岩田 卓 (イワタ タカシ)

Iwata, Takashi

写真a

所属(所属キャンパス)

医学部 産婦人科学教室(婦人科) (信濃町)

職名

専任講師

学歴 【 表示 / 非表示

  • 1995年

    慶応義塾大学, 医学部, 医学科

    卒業

免許・資格 【 表示 / 非表示

  • 日本婦人科腫瘍学会婦人科腫瘍専門医

  • 日本臨床細胞学会細胞診専門医

  • 日本がん治療認定医機構がん治療認定医

  • 日本がん治療認定医機構暫定教育医

  • 日本産科婦人科学会専門医

 

研究分野 【 表示 / 非表示

  • 産婦人科学

研究キーワード 【 表示 / 非表示

  • 婦人科腫瘍の免疫学的特性

  • 子宮頸癌の臨床病理的特徴

  • 子宮頸部での局所免疫応答

 

著書 【 表示 / 非表示

  • 子宮頚癌治療ガイドライン 2017年度版

    岩田 卓, 金原出版株式会社, 2017年07月

論文 【 表示 / 非表示

  • Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia

    Baba S., Taguchi A., Kawata A., Hara K., Eguchi S., Mori M., Adachi K., Mori S., Iwata T., Mitsuhashi A., Maeda D., Komatsu A., Nagamatsu T., Oda K., Kukimoto I., Osuga Y., Fujii T., Kawana K.

    Virology Journal (Virology Journal)  17 ( 1 )  2020年03月

     概要を見る

    © 2020 The Author(s). Background: Human papillomavirus (HPV) infection is a primary cause of cervical cancer. Although epidemiologic study revealed that carcinogenic risk differs according to HPV genotypes, the expression patterns of HPV-derived transcripts and their dependence on HPV genotypes have not yet been fully elucidated. Methods: In this study, 382 patients with abnormal cervical cytology were enrolled to assess the associations between HPV-derived transcripts and cervical intraepithelial neoplasia (CIN) grades and/or HPV genotypes. Specifically, four HPV-derived transcripts, namely, oncogenes E6 and E6*, E1^E4, and viral capsid protein L1 in four major HPV genotypes-HPV 16, 18, 52, and 58-were investigated. Results: The detection rate of E6/E6*increased with CIN progression, whereas there was no significant change in the detection rate of E1^E4 or L1 among CIN grades. In addition, we found that L1 gene expression was HPV type-dependent. Almost all HPV 52-positive specimens, approximately 50% of HPV 58-positive specimens, around 33% of HPV 16-positive specimens, and only one HPV18-positive specimen expressed L1. Conclusions: We demonstrated that HPV-derived transcripts are HPV genotype-dependent. Especially, expression patterns of L1 gene expression might reflect HPV genotype-dependent patterns of carcinogenesis.

  • Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter

    Hirao N., Iwata T., Tanaka K., Nishio H., Nakamura M., Morisada T., Morii K., Maruyama N., Katoh Y., Yaguchi T., Ohta S., Kukimoto I., Aoki D., Kawakami Y.

    Gynecologic Oncology (Gynecologic Oncology)  155 ( 2 ) 340 - 348 2019年11月

    ISSN  00908258

     概要を見る

    © 2019 Elsevier Inc. Objective: To determine the involvement of homeobox D9 (HOXD9) in the survival, proliferation, and metastasis of cervical cancer cells through regulating the expression of human papillomavirus (HPV) 16 E6/E7 genes using the P97 promoter. Methods: One hundred cases of cervical cancer (CC), CC cell lines SKG-I, SKG-II, SKG-IIIa, SKG-IIIb, HeLa, and SiHa, and a human tumor xenograft mouse model were used to examine the roles of HOXD9 in CC. Knockdown experiments employed RNA interference of HOXD9. qPCR, functional assays, western blotting, DNA microarray, and luciferase and ChIP assays were applied for assessments. Results: All CC cell lines expressed HOXD9 mRNA and protein. In uterine CC, HOXD9 gene expression was significantly higher than in normal cervical tissues. A positive correlation of lymphovascular space invasion and lymph node metastasis with high levels of HOXD9 expression was found in patient samples. HOXD9-knockdown cells in the mouse xenograft model only formed small or no tumors. Knockdown of HOXD9 markedly reduced CC cell proliferation, migration and invasion, induced apoptosis, increased P53 protein expression, and suppressed HPV E6/E7 expression by directly binding to the P97 promoter of HPV16 E6/E7 genes. A positive correlation between HOXD9 and HPV16 E6 expression was found in CC patients. Conclusions: HOXD9 promotes HPV16 E6 and E7 expression by direct binding to the P97 promoter, which enhances proliferation, migration, and metastasis of CCr cells. Our results suggest that HOXD9 could be a prognostic biomarker and potential therapeutic target in CC.

  • 妊娠中 子宮頸部円錐切除術 妊娠への配慮

    仲村 勝, 岩田 卓, 宮越 敬, 田中 守, 青木 大輔

    周産期医学 49 ( 11 ) 1453 - 1455 2019年11月

    査読有り

  • A Clinical Trial to Verify the Efficiency of the LC-1000 Exfoliative Cell Analyzer as a New Method of Cervical Cancer Screening

    Nakamura M., Ueda M., Iwata T., Kiguchi K., Mikami Y., Kakuma T., Aoki D.

    Acta Cytologica (Acta Cytologica)  63 ( 5 ) 391 - 400 2019年08月

    ISSN  00015547

     概要を見る

    © 2019 S. Karger AG, Basel. All rights reserved. Objective: The exfoliative cell analyzer, LC-1000 (Sysmex Corporation, Japan), is a medical device that presents the cell proliferation index and 23 research parameters as indicators of cellular proliferative potential. The objective was to evaluate the clinical usability of qualitative assessment by LC-1000 compared with cytology, the human papillomavirus (HPV) test, and histology as gold standard. Study Design: Women that visited 3 sites between July 2015 and March 2017 were registered. The primary endpoint in this study was the comparison between LC-1000 measurement and HPV test for sensitivity and specificity for cervical intraepithelial neoplasia 2+ (CIN2+). A tree model algorithm was newly constructed by a statistical method and its relationship with histological results was evaluated. Results: The sensitivity and specificity of LC-1000 were 78.3 and 74.1%, while those of the HPV test were 94.7 and 85.4%, respectively. A tree model comprising five categories was constructed. The proportion of advanced lesions was higher with the change in the rank classification results from 1 to 5. The positive predictive values of CIN2+ in the categories 4 and 5 were high. Despite the small number of subjects, cancer was undetected in categories 1 and 2. In addition, the comparison with follow-up results in 19 women assessed as CIN1 showed that the rate of progression in the categories 3-5 was 50% (7/14); progression in the categories 1 and 2 was 0% (0/5). Conclusions: LC-1000 may be useful for cervical cancer screening as an index to qualitatively evaluate CIN and cancer based on the changes in characteristics of cells.

  • Local anatomy around terminal ureter related to the anterior leaf of the vesicouterine ligament in radical hysterectomy

    Nakamura M., Tanaka K., Hayashi S., Morisada T., Iwata T., Imanishi N., Aoki D.

    European Journal of Obstetrics Gynecology and Reproductive Biology (European Journal of Obstetrics Gynecology and Reproductive Biology)  235   66 - 70 2019年04月

    ISSN  03012115

     概要を見る

    © 2019 Elsevier B.V. Objectives: Radical hysterectomy is performed for invasive cervical cancer. In this surgery, separation of the anterior leaf and posterior leaves of the vesicouterine ligament (VUL) is important. We studied the local anatomy of the anterior leaf of the VUL, especially the branches of the umbilical artery from the view point of surgery and cadaver dissection. Study Design: We observed the cervicovesical blood vessels and the connective tissue layer continued from umbilical artery and searched for the origin of the cervicovesical blood vessels in radical hysterectomy. We also dissected a formalin-fixed female cadaver, and observed the same points. Results: After separation of the connective tissue of urinary bladder from the cervical fascia, we could discern the outline of the distal ureter near the ureterovesical junction. We separate the connective tissue of the so-called anterior leaf of the VUL enwrapping the ureter gently, and then the ureter with the connective tissue is completely rolled out laterally. We identified a cervicovesical vessel crossing over the ureter. We looked for the central side of the cervicovesical vessel and found that cervicovesical vessel was a branch of the superior vesical artery. And, during cadaver dissection, we found that the connective tissue and the branches of the superior vesical artery were similarly observed. Conclusions: We found the precise anatomy of the connective tissue layer from umbilical artery to urinary bladder and the superior vesical artery. Our procedure based on the precise anatomy obtained in this study is reasonable anatomically as a method for separation of the vesicouterine ligament during radical hysterectomy.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

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研究発表 【 表示 / 非表示

  • 子宮頸癌検査として剥離細胞分析装置LC-1000の臨床的有用性を検証する臨床試験

    仲村 勝、植田 政嗣, 岩田 卓, 木口 一成, 三上 芳喜, 青木 大輔

    第58回日本臨床細胞学会秋季大会, 2019年11月, 岐阜

  • 産後ケア病床の立ち上げの経験(第3報)

    弟子丸 亮太,大熊 優子, 横田 めぐみ, 堀場 裕子, 岩田 卓, 牧田 和也, 青木 大輔, 岸 郁子

    第34回日本女性医学学会学術集会 (福岡) , 2019年11月

  • 当科における子宮体癌術後患者の卵巣欠落症状に対するホルモン補充療法(HRT)

    谷本 慧子, 横田 めぐみ, 山上 亘, 平野 卓朗, 真壁 健, 坂井 健良, 千代田 達幸, 片岡 史夫, 岩田 卓, 牧田 和也, 阪埜 浩司, 青木 大輔

    第34回日本女性医学学会学術集会 (福岡) , 2019年11月

  • 婦人科領域におけるレーザー医療の進歩と課題 子宮頸部上皮内腫瘍(CIN:cervical intraepithelial neoplasia)に対するレーザー治療の実際

    仲村 勝, 飯島 朋子, 西尾 浩, 森定 徹, 岩田 卓, 青木 大輔

    第40回日本レーザー医学会総会 (浜松) , 2019年10月

  • がんゲノム解析とPrecision Medicine 

    岩田卓

    第 28回 日本婦人科がん検診学会総会・学術講演会 (奈良) , 2019年09月, シンポジウム・ワークショップ パネル(指名)

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競争的資金等の研究課題 【 表示 / 非表示

  • 子宮頸癌に対する腫瘍浸潤T細胞療法(TIL療法)実施にむけたTIL培養法の開発

    2019年04月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 岩田 卓, 基盤研究(B), 補助金,  代表

  • HPV陰性子宮頸部腺癌の分子生物学的および腫瘍免疫学的特性の解明

    2015年04月
    -
    2018年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 岩田 卓, 基盤研究(C), 補助金,  代表

 

担当授業科目 【 表示 / 非表示

  • 婦人科学講義

    2020年度

  • 婦人科学講義

    2019年度

 

所属学協会 【 表示 / 非表示

  • 日本免疫学会

     
  • 日本臨床細胞学会

     
  • 日本婦人科腫瘍学会

     
  • 日本産科婦人科内視鏡学会

     
  • 日本女性医学会

     

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