Kurihara, Toshihide

写真a

Affiliation

School of Medicine, Department of Ophthalmology (Shinanomachi)

Position

Associate Professor
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Profile 【 Display / hide 】

  • Toshihide Kurihara is an Associate Professor of Ophthalmology at Keio University, Tokyo, Japan. He has also been appointed as an Adjunct Assistant Professor at the Scripps Research Institute (TSRI) in La Jolla, CA, USA. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at TSRI. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Editorial Board　Member: BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine

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Career 【 Display / hide 】

  • 2001.04
    -
    2003.03

    Keio University Hospital, Department of Ophthalmology, Resident

  • 2002.07
    -
    2003.06

    National Kasumigaura Hospital, Department of Ophthalmology, Resident

  • 2003.04
    -
    2004.03

    Keio University Hospital, Department of Ophthalmology, Clinical Fellow

  • 2004.01
    -
    2005.03

    Tokyo Saiseikai Central Hospital, Ophthalmology, Clinical Fellow

  • 2005.04
    -
    2009.03

    Keio University Graduate School of Medicine, Doctoral Course

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Academic Background 【 Display / hide 】

  • 1995.04
    -
    2001.03

    University of Tsukuba, School of Medicine

    University, Graduated

  • 2005.04
    -
    2009.03

    Keio University, Graduate School of Medicine

    Graduate School, Completed

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Academic Degrees 【 Display / hide 】

  • PhD in Medicine, Keio University, Coursework, 2009.03

    Angiotensin 2 type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina

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Research Areas 【 Display / hide 】

  • Life Science / Ophthalmology (Ophthalmology)

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Papers 【 Display / hide 】

  • 幼少期の強膜穿孔創から58年経過して外因性細菌性眼内炎を発症した1例

    上村綾音, 伴紀充, 國見洋光, 富田洋平, 栗原俊英, 篠田 肇, 根岸一乃

    眼科臨床紀要 17 ( 10 ) 749 - 752 2024.12

    Accepted

  • Acquisition of high-sensitivity human aqueous humor Raman spectra

    Shinojima A, Sawada M, Kuroda M,Lee D, Kinoshita T, Negishi K, Kurihara T†

    Res Sq.  2024.10

    Last author, Corresponding author

  • Deep Spectral Library of Mice Retina for Myopia Research: Proteomics Dataset generated by SWATH and DIA-NN

    Sze YH, Tse DYY, Zuo B, Li KK, Zhao Q, Jiang X, Kurihara T, Tsubota K, Lam TC†

    Sci Data. 11 ( 1 ) 1115 - 1115 2024.10

    Accepted

    　View Summary

    The retina plays a crucial role in processing and decoding visual information, both in normal development and during myopia progression. Recent advancements have introduced a library-independent approach for data-independent acquisition (DIA) analyses. This study demonstrates deep proteome identification and quantification in individual mice retinas during myopia development, with an average of 6,263 ± 86 unique protein groups. We anticipate that the use of a predicted retinal-specific spectral library combined with the robust quantification achieved within this dataset will contribute to a better understanding of the proteome complexity. Furthermore, a comprehensive mice retinal-specific spectral library was generated, encompassing a total identification of 9,401 protein groups, 70,041 peptides, 95,339 precursors, and 761,868 transitions acquired using SWATH-MS acquisition on a ZenoTOF 7600 mass spectrometer. This dataset surpasses the spectral library generated through high-pH reversed-phase fractionation by data-dependent acquisition (DDA). The data is available via ProteomeXchange with the identifier PXD046983. It will also serve as an indispensable reference for investigations in myopia research and other retinal or neurological diseases.

  • Myopic shift in female mice after ovariectomy

    Zhang Y, Mori K, Jeong H, Chen J, Liang Y, Negishi K, Tsubota K†, Kurihara T†

    Sci Rep. 14 ( 1 ) 22946 - 22946 2024.10

    Last author, Corresponding author, Accepted

    　View Summary

    Myopia is a global public health concern, with a higher prevalence in women than that in male. As the relationship between sex hormone and myopia remains unclear, we aimed to reveal the relationship between sex hormone and myopia by removing the ovaries of mice and measuring changes in ocular parameters related to myopia. Lens-induced myopia (LIM) surgeries were performed on 3-week-old male mice and age-matched female mice to evaluate the effects of sex on myopia development, which indicated a high degree of myopia and rapid progression of axial elongation in male mice. Bilateral ovariectomy (OVX) performed on 4-week-old female mice induced myopic refraction status in ovariectomized mice. Although axial length elongation was larger in ovariectomized mice than that in sham control mice, the result was insignificant. To further reveal the relationship between female sex hormones and myopia, LIM combined with OVX was performed, which revealed a magnified myopic refraction status in ovariectomized mice. Nevertheless, elongation of the anterior chamber depth in the - 30 D lens-treated eyes significantly increased in LIM + OVX mice compared with the frame-treated eyes in LIM + OVX mice and - 30 D lens-treated eyes in LIM + Sham surgery mice. Sex hormones play a role in regulating myopia development in female mice.

  • Recent Insights into Roles of Hypoxia-Inducible Factors in Retinal Diseases

    Lee D, Tomita Y, Miwa Y, Kunimi H, Nakai A, Shoda C, Negishi K, Kurihara T†

    Int J Mol Sci. 25 ( 18 ) 10140 2024.09

    Last author, Corresponding author, Accepted,  ISSN  16616596

    　View Summary

    Hypoxia-inducible factors (HIFs) are transcriptional factors that function as strong regulators of oxygen homeostasis and cellular metabolisms. The maintenance of cellular oxygen levels is critical as either insufficient or excessive oxygen affects development and physiologic and pathologic conditions. In the eye, retinas have a high metabolic demand for oxygen. Retinal ischemia can cause visual impairment in various sight-threating disorders including age-related macular degeneration, diabetic retinopathy, and some types of glaucoma. Therefore, understanding the potential roles of HIFs in the retina is highly important for managing disease development and progression. This review focuses on the physiologic and pathologic roles of HIFs as regulators of oxygen homeostasis and cellular metabolism in the retina, drawing on recent evidence. Our summary will promote comprehensive approaches to targeting HIFs for therapeutic purposes in retinal diseases.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • ここまでわかった！近視進行の分子•細胞メカニズム

    栗原俊英

    第463回大阪眼科集談会, 

    2024.12

  • 光遺伝学を用いた遺伝子治療

    栗原俊英

    第63回日本網膜硝子体学会総会 シンポジウム5「網膜疾患に対する遺伝子治療の現状と未来」, 

    2024.12

  • 網膜剥離術後の多焦点眼内レンズ偏位にBelt Loop Techniqueによる再固定を行った1例

    永本崇, 伴紀充, 姜效炎, 國見洋光, 富田洋平, 栗原俊英, 篠田肇, 窪野裕, 川村真理, 鈴木浩太郎, 根岸一乃

    第63回日本網膜硝子体学会総会, 

    2024.12

  • 変性網膜へ光を取り戻す -キメラロドプシンによる視覚再生-

    栗原俊英

    神戸市・NPO法人神戸市難病団体連絡協議会主催 難病医療相談会, 

    2024.12

  • 網膜の発生・生理・病態生理に関わるVEGFの役割

    栗原俊英

    千寿製薬社内講演会, 

    2024.11

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Establishment of therapeutic intervention methods for fibrotic scar formation in age-related macular degeneration through hypoxia response control

    2024.04
    -
    2027.03

    基盤研究(C), Principal investigator

  • 非視覚型光受容体による光マルチセンシング機構の解明と光新規治療法開発

    2022.10
    -
    2028.03

    国立研究開発法人日本医療研究開発機構(AMED), 令和4年度 「革新的先端研究開発支援事業（AMED-CREST）」, No Setting

  • 低酸素応答制御機能を持つ静岡県産魚類由来成分の探索と疾患制御に関する研究

    2022.08
    -
    2025.03

    静岡県, マリンバイオテクノロジーを核としたシーズ創出研究業務委託 ￥286,800,000-, No Setting

  • 低酸素応答を標的とした予防から治療までを網羅する網膜疾患制御技術開発

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Approach for retinal diseases based on regulation of hypoxia response

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

  • ＨＩＦ抑制用組成物

    Date applied： 特願2021-504090  2020.03 

    Date issued： 特許第7598591号  2024.12

    Date registered： 2024.12

    Patent

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Awards 【 Display / hide 】

  • 第46回日本光医学・光生物学会学術奨励賞（医学領域）

    栗原俊英, 2024.07, 日本光医学・光生物学会, 非視覚光受容による近視進行抑制に関わる脳内回路の探索

  • 日本眼科学会評議員会賞

    栗原俊英, 2024.04, 日本眼科学会, 光生物学を基盤とした眼疾患病態生理の理解と治療開発

  • 第62回日本網膜硝子体学会総会優秀演題

    Ayaka Naka, Deokho Lee, Yan Zhang, Chiho Shoda, Satoshi Imanishi, Hiroyuki Nakashizuka, Satoru Yamagami, Kazuno Negishi, Akiharu Kubo, Toshihide Kurihara, 2023.11, 日本網膜硝子体学会, Claudin-1 deficiency in RPE leads to age-related retinal degeneration in mic

  • The Keio Medical Science Rising Star Award

    Toshihide Kurihara, 2023.01, Keio University, Exploring the pathophysiology of the retina and myopia based on photobiology and the clinical adaptation

  • 第72回日本臨床眼科学会学術展示優秀賞

    栗原俊英, 2019.04, 日本眼科学会, 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化

    　View Description

    第123回日本眼科学会総会

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Media Coverage 【 Display / hide 】

  • すんどめ ～網膜色素変性症と生きる〜

    名古屋テレビ放送・テレビ朝日系列全国24社, テレメンタリー2024, 2024.11

    　View Summary

    "すんどめ"の新競技で全国制覇へ！「今を楽しむことが一番」難病がある高校生ボクサーと全盲のシングルマザー 遺伝性のある網膜色素変性症、研究の最前線は

    愛知県岡崎市の石川凌久さんは、“当てないスパーリング”とも呼ばれるマスボクシングに打ち込む高校２年生。母親の智美さんは、２０代で網膜色素変性症という難病で失明した。凌久さんは、高校に入って”殴り合い”がある通常のボクシングをやりたいと思っていたが、受けて失明するのではないかと心配する智美さんの猛反対にあいマスボクシングを選んだ。網膜色素変性症は遺伝する可能性がある。視覚障がい者の選択に光を当てる。
    ナレーター：島貫凌アナウンサー
    名古屋テレビ放送

    https://www.tv-asahi.co.jp/telementary/backnumber/0257/

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Memberships in Academic Societies 【 Display / hide 】

  • The Japanese Society for Photomedicine and Photobiology, 

    2023.05
    -
    Present

  • 日本ロービジョン学会, 

    2022.12
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    Present

  • 日本人類遺伝学会, 

    2021.07
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2022.11
    -
    Present

    Associate Editor for Neurodegeneration, Frontiers in Neuroscience

  • 2022.10
    -
    Present

    眼科 外来医長, 慶應義塾大学病院

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