Details of a Researcher - Kasuga, Yoshifumi

Kasuga, Yoshifumi

写真a

Affiliation: School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) （Shinanomachi）

Position: Assistant Professor/Senior Assistant Professor

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Career 【 Display / hide 】

2007.04

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2009.03

慶應義塾大学病院, 初期臨床研修医
2009.04

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2010.03

慶應義塾大学医学部, 産婦人科
2010.04

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2011.03

川崎市立川崎病院, 産婦人科
2011.04

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2012.03

平塚市民病院, 産婦人科
2012.04

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2017.03

慶應義塾大学医学部, 産婦人科

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Academic Background 【 Display / hide 】

2001.04

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2007.03

Nihon University, 医学部, 医学科

University, Graduated
2013.04

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2017.03

Keio University

Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

博士（医学）, Keio University, Dissertation, 2017.03

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

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Licenses and Qualifications 【 Display / hide 】

医師免許, 2007
日本産科婦人科学会産婦人科専門医, 2012.10
日本周産期・新生児医学会新生児蘇生法インスタラクターコース, 2013.06
日本超音波医学会超音波専門医, 2017.10
母体保護法指定医, 2017.10

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Research Areas 【 Display / hide 】

Life Science / Obstetrics and gynecology (Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD)

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Research Keywords 【 Display / hide 】

Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD

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Books 【 Display / hide 】

広汎性子宮頸部摘出術後妊娠の管理

春日義史，宮越敬, 2020.01
妊娠糖尿病の遺伝情報を臨床にどう活かすか

春日義史, 宮越敬, 田嶋敦ほか, 2019.03
広汎性子宮頸部摘出術における予防的子宮頸管縫縮術の必要性は？

春日義史，田中京子，宮越敬ほか, 2018.04
腹式広汎性子宮頸部摘出術後妊娠の周産期管理

春日義史，宮越敬，田中守, 2017.07
婦人科癌の治療と妊孕性

春日義史，宮越敬，田中守, 2017.04

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Papers 【 Display / hide 】

A capture methyl-seq protocol with improved efficiency and cost-effectiveness using pre-pooling and enzymatic conversion

Hasegawa K., Nakabayashi K., Ishiwata K., Kasuga Y., Hata K., Tanaka M.

BMC Research Notes （BMC Research Notes) 16 （ 1 ） 141 2023.12

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Objective: The opportunities for sequencing-based methylome analysis of clinical samples are increasing. To reduce its cost and the amount of genomic DNA required for library preparation, we aimed to establish a capture methyl-seq protocol, which adopts pre-pooling of multiple libraries before hybridization capture and TET2/APOBEC-mediated conversion of unmethylated cytosine to thymine. Results: We compared a publicly available dataset generated by the standard Agilent protocol of SureSelect XT Human Methyl-Seq Kit and our dataset obtained by our modified protocol, EMCap, that adopted sample pre-pooling and enzymatic conversion. We confirmed that the quality of DNA methylation data was comparable between the two datasets. As our protocol, EMCap, is more cost-effective and reduces the amount of input genomic DNA, it would serve as a better choice for clinical methylome sequencing.
- Access to Document (DOI)
Pregnancy outcomes following radical trachelectomy for early-stage cervical cancer: A retrospective observational study in the Kanto area, Japan.

Kasuga Y, Hasegawa K, Hamuro A, Fukuma Y, Tamai J, Tanaka Y, Ikenoue S, Tanaka M

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics （International Journal of Gynecology and Obstetrics) 2023.06

ISSN 0020-7292

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Objective: The authors aimed to investigate the prevalence of pregnancy and obstetric outcomes in patients who underwent radical trachelectomy (RT) for early-stage cervical cancer in the Kanto area, Japan. Method: A survey among 113 perinatal centers affiliated with the Kanto Society of Obstetrics and Gynecology was conducted to investigate their experience in managing pregnancies following RT, between 2010 and 2020. The association between preterm delivery (before 34 gestational weeks) and a midtrimester short cervix (<13 mm) was evaluated. Results: The authors retrospectively collected maternal and perinatal data from 13 hospitals. There were 135 pregnancies among 115 women following RT. Of the 135 pregnancies, 32 were miscarriages (<12 gestational weeks: n = 22; >12 gestational weeks: n = 10), and 103 were delivered after 22 gestational weeks. The incidences of preterm delivery before 28 and 34 gestational weeks were 8.7% and 30.1%, respectively. A midtrimester short residual cervix was associated with preterm delivery (P = 0.046). Conclusion: Since more than 100 pregnancies were recorded after RT in the Kanto area, many physicians had more opportunities to manage pregnancy after RT. Pregnancy following RT is associated with increased risk of preterm delivery, and midtrimester short residual cervix is a good predictor of preterm delivery.
- Access to Document (DOI)
Genome-wide association study of preterm birth and gestational age in a Japanese population.

Hasegawa K, Kumasaka N, Nakabayashi K, Kamura H, Maehara K, Kasuga Y, Hata K, Tanaka M

Human genome variation （Human Genome Variation) 10 （ 1 ） 19 2023.06

ISSN 2054-345X

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Preterm birth (PTB), defined as the birth of a baby at <37 weeks of gestation, is known to be the main cause of neonatal morbidity and mortality. Here, we report genetic associations between preterm birth and gestational age in a Japanese population. We conducted a genome-wide association study (GWAS) of 384 cases who delivered prematurely and 644 controls and considered gestational age as a quantitative trait in 1028 Japanese women. Unfortunately, we were unable to identify any significant variants associated with PTB or gestational age using the current sample. We also examined genetic associations previously reported in European populations and identified no associations, even with the genome-wide subthreshold (p value < 10–6). This data report aims to provide summary statistics of current GWASs on PTB in a Japanese population for future meta-analyses of genetics and PTB with larger sample sizes.
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Obstetric outcomes after medroxyprogesterone acetate treatment for early stage endometrial cancer or atypical endometrial hyperplasia: a single hospital-based study

Oishi M., Kasuga Y., Fukuma Y., Hamuro A., Tamai J., Tanaka Y., Hasegawa K., Yoshimura T., Ikenoue S., Ochiai D., Yamagami W., Tanaka M.

International Journal of Clinical Oncology （International Journal of Clinical Oncology) 28 （ 4 ） 587 - 591 2023.04

ISSN 13419625

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Background: To investigate perinatal outcomes in pregnancy after high-dose medroxyprogesterone acetate (MPA) therapy for early stage endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) and to determine whether pregnancy after MPA therapy is at a higher risk of placenta accreta. Methods: Data of 51 pregnancies in 46 women who received MPA therapy for EC or AEH and delivered after 22 weeks of gestation at Keio University Hospital were reviewed. A retrospective matched case–control study was performed to determine the risk of placenta accreta in pregnancy after MPA therapy compared with singleton pregnancies without any history of maternal malignancy treatments. Results: The incidence of placenta accreta was higher in the MPA group than in the control group (15.7 vs. 0%, p = 0.0058). However, no differences in other perinatal outcomes were observed between groups. While gestational weeks at delivery in the MPA group were later than those in the control group (p = 0.0058), no difference in the incidence of preterm delivery was recorded between groups. In the MPA therapy group, the number of patients who underwent ≥ 6 dilation and curettage (D&C) was higher in the placenta accreta group than in the non-placenta accreta group (50.0 vs. 14.0%, p = 0.018). Patients with ≥ 6 D&Cs demonstrated a 6.0-fold increased risk of placenta accreta (p = 0.043, 95% CI 1.05–34.1) than those receiving ≤ 3 D&Cs. Conclusion: Pregnancy after MPA therapy is associated with a high risk of placenta accreta. In cases in which the frequency of D&C is high, placenta accreta should be considered.
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染色体異常を伴わない胎児臍帯ヘルニアの2例

木村由実子, 玉井順子, 春日義史, 秋田啓介, 田中邦生, 葉室明香, 福間優花, 長谷川慶太, 大谷利光, 池ノ上学, 青木大輔, 田中守

東京産科婦人科学会会誌（(一社)東京産科婦人科学会) 72 （ 2 ） 327 - 331 2023.04

ISSN 2186-0599

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緒言:今回我々は染色体異常を伴わない胎児臍帯ヘルニアの2例の周産期管理を行ったので報告する.症例1は41歳,1妊0産.体外受精-胚移植により妊娠成立し,妊娠13週に臍帯ヘルニアを指摘された.症例2は40歳,1妊0産.自然妊娠にて妊娠成立し,妊娠12週に胎児腹部腫瘤を指摘された.いずれも妊娠16週の羊水検査で正常核型であり,超音波断層法では肝脱出型臍帯ヘルニアと単一臍帯動脈以外の形態異常は指摘されなかった.出生後の精査にて症例1は食道閉鎖,鎖肛,軟口蓋裂,左多合指症等を認めたためVATER連合,症例2は耳介の形態や高インスリン血症からBeckwith-Wiedemann症候群が疑われた.結論:染色体異常を伴っていない臍帯ヘルニアでは,他の症候群の1症候であり出生後に判明する場合があることを念頭に胎児の慎重な観察と家族への十分な説明を行うことが望ましいと考えられた.(著者抄録)

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Reviews, Commentaries, etc. 【 Display / hide 】

3分でわかる!最新DOHaD講座　未来につなぐ助産を目指して(第6回)(最終回)　そこにもここにもDOHaD

春日義史

ペリネイタルケア ((株)メディカ出版) 42 ( 6 ) 616 - 618 2023.06

ISSN 0910-8718
広汎子宮頸部摘出術後妊娠管理および周産期予後に関する実態調査

春日義史, 長谷川慶太, 葉室明香, 玉井順子, 福間優花, 田中雄也, 大谷利光, 池ノ上学, 青木大輔, 田中守

関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会) 60 ( 2 ) 261 - 261 2023.05

ISSN 2186-0610
3分でわかる!最新DOHaD講座　未来につなぐ助産を目指して(第4回)　胎内も重要だけど、生後早期も重要なんです!

中野有也, 春日義史

ペリネイタルケア ((株)メディカ出版) 42 ( 4 ) 412 - 413 2023.04

ISSN 0910-8718
【図表・チャートでパッと理解! ここまでわかった産婦人科の病態生理】(第1章)周産期　A.妊娠中の産科異常　細菌性腟症

春日義史

産科と婦人科 ((株)診断と治療社) 90 ( Suppl. ) 14 - 17 2023.03

ISSN 0386-9792

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＜文献概要＞Point　細菌性腟症(BV)とは特定の微生物によらない腟炎とされ,女性の1/4〜1/3が罹患している頻度の高い疾患である.BVは流早産のリスク因子であることから,症状のある妊婦に対しては治療を要する.
3分でわかる!最新DOHaD講座〜未来につなぐ助産を目指して(第3回)　赤ちゃんのためには何を食べたらいい?

久保佳範, 春日義史

ペリネイタルケア ((株)メディカ出版) 42 ( 3 ) 292 - 294 2023.03

ISSN 0910-8718

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

The association between maternal glucose status during pregnancy and epigenetic changes in next generation born to mother with gestational diabetes

2023.04

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2026.03

公益財団法人今井精一記念財団, ２０２２年度（第３回）研究助成金, Research grant, Principal investigator
The clinical survey of chronic abruption oligohydramnios sequence

2023.04

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2026.03

関東連合産科婦人科学会, Research grant, Principal investigator
乳製品摂取が妊娠中および産褥期骨密度変化に与える影響

2022.04

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2023.03

一般社団法人　Jミルク, 2022年度「牛乳乳製品健康科学」学術研究, Joint research, No Setting
広汎子宮頸部摘出術後妊娠管理および周産期予後に関する実態調査

2021.03

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2024.03

関東連合産科婦人科学会, 関東連合産科婦人科学会研究助成, Research grant, Principal investigator
子宮頸がん妊孕性温存手術後妊娠における腟内細菌叢解析

2020.04

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2024.03

Research grant, Principal investigator

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Awards 【 Display / hide 】

日本糖尿病妊娠学会大森賞

2022.11, 日本糖尿病・妊娠学会

Type of Award： Award from Japanese society, conference, symposium, etc.
優秀演題賞

2022.10, 第9回日本DOHaD学会

Type of Award： Award from Japanese society, conference, symposium, etc.
71st JSOG Congeress Encouragement Award

2019.04, 日本産科婦人科学会

Type of Award： Award from Japanese society, conference, symposium, etc.
インパクトファクター賞3位

2018.11, 慶應義塾大学医学部産婦人科同窓会

Type of Award： Keio commendation etc.
奨励賞

2016.05, 日本超音波医学会

Type of Award： Award from Japanese society, conference, symposium, etc.