Kurihara, Toshihide

写真a

Affiliation

School of Medicine, Department of Ophthalmology (Shinanomachi)

Position

Associate Professor
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Profile 【 Display / hide 】

  • Toshihide Kurihara is an Associate Professor of Ophthalmology at Keio University, Tokyo, Japan. He has also been appointed as an Adjunct Assistant Professor at the Scripps Research Institute (TSRI) in La Jolla, CA, USA. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at TSRI. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Editorial Board　Member: BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine

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Career 【 Display / hide 】

  • 2001.04
    -
    2003.03

    Keio University Hospital, Department of Ophthalmology, Resident

  • 2002.07
    -
    2003.06

    National Kasumigaura Hospital, Department of Ophthalmology, Resident

  • 2003.04
    -
    2004.03

    Keio University Hospital, Department of Ophthalmology, Clinical Fellow

  • 2004.01
    -
    2005.03

    Tokyo Saiseikai Central Hospital, Ophthalmology, Clinical Fellow

  • 2005.04
    -
    2009.03

    Keio University Graduate School of Medicine, Doctoral Course

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Academic Background 【 Display / hide 】

  • 1995.04
    -
    2001.03

    University of Tsukuba, School of Medicine

    University, Graduated

  • 2005.04
    -
    2009.03

    Keio University, Graduate School of Medicine

    Graduate School, Completed

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Academic Degrees 【 Display / hide 】

  • PhD in Medicine, Keio University, Coursework, 2009.03

    Angiotensin 2 type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina

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Research Areas 【 Display / hide 】

  • Life Science / Ophthalmology (Ophthalmology)

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Papers 【 Display / hide 】

  • Thicker peripapillary choroid may be associated with behavioral factors in Tokyo's children.

    Hashimoto A*, Yotsukura E*, Ogawa M, Mori K, Hanyuda A, Tsubota K, Kurihara T, Negishi K†, Torii H†

    Sci Rep. 15 ( 1 ) 17868 - 17868 2025.05

    Accepted

    　View Summary

    The study goals were measurement of the choroidal thickness (CT) and investigation of related factors among children. Third-grade students at an elementary school in Tokyo participated in this study. A total of 119 schoolchildren underwent measurements of the axial length (AL), non-cycloplegic objective refraction (SE), and CT. The CT was divided into nine regions: the subfoveal area with a diameter of 1 mm (C0), a 5-mm-diameter circle-C0 (C1), and a 9-mm-diameter circle (C2); each was further divided into four quadrants. The SE, AL, and C0 CT were, respectively, - 1.57 ± 1.56 diopters, 23.39 ± 0.80 mm, and 297.73 ± 57.88 μm. Multiple regression analysis showed that the time spent using a computer was associated significantly with the CT in the C0 and the inferior C2 (C0: β = -0.728, P = 0.028; inferior C2: β = -0.527, P = 0.048), and the reading distance was associated significantly with the CT in the superior and nasal C2 (superior, β = 1.664, P = 0.007; nasal, β = 1.128, P = 0.015). In addition, time spent using smartphones, tablets, or handheld gaming devices was associated significantly with the CT in the superior and inferior C2 (superior C2: β = 0.259, P = 0.018; inferior C2: β = 0.262, P = 0.013). In conclusion, reading distance and time spent on digital devices may be associated with choroid thickness in children.

  • Intensive outdoor activity for 1 week increases choroidal thickness in Japanese schoolchildren: a prospective observational study

    Ogawa M, Torii H†, Yotsukura E, Mori K, Hanyuda A, Matsumura J, Fukuoka K, Negishi K, Kurihara T†, Tsubota K†

    BMC Ophthalmol. 25 ( 1 ) 300 2025.05

    Corresponding author, Accepted

    　View Summary

    Background: Outdoor activity is important to prevent myopia progression among schoolchildren, and maintaining the choroidal thickness is important to retard myopia progression. However, no research has reported the effects of short-term intensive outdoor activities on the choroidal thickness. This institution-based prospective observational study aims to assess the impact of outdoor activity for 1 week during a camp program to study ocular parameters including the choroidal thickness. Methods: The intensive outdoor activity program included an average of 6.15 ± 2.98 h of daily time spent outdoors during the camp on subsequent days for 1 week at a low-altitude mountain camp. Twenty-four children participated in this program. Results: The main outcome was the change in the choroidal thickness compared with baseline. The data were measured at the beginning and end of the program over the course of 1 week and the changes analyzed. The mean age of the participants (50% female) was 11.5 ± 0.5 (standard deviation) years, and the mean changes were as follows: the refractive error became more positive, the axial length decreased, and the choroidal thickness (µm) increased, respectively, by 0.21 ± 1.35 diopters (P = 0.742), -0.01 ± 0.02 mm (P = 0.241), and 30.7 ± 20.3 μm (P < 0.001). Conclusion: The results suggested that intensive outdoor activity for only 1 week increased the choroidal thickness in Japanese schoolchildren.

  • Intraocular Vasculature Formation Precedes Extraocular Vasculature Penetration of Mouse Eyes

    Imanishi S., Tomita Y., Negishi K., Tsubota K., Kurihara T†

    SSRN  2025.05

    Last author, Corresponding author

  • Assessing public awareness of myopia after the COVID-19 pandemic: an infodemiology study

    Chen J, Lee D., Ikeda SI, Zhang Y., Negishi K., Tsubota K., Kurihara T†

    BMJ Health Care Inform. 32 ( 1 ) e101156 2025.05

    Last author, Corresponding author, Accepted

    　View Summary

    Objectives Since the COVID-19 pandemic started, an increasing number of individuals use online resources to obtain health-related information, including myopia management. We aimed to obtain the search interest of global public health on myopia and prevention/treatment methods before and after the outbreak of COVID-19. Methods Google Trends was used to assess the global search interest in myopia and related terms. Data spanning from 2019 to 2023 were collected and segmented into three periods: prepandemic (2019), pandemic year (2020) and postpandemic (2021-2023). Each average search volume index was used to examine public awareness with the Kruskal-Wallis test. Results Among commonly used search keywords, Myopia is preferred over more colloquial terms (Nearsighted and Shortsighted). During the pandemic, searches for Myopia remained stable, while postpandemic, interest in Myopia surged (31.54%, p<0.0001). Myopia prevention/treatment awareness from 2019 to 2023 indicated notable shifts. In 2020, searches for Contact lenses and Spectacles decreased (-14.09% and -21.97%, respectively, both p<0.0001). These trends persisted postpandemic, with declining searches for Orthokeratology (-41.38%, p<0.01). Public interest for Light therapy (43.00%, p<0.0001) and Atropine (27.42%, p<0.0001) increased. Discussion The research highlights significant increases in global online awareness of myopia during the COVID-19 pandemic. The extended period of remote work during the pandemic may alter lifestyle habits and affect public perception of treatment options. Those findings could offer valuable perspectives on global interest patterns related to myopia, which supports subsequent myopia studies and is further useful to develop relevant public health policies.

  • Unilateral Common Carotid Artery Occlusion in Adult Mice with Streptozotocin Comorbidity Leads to Early Retinal Inflammation

    Gettinger K*, Lee D*, Negishi K, Kurihara T†

    Int J Mol Sci. 26 ( 9 ) 4385 2025.05

    Last author, Corresponding author, Accepted,  ISSN  16616596

    　View Summary

    Diabetic retinopathy (DR) is a leading cause of visual impairment. To better understand the pathology, clinically relevant experimental models are needed. Widely used DR models (especially streptozotocin (STZ)-induced) require extended timeframes to reach DR phenotype endpoints and lack ischemic phenotypes, which are in contrast to the human condition. Unilateral common carotid artery occlusion (UCCAO) could provide a retinal ischemic insult. We explored the pathologic synergistic effects of UCCAO in STZ mice. STZ (90 mg/kg) was injected intraperitoneally into adult C57BL/6 mice for three days. Four weeks later, right UCCAO was performed. One week after UCCAO, retinal samples were stained with isolectin B4 to analyze cellular and vascular changes. Retinal samples were obtained one day and one week after UCCAO and quantitative PCR (qPCR) were performed to observe inflammatory and ischemic responses. Only the STZ UCCAO group showed increased inflammatory cells. STZ UCCAO retina demonstrated a significant difference in capillary and large vessel size compared to other groups. At one day and one week, there was a change in mRNA expressions in inflammatory genes Ccl2, Ccl12, Bnip3, Pdk1, Hsp25, and Vegfa in the STZ UCCAO group compared to other groups. Our model can serve as an accelerated DR model for studying inflammatory vascular changes.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 進化する近視進行メカニズムの理解

    栗原俊英

    第138回神奈川県眼科医集談会, 

    2025.05

  • 患者さんへ再び光を届けるために -オプトジェネティクスを用いた視覚再生-

    栗原俊英

    第26回ロービジョン学会学術総会 アフタヌーンセミナー「光を再び感じる未来へ ～視覚再生遺伝子治療の挑戦～」, 

    2025.05

  • 視覚障害当事者の受障後の支援ニーズに関する全国調査

    中野泰志, 吉泉豊晴, 宮内久絵, 福田このみ, 山本詩織, 羽入田明子, 堅田侑作, 篠島亜里, 栗原俊英

    第26回日本ロービジョン学会学術総会, 

    2025.05

  • 慶應義塾大学病院ロービジョンケア・ハブにおける相談内容の検討

    福田このみ, 篠島亜里, 山本詩織, 堅田侑作, 羽入田明子, 金井政紀, 堀江智子, 清野華子, 山口義之, 栗原俊英, 根岸一乃

    第26回日本ロービジョン学会学術総会, 

    2025.05

  • 非視覚光応答による近視進行コントロール

    栗原俊英

    第794回新潟医学会例会シンポジウム, 

    2025.05

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Establishment of therapeutic intervention methods for fibrotic scar formation in age-related macular degeneration through hypoxia response control

    2024.04
    -
    2027.03

    基盤研究(C), Principal investigator

  • 非視覚型光受容体による光マルチセンシング機構の解明と光新規治療法開発

    2022.10
    -
    2028.03

    国立研究開発法人日本医療研究開発機構(AMED), 令和4年度 「革新的先端研究開発支援事業（AMED-CREST）」, No Setting

  • 低酸素応答制御機能を持つ静岡県産魚類由来成分の探索と疾患制御に関する研究

    2022.08
    -
    2025.03

    静岡県, マリンバイオテクノロジーを核としたシーズ創出研究業務委託 ￥286,800,000-, No Setting

  • 低酸素応答を標的とした予防から治療までを網羅する網膜疾患制御技術開発

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Approach for retinal diseases based on regulation of hypoxia response

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

  • α１ブロッカーを含む近視進行抑制用点眼剤

    Date applied： 特願2024-519839  2022.08 

    Date published： WO2024/048750  2024.03 

    Date issued： 特許第7640163号  2025.03

    Date registered： 2025.02

    Patent

  • ＨＩＦ抑制用組成物

    Date applied： 特願2021-504090  2020.03 

    Date issued： 特許第7598591号  2024.12

    Date registered： 2024.12

    Patent

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Awards 【 Display / hide 】

  • 第46回日本光医学・光生物学会学術奨励賞（医学領域）

    栗原俊英, 2024.07, 日本光医学・光生物学会, 非視覚光受容による近視進行抑制に関わる脳内回路の探索

  • 日本眼科学会評議員会賞

    栗原俊英, 2024.04, 日本眼科学会, 光生物学を基盤とした眼疾患病態生理の理解と治療開発

  • 第62回日本網膜硝子体学会総会優秀演題

    Ayaka Naka, Deokho Lee, Yan Zhang, Chiho Shoda, Satoshi Imanishi, Hiroyuki Nakashizuka, Satoru Yamagami, Kazuno Negishi, Akiharu Kubo, Toshihide Kurihara, 2023.11, 日本網膜硝子体学会, Claudin-1 deficiency in RPE leads to age-related retinal degeneration in mic

  • The Keio Medical Science Rising Star Award

    Toshihide Kurihara, 2023.01, Keio University, Exploring the pathophysiology of the retina and myopia based on photobiology and the clinical adaptation

  • 第72回日本臨床眼科学会学術展示優秀賞

    栗原俊英, 2019.04, 日本眼科学会, 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化

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    第123回日本眼科学会総会

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Media Coverage 【 Display / hide 】

  • 光遺伝学を活用し、目の難病の視覚再生目指す 慶大など国内初の治験を開始

    サイエンスポータル, 国立研究開発法人 科学技術振興機構, 2025.03

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    神経細胞などの働きを光で制御する「光遺伝学」の手法を活用し、目の難病「網膜色素変性症」で失われた視覚の再生を目指す遺伝子治療薬の臨床試験（治験）を始めた、と慶應義塾大学と名古屋工業大学の共同研究グループが発表した。光遺伝学の臨床応用は国内初という。
    この目の難病は目の内側を覆い、光を受け取って神経の信号に変える働きをする網膜の視細胞が最初に障害を起こし、徐々に機能を失う進行性の失明難病。通常4000人から8000人に1人発症し、根本的な治療法は確立していない。世界の患者は200万人以上とされる。
    慶應大学医学部眼科学教室の栗原俊英准教授らの研究グループは、名古屋工業大学の神取秀樹教授らが開発した「キメラロドプシン」という光に対する感度が高い独自のタンパク質を使い、光遺伝学の手法を応用することで視覚再生効果と視細胞の保護効果があることをマウスで確認し、研究成果を2023年10月に発表していた。
    この成果を生かして慶應大学発のスタートアップ企業「レストアビジョン」（東京都港区）がキメラロドプシンの遺伝子治療薬（視覚再生治療製剤）「RV-001」を開発。栗原准教授らの研究グループは今回、既に視細胞の機能が失われた重症患者1人に対しRV-001を目に注射して1例目の投与を終えた。
    網膜にある双極細胞と呼ばれる神経細胞にキメラロドプシンを作る遺伝子を届け、視細胞の代わりに光の検知を担わせるのが目的。研究グループによると、これまで重い合併症などはないが、今後半年間経過を観察して安全性や有効性を確認する。今後6～15人を対象に治験を続ける予定だ。
    栗原准教授らの研究グループは「（治験を始めたRV-001は）視覚再生治療薬として世界初の実用化を目指す試みで、失明疾患に対する新たな治療法を提供する重要な一歩と位置付けられる」としている。
    光遺伝学は米スタンフォード大学のカール・ダイセロス教授が2005年に技術を確立した。脳研究に大きく貢献し、米国の医学賞であるラスカー賞（基礎分野）の20年授賞者に選ばれ、ノーベル賞の有力候補とされる。
    理化学研究所・脳科学総合研究センターの利根川進センター長（当時）らは2015年に「光遺伝学によってマウスのうつ状態を改善した」と発表した。現在はうつ病や睡眠障害、依存症など精神疾患の仕組みや臓器の働きの制御を研究する分野で活用されている。

  • すんどめ ～網膜色素変性症と生きる〜

    名古屋テレビ放送・テレビ朝日系列全国24社, テレメンタリー2024, 2024.11

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    "すんどめ"の新競技で全国制覇へ！「今を楽しむことが一番」難病がある高校生ボクサーと全盲のシングルマザー 遺伝性のある網膜色素変性症、研究の最前線は

    愛知県岡崎市の石川凌久さんは、“当てないスパーリング”とも呼ばれるマスボクシングに打ち込む高校２年生。母親の智美さんは、２０代で網膜色素変性症という難病で失明した。凌久さんは、高校に入って”殴り合い”がある通常のボクシングをやりたいと思っていたが、受けて失明するのではないかと心配する智美さんの猛反対にあいマスボクシングを選んだ。網膜色素変性症は遺伝する可能性がある。視覚障がい者の選択に光を当てる。
    ナレーター：島貫凌アナウンサー
    名古屋テレビ放送

    https://www.tv-asahi.co.jp/telementary/backnumber/0257/

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Memberships in Academic Societies 【 Display / hide 】

  • Japan Society for Ocular Circulation, 

    2025.04
    -
    Present

  • The Japanese Society for Photomedicine and Photobiology, 

    2023.05
    -
    Present

  • 日本ロービジョン学会, 

    2022.12
    -
    Present

  • 日本人類遺伝学会, 

    2021.07
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2022.11
    -
    Present

    Associate Editor for Neurodegeneration, Frontiers in Neuroscience

  • 2022.10
    -
    Present

    眼科 外来医長, 慶應義塾大学病院

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