Kurihara, Toshihide

写真a

Affiliation

School of Medicine, Department of Ophthalmology ( Shinanomachi )

Position

Associate Professor
Scopus Paper Info  
Paper Count: 211 Citation Count: 7147 h-index: 44

Click to view the Scopus page. The data was downloaded from Scopus API in July 05, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Profile 【 Display / hide 】

  • Toshihide Kurihara is an Associate Professor of Ophthalmology at Keio University, Tokyo, Japan. He has also been appointed as an Adjunct Assistant Professor at the Scripps Research Institute (TSRI) in La Jolla, CA, USA. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at TSRI. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Editorial Board　Member: BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine

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Career 【 Display / hide 】

  • 2001.04
    -
    2003.03

    Keio University Hospital, Department of Ophthalmology, Resident

  • 2002.07
    -
    2003.06

    National Kasumigaura Hospital, Department of Ophthalmology, Resident

  • 2003.04
    -
    2004.03

    Keio University Hospital, Department of Ophthalmology, Clinical Fellow

  • 2004.01
    -
    2005.03

    Tokyo Saiseikai Central Hospital, Ophthalmology, Clinical Fellow

  • 2005.04
    -
    2009.03

    Keio University Graduate School of Medicine, Doctoral Course

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Academic Background 【 Display / hide 】

  • 1995.04
    -
    2001.03

    University of Tsukuba, School of Medicine

    University, Graduated

  • 2005.04
    -
    2009.03

    Keio University, Graduate School of Medicine

    Graduate School, Completed

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Academic Degrees 【 Display / hide 】

  • PhD in Medicine, Keio University, Coursework, 2009.03

    Angiotensin 2 type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina

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Research Areas 【 Display / hide 】

  • Life Science / Ophthalmology (Ophthalmology)

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Papers 【 Display / hide 】

  • The choroidal macrophage polarization significantly influences myopia development in murine models

    Hou J*, Ikeda SI*, Yang Y*, Fukuchi T, Ikeda C, Imanishi S, Ma Z, Chen J, Mori K, Torii H, Fujii H, Negishi K, Tsubota K†, Kurihara T†

    iScience. (Elsevier BV)  29 ( 5 ) 115764 2026.04

    Last author, Corresponding author, Accepted,  ISSN  2589-0042

    　View Summary

    While choroidal macrophages regulate homeostasis in macular degeneration, their role in myopia is unclear. In this study, depleting choroidal macrophages via clodronate liposome injections induced myopia. To further dissect their function, introducing polarized classically activated (M1) or alternatively activated (M2) macrophages into a myopia model revealed that both the presence and polarization of choroidal macrophages affect myopia progression. Further exploration in normal mice showed that choroidal M1 macrophages polarization triggered choroidal thinning and promoted myopia progression, whereas M2 macrophages polarization enhanced choroidal thickening and suppressed myopia development. These opposite effects of M1 and M2 macrophages on choroidal thickness and myopia progression appeared to be related to their differential regulation of inflammatory responses and oxidative stress. Taken together, these results support a role for choroidal macrophages and their polarization states in myopia onset and progression, suggesting potential therapeutic strategies for controlling the development and progression of myopia.

  • Recurrent Spontaneous Closure of a Full-Thickness Macular Hole Following IOL Scleral Fixation: A Case Report

    Ogawa M, Tomita Y†, Ota Y, Ban N, Kunimi H, Hayashi I, Jiang X, Kurihara T, Shinoda H, Negishi K

    Am J Ophthalmol Case Rep. (Elsevier BV)  42   102573 - 102573 2026.03

    Accepted,  ISSN  2451-9936

    　View Summary

    Purpose To report a rare case of a full-thickness macular hole (FTMH) that underwent spontaneous closure on two separate occasions following vitrectomy and intraocular lens (IOL) scleral fixation. Observations A 58-year-old man, who had undergone IOL scleral fixation and vitrectomy for a dislocated IOL, developed an FTMH (minimum diameter: 21 μm) in the left eye approximately one year post-surgery. While awaiting surgical intervention, the macular hole closed spontaneously two months after its discovery. Two years and nine months later, the FTMH recurred (minimum diameter: 180 μm) and closed spontaneously again within four weeks. Optical coherence tomography (OCT) confirmed the presence of epiretinal proliferation (EP) at the macular surface during both occurrences. Conclusions and Importance Small-diameter FTMHs that form after vitrectomy, particularly those with associated EP, may have the potential for spontaneous closure. This case indicates that short-term observation may be a reasonable management option for select cases of small post-vitrectomy macular holes before proceeding with further surgery.

  • Near work affects ocular higher order aberrations in children—a longitudinal study before and after COVID-19: The Tokyo Myopia Study

    Shimizu Y*, Yotsukura E*, Ogawa M, Hanyuda A, Tsubota K, Kurihara T, Torii H*†, Negishi K†

    Sci Rep. (Springer Science and Business Media LLC)  16 ( 1 )  2026.03

    Accepted

    　View Summary

    The myopia epidemic is a major public health concern, yet the underlying causes and mechanisms of myopia progression remain unclear. Recent studies have reported an association between myopia progression and higher order aberrations (HOAs). However, to our knowledge, no research has reported the relationship between HOAs and environmental factors, which are well-established contributors to myopia progression. In this prospective study, we investigated this association across the COVID-19 pandemic. Children aged 6 to 12 years from one elementary school in Tokyo were enrolled. Non-cycloplegic refraction and ocular biometry were measured. Investigations were carried out every summer from 2018 to 2021. We adopted ocular spherical aberration (SA), third- and fourth-order aberrations (S3 and S4), and total HOAs (THOA) (calculated as the root mean squares from the third- to sixth-order Zernike coefficients) evaluated with a natural pupillary diameter. We analyzed 357 students during 2018 to 2019 (pre-pandemic period), 217 during 2019 to 2020 (pandemic period), and 285 during 2020 to 2021 (post-pandemic period). The time spent outdoors decreased significantly from 100.5 min/day in 2018 to 66.2 min/day in 2020 (p < 0.001). The time spent on near work including digital device usage initially decreased and then increased during the observation period. The time spent on smartphones was correlated inversely with the changes in S3, S4, and THOA in the pre-pandemic period. During the pandemic, the time spent on computers was correlated positively with the changes in the SA, S3, S4, and THOA. In the post-pandemic period, the time spent on reading and studying was correlated positively with the changes in THOA. Remarkably, the outdoor time was not a significant variable during any period. In conclusion, lifestyle factors changed dramatically throughout the pandemic and, particularly near work, may have been associated with the HOAs in children.

  • The impact of introducing a low vision care hub on visitor satisfaction at a university hospital

    Sakagami T, Shinojima A, Fukuda K, Yamamoto S, Katada Y, Hanyuda A, Kanai M, Kiyono H, Horie T, KuriharaT†, Negishi K

    Jpn J Ophthalmol.  2026.03

    Corresponding author, Accepted,  ISSN  00215155

    　View Summary

    Purpose: Although Japan has an established welfare system for individuals with visual impairments, medical-welfare coordination remains limited. To address this gap, the Low Vision Care Hub (LVCH) was established within a university hospital. We evaluated the impact of LVCH on visitor satisfaction before and after consultation Study design: A single-center, one-group pre–post study Methods: Individuals with self-reported functional vision difficulties who visited LVCH between July 1 and December 20, 2024 were included. Consultation was provided based on seven domains of low vision care outlined by the Japan Society for Low-Vision Research and Rehabilitation. Satisfaction was measured on a custom 6-point ordinal scale (0–5) pre/post consultation. Changes in satisfaction scores were analyzed using the Wilcoxon signed-rank test. Multivariable logistic regression adjusted for potential confounders Results: Ninety-three participants were included. Satisfaction scores significantly increased after consultation (p <.001) and improvements were consistent across sex, age groups, and visual impairment classification using the International Council of Ophthalmology (ICO) criteria (all p <.001). Notably, participants not meeting the ICO-defined low vision criteria also improved (p <.001). On multivariable logistic regression, only older age (≥ 60 years) remained significantly associated with a markedly improved satisfaction score (OR = 2.98, 95% CI 1.10–8.05, p =.03) Conclusion: Consultations provided at LVCH significantly improved visitor satisfaction, including those who did not meet the ICO low vision criteria. Consultation may be particularly effective in individuals aged over 60 years. Overall, early-stage intervention through structured consultation may benefit individuals with functional vision difficulties

  • Photobiomodulation Therapy: The Dawn of Myopia Control

    Gettinger K*, Huang Y*, Tsubota K, Negishi K, Kurihara T†

    Cells (MDPI AG)  15 ( 6 ) 526 - 526 2026.03

    Last author, Corresponding author, Accepted

    　View Summary

    As the prevalence of myopia, or near-sightedness, continues to rise globally, it becomes imperative to determine the mechanisms driving myopia so that appropriate interventions to mitigate it can be developed. Light appears to be critical for normal ocular development, and over the past several decades research has explored the connection between light exposure and myopia development. This review explores the growing field of photobiomodulation, or the use of light to modulate biological processes, to prevent myopia development. To complete this review, relevant texts published from January 1990 to December 2025 were retrieved from the PubMed database using a combination of search terms covering myopia and ocular development, light exposure conditions related to myopia, myopia development in relation to circadian and diurnal regulation, nonvisual opsins and myopia, and light-induced ocular damage. Through this review, we see that photobiomodulation offers a potential intervention to control myopia progression, but the mechanisms behind light’s influence on ocular development remain complex and incompletely understood. This review aims to summarize what is currently known to serve as a basis for future research and to delineate important findings.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 改変型GtACR2による網膜変性マウスモデルの光応答再建

    栗原俊英, 李墨然, 須賀晶子, 細島頌子, 根岸一乃, 神取秀樹, 堅田侑作

    第48回日本光医学・光生物学会, 

    2026.07

  • Optogenetic Therapy for Inherited Retinal Degenerations: Evaluation of Visual Restoration by Intravitreal RV-001

    Toshihide Kurihara, Yohei Tomita, Kazuno Negishi, Yusaku Katada

    The 40th World Ophthalmology Congress, 

    2026.06

  • 近視進行の分子・細胞メカニズム

    栗原俊英

    ゲノム創薬・創発フォーラム 第22回シンポジウム, 

    2026.06

  • 長期近視誘導マウスモデルにおけるクロセチンの網膜血流・血管 構造に対する保護効果

    張雨竹, 楊雅靜, 池田真一, 坪田一男, 根岸一乃, 栗原俊英, 富田洋平

    第8回日本近視学会総会, 

    2026.06

  • 近視進行の分子メカニズム: 焦点合わせと眼軸長伸長の生物学

    栗原俊英

    第8回日本近視学会総会 ランチョンセミナー5「近視抑制治療をめぐる基礎と臨床の視点」, 

    2026.06

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Establishment of therapeutic intervention methods for fibrotic scar formation in age-related macular degeneration through hypoxia response control

    2024.04
    -
    2027.03

    基盤研究(C), Principal investigator

  • 非視覚型光受容体による光マルチセンシング機構の解明と光新規治療法開発

    2022.10
    -
    2028.03

    国立研究開発法人日本医療研究開発機構(AMED), 令和4年度 「革新的先端研究開発支援事業（AMED-CREST）」, No Setting

  • 低酸素応答制御機能を持つ静岡県産魚類由来成分の探索と疾患制御に関する研究

    2022.08
    -
    2025.03

    静岡県, マリンバイオテクノロジーを核としたシーズ創出研究業務委託 ￥286,800,000-, No Setting

  • 低酸素応答を標的とした予防から治療までを網羅する網膜疾患制御技術開発

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Approach for retinal diseases based on regulation of hypoxia response

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 近視を予防または治療するための方法および組成物

    Date applied： 特願2024-103695  2024.06 

    Date announced： 特開2025-73060  2025.05 

    Patent

  • α１ブロッカーを含む近視進行抑制用点眼剤

    Date applied： 特願2024-519839  2022.08 

    Date published： WO2024/048750  2024.03 

    Date issued： 特許第7640163号  2025.03

    Date registered： 2025.02

    Patent

  • ＨＩＦ抑制用組成物

    Date applied： 特願2021-504090  2020.03 

    Date issued： 特許第7598591号  2024.12

    Date registered： 2024.12

    Patent

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Awards 【 Display / hide 】

  • 第46回日本光医学・光生物学会学術奨励賞（医学領域）

    栗原俊英, 2024.07, 日本光医学・光生物学会, 非視覚光受容による近視進行抑制に関わる脳内回路の探索

  • 日本眼科学会評議員会賞

    栗原俊英, 2024.04, 日本眼科学会, 光生物学を基盤とした眼疾患病態生理の理解と治療開発

  • 第62回日本網膜硝子体学会総会優秀演題

    Ayaka Naka, Deokho Lee, Yan Zhang, Chiho Shoda, Satoshi Imanishi, Hiroyuki Nakashizuka, Satoru Yamagami, Kazuno Negishi, Akiharu Kubo, Toshihide Kurihara, 2023.11, 日本網膜硝子体学会, Claudin-1 deficiency in RPE leads to age-related retinal degeneration in mic

  • The Keio Medical Science Rising Star Award

    Toshihide Kurihara, 2023.01, Keio University, Exploring the pathophysiology of the retina and myopia based on photobiology and the clinical adaptation

  • 第72回日本臨床眼科学会学術展示優秀賞

    栗原俊英, 2019.04, 日本眼科学会, 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化

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    第123回日本眼科学会総会

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, OPHTHALMOLOGY

    2026

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Media Coverage 【 Display / hide 】

  • （扉）光遺伝学、視覚再生へ進む治験 狙った細胞を操作、脳への実用化には課題も

    朝日新聞社, 朝日新聞 (朝日新聞デジタル) , 2025.11

  • （扉）遺伝子治療、がんや希少疾患に 患者に合わせ、「土台」応用し費用・期間省く

    朝日新聞社, 朝日新聞 (朝日新聞デジタル) , 2025.10

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    体の細胞の遺伝子操作をする「遺伝子治療」。国内初の実施から３０年たち、多様な治療法が開発され、対象となる病気の種類も増えた。高額な開発費を抑える方法が模索されている。

  • 光遺伝学を活用し、目の難病の視覚再生目指す 慶大など国内初の治験を開始

    サイエンスポータル, 国立研究開発法人 科学技術振興機構, 2025.03

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    神経細胞などの働きを光で制御する「光遺伝学」の手法を活用し、目の難病「網膜色素変性症」で失われた視覚の再生を目指す遺伝子治療薬の臨床試験（治験）を始めた、と慶應義塾大学と名古屋工業大学の共同研究グループが発表した。光遺伝学の臨床応用は国内初という。
    この目の難病は目の内側を覆い、光を受け取って神経の信号に変える働きをする網膜の視細胞が最初に障害を起こし、徐々に機能を失う進行性の失明難病。通常4000人から8000人に1人発症し、根本的な治療法は確立していない。世界の患者は200万人以上とされる。
    慶應大学医学部眼科学教室の栗原俊英准教授らの研究グループは、名古屋工業大学の神取秀樹教授らが開発した「キメラロドプシン」という光に対する感度が高い独自のタンパク質を使い、光遺伝学の手法を応用することで視覚再生効果と視細胞の保護効果があることをマウスで確認し、研究成果を2023年10月に発表していた。
    この成果を生かして慶應大学発のスタートアップ企業「レストアビジョン」（東京都港区）がキメラロドプシンの遺伝子治療薬（視覚再生治療製剤）「RV-001」を開発。栗原准教授らの研究グループは今回、既に視細胞の機能が失われた重症患者1人に対しRV-001を目に注射して1例目の投与を終えた。
    網膜にある双極細胞と呼ばれる神経細胞にキメラロドプシンを作る遺伝子を届け、視細胞の代わりに光の検知を担わせるのが目的。研究グループによると、これまで重い合併症などはないが、今後半年間経過を観察して安全性や有効性を確認する。今後6～15人を対象に治験を続ける予定だ。
    栗原准教授らの研究グループは「（治験を始めたRV-001は）視覚再生治療薬として世界初の実用化を目指す試みで、失明疾患に対する新たな治療法を提供する重要な一歩と位置付けられる」としている。
    光遺伝学は米スタンフォード大学のカール・ダイセロス教授が2005年に技術を確立した。脳研究に大きく貢献し、米国の医学賞であるラスカー賞（基礎分野）の20年授賞者に選ばれ、ノーベル賞の有力候補とされる。
    理化学研究所・脳科学総合研究センターの利根川進センター長（当時）らは2015年に「光遺伝学によってマウスのうつ状態を改善した」と発表した。現在はうつ病や睡眠障害、依存症など精神疾患の仕組みや臓器の働きの制御を研究する分野で活用されている。

  • すんどめ ～網膜色素変性症と生きる〜

    名古屋テレビ放送・テレビ朝日系列全国24社, テレメンタリー2024, 2024.11

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    "すんどめ"の新競技で全国制覇へ！「今を楽しむことが一番」難病がある高校生ボクサーと全盲のシングルマザー 遺伝性のある網膜色素変性症、研究の最前線は

    愛知県岡崎市の石川凌久さんは、“当てないスパーリング”とも呼ばれるマスボクシングに打ち込む高校２年生。母親の智美さんは、２０代で網膜色素変性症という難病で失明した。凌久さんは、高校に入って”殴り合い”がある通常のボクシングをやりたいと思っていたが、受けて失明するのではないかと心配する智美さんの猛反対にあいマスボクシングを選んだ。網膜色素変性症は遺伝する可能性がある。視覚障がい者の選択に光を当てる。
    ナレーター：島貫凌アナウンサー
    名古屋テレビ放送

    https://www.tv-asahi.co.jp/telementary/backnumber/0257/

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Memberships in Academic Societies 【 Display / hide 】

  • Japan Society of Gene and Cell Therapy, 

    2026.04
    -
    Present

  • The Japanese Society for Clinical Electrophysiology of Vision (JSCEV), 

    2026.01
    -
    Present

  • The Macular Society, 

    2025.10
    -
    Present

  • Japan Society for Ocular Circulation, 

    2025.04
    -
    Present

  • The Japanese Society for Photomedicine and Photobiology, 

    2023.05
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2022.11
    -
    Present

    Associate Editor for Neurodegeneration, Frontiers in Neuroscience

  • 2022.10
    -
    Present

    眼科 外来医長, 慶應義塾大学病院

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