Tanaka, Mamoru

写真a

Affiliation

School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) （Shinanomachi）

Position

Professor

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Career 【 Display / hide 】

  • 1986.05
    -
    1992.05

    慶應義塾大学医学部, 産婦人科学

  • 1992.06
    -
    1998.06

    さいたま市立病院, 産婦人科, 出向

  • 1998.07
    -
    2000.12

    ユタ大学, 産婦人科, 留学

  • 2001.01
    -
    2012.03

    慶應義塾大学医学部, 産婦人科学

  • 2012.04
    -
    2014.05

    聖マリアンナ医科大学, 産婦人科学, 教授

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Academic Degrees 【 Display / hide 】

  • 医学博士, Keio University, 1996.02

    一過性虚血再灌流障害を用いた子宮内胎児発育遅延モデルの作成

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Licenses and Qualifications 【 Display / hide 】

  • 日本超音波学会超音波専門医・指導医

  • 日本周産期・新生児学会暫定指導医

  • 日本産科婦人科学会専門医・指導医

  • 臨床修練指導医

  • 母体保護法指定医師

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Research Areas 【 Display / hide 】

  • Life Science / Obstetrics and gynecology (産婦人科)

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Research Keywords 【 Display / hide 】

  • エピジェネティクス

  • 受精

  • 周産期

  • 発生生物学

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Papers 【 Display / hide 】

  • Effects of maternal and fetal choline concentrations on the fetal growth and placental DNA methylation of 12 target genes related to fetal growth, adipogenesis, and energy metabolism

    Nakanishi M., Funahashi N., Fukuoka H., Nammo T., Sato Y., Yoshihara H., Oishi H., Tanaka M., Yano T., Minoura S., Kato N., Yasuda K.

    Journal of Obstetrics and Gynaecology Research （Journal of Obstetrics and Gynaecology Research)  47 （ 2 ） 734 - 744 2021.02

    ISSN  13418076

    　View Summary

    © 2020 Japan Society of Obstetrics and Gynecology Aim: We performed a birth cohort study involving 124 mother–infant pairs to investigate whether placental DNA methylation is associated with maternal choline status and fetal development. Methods: Plasma choline concentration was assayed longitudinally in the 1st and 3rd trimesters and at term-pregnancy in mothers and cord blood. Placental DNA methylation was measured for 12 target candidate genes that are related to fetal growth, adipogenesis, lipid and energy metabolism, or long interspersed nuclear elements. Results: Higher maternal plasma and cord blood choline levels at term tended to associate with lower birthweight (r = −0.246, P < 0.013; r = −0.290, P < 0.002) and body mass index (BMI) at birth (r = 0.344, P < 1E−3; r = −0.360, P < 1E−3). The correlation between maternal plasma choline level and cord blood choline level was relatively modest (r = 0.049, P = 0.639). There was an inverse correlation between placental DNA methylation at the retinoid X receptor alpha (RXRA) gene and maternal plasma choline level (r = −0.188 to r = −0.452, P = 0.043 to P < 1E−3 at three points). RXRA methylation level was positively associated with birthweight and BMI at birth (r = 0.306, P = 0.001; r = 0.390, P < 1E−3). Further, RXRA methylation was inversely correlated with RXRA gene expression level (r = 0.333, P < 1E−3). Conclusion: Our results suggest that the association between maternal choline status and placental RXRA methylation represents a potential fetal programing mechanism contributing to fetal growth.

  • Amniotic fluid stem cells as a novel strategy for the treatment of fetal and neonatal neurological diseases

    Abe Y., Ochiai D., Sato Y., Otani T., Fukutake M., Ikenoue S., Kasuga Y., Tanaka M.

    Placenta （Placenta)  104   247 - 252 2021.01

    ISSN  01434004

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    © 2021 Elsevier Ltd Even in the context of modern medicine, infants with fetal and neonatal neurological diseases such as cerebral palsy and myelomeningocele suffer serious long-lasting impairment due to the irreversible neuronal damage. The promotion of neurologically intact survival in patients with perinatal intractable neurological diseases requires the development of novel strategies. One promising strategy involves the use of human amniotic fluid stem cells (hAFSCs), which have attracted much attention in recent years and are known to exert anti-inflammatory and neuroprotective effects. In recent years, the therapeutic effects of hAFSCs on fetal-neonatal neurological diseases have become evident as per intense research efforts by our group and others. Specifically, hAFSCs administered into the nasal cavity migrated to the brain and controlled local inflammation in a rodent model of neonatal hypoxic-ischemic encephalopathy. In contrast, hAFSCs administered intraperitoneally did not migrate to the brain; they rather formed spheroids in the abdominal cavity, resulting in the suppression of systemic inflammation (including in the brain) via the secretion of anti-inflammatory cytokines in concert with peritoneal macrophages in a rodent model of periventricular leukomalacia. Moreover, studies in a rat model of myelomeningocele suggested that hAFSCs administered in utero secreted hepatocyte growth factor and protected the exposed spinal cord during pregnancy. Importantly, autologous hAFSCs, whose use for fetal-neonatal treatment does not raise ethical issues, can be collected during pregnancy and prepared in sufficient numbers for therapeutic use. This article outlines the results of preclinical research on fetal stem cell therapy, mainly involving hAFSCs, in the context of perinatal neurological diseases.

  • Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality

    Yamada M., Sato S., Ooka R., Akashi K., Nakamura A., Miyado K., Akutsu H., Tanaka M.

    Reproductive Medicine and Biology （Reproductive Medicine and Biology)  20 （ 1 ） 53 - 61 2021.01

    ISSN  14455781

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    © 2020 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. Background: Pathogenic mitochondrial (mt)DNA mutations, which often cause life-threatening disorders, are maternally inherited via the cytoplasm of oocytes. Mitochondrial replacement therapy (MRT) is expected to prevent second-generation transmission of mtDNA mutations. However, MRT may affect the function of respiratory chain complexes comprised of both nuclear and mitochondrial proteins. Methods: Based on the literature and current regulatory guidelines (especially in Japan), we analyzed and reviewed the recent developments in human models of MRT. Main findings: MRT does not compromise pre-implantation development or stem cell isolation. Mitochondrial function in stem cells after MRT is also normal. Although mtDNA carryover is usually less than 0.5%, even low levels of heteroplasmy can affect the stability of the mtDNA genotype, and directional or stochastic mtDNA drift occurs in a subset of stem cell lines (mtDNA genetic drift). MRT could prevent serious genetic disorders from being passed on to the offspring. However, it should be noted that this technique currently poses significant risks for use in embryos designed for implantation. Conclusion: The maternal genome is fundamentally compatible with different mitochondrial genotypes, and vertical inheritance is not required for normal mitochondrial function. Unresolved questions regarding mtDNA genetic drift can be addressed by basic research using MRT.

  • Differences in fetal fractional limb volume changes in normal and gestational diabetic pregnancies: an exploratory observational study

    Akiba Y., Ikenoue S., Endo T., Kasuga Y., Ochiai D., Miyakoshi K., Ishii R., Yakubo K., Tanaka M.

    BJOG: An International Journal of Obstetrics and Gynaecology （BJOG: An International Journal of Obstetrics and Gynaecology)  128 （ 2 ） 329 - 335 2021.01

    ISSN  14700328

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    © 2020 Royal College of Obstetricians and Gynaecologists Objective: Fetal fractional limb volume has been proposed as a useful measure for quantifying fetal soft tissue development. The aim of this study was to investigate the growth of fractional arm volume (AVol) and fractional thigh volume (TVol) of fetuses with maternal gestational diabetes (GDM) compared with those of fetuses with normal glucose tolerance (NGT). We hypothesised fetal fractional limb volume would be larger in the GDM group than in the NGT group in late gestation. Design: Exploratory observational study. Setting: Saitama Municipal Hospital. Sample: A total of 165 (125 NGT and 40 GDM) singleton Japanese pregnant women. Methods: AVol and TVol were assessed between 20 and 37 weeks’ gestation as cylindrical limb volumes based on 50% of the fetal humeral or femoral diaphysis length. Women were diagnosed as GDM based on the criteria of the Japan Society of Obstetrics and Gynecology. Main outcome measures: AVol and TVol were compared between women with NGT and those with GDM at each gestational age period (2-week intervals from 20 to 37 weeks’ gestation). Results: Overall, 287 ultrasound scans were performed (NGT group, 205 scans; GDM group, 82 scans). There was no significant difference of AVol between the groups before 32 weeks’ gestation. AVol was significantly larger in the GDM group than in the NGT group after 32 weeks’ gestation (P < 0.05). TVol was not statistically different between the groups across gestation. Conclusions: Detection of variations in fetal AVol may provide greater insight into understanding the origins of altered fetal body proportion in GDM. Tweetable abstract: AVol, but not TVol, is significantly larger in fetuses with GDM than in those with NGT after 32 weeks’ gestation.

  • Risk of preterm birth after the excisional surgery for cervical lesions: a propensity-score matching study in Japan

    Miyakoshi K., Itakura A., Abe T., Kondoh E., Terao Y., Tabata T., Hamada H., Tanaka K., Tanaka M., Kanayama N., Takeda S.

    Journal of Maternal-Fetal and Neonatal Medicine （Journal of Maternal-Fetal and Neonatal Medicine)  34 （ 6 ） 845 - 851 2021

    ISSN  14767058

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    © 2019 Informa UK Limited, trading as Taylor & Francis Group. Introduction: There is a paucity of data on the risk of preterm birth subcategorized by gestational age in pregnancies after the pre-pregnancy excisional treatment for cervical lesions. In addition, little is known about the effect of prophylactic cerclage on the risk of preterm birth. The aim of this study was to investigate the risk of preterm birth stratified by gestational period and its reduction by the prophylactic cerclage in women with prior excisional surgery. Materials and methods: We retrospectively analyzed a cohort of singleton pregnancies in the Japan Perinatal Registry Network Database (2013–2014, n = 307,001). Cases included pregnancies after the surgery (i.e. conization and loop electrosurgical excision procedure). Controls comprised the propensity-score matched pregnancies without pre-pregnancy surgery. The main outcome was the occurrence of preterm birth. The effect of prophylactic cervical cerclage on the risk of preterm birth after the excisional surgery was also examined using cases. Results: In the propensity-score matched population (cases, n = 1389; controls, n = 1389), cases exhibited a higher risk of preterm birth and preterm prelabor rupture of membranes (PROM), compared with controls (preterm birth: 25.3 versus 10.6%; preterm PROM: 14.0 versus 3.5%: both p <.0001). Odds ratios (OR; 95% confidence interval [CI]) for preterm birth at 22–27 weeks, 28–31 weeks, 32–33 weeks, and 34–36 weeks were 3.4 [1.8–6.5], 4.6 [2.7–7.7], 2.2 [1.4–3.5], and 2.1 [1.6–2.7], respectively. The association was stronger for preterm PROM at earlier gestational age (22–27 weeks, 28–31 weeks, 32–33 weeks, and 34–36 weeks: 5.2 [2.3–11.8], 7.1 [3.4–15.0], 3.8 [1.7–8.3], and 3.9 [1.8–4.6], respectively). In cases, 171 underwent the prophylactic cervical cerclage. The occurrence of preterm birth and preterm PROM was comparable between those with and without the cerclage (28.7 versus 24.2, and 12.9 versus 13.3%, respectively). Conclusions: Pre-pregnancy excisional cervical surgery was associated with the increased risk of preterm birth, especially before 32 weeks of gestation. The prophylactic cerclage did not reduce the risk of preterm birth.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Preterm delivery and hypertensive disorder of pregnancy were reduced during the COVID-19 pandemic: A single hospital-based study

    Kasuga Y., Tanaka M., Ochiai D.

    Journal of Obstetrics and Gynaecology Research (Journal of Obstetrics and Gynaecology Research)  46 ( 12 ) 2703 - 2704 2020.12

    ISSN  13418076

  • Screening maternity populations during the COVID-19 pandemic

    Iida M., Tanaka M.

    BJOG: An International Journal of Obstetrics and Gynaecology (BJOG: An International Journal of Obstetrics and Gynaecology)  127 ( 12 )  2020.11

    ISSN  14700328

  • A new diagnostic strategy for gestational diabetes during the COVID-19 pandemic for the Japanese population

    Kasuga Y., Saisho Y., Ikenoue S., Ochiai D., Tanaka M.

    Diabetes/Metabolism Research and Reviews (Diabetes/Metabolism Research and Reviews)  36 ( 8 )  2020.11

    ISSN  15207552

  • Sonographic findings of cervical laceration caused by vaginal delivery in pregnancy after radical trachelectomy

    Kasuga Y., Miyakoshi K., Endo T., Takeda T., Nakamura M., Ochiai D., Tanaka M.

    Journal of Medical Ultrasonics (Journal of Medical Ultrasonics)  47 ( 4 ) 655 - 657 2020.10

    ISSN  13464523

  • Glycemic and metabolic features in gestational diabetes: Singleton versus twin pregnancies

    Akiba Y., Miyakoshi K., Ikenoue S., Saisho Y., Kasuga Y., Ochiai D., Matsumoto T., Tanaka M.

    Endocrine Journal (Endocrine Journal)  66 ( 7 ) 647 - 651 2019

    ISSN  09188959

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    © The Japan Endocrine Society. A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin SecretionSensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60% vs. 71%). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0% vs. 5.2%, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45% vs. 32% and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.

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Presentations 【 Display / hide 】

  • Rapid replacement of somatic linker histones with the oocyte-specific linker histone in mouse nuclear transfer

    TANAKA MAMORUTAKAHIDE TERANISHI MASATAKA FURUYA HITOSHI ISHIMOTO KAZUHIRO MINEGISHI KEI MIYAKOSHI TOMOHIRO KONO YASUNORI YOSHIMURA

    52nd Annual Meeting Society of Gynecologic Investigation (Los Angeles, CA) , 

    2005.03
    , 

    Poster presentation, Society of Gynecologic Investigation

  • 肝右葉梗塞を発症した重症妊娠中毒症の１例

    小野晃子， 宮越　敬， 丸山哲夫， 大野暁子， 田中　守， 吉村泰典， 野澤志朗

    第106回日本産科婦人科学会関東連合地方部会総会・学術集会 (静岡県静岡市) , 

    2003.10
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    Poster presentation

  • 胎児診断した仙尾部奇形腫の画像検査所見の検討

    松本　直， 宮越　敬， 服部純尚， 上野和典， 田中　守， 吉村泰典

    第15回日本超音波医学会関東甲信越地方会学術集会 (東京) , 

    2003.10
    , 

    Oral presentation (general)

  • 18トリソミーにおける胎児超音波異常所見の後方視的検討

    上野和典， 宮越　敬， 服部純尚， 松本　直， 田中　守， 吉村泰典

    第15回日本超音波医学会関東甲信越地方会学術集会 (東京) , 

    2003.10
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    Oral presentation (general)

  • ヒト卵子における卵子特異的ヒストンH1の同定

    田中雄大， 久慈直昭， 楊　　毅， 吉井　毅， 吉田宏之， 田中　守， 末岡　浩， 吉村泰典，　加藤真吾

    第21回日本受精着床学会学術講演会 (東京) , 

    2003.10
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    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 胎児期からはじめる、自己羊水由来幹細胞を用いた多面的な脳性麻痺予防法の開発

    2021.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • ヒト羊水幹細胞による子宮炎症制御を介した早産/胎児炎症反応症候群治療薬の開発

    2019.06
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

  • 出生直後からの先制医療を目指した、羊水幹細胞による難治性早産合併症の治療法開発

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 自己羊水幹細胞シートを用いた新生児難治性疾患に対する新規治療法の開発

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Principal investigator

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Courses Taught 【 Display / hide 】

  • OBSTETRICS AND GYNECOLOGY: SEMINAR

    2024

  • OBSTETRICS AND GYNECOLOGY: PRACTICE

    2024

  • OBSTETRICS AND GYNECOLOGY

    2024

  • LECTURE SERIES, OBSTETRICS

    2024

  • LECTURE SERIES, GYNECOLOGY

    2024

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Memberships in Academic Societies 【 Display / hide 】

  • 日本胎児心臓病学会

    　

  • 日本受精着床学会

    　

  • 日本生殖医学会

    　

  • 日本卵子学会

    　

  • 日本胎児治療学会

    　

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