田中 守 (タナカ マモル)

Tanaka, Mamoru

写真a

所属(所属キャンパス)

医学部 産婦人科学教室(産科) (信濃町)

職名

教授

外部リンク

経歴 【 表示 / 非表示

  • 1986年05月
    -
    1992年05月

    慶應義塾大学医学部, 産婦人科学

  • 1992年06月
    -
    1998年06月

    さいたま市立病院, 産婦人科, 出向

  • 1998年07月
    -
    2000年12月

    ユタ大学, 産婦人科, 留学

  • 2001年01月
    -
    2012年03月

    慶應義塾大学医学部, 産婦人科学

  • 2012年04月
    -
    2014年05月

    聖マリアンナ医科大学, 産婦人科学, 教授

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学位 【 表示 / 非表示

  • 医学博士, 慶應義塾, 1996年02月

    一過性虚血再灌流障害を用いた子宮内胎児発育遅延モデルの作成

免許・資格 【 表示 / 非表示

  • 母体保護法指定医師

  • 臨床遺伝専門医

  • 臨床修練指導医

  • 日本超音波学会超音波専門医・指導医

  • 日本周産期・新生児学会暫定指導医

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研究分野 【 表示 / 非表示

  • 産婦人科学 (産婦人科)

研究キーワード 【 表示 / 非表示

  • エピジェネティクス

  • 受精

  • 周産期

  • 発生生物学

 

論文 【 表示 / 非表示

  • Successful Pregnancy After Sacrectomy Combined With Chemotherapy and Radiation for Ewing Sarcoma

    Kakogawa Jun, Nako Takafumi, Kawamura Kazuhiro, Nakamura Shin, Mochiduki Ayako, Kanayama Naohiro, Tanaka Mamoru

    Journal of Pediatric and Adolescent Gynecology 28 ( 3 ) e79 - e81 2015年06月

    ISSN  1083-3188

     概要を見る

    <p>Ewing sarcoma is considered to have a poor prognosis. Recent advances in multidisciplinary management have resulted in a marked improvement in long-term survival. Case: We describe a case of successful pregnancy in a patient who underwent sacrectomy combined with multi-agent chemotherapy and radiotherapy for Ewing sarcoma. The patient was diagnosed with Ewing sarcoma of the sacrum at the age of 16. The ovaries were transposed, the uterus was shielded, and a gonadotropin-releasing hormone agonist was used during treatment to protect ovarian function. The patient spontaneously conceived at the age of 27. After an uneventful pregnancy, the patient delivered a healthy neonate at term by cesarean section. Summary and Conclusions: Successful pregnancy and delivery can be achieved after multi-modality treatment with pretreatment intervention for fertility preservation.</p>

  • Intracranial sonographic features demonstrating in utero development of hemorrhagic brain damage leading to schizencephaly-associated COL4A1 mutation

    Matsumoto Tadashi, Miyakoshi Kei, Fukutake Marie, Ochiai Daigo, Minegishi Kazuhiro, Tanaka Mamoru

    Journal of Medical Ultrasonics 2015年01月

    ISSN  1346-4523

  • Analysis of late-onset ovarian insufficiency after ovarian surgery

    Takae Seido, Kawamura Kazuhiro, Sato Yorino, Nishijima Chie, Yoshioka Nobuhito, Sugishita Yodo, Horage Yuki, Tanaka Mamoru, Ishizuka Bunpei, Suzuki Nao

    PLoS ONE 9 ( 5 )  2014年05月

     概要を見る

    <p>The primary objectives of the present study are to determine the period of onset of ovarian insufficiency after surgery and to confirm potential risk factors for ovarian insufficiency after surgery for the removal of benign ovarian cysts. Data were obtained from 75 patients who underwent surgery for benign ovarian cysts prior to the onset of ovarian insufficiency. Our analysis included 835 ovarian insufficiency patients who were referred to our institution from July 2003 to July 2013. Several epidemiological parameters of ovarian insufficiency after surgery (age at operation, period of onset of ovarian insufficiency, operation procedure, and pathological diagnosis) were investigated. Of the 835 patients who had ovarian insufficiency, 75 patients (9.0%) underwent ovarian surgery before the onset of ovarian insufficiency. Of those 75 patients, 66 patients (88.0%) underwent cystectomy. For the majority of the 75 patients the surgical indication was the presence of endometriotic cysts (57 patients; 76.0%). Twelve patients (16.0%) underwent multiple surgeries (all bilateral cystectomies). The mean age of the patients at the time of surgery was 27.8±5.5 years-old, and the mean period of onset of ovarian insufficiency was 5.8±3.8 years. In patients with cystectomy, the patient's age at the time of surgery and period of onset of ovarian insufficiency was well-correlated (coefficient of correlation; hemilateral endometriotic cystectomy: 20.64, bilateral endometriotic cystectomy: 20.61, and multiple endimetriotic cystectomy: 20.40). We found that cystectomy of endometriotic cysts is the potential risk factor for ovarian insufficiency after surgery, at times, the onset of ovarian insufficiency long after cystectomy. Therefore, it is important to monitor ovarian reserve for an extended period of time after ovarian surgery. It is particularly important to monitor ovarian reserve long-term for patients who wish to conceive in the future and to suggest a variety of infertility treatments appropriate for their ovarian reserve. © 2014 Takae et al.</p>

  • Thrombomodulin improves maternal and fetal conditions in an experimental pre-eclampsia rat model

    Shin Mihwa, Hino Hirofumi, Tamura Midori, Ishizuka Bunpei, Tanaka Mamoru, Suzuki Nao, Tateda Takeshi

    Journal of Obstetrics and Gynaecology Research 40 ( 5 ) 1226 - 1234 2014年

    ISSN  1341-8076

     概要を見る

    <p>Aim: The aim of this study was to investigate whether the consecutive administration of recombinant thrombomodulin (r-TM) for 4 days improves maternal and fetal conditions and physiological outcomes in an N'-nitro-L-arginine- methyl ester hydrochloride-induced and low-dose endotoxin-induced pre-eclampsia (PE). Methods: r-TM or saline was administrated i.v. to normal pregnant and experimental PE rats for 4 days. The maternal condition, vascular endothelial growth factor receptor-1 (VEGFR-1), fetal conditions, uteroplacental blood flow (UPBF), and oxygenation in the placenta and fetal brain was evaluated on gestational day 21. Results: Significant increases in the mean arterial blood pressure, VEGFR-1 values and fetal death rate were observed in PE rats compared with control rats, while maternal and fetal bodyweight and fetal brain weight were substantially lower. Hypoperfusion and hypo-oxygenation in both the placenta and fetal brain tissues occurred in PE rats. Although r-TM failed to improve hypertension and affect the differences in maternal bodyweight between the groups, r-TM significantly improved hypoperfusion and fetal and maternal conditions, including VEGFR-1 values (6.5 ± 4.0 vs 2.2 ± 2.7 ng/mL, PE vs PE with r-TM, respectively; P &lt; 0.05). Although not significant, a decrease in the fetal death rate was observed in PE rats administrated r-TM (36.1 ± 17.6% vs 25.0 ± 23.8%, P = 0.077). Conclusion: The severe reductions in the UPBF and the placental oxygenation imply that regional hypoperfusion occurs in association with systemic mean arterial pressure. r-TM may be a candidate medical treatment for PE complications. © 2014 Japan Society of Obstetrics and Gynecology.</p>

  • Compilation of copy number variants identified in phenotypically normal and parous Japanese women

    Migita Ohsuke, Maehara Kayoko, Kamura Hiromi, Miyakoshi Kei, Tanaka Mamoru, Morokuma Seiichi, Fukushima Kotaro, Shimamoto Tomihiro, Saito Shigeru, Sago Haruhiko, Nishihama Keiichiro, Abe Kosei, Nakabayashi Kazuhiko, Umezawa Akihiro, Okamura Kohji, Hata Kenichiro

    Journal of Human Genetics 59 ( 6 ) 326 - 331 2014年

    ISSN  1434-5161

     概要を見る

    <p>With increasing public concern about infertility and the frequent involvement of chromosomal anomalies in miscarriage, analyses of copy number variations (CNVs) have been used to identify the genomic regions responsible for each process of childbearing. Although associations between CNVs and diseases have been reported, many CNVs have also been identified in healthy individuals. Like other types of mutations, phenotypically indefinite CNVs may have been retained and accumulated during anthropogenesis. Therefore to distinguish causative variants from other variants is a formidable task. Furthermore, because previous studies have predominantly focused on European and African populations, comprehensive detection of common Asian CNVs is eagerly awaited. Here, using a high-resolution genotyping array and samples from 411 Japanese women with normal parity without significant complications, we have compiled 1043 copy number variable regions. In total, the collected regions cover 164 Mb, or up to 0.5% of the genome. The copy number differences in these regions may be irrelevant not only to infertility but also to a wide range of diseases. The utility of this resource in reducing the candidate pathogenetic variants, especially in Japanese subjects, is also demonstrated. © 2014 The Japan Society of Human Genetics. All rights reserved.</p>

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • Rapid replacement of somatic linker histones with the oocyte-specific linker histone in mouse nuclear transfer

    田中 守

    52nd Annual Meeting Society of Gynecologic Investigation (Los Angeles, CA) , 2005年03月, ポスター(一般), Society of Gynecologic Investigation

  • 肝右葉梗塞を発症した重症妊娠中毒症の1例

    小野晃子, 宮越 敬, 丸山哲夫, 大野暁子, 田中 守, 吉村泰典, 野澤志朗

    第106回日本産科婦人科学会関東連合地方部会総会・学術集会 (静岡県静岡市) , 2003年10月, ポスター(一般)

  • 胎児診断した仙尾部奇形腫の画像検査所見の検討

    松本 直, 宮越 敬, 服部純尚, 上野和典, 田中 守, 吉村泰典

    第15回日本超音波医学会関東甲信越地方会学術集会 (東京) , 2003年10月, 口頭(一般)

  • 18トリソミーにおける胎児超音波異常所見の後方視的検討

    上野和典, 宮越 敬, 服部純尚, 松本 直, 田中 守, 吉村泰典

    第15回日本超音波医学会関東甲信越地方会学術集会 (東京) , 2003年10月, 口頭(一般)

  • ヒト卵子における卵子特異的ヒストンH1の同定

    田中雄大, 久慈直昭, 楊  毅, 吉井 毅, 吉田宏之, 田中 守, 末岡 浩, 吉村泰典, 加藤真吾

    第21回日本受精着床学会学術講演会 (東京) , 2003年10月, 口頭(一般)

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競争的資金等の研究課題 【 表示 / 非表示

  • ヒト羊水幹細胞による子宮炎症制御を介した早産/胎児炎症反応症候群治療薬の開発

    2019年06月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 田中 守, 挑戦的研究(萌芽), 補助金,  代表

  • 出生直後からの先制医療を目指した、羊水幹細胞による難治性早産合併症の治療法開発

    2017年04月
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    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 田中 守, 基盤研究(B), 補助金,  代表

  • 自己羊水幹細胞シートを用いた新生児難治性疾患に対する新規治療法の開発

    2016年04月
    -
    2019年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 田中 守, 挑戦的萌芽研究, 補助金,  代表

 

担当授業科目 【 表示 / 非表示

  • 産婦人科学演習

    2020年度

  • 産婦人科学実習

    2020年度

  • 産婦人科学

    2020年度

  • 生命倫理学

    2020年度

  • 産科学講義

    2020年度

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