Details of a Researcher - Kasuga, Yoshifumi

Kasuga, Yoshifumi

写真a

Affiliation: School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) (Shinanomachi)

Position: Assistant Professor/Senior Assistant Professor

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Career 【 Display / hide 】

2007.04

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2009.03

慶應義塾大学病院, 初期臨床研修医
2009.04

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2010.03

慶應義塾大学医学部, 産婦人科
2010.04

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2011.03

川崎市立川崎病院, 産婦人科
2011.04

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2012.03

平塚市民病院, 産婦人科
2012.04

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2017.03

慶應義塾大学医学部, 産婦人科

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Academic Background 【 Display / hide 】

2001.04

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2007.03

Nihon University, 医学部, 医学科

University, Graduated
2013.04

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2017.03

Keio University

Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

博士（医学）, Keio University, Dissertation, 2017.03

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

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Licenses and Qualifications 【 Display / hide 】

医師免許, 2007
日本産科婦人科学会産婦人科専門医, 2012.10
日本周産期・新生児医学会新生児蘇生法インスタラクターコース, 2013.06
日本超音波医学会超音波専門医, 2017.10
母体保護法指定医, 2017.10

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Research Areas 【 Display / hide 】

Life Science / Obstetrics and gynecology (Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD)

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Research Keywords 【 Display / hide 】

Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD

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Books 【 Display / hide 】

広汎性子宮頸部摘出術後妊娠の管理

春日義史，宮越敬, 2020.01
妊娠糖尿病の遺伝情報を臨床にどう活かすか

春日義史, 宮越敬, 田嶋敦ほか, 2019.03
広汎性子宮頸部摘出術における予防的子宮頸管縫縮術の必要性は？

春日義史，田中京子，宮越敬ほか, 2018.04
腹式広汎性子宮頸部摘出術後妊娠の周産期管理

春日義史，宮越敬，田中守, 2017.07
婦人科癌の治療と妊孕性

春日義史，宮越敬，田中守, 2017.04

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Papers 【 Display / hide 】

Perinatal outcomes in RhD-negative pregnant women in Japan

Takahashi K., Yoshida S., Aoki S., Tanaka S., Kawashima A., Kajiwara K., Kato N., Matsui H., Serizawa M., Tsuji S., Yamamoto T., Kinjo T., Nakamura N., Sagawa M., Sato M., Abe E., Nakanishi S., Fujimoto Y., Takahashi S., Sasaki H., Mukai Y., Hara S., Fukuta K., Kikuchi N., Hara E., Shiga T., Horiuchi C., Sado T., Matsubara Y., Akabane K., Harada A., Nagase H., Maeda K., Katagiri H., Sasahara J., Sugii H., Tamaru S., Waratani M., Tsukahara S., Shibukawa S., Kiyama T., Kasuga Y., Egawa M., Sato H., Tamamura C., Suemitsu T., Okamoto A., Samura O.

Scientific Reports 15 ( 1 ) 9921 2025.12

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Managing RhD-negative pregnancies is vital for preventing hemolytic disease of the fetus and newborn, which occurs when RhD-negative mothers develop anti-D antibodies after exposure to RhD-positive fetal blood. This retrospective cohort study evaluated the proportion of RhD-negative pregnancies and newborns in Japan by assessing current management practices and outcomes. This study included RhD-negative pregnant women who delivered at 22 weeks or later at 47 Japanese facilities between April 2018 and March 2023. Pregnancies with unknown newborn RhD status were excluded. Data were obtained from medical records. Among the 1088 RhD-negative women, 1062 met the inclusion criteria. RhD-negative pregnancies comprised 0.71% of the total cohort, with 8.7% RhD-negative newborns. Anti-D immunoglobulin was administered in 96.5% of pregnancies, with a maternal spontaneous sensitization rate of 0.6% before 28 weeks and no sensitization detected from 28 weeks to postpartum. Sensitized RhD-negative women had higher cesarean section, preterm delivery, and neonatal hemolytic anemia rates than the non-sensitized group, leading to increased neonatal intensive care unit admissions. Despite the low incidence of RhD-negative pregnancies, this study underscores the need for tailored management strategies, suggesting that non-invasive prenatal diagnosis of fetal RhD status could prevent unnecessary anti-D immunoglobulin administration, improving outcomes and resource utilization in Japan.
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Maternal Serum 25-Hydroxyvitamin D as a Possible Modulator of Fetal Adiposity: A Prospective Longitudinal Study

Akita K., Ikenoue S., Tamai J., Otani T., Fukutake M., Kasuga Y., Tanaka M.

International Journal of Molecular Sciences 26 ( 9 ) 2025.05

ISSN 16616596

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25-hydroxyvitamin D (25(OH)D) regulates lipid metabolism, and its decrease is proposed as a pathogenesis of metabolic syndrome, gestational diabetes mellitus (GDM), and eventually fetal adiposity. Decreased 25(OH)D is also linked with the development of gestational diabetes mellitus (GDM), which is associated with increased fetal adiposity. Fetuses are dependent on the supply of 25(OH)D from maternal circulation. However, the influence of maternal serum 25(OH)D on fetal adiposity remains unclear. This study aimed to investigate the association between maternal serum 25(OH)D and fetal adiposity. A prospective longitudinal study was conducted in a cohort of 89 (including 21 GDM) singleton pregnancies. Maternal blood samples were obtained at 10, 24, 30, and 36 weeks, and fetal ultrasonography was performed at 24, 30, and 36 weeks of gestation. Estimated fetal adiposity (EFA) was calculated as the average z-score of cross-sectional arm and thigh percentage fat area and anterior abdominal wall thickness as previously reported. The multiple linear regression analyses indicated that maternal 25(OH)D levels across gestation were not associated with EFA at 24 and 30 weeks, while maternal 25(OH)D at 24 weeks was inversely correlated with EFA at 36 weeks. Particularly, in the GDM group, maternal 25(OH)D levels at 10, 24, 30, and 36 weeks all showed a significant negative correlation with EFA at 36 weeks. Decreased maternal serum 25(OH)D level could be an early biomarker of increased fetal adiposity in late gestation, especially in diabetic pregnancies.
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The Association Between Glucose Variability and Insulin Parameters in Gestational Diabetes Diagnosed After 24 Gestational Weeks

Kasuga Y., Kajikawa K., Ishikawa N., Ogata Y., Takahashi M., Akita K., Tamai J., Fukuma Y., Tanaka Y., Otani T., Fukutake M., Ikenoue S., Tanaka M.

Nutrients 17 ( 3 ) 2025.02

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Background/Objectives: Recently, it was reported that glucose variability (GV) calculated using the 75 g oral glucose tolerance test (OGTT) is associated with adverse perinatal outcomes. However, its role in gestational diabetes mellitus (GDM) remains unclear. We investigated the association between GV and insulin parameters in Japanese women diagnosed with GDM after 24 weeks of gestation (late GDM). Methods: A total of 280 mothers with late GDM cared for at Keio University Hospital were included in this study. Using 75 g OGTT, the initial increase and subsequent decrease were calculated as the GV. Results: The initial increase was significantly positively associated with 1 h plasma glucose level (PG) and 2 h PG with 75 g OGTT (p < 0.001), but fasting PG, insulinogenic index (IGI), and homeostasis model assessment—insulin resistance were negatively associated with the initial increase (all p < 0.001). The subsequent decrease was significantly positively correlated with 1 h PG (p < 0.001) but negatively correlated with 2 h PG (p < 0.001), IGI (p = 0.009), and the whole-body insulin sensitivity index derived from the OGTT (p = 0.02). Insulin Secretion-Sensitivity Index-2 was not associated with an initial increase or subsequent decrease. Conclusions: Since the initial increase might reflect insulin secretion and the subsequent decrease might reflect insulin sensitivity in Japanese women with late GDM, GV could alter several insulin parameters. Further studies are required to investigate the usefulness of GV in the management of GDM.
- Access to Document (DOI)
Should the Definition of Low Birth Weight Be Same in Every Ethnicity Considering the DOHaD Concept?

Kasuga Y, Tanaka M

Pediatric reports 17 ( 1 ) 2025.01

ISSN 2036-749X

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Low birth weight (LBW) is a significant concern not only because of its association with perinatal outcomes, but also because of its long-term impact on future health. Despite the physical differences among individuals of different ethnicities, the definition of LBW remains the same for all ethnicities. This study aimed to explore and discuss this issue. We compiled national data from several countries and found that maternal height was negatively correlated with LBW incidence. We discovered the INTERGROWTH-21st chart may not be suitable for the Japanese population, as the Japanese birth weight chart differs from the INTERGROWTH-21st chart. Researchers have reported different LBW cutoff values used to assess adverse perinatal outcomes for different countries. However, there is currently no definition of LBW independent of the mother’s country of origin that can be used for predicting the risk of adverse health outcomes. Therefore, the current era of personalized healthcare may be the perfect time to establish a standard definition of LBW which is independent of the mother’s country of origin. Considering the future of healthcare, it seems an apt time to discuss the development of a more meaningful definition of LBW that can be applied across ethnicities. Further research is needed to investigate the cutoff values of LBW in every ethnicity.
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ジノプロストン腟用剤を用いて計画分娩を行った抗リン脂質抗体症候群および特発性血小板減少性紫斑病合併妊娠の1例

三浦あかり, 白石慧, 春日義史, 山上亘, 田中守

産科と婦人科 ((株)診断と治療社) 92 ( 1 ) 115 - 119 2025.01

ISSN 0386-9792

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＜文献概要＞腎梗塞や脳梗塞の既往がある抗リン脂質抗体症候群と特発性血小板減少性紫斑病を合併した初産婦に対して,抗凝固療法を中止する時間を極力短縮したうえで計画分娩を行うため,ジノプロストン腟用剤を使用し経腟分娩に至った症例を経験した.抗凝固療法を行い,かつ血小板低下のある妊婦に対して,計画分娩を行う際にはジノプロストン腟用剤は1つの選択肢となる可能性が示唆された.

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Papers, etc., Registered in KOARA 【 Display / hide 】

日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016

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Reviews, Commentaries, etc. 【 Display / hide 】

妊娠中体重減少が周産期予後に与える影響

木村由実子, 春日義史, 秋田啓介, 玉井順子, 福間優花, 田中雄也, 大谷利光, 池ノ上学, 山上亘, 田中守

日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会) 77 ( 臨増 ) S - 619 2025.02

ISSN 0300-9165
当院における卵子提供後妊娠の後方視的検討

石川直嗣, 春日義史, 緒方泰彦, 梶川かおる, 秋田啓介, 玉井順子, 福間優花, 田中雄也, 大谷利光, 池ノ上学, 山上亘, 田中守

日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会) 77 ( 臨増 ) S - 400 2025.02

ISSN 0300-9165
胎児に構造異常を認め人工妊娠中絶あるいは子宮内胎児死亡に至った家系に対する遺伝学的アプローチ

田中雄也, 春日義史, 石川直嗣, 緒方泰彦, 梶川かおる, 秋田啓介, 玉井順子, 福間優花, 大谷利光, 池ノ上学, 山上亘, 田中守

日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会) 77 ( 臨増 ) S - 464 2025.02

ISSN 0300-9165
胎児に構造異常を認め人工妊娠中絶あるいは子宮内胎児死亡に至った家系に対する遺伝学的アプローチ

田中雄也, 山田茉未子, 春日義史, 大谷利光, 池ノ上学, 鈴木寿人, 宮冬樹, 稲垣昇, 田中守, 小崎健次郎

日本小児科学会雑誌 ((公社)日本小児科学会) 129 ( 2 ) 179 - 179 2025.02

ISSN 0001-6543
関東連合産科婦人科学会所属周産期母子医療センターにおける慢性早剥羊水過少症候群の実態調査

福間優花, 春日義史, 緒方泰彦, 石川直嗣, 梶川かおる, 秋田啓介, 玉井順子, 田中雄也, 大谷利光, 池ノ上学, 山上亘, 田中守

日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会) 77 ( 臨増 ) S - 420 2025.02

ISSN 0300-9165

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

妊娠糖尿病における新生児低血糖予防を目的とした新たな管理法の検討

2025.04

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2029.03

Research grant, Principal investigator
コロナ禍における妊娠糖尿病診断基準変更が周産期予後に与えた影響に関する検討

2025

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2026.03

公益財団法人鈴木万平糖尿病財団, 若手研究者調査研究, Research grant, Principal investigator
The clinical survey of chronic abruption oligohydramnios sequence

2023.04

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2026.03

関東連合産科婦人科学会, Research grant, Principal investigator
The association between maternal glucose status during pregnancy and epigenetic changes in next generation born to mother with gestational diabetes

2023.04

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2026.03

公益財団法人今井精一記念財団, ２０２２年度（第３回）研究助成金, Research grant, Principal investigator
乳製品摂取が妊娠中および産褥期骨密度変化に与える影響

2022.04

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2023.03

一般社団法人　Jミルク, 2022年度「牛乳乳製品健康科学」学術研究, Joint research, No Setting

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Awards 【 Display / hide 】

令和6年度日本周産期・新生児医学会臨床研究Award

2024.06

Type of Award： Award from Japanese society, conference, symposium, etc.
第15回ロート女性健康科学研究賞

2024.04

Type of Award： Award from publisher, newspaper, foundation, etc.
日本糖尿病妊娠学会大森賞

2022.11, 日本糖尿病・妊娠学会

Type of Award： Award from Japanese society, conference, symposium, etc.
優秀演題賞

2022.10, 第9回日本DOHaD学会

Type of Award： Award from Japanese society, conference, symposium, etc.
71st JSOG Congeress Encouragement Award

2019.04, 日本産科婦人科学会

Type of Award： Award from Japanese society, conference, symposium, etc.