Kurihara, Toshihide

写真a

Affiliation

School of Medicine, Department of Ophthalmology ( Shinanomachi )

Position

Associate Professor
Scopus Paper Info  
Paper Count: 203 Citation Count: 6725 h-index: 42

Click to view the Scopus page. The data was downloaded from Scopus API in February 09, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Profile 【 Display / hide 】

  • Toshihide Kurihara is an Associate Professor of Ophthalmology at Keio University, Tokyo, Japan. He has also been appointed as an Adjunct Assistant Professor at the Scripps Research Institute (TSRI) in La Jolla, CA, USA. He received his M.D. degree from the Faculty of Medicine, University of Tsukuba, Ibaraki, Japan, in 2001. He completed his ophthalmology residency at Keio University Hospital in 2005, and obtained his Ph.D. degree under the supervision of Professor Kazuo Tsubota from Keio University Graduate School of Medicine in 2009. Dr. Kurihara did his postdoctoral training under the mentorship of Professor Martin Friedlander at TSRI. His research interest is hypoxia responses in development, physiology, and pathophysiology of the retina. Editorial Board　Member: BioMed Research International, Journal of Ophthalmology, and Case Reports in Ophthalmological Medicine

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Career 【 Display / hide 】

  • 2001.04
    -
    2003.03

    Keio University Hospital, Department of Ophthalmology, Resident

  • 2002.07
    -
    2003.06

    National Kasumigaura Hospital, Department of Ophthalmology, Resident

  • 2003.04
    -
    2004.03

    Keio University Hospital, Department of Ophthalmology, Clinical Fellow

  • 2004.01
    -
    2005.03

    Tokyo Saiseikai Central Hospital, Ophthalmology, Clinical Fellow

  • 2005.04
    -
    2009.03

    Keio University Graduate School of Medicine, Doctoral Course

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Academic Background 【 Display / hide 】

  • 1995.04
    -
    2001.03

    University of Tsukuba, School of Medicine

    University, Graduated

  • 2005.04
    -
    2009.03

    Keio University, Graduate School of Medicine

    Graduate School, Completed

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Academic Degrees 【 Display / hide 】

  • PhD in Medicine, Keio University, Coursework, 2009.03

    Angiotensin 2 type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina

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Research Areas 【 Display / hide 】

  • Life Science / Ophthalmology (Ophthalmology)

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Papers 【 Display / hide 】

  • Light and myopia: a focus on the expanding role of non-visual opsins

    Gettinger K, Tsubota K, Negishi K, Kurihara T†

    Eye Vis. (Springer Science and Business Media LLC)  13 ( 1 ) 6 2026.01

    Last author, Corresponding author, Accepted

    　View Summary

    Abstract

    Myopia, or near-sightedness, is a growing global concern as its incidence rate continues to dramatically rise. It has been linked to significant ocular morbidity and reduced quality of life. Despite this, much is still largely unknown about the development of and the mechanisms driving the pathogenesis of myopia. As such, myopia prevention and myopia mitigation treatment strategies are occasionally ineffective, can be difficult to adhere to, and have diminishing returns over time. Recently, non-visual opsins (OPN3, OPN4, and OPN5) have emerged as potentially impacting myopia regulation. This narrative review aims to summarize the current understanding of the non-visual opsins and how they might influence myopia. In addition, this review explores how utilizing this knowledge can help develop promising future treatment strategies to reduce the incidence and severity of myopia.

  • Ocular siderosis caused by a subretinal iron foreign body masquerading as a blood clot: a case report

    Lin JS, Nagamoto T, Ban N†, Moriya M, Jiang X, Kunimi H, Tomita Y, Kurihara T, Shinoda H, Negishi K

    Am J Ophthalmol Case Rep.  2026.01

    Accepted

  • Clinical implications of systolic blood pressure for diabetic retinopathy across HbA1c levels in a Japanese population

    Sasaki M*†, Ofuji Y*, Hanyuda A, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Yamagishi K†, Yuki K, Sawada N, Tsubota K, Negishi K, Tsugane S, Iso H

    Sci Rep.  2026.01

    Accepted

  • Violet light-transmitting intraocular lens increases choroidal thickness: 1-year prospective, randomised controlled trial

    Yotsukura E*, Torii H*†, Hayashi K, Hayashi S, Ohnuma K, Mori K, Ogawa M, Hanyuda A, Kurihara T†, Tsubota K†, Negishi K

    BMJ Open Ophthalmol. (BMJ)  10 ( 1 ) e002441 - e002441 2025.12

    Corresponding author, Accepted

    　View Summary

    Aims

    To compare the changes in ocular parameters after implantation of two types of intraocular lenses (IOLs) following cataract surgery. One IOL transmits violet light (VL), and the other does not.

    Methods

    A total of 402 patients were randomly assigned to receive either a VL-non-transmitting IOL or a VL-transmitting IOL. Ocular parameters were measured preoperatively and postoperatively, and participants completed a lifestyle questionnaire. The choroidal thickness (CT) was measured using the PLEX Elite 9000 (Carl Zeiss Meditec). The associations between changes in CT and age, sex, type of IOL, preoperative CT, time spent outdoors, time spent using a smartphone or tablet and time spent reading were examined using stepwise multiple regression analysis (SPSS V.28.0 for Windows, IBM-SPSS).

    Results

    The baseline mean spherical equivalents were −4.00±5.97 D and −2.19±4.73 D, the axial lengths were 24.84±1.82 mm and 24.19±1.65 mm, and the CTs were 213.78±102.93 µm and 239.20±104.98 µm for the VL-non-transmitting and VL-transmitting IOL groups, respectively. The mean changes in the CT from 3 to 12 months postoperatively were −0.30±18.32 µm for the VL-non-transmitting IOLs and 3.48±16.46 µm for the VL-transmitting IOLs (p=0.012). Multiple regression analysis identified significant choroidal thickening associated with female sex (p=0.004), VL-transmitting IOL implantation (p=0.049) and increased outdoor exposure (p=0.008).

    Conclusion

    The choroidal thickening after cataract surgery was associated with the VL-transmitting IOL and longer time spent outdoors with exposure to abundant VL. Despite these findings, this study has several limitations, including a relatively short follow-up period, and it did not assess postoperative lifestyle, VL exposure or actual peripheral defocus in the patients.

    Trial registration number

    UMIN000038961.

  • Effect of Anti-VEGF Therapy on Wide-Field Retinal and Choroidal Thickness in Macular Edema Secondary to Retinal Vein Occlusion

    Araki R, Tomita Y†, Yuda T, Jiang X, Ban N, Kunimi H, Uchida A, Kurihara T, Shinoda H, Negishi K

    AJO Int. (Elsevier BV)  3 ( 1 ) 100207 2025.12

    Accepted,  ISSN  2950-2535

    　View Summary

    Objective or Purpose: To investigate the effect of anti-VEGF therapy on wide-field retinal and choroidal thickness in patients with macular edema secondary to RVO, and to identify how these effects vary based on clinical characteristics such as occlusion location and patient sex. Design: Retrospective observational study. Subjects, Participants, and/or Controls: Thirty-eight patients (38 eyes) with RVO treated at Keio University Hospital (26 males, 12 females; mean age, 67.7 ± 8.5 years). Seventeen fellow eyes without injection served as internal controls. Methods, Intervention, or Testing: We analyzed 38 eyes with RVO who received intravitreal injections of aflibercept (n = 31) or ranibizumab (n = 7). Wide-field optical coherence tomography (OCT) was performed at baseline (within 7 days before the injection) and at the follow-up visit (30 ± 14 days after the injection). Changes in retinal and choroidal thickness were analyzed across nine predefined regions: a central 5-mm subfield (C0) and eight surrounding peripheral sectors: temporal (L1), superior-temporal (L2), superior (L3), superior-nasal (L4), nasal (L5), inferior-nasal (L6), inferior (L7), and inferior-temporal (L8). Statistical analysis was performed using the Wilcoxon signed-rank test and Bonferroni correction for nine regions. Main Outcome Measures: Changes in regional retinal and choroidal thickness Results: Post-injection, retinal thickness significantly decreased in all regions except L4 and L6 (p < 0.0056). Choroidal thickness showed a significant reduction in L2, L5, and L8 (p < 0.0056). Subgroup analyses revealed no significant changes in choroidal thickness in either the superior RVO group (n = 9) or the inferior RVO group (n = 17). A clear sex-based difference was also observed: male patients (n = 26) exhibited choroidal thinning in L4, L5, L6, and L8 (p < 0.0056), whereas female patients (n = 12) showed no significant changes in any region. Conclusion: Anti-VEGF therapy reduced retinal and choroidal thickness in specific regions in eyes with RVO. No significant differences were observed between eyes with superior and inferior occlusions. In male patients, significant thinning was observed in multiple peripheral regions, whereas no significant changes were noted in female patients. These findings suggest that the choroidal response to anti-VEGF therapy is complex and warrants further investigation.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 進化する近視進行メカニズムの理解と治療開発

    栗原俊英

    第9回日大‐城北眼科アップデートセミナー, 

    2026.01

  • The role of immune cells in the choroid of the eye: Mast cells as regulators of myopia

    Shin-ichi Ikeda, Tomokazu Fukuchi, Jue Shi, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara

    第54回日本免疫学会学術集会, 

    2025.12

  • IOL強膜内固定術後に自然閉鎖を2度繰り返した全層黄斑円孔の1例

    小川茉里奈, 富田洋平, 太田友香, 伴紀充, 國見洋光, 林勇, 姜效炎, 栗原俊英, 篠田肇, 根岸一乃

    第64回日本網膜硝子体学会総会, 

    2025.12

  • 超広角光干渉断層計を用いた網膜前膜への硝子体切除術後の網膜厚変化の評価

    湯田智規, 富田洋平, 荒木梨沙, 張琰, 姜效炎, 伴紀充, 林勇海, 國見洋光, 栗原俊英, 篠田肇, 根岸一乃

    第64回日本網膜硝子体学会総会, 

    2025.12

  • 経口避妊薬内服中止により軽快した基礎疾患のない網膜中心静脈閉塞症の1症例

    世良裕朝, 栗原俊英, 姜效炎, 國見洋光, 富田洋平, 伴紀充, 篠田肇, 根岸一乃

    第64回日本網膜硝子体学会総会, 

    2025.12

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Establishment of therapeutic intervention methods for fibrotic scar formation in age-related macular degeneration through hypoxia response control

    2024.04
    -
    2027.03

    基盤研究(C), Principal investigator

  • 非視覚型光受容体による光マルチセンシング機構の解明と光新規治療法開発

    2022.10
    -
    2028.03

    国立研究開発法人日本医療研究開発機構(AMED), 令和4年度 「革新的先端研究開発支援事業（AMED-CREST）」, No Setting

  • 低酸素応答制御機能を持つ静岡県産魚類由来成分の探索と疾患制御に関する研究

    2022.08
    -
    2025.03

    静岡県, マリンバイオテクノロジーを核としたシーズ創出研究業務委託 ￥286,800,000-, No Setting

  • 低酸素応答を標的とした予防から治療までを網羅する網膜疾患制御技術開発

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Approach for retinal diseases based on regulation of hypoxia response

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

  • 近視を予防または治療するための方法および組成物

    Date applied： 特願2024-103695  2024.06 

    Date announced： 特開2025-73060  2025.05 

    Patent

  • α１ブロッカーを含む近視進行抑制用点眼剤

    Date applied： 特願2024-519839  2022.08 

    Date published： WO2024/048750  2024.03 

    Date issued： 特許第7640163号  2025.03

    Date registered： 2025.02

    Patent

  • ＨＩＦ抑制用組成物

    Date applied： 特願2021-504090  2020.03 

    Date issued： 特許第7598591号  2024.12

    Date registered： 2024.12

    Patent

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Awards 【 Display / hide 】

  • 第46回日本光医学・光生物学会学術奨励賞（医学領域）

    栗原俊英, 2024.07, 日本光医学・光生物学会, 非視覚光受容による近視進行抑制に関わる脳内回路の探索

  • 日本眼科学会評議員会賞

    栗原俊英, 2024.04, 日本眼科学会, 光生物学を基盤とした眼疾患病態生理の理解と治療開発

  • 第62回日本網膜硝子体学会総会優秀演題

    Ayaka Naka, Deokho Lee, Yan Zhang, Chiho Shoda, Satoshi Imanishi, Hiroyuki Nakashizuka, Satoru Yamagami, Kazuno Negishi, Akiharu Kubo, Toshihide Kurihara, 2023.11, 日本網膜硝子体学会, Claudin-1 deficiency in RPE leads to age-related retinal degeneration in mic

  • The Keio Medical Science Rising Star Award

    Toshihide Kurihara, 2023.01, Keio University, Exploring the pathophysiology of the retina and myopia based on photobiology and the clinical adaptation

  • 第72回日本臨床眼科学会学術展示優秀賞

    栗原俊英, 2019.04, 日本眼科学会, 白内障手術患者を対象とした血漿-房水グルコース濃度相関の血糖変動状態による変化

    　View Description

    第123回日本眼科学会総会

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Media Coverage 【 Display / hide 】

  • （扉）光遺伝学、視覚再生へ進む治験 狙った細胞を操作、脳への実用化には課題も

    朝日新聞社, 朝日新聞 (朝日新聞デジタル) , 2025.11

  • （扉）遺伝子治療、がんや希少疾患に 患者に合わせ、「土台」応用し費用・期間省く

    朝日新聞社, 朝日新聞 (朝日新聞デジタル) , 2025.10

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    体の細胞の遺伝子操作をする「遺伝子治療」。国内初の実施から３０年たち、多様な治療法が開発され、対象となる病気の種類も増えた。高額な開発費を抑える方法が模索されている。

  • 光遺伝学を活用し、目の難病の視覚再生目指す 慶大など国内初の治験を開始

    サイエンスポータル, 国立研究開発法人 科学技術振興機構, 2025.03

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    神経細胞などの働きを光で制御する「光遺伝学」の手法を活用し、目の難病「網膜色素変性症」で失われた視覚の再生を目指す遺伝子治療薬の臨床試験（治験）を始めた、と慶應義塾大学と名古屋工業大学の共同研究グループが発表した。光遺伝学の臨床応用は国内初という。
    この目の難病は目の内側を覆い、光を受け取って神経の信号に変える働きをする網膜の視細胞が最初に障害を起こし、徐々に機能を失う進行性の失明難病。通常4000人から8000人に1人発症し、根本的な治療法は確立していない。世界の患者は200万人以上とされる。
    慶應大学医学部眼科学教室の栗原俊英准教授らの研究グループは、名古屋工業大学の神取秀樹教授らが開発した「キメラロドプシン」という光に対する感度が高い独自のタンパク質を使い、光遺伝学の手法を応用することで視覚再生効果と視細胞の保護効果があることをマウスで確認し、研究成果を2023年10月に発表していた。
    この成果を生かして慶應大学発のスタートアップ企業「レストアビジョン」（東京都港区）がキメラロドプシンの遺伝子治療薬（視覚再生治療製剤）「RV-001」を開発。栗原准教授らの研究グループは今回、既に視細胞の機能が失われた重症患者1人に対しRV-001を目に注射して1例目の投与を終えた。
    網膜にある双極細胞と呼ばれる神経細胞にキメラロドプシンを作る遺伝子を届け、視細胞の代わりに光の検知を担わせるのが目的。研究グループによると、これまで重い合併症などはないが、今後半年間経過を観察して安全性や有効性を確認する。今後6～15人を対象に治験を続ける予定だ。
    栗原准教授らの研究グループは「（治験を始めたRV-001は）視覚再生治療薬として世界初の実用化を目指す試みで、失明疾患に対する新たな治療法を提供する重要な一歩と位置付けられる」としている。
    光遺伝学は米スタンフォード大学のカール・ダイセロス教授が2005年に技術を確立した。脳研究に大きく貢献し、米国の医学賞であるラスカー賞（基礎分野）の20年授賞者に選ばれ、ノーベル賞の有力候補とされる。
    理化学研究所・脳科学総合研究センターの利根川進センター長（当時）らは2015年に「光遺伝学によってマウスのうつ状態を改善した」と発表した。現在はうつ病や睡眠障害、依存症など精神疾患の仕組みや臓器の働きの制御を研究する分野で活用されている。

  • すんどめ ～網膜色素変性症と生きる〜

    名古屋テレビ放送・テレビ朝日系列全国24社, テレメンタリー2024, 2024.11

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    "すんどめ"の新競技で全国制覇へ！「今を楽しむことが一番」難病がある高校生ボクサーと全盲のシングルマザー 遺伝性のある網膜色素変性症、研究の最前線は

    愛知県岡崎市の石川凌久さんは、“当てないスパーリング”とも呼ばれるマスボクシングに打ち込む高校２年生。母親の智美さんは、２０代で網膜色素変性症という難病で失明した。凌久さんは、高校に入って”殴り合い”がある通常のボクシングをやりたいと思っていたが、受けて失明するのではないかと心配する智美さんの猛反対にあいマスボクシングを選んだ。網膜色素変性症は遺伝する可能性がある。視覚障がい者の選択に光を当てる。
    ナレーター：島貫凌アナウンサー
    名古屋テレビ放送

    https://www.tv-asahi.co.jp/telementary/backnumber/0257/

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Memberships in Academic Societies 【 Display / hide 】

  • The Japanese Society for Clinical Electrophysiology of Vision (JSCEV), 

    2026.01
    -
    Present

  • The Macular Society, 

    2025.10
    -
    Present

  • Japan Society for Ocular Circulation, 

    2025.04
    -
    Present

  • The Japanese Society for Photomedicine and Photobiology, 

    2023.05
    -
    Present

  • 日本ロービジョン学会, 

    2022.12
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2022.11
    -
    Present

    Associate Editor for Neurodegeneration, Frontiers in Neuroscience

  • 2022.10
    -
    Present

    眼科 外来医長, 慶應義塾大学病院

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