Details of a Researcher - Kasuga, Yoshifumi

Kasuga, Yoshifumi

写真a

Affiliation: School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) (Shinanomachi)

Position: Assistant Professor/Senior Assistant Professor

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Career 【 Display / hide 】

2007.04

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2009.03

慶應義塾大学病院, 初期臨床研修医
2009.04

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2010.03

慶應義塾大学医学部, 産婦人科
2010.04

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2011.03

川崎市立川崎病院, 産婦人科
2011.04

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2012.03

平塚市民病院, 産婦人科
2012.04

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2017.03

慶應義塾大学医学部, 産婦人科

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Academic Background 【 Display / hide 】

2001.04

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2007.03

Nihon University, 医学部, 医学科

University, Graduated
2013.04

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2017.03

Keio University

Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

博士（医学）, Keio University, Dissertation, 2017.03

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

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Licenses and Qualifications 【 Display / hide 】

医師免許, 2007
日本産科婦人科学会産婦人科専門医, 2012.10
日本周産期・新生児医学会新生児蘇生法インスタラクターコース, 2013.06
日本超音波医学会超音波専門医, 2017.10
母体保護法指定医, 2017.10

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Research Areas 【 Display / hide 】

Life Science / Obstetrics and gynecology (Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD)

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Research Keywords 【 Display / hide 】

Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD

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Books 【 Display / hide 】

広汎性子宮頸部摘出術後妊娠の管理

春日義史，宮越敬, 2020.01
妊娠糖尿病の遺伝情報を臨床にどう活かすか

春日義史, 宮越敬, 田嶋敦ほか, 2019.03
広汎性子宮頸部摘出術における予防的子宮頸管縫縮術の必要性は？

春日義史，田中京子，宮越敬ほか, 2018.04
腹式広汎性子宮頸部摘出術後妊娠の周産期管理

春日義史，宮越敬，田中守, 2017.07
婦人科癌の治療と妊孕性

春日義史，宮越敬，田中守, 2017.04

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Papers 【 Display / hide 】

The Association Between Glucose Variability and Insulin Parameters in Gestational Diabetes Diagnosed After 24 Gestational Weeks

Kasuga Y., Kajikawa K., Ishikawa N., Ogata Y., Takahashi M., Akita K., Tamai J., Fukuma Y., Tanaka Y., Otani T., Fukutake M., Ikenoue S., Tanaka M.

Nutrients 17 ( 3 ) 2025.02

　View Summary

Background/Objectives: Recently, it was reported that glucose variability (GV) calculated using the 75 g oral glucose tolerance test (OGTT) is associated with adverse perinatal outcomes. However, its role in gestational diabetes mellitus (GDM) remains unclear. We investigated the association between GV and insulin parameters in Japanese women diagnosed with GDM after 24 weeks of gestation (late GDM). Methods: A total of 280 mothers with late GDM cared for at Keio University Hospital were included in this study. Using 75 g OGTT, the initial increase and subsequent decrease were calculated as the GV. Results: The initial increase was significantly positively associated with 1 h plasma glucose level (PG) and 2 h PG with 75 g OGTT (p < 0.001), but fasting PG, insulinogenic index (IGI), and homeostasis model assessment—insulin resistance were negatively associated with the initial increase (all p < 0.001). The subsequent decrease was significantly positively correlated with 1 h PG (p < 0.001) but negatively correlated with 2 h PG (p < 0.001), IGI (p = 0.009), and the whole-body insulin sensitivity index derived from the OGTT (p = 0.02). Insulin Secretion-Sensitivity Index-2 was not associated with an initial increase or subsequent decrease. Conclusions: Since the initial increase might reflect insulin secretion and the subsequent decrease might reflect insulin sensitivity in Japanese women with late GDM, GV could alter several insulin parameters. Further studies are required to investigate the usefulness of GV in the management of GDM.
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Should the Definition of Low Birth Weight Be Same in Every Ethnicity Considering the DOHaD Concept?

Kasuga Y, Tanaka M

Pediatric reports 17 ( 1 ) 2025.01

ISSN 2036-749X
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胎児発育不全に右大動脈弓を伴った9番染色体トリソミーモザイクの1例

酒井美晴, 秋田啓介, 春日義史, 福間優花, 玉井順子, 田中雄也, 長谷川慶太, 大谷利光, 池ノ上学, 丸山哲夫, 青木大輔, 田中守

関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会) 61 ( 4 ) 392 - 396 2024.11

ISSN 2186-0610

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【緒言】9番染色体トリソミーモザイクは心奇形などを合併する周産期死亡率の高い予後不良な染色体異常である.今回我々は当院で周産期管理を行った胎児9番染色体トリソミーモザイクの1例を経験したので報告する.【症例】39歳.G2P1(第1子は妊娠36週で常位胎盤早期剥離による死産分娩).タイミング法で妊娠成立後,妊娠11週の頭殿長より分娩予定日を決定,当院で妊婦健診を行っていた.なお,無侵襲的出生前遺伝学的検査や羊水検査の受検はなかった.妊娠21週の胎児超音波断層法で大動脈縮窄症を疑い,精査を行った.妊娠23週時に胎児発育不全(-2.0SD),単一臍帯動脈,右大動脈弓,左上大静脈遺残と診断した.妊娠31週には推定体重1,071g(-3.0SD)となったことから入院管理とした.妊娠34週6日,胎児機能不全の診断で緊急帝王切開術を施行した.児は女児,1,119g(-4.0SD),Apgar score 7/8点(1/5分値),上記診断の他に眼瞼裂斜上,耳介低位,小顎を認めた.さらに,出生後の染色体検査で9番染色体トリソミーモザイクと診断された.【結語】今回我々は胎児発育不全に右大動脈弓を伴った9番染色体トリソミーモザイクの1例を経験した.本症例のように右大動脈弓を合併する場合もあり,9番染色体トリソミーモザイクは多彩な臨床像を呈することが再認識された.(著者抄録)
Abstracts of the 34th World Congress on Ultrasound in Obstetrics and Gynecology, 15-18 September 2024, Budapest, Hungary

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 64 2024.09
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Use of the Japanese gestational diabetes mellitus diagnostic strategy during the COVID-19 pandemic in Japan: A questionnaire survey

Kasuga Y., Miyakoshi K., Yokoyama M., Nakanishi S., Iwama N., Ichikawa R., Abiko A., Harashima S., Sugiyama T.

Journal of Obstetrics and Gynaecology Research 50 ( 6 ) 955 - 960 2024.06

ISSN 13418076

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Aim: Some concerns exist that diagnosis of gestational diabetes mellitus (GDM) may be missed when the simplified diagnostic criteria of the Japanese Society of Diabetes and Pregnancy (JSDP) for GDM (published during the COVID-19 pandemic) are used. Moreover, limited data is available regarding how widespread these diagnostic criteria are used when managing GDM during the COVID-19 pandemic. Therefore, this study aimed to determine how GDM diagnosis has changed during the COVID-19 pandemic in Japan. Methods: The changes in GDM diagnosis during the COVID-19 pandemic were investigated using an online questionnaire to 2159 obstetric facilities in Japan. The questionnaire collected data on facility type, awareness of Japanese GDM diagnostic strategies, modifications to diagnostic methods for early and late GDM, and opinions on GDM management, with the pandemic divided into seven periods. Results: We received responses from 593 facilities (27%). Approximately 90% of the facilities did not change their diagnostic process for early GDM or late GDM (occurring after 24 weeks gestation). However, during the COVID-19 pandemic, 19 facilities discontinued the use of 75-g oral glucose tolerance tests before 24 weeks of gestation, and 17 facilities discontinued it after 24 weeks of gestation, instead using the aforementioned Japanese GDM diagnostic strategy. Conclusions: Although a limited number of facilities modified their diagnostic method in response to the COVID-19 pandemic, this study demonstrated that those that adjusted their diagnostic method primarily used the Japanese COVID-19 GDM strategy by the JSDP.
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Papers, etc., Registered in KOARA 【 Display / hide 】

日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016

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Reviews, Commentaries, etc. 【 Display / hide 】

【DOHaDと周産期医療】DOHaD研究の歴史　日本の研究の現状

春日義史

周産期医学 ((株)東京医学社) 54 ( 11 ) 1461 - 1464 2024.11

ISSN 0386-9881

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＜文献概要＞はじめに　Developmental origins of health and disease(DOHaD)研究と聞くと「基礎研究や公衆衛生的な難しい話」や「痩せ妊婦の話」などといわれてしまうことがある。実際,実験動物を使用した基礎研究は不可欠であり,わが国においては痩せ妊婦が次世代に与える影響を議論することが多いのは事実である。一方で,DOHaD研究はすべての医療従事者にとって決して馴染みのないものではなく,むしろ日常臨床で行っている日々の診療はDOHaDに直結していると筆者は考えている。
DOHaDを含めた妊娠出産に関する講義は非医療系学部大学生の妊娠出産に関する意識をどのように変えるか

春日義史, 白柳花萌, 深澤俊輔, 秋田啓介, 福間優花, 玉井順子, 田中雄也, 祝井麻希, 大谷利光, 池ノ上学, 山上亘, 田中守

関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会) 61 ( 3 ) 283 - 283 2024.10

ISSN 2186-0610
初期妊娠糖尿病におけるGlucose variabilityの検討

梶川かおる, 春日義史, 福間優花, 池ノ上学, 田中守

糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会) 24 ( 3 ) S - 108 2024.10

ISSN 1347-9172
DREAMBee Studyデータを用いた妊娠24週以降非常時妊娠糖尿病診断基準の検証

春日義史, 宮越敬, 川崎麻紀, 荒田尚子, 杉山隆

糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会) 24 ( 3 ) S - 109 2024.10

ISSN 1347-9172
経腟分娩出血過多例に対するカルボキシマルトース第二鉄の有用性に関する後方視的検討

緒方泰彦, 春日義史, 石川直嗣, 梶川かおる, 秋田啓介, 玉井順子, 福間優花, 田中雄也, 大谷利光, 池ノ上学, 山上亘, 田中守

関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会) 61 ( 3 ) 291 - 291 2024.10

ISSN 2186-0610

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

コロナ禍における妊娠糖尿病診断基準変更が周産期予後に与えた影響に関する検討

2025

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2026.03

公益財団法人鈴木万平糖尿病財団, 若手研究者調査研究, Research grant, Principal investigator
The association between maternal glucose status during pregnancy and epigenetic changes in next generation born to mother with gestational diabetes

2023.04

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2026.03

公益財団法人今井精一記念財団, ２０２２年度（第３回）研究助成金, Research grant, Principal investigator
The clinical survey of chronic abruption oligohydramnios sequence

2023.04

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2026.03

関東連合産科婦人科学会, Research grant, Principal investigator
乳製品摂取が妊娠中および産褥期骨密度変化に与える影響

2022.04

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2023.03

一般社団法人　Jミルク, 2022年度「牛乳乳製品健康科学」学術研究, Joint research, No Setting
広汎子宮頸部摘出術後妊娠管理および周産期予後に関する実態調査

2021.03

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2024.03

関東連合産科婦人科学会, 関東連合産科婦人科学会研究助成, Research grant, Principal investigator

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Awards 【 Display / hide 】

令和6年度日本周産期・新生児医学会臨床研究Award

2024.06

Type of Award： Award from Japanese society, conference, symposium, etc.
第15回ロート女性健康科学研究賞

2024.04

Type of Award： Award from publisher, newspaper, foundation, etc.
日本糖尿病妊娠学会大森賞

2022.11, 日本糖尿病・妊娠学会

Type of Award： Award from Japanese society, conference, symposium, etc.
優秀演題賞

2022.10, 第9回日本DOHaD学会

Type of Award： Award from Japanese society, conference, symposium, etc.
71st JSOG Congeress Encouragement Award

2019.04, 日本産科婦人科学会

Type of Award： Award from Japanese society, conference, symposium, etc.