Kurihara, Toshihide



School of Medicine, Department of Ophthalmology (Shinanomachi)


Associate Professor

Profile 【 Display / hide

  • Toshihide Kurihara is an Associate Professor of Ophthalmology at Keio University, Tokyo, Japan. He has also been appointed as an Adjunct Assistant Professor at the Scripps Research Institute (TSRI) in La Jolla, CA, USA. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at TSRI. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Editorial Board Member: BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine

Career 【 Display / hide

  • 2001.04

    Keio University Hospital, Department of Ophthalmology, Resident

  • 2002.07

    National Kasumigaura Hospital, Department of Ophthalmology, Resident

  • 2003.04

    Keio University Hospital, Department of Ophthalmology, Clinical Fellow

  • 2004.01

    Tokyo Saiseikai Central Hospital, Ophthalmology, Clinical Fellow

  • 2005.04

    Keio University Graduate School of Medicine, Doctoral Course

display all >>

Academic Background 【 Display / hide

  • 1995.04

    University of Tsukuba, School of Medicine

    University, Graduated

  • 2005.04

    Keio University, Graduate School of Medicine

    Graduate School, Completed

Academic Degrees 【 Display / hide

  • PhD in Medicine, Keio University, Coursework, 2009.03

    Angiotensin 2 type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina


Research Areas 【 Display / hide

  • Life Science / Ophthalmology (Ophthalmology)


Papers 【 Display / hide

  • Relationship of choroidal thickness and axial length with posterior vitreous detachment in patients with high myopia

    Hanyuda A*, Torii H*, Hayashi K, Uchida A, Mori K, Yotsukura E, Ogawa M, Negishi K, Kurihara T†, Tsubota T†

    Sci Rep. (Springer Science and Business Media LLC)  12 ( 1 ) 4093 2022.12


     View Summary

    <title>Abstract</title>Although accumulating evidence suggests a higher prevalence of posterior vitreous detachment (PVD) in highly myopic eyes, the relation between ocular biometric features and PVD stages in such eyes remains unclear. Therefore, we enrolled 170 patients with high myopia (axial length ≥ 26.0 mm) to investigate the status of PVD regarding subfoveal choroidal thickness and axial length. Utilising swept-source optical coherence tomography, we classified the PVD status into five stages. The distribution of PVD grades increased as the choroidal thickness decreased and axial length increased (P &lt; 0.01). On adjusting for age and sex, decreased choroidal thickness and increased axial length were associated with more advanced PVD stages: odds ratios with the highest vs. lowest groups were 0.31 (95% confidence interval [CI] 0.09–1.01; P<sub>trend</sub> = 0.009) for choroidal thickness and 5.16 (95% CI 1.34–19.80; P<sub>trend</sub> = 0.002) for axial length. The inverse association between choroidal thickness and PVD status seemed stronger in women than in men (P<sub>interaction</sub> = 0.05). In conclusion, we firstly observed a significant trend of decreased choroidal thickness, along with increased axial length, with increased grade of PVD, particularly among women with highly myopic eyes, suggesting that advanced morphological myopic changes contribute to PVD in middle-aged adults.

  • Relation between Dry Eye and Myopia Based on Tear Film Breakup Time, Higher Order Aberration, Choroidal Thickness, and Axial Length

    Hazra D*, Yotsukura E*, Torii H*†, Mori K, Maruyama T, Ogawa M, Hanyuda A, Tsubota K, Kurihara T†, Negishi K†

    Sci Rep. (Scientific Reports)  12 ( 1 ) 10891 2022.12


     View Summary

    The purpose of this study was to investigate the association between dry eye disease (DED) and myopia by evaluating higher order aberrations (HOAs) and choroidal thickness (CT). We recruited 72 myopic children with DED symptoms (mean age 12.8 years), measured the tear film breakup time (TBUT), corneal/intraocular/total ocular HOAs, CT, and axial length (AL), administered lifestyle questionnaires, and evaluated the relationships among TBUT, HOAs, CT, and AL. The TBUT was correlated significantly with the corneal HOAs and intraocular HOAs but not with the total ocular HOAs. Multiple regression analyses showed that the AL was associated significantly with the TBUT (β = − 0.067, P = 0.004), the intraocular HOAs, and total ocular HOAs but not with the corneal HOAs. The CT was associated significantly with the TBUT and AL (β = 9.15 and − 7.85, respectively; P < 0.001 and = 0.01, respectively). Our data suggested the association between DED and myopia might be independent of the HOAs. We showed that the TBUT was associated with the CT, which is related to the AL. Because the parasympathetic nervous system affects the lacrimal glands and CT, the parasympathetic nervous system might be a common upstream factor in the association between DED and myopia.

  • Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial

    Torii H*†, Mori K*, Takashi Okano T, Kondo S, Yang HY, Yotsukura E, Hanyuda A, Ogawa M, Negishi K, Kurihara T†, Tsubota K†

    J Clin Med. 11 ( 20 ) 6000 2022.10

    Corresponding author, Accepted

  • Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

    Ikeda SI, Kurihara T†, Jiang X, Miwa Y, Lee D, Serizawa N, Jeong H, Mori K, Katada Y, Kunimi H, Ozawa N, Shoda C, Ibuki M, Negishi K, Torii H, Tsubota K†

    Nat Commun. (Springer Science and Business Media LLC)  13 ( 1 ) 5859 2022.10

    Corresponding author, Accepted

     View Summary


    Axial length is the primary determinant of eye size, and it is elongated in myopia. However, the underlying mechanism of the onset and progression of axial elongation remain unclear. Here, we show that endoplasmic reticulum (ER) stress in sclera is an essential regulator of axial elongation in myopia development through activation of both PERK and ATF6 axis followed by scleral collagen remodeling. Mice with lens-induced myopia (LIM) showed ER stress in sclera. Pharmacological interventions for ER stress could induce or inhibit myopia progression. LIM activated all IRE1, PERK and ATF6 axis, and pharmacological inhibition of both PERK and ATF6 suppressed myopia progression, which was confirmed by knocking down above two genes via CRISPR/Cas9 system. LIM dramatically changed the expression of scleral collagen genes responsible for ER stress. Furthermore, collagen fiber thinning and expression of dysregulated collagens in LIM were ameliorated by 4-PBA administration. We demonstrate that scleral ER stress and PERK/ATF6 pathway controls axial elongation during the myopia development in vivo model and 4-PBA eye drop is promising drug for myopia suppression/treatment.

  • Degeneration of retinal ganglion cells in hypoxic responses: hypoxia-inducible factor inhibition, a new therapeutic insight

    Lee D, Kunimi H, Negishi K, Kurihara T†

    Neural Regen Res. (Neural Regeneration Research)  17 ( 10 ) 2230 - 2231 2022.10

    Accepted,  ISSN  16735374

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Presentations 【 Display / hide

  • 教育セミナー(眼科)糖尿病網膜症と腎症の類似点と相違点:ディスカッサント




  • 天然物食品由来因子による低酸素応答制御を介した網膜視神経疾患への新たなアプローチ


    第76回日本臨床眼科学会 シンポジウム 2「網膜疾患・緑内障薬物治療の新しい局面」, 


  • 近視という病態を考える


    第76回日本臨床眼科学会 ランチョンセミナー 13「近視を学ぶ ~近視の病態とアプローチ~」, 


  • 水晶体嚢拡張リング (CTR) 併用眼内レンズ挿入眼に発症した急性隅角閉塞の2例

    横溝真由美, 伴紀充, 内田敦郎, 藤岡俊平, 栗原俊英, 篠田肇, 根岸一乃



  • A Randomized Controlled Trial for The Effect of Violet Light Transmitting Eyeglasses on Myopia Progression In Children

    Kiwako Mori, Hidemasa Torii, Yutaka Hara, Michiko Hara, Erisa Yotsukura, Akiko Hanyuda, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota

    The 18th International Myopia Conference, 


display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 非視覚型光受容体による光マルチセンシング機構の解明と光新規治療法開発


    国立研究開発法人日本医療研究開発機構(AMED), 令和4年度 「革新的先端研究開発支援事業(AMED-CREST)」, No Setting

  • 低酸素応答制御機能を持つ静岡県産魚類由来成分の探索と疾患制御に関する研究


    静岡県, マリンバイオテクノロジーを核としたシーズ創出研究業務委託 ¥286,800,000-, No Setting

  • 低酸素応答を標的とした予防から治療までを網羅する網膜疾患制御技術開発


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Approach for retinal diseases based on regulation of hypoxia response


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

Awards 【 Display / hide

  • 第72回日本臨床眼科学会学術展示優秀賞

    栗原俊英, 2019.04, 日本眼科学会, 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化

     View Description



    2018.04, ロート製薬株式会社, 低酸素応答を基軸としたトランスレーショナルリサーチの推進

  • 2016年度日本抗加齢医学会研究奨励賞

    2016.06, 日本抗加齢医学会, 低酸素応答の加齢黄斑変性における役割

  • 平成28年度三四会賞「北里賞」

    2016.06, 慶應義塾大学医学部, 網膜の発生と病態生理における低酸素応答の役割

  • 第8回田野Young Investigator's Award

    2015.12, 日本網膜硝子体学会

display all >>


Memberships in Academic Societies 【 Display / hide

  • 日本人類遺伝学会, 


Committee Experiences 【 Display / hide

  • 2022.10

    眼科 外来医長, 慶應義塾大学病院