春日　義史 (カスガ　ヨシフミ)

Kasuga, Yoshifumi

写真a

所属（所属キャンパス）

医学部 産婦人科学教室 （信濃町）

職名

助教（有期）
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経歴 【 表示 ／ 非表示 】

  • 2007年04月
    -
    2009年03月

    慶應義塾大学病院, 初期臨床研修医

  • 2009年04月
    -
    2010年03月

    慶應義塾大学医学部, 産婦人科

  • 2010年04月
    -
    2011年03月

    川崎市立川崎病院, 産婦人科

  • 2011年04月
    -
    2012年03月

    平塚市民病院, 産婦人科

  • 2012年04月
    -
    2017年03月

    慶應義塾大学医学部, 産婦人科

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学歴 【 表示 ／ 非表示 】

  • 2001年04月
    -
    2007年03月

    日本大学, 医学部, 医学科

    大学, 卒業

  • 2013年04月
    -
    2017年03月

    慶應義塾大学

    大学院, 卒業, 博士

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学位 【 表示 ／ 非表示 】

  • 博士（医学）, 慶應義塾大学, 論文, 2017年03月

    Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

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免許・資格 【 表示 ／ 非表示 】

  • 医師免許, 2007年

  • 日本産科婦人科学会産婦人科専門医, 2012年10月

  • 日本周産期・新生児医学会新生児蘇生法インスタラクターコース, 2013年06月

  • 日本超音波医学会超音波専門医, 2017年10月

  • 母体保護法指定医, 2017年10月

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著書 【 表示 ／ 非表示 】

  • 広汎性子宮頸部摘出術後妊娠の管理

    春日義史，宮越敬, 2020年01月

  • 妊娠糖尿病の遺伝情報を臨床にどう活かすか

    春日義史, 宮越敬, 田嶋敦ほか, 2019年03月

  • 広汎性子宮頸部摘出術における予防的子宮頸管縫縮術の必要性は？

    春日義史，田中京子，宮越敬ほか, 2018年04月

  • 腹式広汎性子宮頸部摘出術後妊娠の周産期管理

    春日義史，宮越敬，田中守, 2017年07月

  • 婦人科癌の治療と妊孕性

    春日義史，宮越敬，田中守, 2017年04月

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論文 【 表示 ／ 非表示 】

  • DNA methylation analysis of cord blood samples in neonates born to gestational diabetes mothers diagnosed before 24 gestational weeks

    Kasuga Y., Kawai T., Miyakoshi K., Hori A., Tamagawa M., Hasegawa K., Ikenoue S., Ochiai D., Saisho Y., Hida M., Tanaka M., Hata K.

    BMJ Open Diabetes Research and Care （BMJ Open Diabetes Research and Care)  10 （ 1 ）  2022年01月

    査読有り

    　概要を見る

    Introduction Genome-wide methylation analyses of gestational diabetes mellitus (GDM) diagnosed after 24 gestational weeks (late GDM (L-GDM)) using cord blood have been reported. However, epigenetic changes in neonates born to mothers with GDM diagnosed before 24 gestational weeks (early GDM (E-GDM)) have not been reported. We investigated DNA methylation in neonates born to mothers with E-GDM using cord blood samples. Research design and methods Genome-wide DNA methylation analysis was performed using an Illumina EPIC array to compare methylation rates of 754 255 autosomal sites in cord blood samples from term neonates born to 162 mothers with GDM (E-GDM: n=84, L-GDM: n=78) and 60 normal glucose tolerance (normal OGTT) pregnancies. GDM was diagnosed based on Japan Society of Obstetrics and Gynecology criteria modified with International Association of Diabetes in Pregnancy Study Group criteria. In this study, all GDM mothers underwent dietary management, while self-monitoring of blood glucose and insulin administration was initiated when dietary modification did not achieve glycemic control. Results There were no significant differences in genome-wide DNA methylation of cord blood samples between the GDM (E-GDM and L-GDM) groups and normal OGTT group or between the E-GDM and normal OGTT groups, L-GDM and normal OGTT groups, and E-GDM and L-GDM groups. Conclusions This is the first report to determine the DNA methylation patterns in neonates born to mothers with E-GDM. Neonates born to mothers with GDM, who were diagnosed based on Japan Society of Obstetrics and Gynecology criteria, may not differ in DNA methylation compared with those born to normal OGTT mothers.

  • Deep neural network-based classification of cardiotocograms outperformed conventional algorithms

    Ogasawara J., Ikenoue S., Yamamoto H., Sato M., Kasuga Y., Mitsukura Y., Ikegaya Y., Yasui M., Tanaka M., Ochiai D.

    Scientific Reports （Scientific Reports)  11 （ 1 ） 13367 2021年12月

    査読有り

    　概要を見る

    Cardiotocography records fetal heart rates and their temporal relationship to uterine contractions. To identify high risk fetuses, obstetricians inspect cardiotocograms (CTGs) by eye. Therefore, CTG traces are often interpreted differently among obstetricians, resulting in inappropriate interventions. However, few studies have focused on quantitative and nonbiased algorithms for CTG evaluation. In this study, we propose a newly constructed deep neural network model (CTG-net) to detect compromised fetal status. CTG-net consists of three convolutional layers that extract temporal patterns and interrelationships between fetal heart rate and uterine contraction signals. We aimed to classify the abnormal group (umbilical artery pH < 7.20 or Apgar score at 1 min < 7) and the normal group from CTG data. We evaluated the performance of the CTG-net with the F1 score and compared it with conventional algorithms, namely, support vector machine and k-means clustering, and another deep neural network model, long short-term memory. CTG-net showed the area under the receiver operating characteristic curve of 0.73 ± 0.04, which was significantly higher than that of long short-term memory. CTG-net, a quantitative and automated diagnostic aid system, enables early intervention for putatively abnormal fetuses, resulting in a reduction in the number of cases of hypoxic injury.

  • Prepregnancy assessment of liver function to predict perinatal and postpregnancy outcomes in biliary atresia patients with native liver

    Takahashi N., Ochiai D., Yamada Y., Tamagawa M., Kanamori H., Kato M., Ikenoue S., Kasuga Y., Kuroda T., Tanaka M.

    Journal of Clinical Medicine （Journal of Clinical Medicine)  10 （ 17 ）  2021年09月

    査読有り

    　概要を見る

    Considering that some biliary atresia (BA) survivors with native liver have reached reproductive age and face long‐lasting complications, specific attention needs to be paid to pregnant cases. This study aimed to investigate the relationship between liver function, perinatal outcomes, and prognosis. A database review was conducted to identify pregnant BA cases with native liver and perinatal data, and clinical information on BA‐related complications was analyzed. Perinatal serum cholinesterase (ChE) levels, model for end‐stage liver‐disease (MELD) score, and platelet trends were analyzed, and the association between these indicators and perinatal outcomes was investigated. Patients were categorized into three groups according to the perinatal clinical outcomes: favorable (term babies with or without several episodes of cholangitis; n = 3), borderline (term baby and following liver dysfunction; n = 1), and unfavorable (premature delivery with subsequent liver failure; n = 1). Lower serum ChE levels, lower platelet counts, and higher MELD scores were observed in the unfavorable category. Borderline and unfavorable patients displayed a continuous increase in MELD score, with one eventually needing a liver transplantation. Pregnancy in patients with BA requires special attention. Serum ChE levels, platelet counts, and MELD scores are all important markers for predicting perinatal prognosis.

  • Clinical results of a massive blood transfusion protocol for postpartum hemorrhage in a university hospital in japan: A retrospective study

    Ochiai D., Abe Y., Yamazaki R., Uemura T., Toriumi A., Matsuhashi H., Tanaka Y., Ikenoue S., Kasuga Y., Tanosaki R., Tanaka M.

    Medicina (Lithuania) （Medicina (Lithuania))  57 （ 9 ）  2021年09月

    査読有り,  ISSN  1010660X

    　概要を見る

    Background and objectives: Massive postpartum hemorrhage (PPH) is the most common cause of maternal death worldwide. A massive transfusion protocol (MTP) may be used to provide significant benefits in the management of PPH; however, only a limited number of hospitals use MTP protocol to manage massive obstetric hemorrhages, especially in Japan. This study aimed to assess the clinical outcomes in patients in whom MTP was activated in our hospital. Materials and Methods: We retrospectively reviewed the etiology of PPH, transfusion outcomes, and laboratory findings among the patients treated with MTP after delivery in our hospital. Results: MTP was applied in 24 cases (0.7% of deliveries). Among them, MTP was activated within 2 h of delivery in 15 patients (62.5%). The median estimated blood loss was 5017 mL. Additional procedures to control bleeding were performed in 19 cases, including transarterial embolization (18 cases, 75%) and hysterectomy (1 case, 4.2%). The mean number of units of red blood cells, fresh frozen plasma, and platelets were 17.9, 20.2, and 20.4 units, respectively. The correlation coefficients of any two items among red blood cells, fresh frozen plasma, platelets, blood loss, and obstetrical disseminated intravascular coagulation score ranged from 0.757 to 0.892, indicating high levels of correlation coefficients. Although prothrombin time and activated partial thromboplastin time levels were significantly higher in the <150 mg/dL fibrinogen group than in the ≥150 mg/dL fibrinogen group at the onset of PPH, the amount of blood loss and blood transfusion were comparable between the two groups. Conclusions: Our MTP provides early access to blood products for patients experiencing severe PPH and could contribute to improving maternal outcomes after resuscitation in our hospital. Our study suggests the implementation of a hospital-specific MTP protocol to improve the supply and utilization of blood products to physicians managing major obstetric hemorrhage.

  • The efficacy of transarterial embolization for postpartum hemorrhage complicated with disseminated intravascular coagulation: A single‐center experience

    Ochiai D., Nakatsuka S., Abe Y., Ikenoue S., Kasuga Y., Inoue M., Jinzaki M., Tanaka M.

    Journal of Clinical Medicine （Journal of Clinical Medicine)  10 （ 18 ）  2021年09月

    査読有り

    　概要を見る

    Indications for the use of transarterial embolization (TAE) for postpartum hemorrhage (PPH) have been established. However, the efficacy of TAE for PPH complicated by disseminated intravascular coagulation (DIC) remains controversial. In this study, we investigated the efficacy of TAE for PPH complicated by DIC. A database review was conducted to identify patients who were treated with TAE for PPH at our hospital. TAE was performed in 41 patients during the study period. Effective hemostasis was achieved in all cases, but additional procedures, such as reembolization or hysterectomy, were required in five patients (12.2%). The typical causes of PPH included uterine atony (18 cases), placenta previa (15 cases), amniotic fluid embolism (DIC‐type) (11 cases), and placenta accreta spectrum (10 cases). The mean blood loss was 3836 mL. The mean obstetrical DIC and the International Society on Thrombosis and Hemostasis DIC scores were 7.9 and 2.6, respectively. The efficacy of hemostasis was comparable between patients with and without DIC. However, the complete success rate of TAE was lower in patients with DIC as the condition worsened than that in non‐DIC patients. Overall, TAE is effective as a minimally invasive treatment for PPH complicated by DIC.

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総説・解説等 【 表示 ／ 非表示 】

  • 日本人妊娠糖尿病における臍帯血DNAメチル化解析

    春日 義史, 宮越 敬, 池ノ上 学, 税所 芳史, 田中 守

    糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会)  21 ( 3 ) S - 106 2021年11月

    ISSN  1347-9172

  • 【妊娠糖尿病・糖尿病合併妊娠のマネジメント　血糖コントロールと助産ケア　最新ガイド】母体急変時(特殊な血糖値異常)への対応　「イザという時」に役立つ!

    春日 義史

    ペリネイタルケア ((株)メディカ出版)  40 ( 11 ) 1113 - 1117 2021年11月

    ISSN  0910-8718

  • 妊娠中に診断し、異なる経過を辿った頸髄腫瘍合併妊娠の2例

    竹田 将人, 春日 義史, 田中 優花, 葉室 明香, 田中 雄也, 長谷川 慶太, 池ノ上 学, 落合 大吾, 田中 守, 青木 大輔

    関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会)  58 ( 3 ) 432 - 432 2021年10月

    ISSN  2186-0610

  • Vasa previa with fetal vessels running transversely across the cervix: a diagnostic pitfall

    Ochiai D., Endo T., Oishi M., Kasuga Y., Ikenoue S., Tanaka M.

    Ultrasound in Obstetrics and Gynecology (Ultrasound in Obstetrics and Gynecology)  58 ( 3 ) 485 - 486 2021年09月

    ISSN  09607692

  • 【婦人科がん機能温存治療のすべて】機能温存治療と周産期医学

    春日 義史, 大石 真希, 田中 守

    産科と婦人科 ((株)診断と治療社)  88 ( 7 ) 778 - 782 2021年07月

    ISSN  0386-9792

    　概要を見る

    子宮頸がんに対する妊孕性温存術式としては子宮頸部円錐切除術および広汎子宮頸部摘出術があるが、術後妊娠例は早産ハイリスクである。また、子宮体がんに対する高用量黄体ホルモン療法は頻回な子宮内膜全面爬術の影響による癒着胎盤のリスクおよび肥満に伴う周産期合併症のリスクを伴う。各々の治療法は悪性腫瘍に対する治療というのみならず、妊孕性温存手術であるため、周産期リスクまでを念頭に置いたインフォームド・コンセントが重要である。(著者抄録)

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 広汎子宮頸部摘出術後妊娠管理および周産期予後に関する実態調査

    2021年03月
    -
    2024年03月

    関東連合産科婦人科学会, 関東連合産科婦人科学会研究助成, 春日義史, 補助金,  研究代表者

  • 子宮頸がん妊孕性温存手術後妊娠における腟内細菌叢解析

    2020年04月
    -
    2024年03月

    補助金,  研究代表者

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受賞 【 表示 ／ 非表示 】

  • 71st JSOG Congeress Encouragement Award

    2019年04月, 日本産科婦人科学会

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • 奨励賞

    2016年05月, 日本超音波医学会

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • International Session Encouragement Award

    2016年04月, 日本産科婦人科学会

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • 学部長賞

    2007年03月, 日本大学医学部

    受賞区分： その他

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担当授業科目 【 表示 ／ 非表示 】

  • 産科学講義

    2022年度

  • 産科学講義

    2021年度

  • 産科学講義

    2020年度

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