Kurihara, Toshihide

写真a

Affiliation

School of Medicine, Department of Ophthalmology (Shinanomachi)

Position

Associate Professor
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Profile 【 Display / hide 】

  • Toshihide Kurihara is an Associate Professor of Ophthalmology at Keio University, Tokyo, Japan. He has also been appointed as an Adjunct Assistant Professor at the Scripps Research Institute (TSRI) in La Jolla, CA, USA. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at TSRI. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Editorial Board　Member: BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine

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Career 【 Display / hide 】

  • 2001.04
    -
    2003.03

    Keio University Hospital, Department of Ophthalmology, Resident

  • 2002.07
    -
    2003.06

    National Kasumigaura Hospital, Department of Ophthalmology, Resident

  • 2003.04
    -
    2004.03

    Keio University Hospital, Department of Ophthalmology, Clinical Fellow

  • 2004.01
    -
    2005.03

    Tokyo Saiseikai Central Hospital, Ophthalmology, Clinical Fellow

  • 2005.04
    -
    2009.03

    Keio University Graduate School of Medicine, Doctoral Course

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Academic Background 【 Display / hide 】

  • 1995.04
    -
    2001.03

    University of Tsukuba, School of Medicine

    University, Graduated

  • 2005.04
    -
    2009.03

    Keio University, Graduate School of Medicine

    Graduate School, Completed

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Academic Degrees 【 Display / hide 】

  • PhD in Medicine, Keio University, Coursework, 2009.03

    Angiotensin 2 type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina

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Research Areas 【 Display / hide 】

  • Life Science / Ophthalmology (Ophthalmology)

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Papers 【 Display / hide 】

  • Establishment of an in vitro choroid complex system for vascular response screening

    Jeong H, Lee D, Negishi K, Tsubota K†, Kurihara T†

    Sci Rep. 14   16129 2024.07

    Corresponding author, Accepted

  • Long-term Outcomes of Anti-Vascular Endothelial Growth Factor Drug Therapies for Neovascular Age-related Macular Degeneration Based on its Subtypes

    Kato S, Uchida A†, Nagai N, Suzuki M, Minami S, Shinojima A, Ban N, Horiuchi N, Fujioka S,Kurihara T, Shinoda H, Ozawa Y, Negishi K

    J Jpn Ophthalmol Soc. 128 ( 6 ) 473 - 486 2024.06

    Accepted

  • Choroidal thinning in myopia is associated with axial elongation and severity of myopic maculopathy

    Midorikawa M*, Mori K*, Torii H, Tomita Y, Zhang Y, Tsubota K, Kurihara T†, Negishi K

    Res Sq. (Research Square Platform LLC)  14 ( 1 ) 17600 2024.05

    Corresponding author

    　View Summary

    Abstract <p>High myopia can lead to pathologic myopia and visual impairment, whereas its causes are unclear. We retrospectively researched high myopia cases from patient records to investigate the association between axial elongation and myopic maculopathy. Sixty-four eyes were examined in patients who visited the department between July 2017 and June 2018, had an axial length of 26 mm or more, underwent fundus photography, and had their axial length measured twice or more. The average axial length was 28.29±1.69 mm (mean±standard deviation). The average age was 58.3 ± 14.4 years old. Myopic maculopathy was categorized as mild (grades 0 and 1) and severe (grades 2, 3, and 4). The severe group had longer axial lengths than the mild group (p&lt;0.05). Moreover, the severe group exhibited thinner choroidal thickness than the mild group (p&lt;0.05). When subjects were grouped by axial elongation over median value within a year, the elongation group showed thinner central choroidal thickness than the non-elongation group (142.1±91.9 vs. 82.9±69.8 ㎛, p&lt;0.05). In conclusion, in patients with high myopia, the severity of maculopathy correlated with choroidal thickness and axial length. Thinner choroidal thickness was associated with axial elongation based on the baseline axial length.</p>

  • Myopia Is an Ischemic Eye Condition: A Review from the Perspective of Choroidal Blood Flow

    Baksh J*, Lee D*, Mori K, Zhang Y, Torii H, Jeong H, Hou J, Negishi K, Tsubota K†, Kurihara T†

    J Clin Med. (MDPI AG)  13 ( 10 ) 2777 - 2777 2024.05

    Last author, Corresponding author, Accepted

    　View Summary

    Myopia is a common refractive error that affects a large proportion of the population. Recent studies have revealed that alterations in choroidal thickness (ChT) and choroidal blood flow (ChBF) play important roles in the progression of myopia. Reduced ChBF could affect scleral cellular matrix remodeling, which leads to axial elongation and further myopia progression. As ChT and ChBF could be used as potential biomarkers for the progression of myopia, several recent myopia treatments have targeted alterations in ChT and ChBF. Our review provides a comprehensive overview of the recent literature review on the relationship between ChBF and myopia. We also highlight the importance of ChT and ChBF in the progression of myopia and the potential of ChT as an important biomarker for myopia progression. This summary has significant implications for the development of novel strategies for preventing and treating myopia.

  • Retinal ischemic diseases and promising therapeutic molecular targets

    Lee D*, Tomita Y*, Negishi K, Kurihara T†

    Histol Histopathol.    18756 2024.05

    Last author, Corresponding author, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 多様な光受容の進化に基づく眼疾患治療開発

    栗原俊英

    第43回比較眼科学会年次大会 基礎部会セッション「眼科治療薬開発の最前線」, 

    2024.08
    -
    2024.09

  • 新型コロナウイルス流行収束後の慶應大における眼科手術数の回復

    利根川直也, 伴紀充, 永本崇, 國見洋光, 富田洋平, 栗原俊英, 篠田肇, 根岸一乃

    第817回東京眼科集談会, 

    2024.08

  • 上唾液核は脈絡膜厚を制御する

    馬子妍, 丁憲煜, 吉田哲, 郭錦欣, 根岸一乃, 田中謙二, 坪田一男, 栗原俊英

    第24回日本光生物学協会年会, 

    2024.08

  • 紫光照射による持続的近視進行抑制効果機構

    吉田哲, 馬子妍, 池田真一, 根岸一乃, 坪田一男, 栗原俊英

    第24回日本光生物学協会年会, 

    2024.08

  • Myopia Development and Control by Non-Visual Opsins

    Toshihide Kurihara

    The 2nd International Symposium for Biology of the Non-Visual Opsin: AMED Joint Session, 

    2024.07

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Establishment of therapeutic intervention methods for fibrotic scar formation in age-related macular degeneration through hypoxia response control

    2024.04
    -
    2027.03

    基盤研究(C), Principal investigator

  • 非視覚型光受容体による光マルチセンシング機構の解明と光新規治療法開発

    2022.10
    -
    2028.03

    国立研究開発法人日本医療研究開発機構(AMED), 令和4年度 「革新的先端研究開発支援事業（AMED-CREST）」, No Setting

  • 低酸素応答制御機能を持つ静岡県産魚類由来成分の探索と疾患制御に関する研究

    2022.08
    -
    2025.03

    静岡県, マリンバイオテクノロジーを核としたシーズ創出研究業務委託 ￥286,800,000-, No Setting

  • 低酸素応答を標的とした予防から治療までを網羅する網膜疾患制御技術開発

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Approach for retinal diseases based on regulation of hypoxia response

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Awards 【 Display / hide 】

  • 日本眼科学会評議員会賞

    栗原俊英, 2024.04, 日本眼科学会, 光生物学を基盤とした眼疾患病態生理の理解と治療開発

  • 第62回日本網膜硝子体学会総会優秀演題

    Ayaka Naka, Deokho Lee, Yan Zhang, Chiho Shoda, Satoshi Imanishi, Hiroyuki Nakashizuka, Satoru Yamagami, Kazuno Negishi, Akiharu Kubo, Toshihide Kurihara, 2023.11, 日本網膜硝子体学会, Claudin-1 deficiency in RPE leads to age-related retinal degeneration in mic

  • The Keio Medical Science Rising Star Award

    Toshihide Kurihara, 2023.01, Keio University, Exploring the pathophysiology of the retina and myopia based on photobiology and the clinical adaptation

  • 第72回日本臨床眼科学会学術展示優秀賞

    栗原俊英, 2019.04, 日本眼科学会, 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化

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    第123回日本眼科学会総会

  • 第23回ROHTO AWARD

    2018.04, ロート製薬株式会社, 低酸素応答を基軸としたトランスレーショナルリサーチの推進

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Memberships in Academic Societies 【 Display / hide 】

  • The Japanese Society for Photomedicine and Photobiology, 

    2023.05
    -
    Present

  • 日本ロービジョン学会, 

    2022.12
    -
    Present

  • 日本人類遺伝学会, 

    2021.07
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2022.11
    -
    Present

    Associate Editor for Neurodegeneration, Frontiers in Neuroscience

  • 2022.10
    -
    Present

    眼科 外来医長, 慶應義塾大学病院

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