岩田 卓 (イワタ タカシ)

Iwata, Takashi

写真a

所属(所属キャンパス)

医学部 産婦人科学教室(婦人科) (信濃町)

職名

専任講師

学歴 【 表示 / 非表示

  • 1995年

    慶応義塾大学, 医学部, 医学科

    卒業

免許・資格 【 表示 / 非表示

  • 日本産科婦人科学会専門医

  • 日本婦人科腫瘍学会婦人科腫瘍専門医

  • 日本臨床細胞学会細胞診専門医

  • 日本がん治療認定医機構がん治療認定医

  • 日本がん治療認定医機構暫定教育医

 

研究分野 【 表示 / 非表示

  • 産婦人科学

研究キーワード 【 表示 / 非表示

  • 婦人科腫瘍の免疫学的特性

  • 子宮頸癌の臨床病理的特徴

  • 子宮頸部での局所免疫応答

 

著書 【 表示 / 非表示

  • 子宮頚癌治療ガイドライン 2017年度版

    岩田 卓, 金原出版株式会社, 2017年07月

論文 【 表示 / 非表示

  • The validity of the subsequent pregnancy index score for fertility-sparing trachelectomy in early-stage cervical cancer.

    Iwata T, Machida H, Matsuo K, Okugawa K, Saito T, Tanaka K, Morishige K, Kobayashi H, Yoshino K, Tokunaga H, Ikeda T, Shozu M, Yaegashi N, Enomoto T, Mikami M

    Fertility and sterility (Fertility and Sterility)  2021年02月

    ISSN  0015-0282

     概要を見る

    Objective: To evaluate timing and a prediction model for pregnancy in early-stage cervical cancer patients who underwent fertility-sparing trachelectomy. Design: Retrospective cohort. Setting: Academic multicenter. Patient(s): Women ages <45 years with clinical stage I–II cervical cancer were enrolled between 2009 and 2013 (n = 393). Intervention(s): Planned fertility-sparing trachelectomy. Main Outcome Measure(s): Cumulative incidences and clinicopathological characteristics of those who developed subsequent pregnancy were examined. Result(s): There were 77 (21.6%) women who had subsequent pregnancies after fertility-sparing trachelectomy with 1-, 2-, and 5-year cumulative pregnancy rates of 2.8%, 6.2%, and 17.4%, respectively. The median time to develop subsequent pregnancy was 3.2 years. In a competing risk analysis, women had a higher risk of recurrent cancer than conception during the first 11 months postsurgery. On multivariable analysis, younger age, being married, and postoperative reproductive treatment were independently associated with an increased chance of developing a subsequent pregnancy. The subsequent pregnancy index (SPI) score to predict the likelihood of having pregnancy was proposed, and it was calculated based on age, marital status, and reproductive treatment (2, 2, and 4 points, respectively). Women with a higher SPI score had significantly higher subsequent pregnancy rates (5-year pregnancy rate; the score was 3 in 4.7% of cases; 4 to 5 in 11.3%; 6 to 7 in 27.4%; and 8 in 50.8%), but they had similar recurrence rates (5.0%). Conclusion(s): The SPI score proposed in our study is useful in predicting subsequent pregnancy in women with early-stage cervical cancer undergoing fertility-sparing trachelectomy.

  • 子宮頸癌の治療 子宮頸癌の手術

    岩田 卓

    日本産科婦人科学会雑誌 72 ( 12 ) 1688 - 1693 2020年12月

    査読有り

  • Outcomes in patients with extramammary Paget disease with brain metastasis: A retrospective analysis.

    Fusumae T, Fukuda K, Hirai I, Nakamura Y, Tanese K, Iwata T, Funakoshi T

    Journal of the American Academy of Dermatology 83 ( 6 ) 1832 - 1834 2020年12月

    ISSN  0190-9622

  • Current status of cancer immunotherapy for gynecologic malignancies.

    Nishio H, Iwata T, Aoki D

    Japanese journal of clinical oncology (Japanese journal of clinical oncology)  51 ( 2 ) 167 - 172 2020年11月

    ISSN  0368-2811

     概要を見る

    Recent cancer immunotherapy development with immune checkpoint inhibitors has shown durable clinical responses in a wide variety of tumor types. These drugs targeting programmed cell death 1, its ligand programmed death ligand 1 and cytotoxic T cell lymphocyte-associated antigen 4 have revolutionized the field of cancer treatment. It is of significant interest in optimizing the immunotherapy for cancer patients beyond the conventional treatments such as surgery, chemotherapy and radiation. Many clinical trials evaluating the safety and efficacy of various combined regimens with immune checkpoint inhibitors have been reported and are in progress. Among gynecologic malignancy, endometrial cancers have distinct subtypes with microsatellite instability-high status and polymerase ɛ mutation. These types have been shown to immunogenic tumors and appropriated candidate for immune checkpoint inhibitors. Also, recurrent cervical cancer showed a promising objective response with single anti-PD1 Ab treatment. Despite their definite outcome and considerable potential of immunotherapy, not all patients received a survival benefit and further understanding of human tumor immunology is essential to improve this type of therapy. In this review, we have summarized the updated results of clinical trials of cancer immunotherapy for gynecologic malignancies and discussed the future perspectives.

  • High Levels of Within-Host Variations of Human Papillomavirus 16 E1/E2 Genes in Invasive Cervical Cancer

    Hirose Y., Yamaguchi-Naka M., Onuki M., Tenjimbayashi Y., Tasaka N., Satoh T., Tanaka K., Iwata T., Sekizawa A., Matsumoto K., Kukimoto I.

    Frontiers in Microbiology (Frontiers in Microbiology)  11   596334 2020年11月

     概要を見る

    © Copyright © 2020 Hirose, Yamaguchi-Naka, Onuki, Tenjimbayashi, Tasaka, Satoh, Tanaka, Iwata, Sekizawa, Matsumoto and Kukimoto. Human papillomavirus type 16 (HPV16) is the most common HPV genotype found in invasive cervical cancer (ICC). Recent comprehensive genomics studies of HPV16 have revealed that a large number of minor nucleotide variations in the viral genome are present in each infected woman; however, it remains unclear whether such within-host variations of HPV16 are linked to cervical carcinogenesis. Here, by employing next-generation sequencing approaches, we explored the mutational profiles of the HPV16 genome within individual clinical specimens from ICC (n = 31) and normal cervix (n = 21) in greater detail. A total of 367 minor nucleotide variations (167 from ICC and 200 from the normal cervix) were detected throughout the viral genome in both groups, while nucleotide variations at high frequencies (>10% abundance in relative read counts in a single sample) were more prevalent in ICC (10 in ICC versus 1 in normal). Among the high-level variations found in ICC, six were located in the E1/E2 genes, and all of them were non-synonymous substitutions (Q142K, M207I, and L262V for E1; D153Y, R302T, and T357A for E2). In vitro functional analyses of these E1/E2 variants revealed that E1/M207I, E2/D153Y, and E2/R302T had reduced abilities to support viral replication, and that E2/D153Y and E2/R302T failed to suppress the viral early promoter. These results imply that some within-host variations of E1/E2 present at high levels in ICC may be positively selected for and contribute to cervical cancer development through dysfunction or de-stabilization of viral replication/transcription proteins.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

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総説・解説等 【 表示 / 非表示

  • 子宮頸部上皮内腫瘍に対する治療法の選択 円錐切除術?または蒸散術?

    仲村 勝, 西尾 浩, 森定 徹, 岩田 卓, 青木 大輔

    日本婦人科腫瘍学会雑誌 ((公社)日本婦人科腫瘍学会)  39 ( 1 ) 217 - 217 2021年01月

    ISSN  1347-8559

  • Trachelectomy for early-stage cervical cancer: A proposal of an ideal candidate(和訳中)

    岩田 卓

    日本婦人科腫瘍学会雑誌 ((公社)日本婦人科腫瘍学会)  39 ( 1 ) 246 - 247 2021年01月

    ISSN  1347-8559

  • 子宮頸癌の治療 子宮頸癌の手術

    岩田 卓

    日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会)  72 ( 12 ) 1688 - 1693 2020年12月

    ISSN  0300-9165

  • 咽頭部違和感症を訴える更年期女性に対する、半夏厚朴湯の効果と検討

    大野 あゆみ, 横田 めぐみ, 谷本 慧子, 堀場 裕子, 千代田 達幸, 山上 亘, 弟子丸 亮太, 岩田 卓, 阪埜 浩司, 青木 大輔

    日本女性医学学会雑誌 ((一社)日本女性医学学会)  28 ( 1 ) 165 - 165 2020年10月

    ISSN  2185-8861

  • 当科における悪性卵巣腫瘍術後患者へのホルモン補充療法(HRT)の有用性に関する検討

    谷本 慧子, 横田 めぐみ, 千代田 達幸, 黒田 由香, 吉村 拓馬, 平野 卓朗, 山上 亘, 弟子丸 亮太, 岩田 卓, 阪埜 浩司, 青木 大輔

    日本女性医学学会雑誌 ((一社)日本女性医学学会)  28 ( 1 ) 120 - 120 2020年10月

    ISSN  2185-8861

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研究発表 【 表示 / 非表示

  • 腫瘍免疫学の基礎と最新トピックス

    岩田卓

    第7回婦人科腫瘍学会研修会 (東京) , 2020年12月, 口頭(招待・特別)

  • 遺伝子パネル検査に基づくがんゲノム医療の現状

    岩田卓

    Kansai Ovarian cancer Gynecologic seminar (大阪) , 2020年12月, 口頭(招待・特別)

  • 遺伝子パネル検査に基づくがんゲノム医療の現状

    岩田卓

    第52回 日本臨床分子形態学会総会・学術集会, 2020年12月, 口頭(招待・特別)

  • 咽頭部違和感症を訴える更年期女性に対する、半夏厚朴湯の効果と検討

    大野 あゆみ(慶応義塾大学 医学部産婦人科), 横田 めぐみ, 谷本 慧子, 堀場 裕子, 千代田 達幸, 山上 亘, 弟子丸 亮太, 岩田 卓, 阪埜 浩司, 青木 大輔

    (東京) , 2020年11月, 口頭(一般)

  • 当科における悪性卵巣腫瘍術後患者へのホルモン補充療法(HRT)の有用性に関する検討

    谷本 慧子(慶応義塾大学 医学部産婦人科学教室), 横田 めぐみ, 千代田 達幸, 黒田 由香, 吉村 拓馬, 平野 卓朗, 山上 亘, 弟子丸 亮太, 岩田 卓, 阪埜 浩司, 青木 大輔

    (東京) , 2020年11月, 口頭(一般)

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競争的資金等の研究課題 【 表示 / 非表示

  • 子宮頸癌に対する腫瘍浸潤T細胞療法(TIL療法)実施にむけたTIL培養法の開発

    2019年04月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 岩田 卓, 基盤研究(B), 補助金,  代表

  • HPV陰性子宮頸部腺癌の分子生物学的および腫瘍免疫学的特性の解明

    2015年04月
    -
    2018年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 岩田 卓, 基盤研究(C), 補助金,  代表

 

担当授業科目 【 表示 / 非表示

  • メディカル・プロフェッショナリズムⅥ

    2021年度

  • 婦人科学講義

    2021年度

  • 婦人科学講義

    2020年度

  • 婦人科学講義

    2019年度

 

所属学協会 【 表示 / 非表示

  • 日本免疫学会

     
  • 日本産婦人科学会

     
  • 日本癌学会

     
  • 日本癌治療学会

     
  • 日本臨床細胞学会

     

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