page. The data was downloaded from Scopus API inMarch 01, 2026, via http://api.elsevier.com and http://www.scopus.com .

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経歴 【 表示 ／ 非表示 】

  • 1998年04月
    -
    2004年03月

    東京歯科大学市川総合病院, 眼科, 教授

  • 2004年04月
    -
    継続中

    慶應義塾大学医学部, 眼科学教室, 教授

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学歴 【 表示 ／ 非表示 】

  • 1974年04月
    -
    1980年08月

    慶應義塾大学, 医学部, 眼科

    大学, 卒業

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 眼科学

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著書 【 表示 ／ 非表示 】

  • ごきげんナースとごきげんドクター ギスバート・ヴァンサッテン先生、勉強部屋を作る

    坪田 一男, 眼科ケア, 2005年01月

    担当範囲: 64-65

  • ごきげんナースとごきげんドクター 夏休みモードと夏休みの宿題

    坪田 一男, 眼科ケア, 2004年12月

    担当範囲: 70-71

  • 眼科医にすすめる100冊の本‐11月の推薦図書‐「Healing the Eye (Edward C. Kondrot, MD著)」

    坪田 一男, あたらしい眼科, 2004年11月

    担当範囲: 1509-1510

  • ドライアイ研究の基礎と臨床

    坪田 一男, 日本眼科学会雑誌, 2004年09月

    担当範囲: 547-548

  • 眼科医にすすめる100冊の本‐9月の推薦図書‐「代替療法の医学的証拠-民間療法を正しく判断する手引き-(米国医師会編,田村康二訳)」

    坪田 一男, あたらしい眼科, 2004年09月

    担当範囲: 1221-1222

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論文 【 表示 ／ 非表示 】

  • Motor function benefits of visual restoration measured in age-related cataract and simulated patients

    Ayaki Masahiko, Nagura Takeo, Toyama Yoshiaki, Negishi Kazuno, Tsubota Kazuo

    Scientific Reports 5 2015年09月

    　概要を見る

    <p>The aim of the present study was to measure gait velocity in cataract and simulated patients. The study was performed on 239 cataract patients, 115 age-matched subjects, and 11 simulated patients. We measured gait velocity and analyzed gait using a three-dimensional motion analysis system. Mean gait velocity before and 2 and 7 months after cataract surgery was 0.91 ± 0.19, 1.04 ± 0.21, and 1.06 ± 0.21 m/s, respectively, for males and 0.84 ± 0.22, 0.91 ± 0.24, and 0.92 ± 0.25 m/s, respectively, for females. The increase after surgery was significant in both groups at 7 months (P &lt; 0.05). Gait velocity was significantly slower in cataract patients compared with controls before surgery, but no longer different after surgery. In simulated patients, mean velocity was 87.0 ± 11.4% of normal vision with a 3° visual field and 92.4 ± 12.3% of normal when counting fingers. Initial velocity was 89.1 ± 14.6% of normal vision with a 3° visual field and 92.7 ± 11.6% of normal when counting fingers. There was a significant difference between normal and impaired visual function (P &lt; 0.05). The results demonstrate the close relationship between visual function and gait in cataract patients and simulated patients.</p>

  • Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz's disease

    Fukui Masaki, Ogawa Yoko, Shimmura Shigeto, Hatou Shin, Ichihashi Yoshiyuki, Yaguchi Saori, Hirayama Masatoshi, Kawakita Tetsuya, Tsubota Kazuo

    Modern Rheumatology 25 （ 5 ） 737 - 743 2015年09月

    ISSN  1439-7595

    　概要を見る

    <p>Objective. Immunoglobulin G4 (IgG4)-related Mikulicz's disease (MD) is a fibrosis-associated inflammatory disease, often accompanied by lacrimal gland swelling. Although much attention has been paid to the inflammatory aspects of this disease, the mechanisms of the fibrotic processes are still unclear. We focused on the fibrotic changes occurring in the lacrimal glands of IgG4-related MD patients, by examining molecules involved in the epithelial-mesenchymal transition (EMT). Methods. Lacrimal gland tissue specimens were obtained from 3 IgG4-related MD patients and 3 control patients with Sjögren's syndrome (SS). The glands were examined by immunohistochemistry and transmission electron microscopy. Results. Storiform fibrosis, a characteristic of IgG4-related MD, was observed in the lacrimal glands of IgG4-related MD, but rarely in those of SS. Reduced E-cadherin expression, increased phalloidin-stained filamentous actin, and increased α-smooth muscle actin, snail, and heat-shock protein 47 levels were observed in the lacrimal glands of IgG4-related MD compared with those of SS. Transmission electron microscopy revealed an abnormal periodicity of collagen bundles, and basal membrane thickening in the IgG4-related MD compared with that in the SS tissues. Conclusion. EMT-like changes were frequently observed in the lacrimal gland epithelia from patients with IgG4-related MD. Thus, EMT may be involved in the pathology of IgG4-related MD fibrosis.</p>

  • Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling

    Tomita Yohei, Kurihara Toshihide, Uchida Atsuro, Nagai Norihiro, Shinoda Hajime, Tsubota Kazuo, Ozawa Yoko

    Scientific Reports 5 2015年09月

    　概要を見る

    <p>Wide-angle viewing systems (WAVSs) were originally established for pars plana vitrectomy. However, their application to scleral buckling surgery was recently reported. In this study, we compared the outcomes of scleral buckling using a noncontact WAVS with that of scleral buckling using conventional indirect ophthalmoscopy for rhegmatogenous retinal detachment. The clinical records of 39 eyes (39 patients) with rhegmatogenous retinal detachment primarily treated between November 2012 and June 2014 at the Vitreo-Retina Surgical Division Clinic at the Department of Ophthalmology, Keio University Hospital were retrospectively reviewed. Scleral bucking was performed using WAVS with surgical placement of an endoilluminator in 16 eyes and indirect ophthalmoscopy in 23 eyes. The patients in these groups were consecutive over different intervals. The preoperative demographics, success rate of retinal reattachment, intraoperative findings, and postoperative complications were evaluated. There were no significant differences in pre- or postoperative conditions between groups, and similar surgical outcomes were achieved with the WAVS and conventional procedures. However, compared with the conventional procedure, the WAVS procedure resulted in fewer intraoperative corneal epithelial disorders (p = 0.049) and decreased the surgical duration of segmental buckling (p = 0.02); therefore, it may be suggested as an effective alternative procedure.</p>

  • Vision loss by central retinal vein occlusion after kaatsu training

    Ozawa Yoko, Koto Takashi, Shinoda Hajime, Tsubota Kazuo

    Medicine (United States) 94 （ 36 ）  2015年09月

    ISSN  0025-7974

    　概要を見る

    <p>Kaatsu training is an exercise method involving the application of pressure to the target muscle, and is being increasingly used in rehabilitation programs for heart disease patients in some hospitals. This method restricts blood flow to the muscles during exercise, and the resultant hypoxia effectively causes muscle hypertrophy and strengthening. However, no medical guidelines or risk factors for its use have been established. We report a case involving a 45-year-old man who suffered from 2 episodes of central retinal vein occlusion (CRVO), both occurring on the day following a Kaatsu training session. As a characteristic of the CRVO and its subsequent complications, the affected eye lost vision despite treatment. The patient had a history of hypertension and diabetes, and thus was at an increased risk of CRVO. Kaatsu training, which changes the heart rate and serum growth hormone levels, may have triggered the onset of CRVO. This case highlights that underlying medical conditions such as hypertension, diabetes, and the consequent inflammation, could be risk factors for vascular side effects resulting from Kaatsu training. Further studies are required before the medical and recreational use of Kaatsu training become widespread.</p>

  • Diquafosol sodium ophthalmic solution for the treatment of dry eye

    Shigeyasu Chika, Yamada Masakazu, Akune Yoko, Tsubota Kazuo

    Japanese Journal of Ophthalmology 2015年08月

    ISSN  0021-5155

    　概要を見る

    <p>Purpose: To evaluate the clinical efficacy of 3 % diquafosol sodium ophthalmic solution for dry eye, and to analyze the concentration of tear proteins and mucin-like substances after the treatment. Methods: Fifty eyes of 25 patients with dry eye syndrome were prospectively enrolled. The patients were treated with diquafosol solution at a dose of 1 drop in each eye 6 times daily for 4 weeks. The parameters of clinical efficacy were tear osmolarity, tear breakup time (BUT), fluorescein staining scores for the cornea and conjunctiva, Schirmer test values, and subjective symptoms evaluated using the ocular surface disease index (OSDI). Tears collected with Schirmer test strips were analyzed by high-performance liquid chromatography, and the concentrations of the total protein and the 4 major tear proteins, namely, secretory IgA, lactoferrin, lipocalin-1, lysozyme, and N-acetyl-neuraminic acid (Neu5Ac), were measured. Neu5Ac is a major sialic acid, a marker of secretory mucins. Results: The BUT, keratoconjunctival staining scores, and Schirmer test values were improved with statistical significance after the treatment with diquafosol solution, while changes in the other parameters, including tear osmolarity, corneal staining scores, and OSDI scores were not significant. The Neu5Ac concentration was significantly increased, which was not accompanied by changes in tear proteins. Conclusions: Topical application of diquafosol significantly improved the clinical parameters of the BUT, keratoconjunctival staining scores, and Schirmer test values and was accompanied by increased sialic acid content in the tears of patients with dry eye.</p>

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研究発表 【 表示 ／ 非表示 】

  • シェーグレン症候群PBLからのIg G 産生におけるサイトカインの関与.

    小笠原未恵, 吉本桂子, 勝島麻衣, 小川葉子, 津坂憲政, 足立達, 坪田一男, 竹内勤.

    [国内会議]  第34回日本免疫学会総会学術集会 （札幌） , 

    2004年12月
    , 

    その他

  • アンタイエージング

    坪田 一男

    [国内会議]  第58回日本臨床眼科学会 （東京） , 

    2004年11月
    , 

    その他

  • 難治性ドライアイに対する確実な涙点閉鎖術

    本田理恵、村戸ドール、後藤英樹、田中まり、高野洋之、佐伯めぐみ、佐藤幸恵、戸田郁子、坪田一男

    第58回日本臨床眼科学会 （東京） , 

    2004年11月

  • 新しい涙点プラグ（Smart　PlugTM）の臨床評価

    小島隆司、原修哉、石田玲子、後藤英樹、松本幸裕、坪田一男

    第58回日本臨床眼科学会 （東京） , 

    2004年11月

  • アレルギー性結膜炎の涙液動態の評価

    鈴木慎太郎、後藤英樹、村戸ドール、小島隆司、佐伯めぐみ、松本幸裕、田中まり、石田玲子、加藤直子、藤島浩、島崎潤、坪田一男

    第58回日本臨床眼科学会 （東京） , 

    2004年11月

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 非視覚型オプシンによる眼軸伸長制御機構の解明

    2021年04月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 坪田 一男, 基盤研究(B), 補助金,  研究代表者

  • Sirtuinを標的とした眼疾患の新しい予防、治療方法の開発

    2017年04月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 坪田　一男, 基盤研究(B), 補助金,  研究代表者

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Works 【 表示 ／ 非表示 】

  • 学務委員会委員

    2003年10月
    -
    2005年09月
    , 

    その他

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担当授業科目 【 表示 ／ 非表示 】

  • 早期体験学習（薬科学科）

    2025年度

  • 化学Ⅱ

    2025年度

  • メディカル・プロフェッショナリズムⅡ

    2024年度

  • 眼科学講義

    2024年度

  • 化学Ⅱ

    2024年度

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担当経験のある授業科目 【 表示 ／ 非表示 】

  • 眼科学

    慶應義塾

    2015年04月
    -
    2016年03月
    , 

    通年, 講義, 専任

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