Details of a Researcher - Kasuga, Yoshifumi

Kasuga, Yoshifumi

写真a

Affiliation: School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) (Shinanomachi)

Position: Assistant Professor/Senior Assistant Professor

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Career 【 Display / hide 】

2007.04

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2009.03

慶應義塾大学病院, 初期臨床研修医
2009.04

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2010.03

慶應義塾大学医学部, 産婦人科
2010.04

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2011.03

川崎市立川崎病院, 産婦人科
2011.04

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2012.03

平塚市民病院, 産婦人科
2012.04

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2017.03

慶應義塾大学医学部, 産婦人科

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Academic Background 【 Display / hide 】

2001.04

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2007.03

Nihon University, 医学部, 医学科

University, Graduated
2013.04

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2017.03

Keio University

Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

博士（医学）, Keio University, Dissertation, 2017.03

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

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Licenses and Qualifications 【 Display / hide 】

医師免許, 2007
日本産科婦人科学会産婦人科専門医, 2012.10
日本周産期・新生児医学会新生児蘇生法インスタラクターコース, 2013.06
日本超音波医学会超音波専門医, 2017.10
母体保護法指定医, 2017.10

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Research Areas 【 Display / hide 】

Life Science / Obstetrics and gynecology (Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD)

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Research Keywords 【 Display / hide 】

Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD

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Books 【 Display / hide 】

広汎性子宮頸部摘出術後妊娠の管理

春日義史，宮越敬, 2020.01
妊娠糖尿病の遺伝情報を臨床にどう活かすか

春日義史, 宮越敬, 田嶋敦ほか, 2019.03
広汎性子宮頸部摘出術における予防的子宮頸管縫縮術の必要性は？

春日義史，田中京子，宮越敬ほか, 2018.04
腹式広汎性子宮頸部摘出術後妊娠の周産期管理

春日義史，宮越敬，田中守, 2017.07
婦人科癌の治療と妊孕性

春日義史，宮越敬，田中守, 2017.04

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Papers 【 Display / hide 】

Perinatal outcomes in RhD-negative pregnant women in Japan

Takahashi K., Yoshida S., Aoki S., Tanaka S., Kawashima A., Kajiwara K., Kato N., Matsui H., Serizawa M., Tsuji S., Yamamoto T., Kinjo T., Nakamura N., Sagawa M., Sato M., Abe E., Nakanishi S., Fujimoto Y., Takahashi S., Sasaki H., Mukai Y., Hara S., Fukuta K., Kikuchi N., Hara E., Shiga T., Horiuchi C., Sado T., Matsubara Y., Akabane K., Harada A., Nagase H., Maeda K., Katagiri H., Sasahara J., Sugii H., Tamaru S., Waratani M., Tsukahara S., Shibukawa S., Kiyama T., Kasuga Y., Egawa M., Sato H., Tamamura C., Suemitsu T., Okamoto A., Samura O.

Scientific Reports 15 ( 1 ) 9921 2025.12

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Managing RhD-negative pregnancies is vital for preventing hemolytic disease of the fetus and newborn, which occurs when RhD-negative mothers develop anti-D antibodies after exposure to RhD-positive fetal blood. This retrospective cohort study evaluated the proportion of RhD-negative pregnancies and newborns in Japan by assessing current management practices and outcomes. This study included RhD-negative pregnant women who delivered at 22 weeks or later at 47 Japanese facilities between April 2018 and March 2023. Pregnancies with unknown newborn RhD status were excluded. Data were obtained from medical records. Among the 1088 RhD-negative women, 1062 met the inclusion criteria. RhD-negative pregnancies comprised 0.71% of the total cohort, with 8.7% RhD-negative newborns. Anti-D immunoglobulin was administered in 96.5% of pregnancies, with a maternal spontaneous sensitization rate of 0.6% before 28 weeks and no sensitization detected from 28 weeks to postpartum. Sensitized RhD-negative women had higher cesarean section, preterm delivery, and neonatal hemolytic anemia rates than the non-sensitized group, leading to increased neonatal intensive care unit admissions. Despite the low incidence of RhD-negative pregnancies, this study underscores the need for tailored management strategies, suggesting that non-invasive prenatal diagnosis of fetal RhD status could prevent unnecessary anti-D immunoglobulin administration, improving outcomes and resource utilization in Japan.
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Mirror syndrome and placental ectopic liver in association with de novo SOS1 variant

Tanaka Y., Ikenoue S., Ueno A., Masugi Y., Yamada M., Suzuki H., Otani T., Fukutake M., Kasuga Y., Kosaki K., Tanaka M.

European Journal of Medical Genetics 77 105039 2025.10

ISSN 17697212

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Mirror syndrome is a rare obstetric condition characterized by maternal fluid retention mirroring fetal hydrops. Placental ectopic liver tissue is an extremely rare non-trophoblastic placental tumor, potentially arising from aberrant hepatoblast migration. While its association with fetal hydrops has been reported, the clinical significance remains uncertain. We present a patient of maternal mirror syndrome linked to fetal hydrops due to a de novo SOS1 variant, with histopathological identification of placental ectopic liver tissue. A 32-year-old woman was admitted at 31 weeks’ gestation with fetal hydrops, presenting with bilateral pleural effusions, ascites, and subcutaneous edema. Due to worsening maternal pleural effusion, she was transferred to our hospital at 31 weeks and 6 days. Given progressive maternal and fetal deterioration, an emergency cesarean section was performed at 32 weeks due to concerns regarding maternal mirror syndrome. The female infant was delivered with severe respiratory distress and succumbed at 9 days of age. Trio-based exome sequencing identified a de novo heterozygous SOS1 variant (NM_005633.4:c.512T > A [p.V171G]), confirming a postmortem diagnosis of Noonan syndrome. Histopathological analysis of the placenta revealed ectopic liver tissue within the villi, confirmed by positive immunostaining for hepatocyte markers. A recent report of RIT1-associated mirror syndrome and non-immune hydrops fetalis (NIHF) further supports the role of Rasopathies in the pathogenesis of mirror syndrome. Our findings confirm that mirror syndrome is a potential manifestation of Rasopathies, while the role of ectopic liver tissue in the placenta remains uncertain. Future research should focus on genetic factors underlying mirror syndrome rather than incidental placental anomalies.
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ARID1A gene variants and fetal hydrocephalus: First evidence of mRNA decay escape.

Tanaka Y, Yamada M, Miya F, Otani T, Kasuga Y, Suzuki H, Inagaki N, White SM, Tanaka M, Kosaki K

European journal of medical genetics 105048 2025.09

ISSN 1769-7212
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Perinatal Outcomes of Chronic Abruption Oligohydramnios Sequence: A Multicenter Retrospective Observational Study

Kasuga Y., Fukuma Y., Kajikawa K., Akita K., Tamai J., Tanaka Y., Otani T., Fukutake M., Ikenoue S., Tanaka M.

Journal of Clinical Medicine 14 ( 15 ) 2025.08

ISSN 2077-0383

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Objective: This study aimed to describe the perinatal and neonatal outcomes of chronic abruption oligohydramnios sequence in the Kanto region of Japan. Methods: This survey was conducted at 123 perinatal centers affiliated to this area. Data on the experience of managing chronic abruption oligohydramnios sequence between 1 January 2017, and 31 December 2022, were collected and analyzed. Results: Among the 82 cases of chronic abruption oligohydramnios sequence that were included in this study, there were seven miscarriages, five artificial abortions, and 70 deliveries beyond 22 gestational weeks (singleton: 68; twin: 2). In 82 patients, vaginal bleeding was the initial symptom of chronic abruption oligohydramnios sequence (88%). The mean gestational duration at the initial symptom onset was 17.3 ± 5.0 weeks. Of the 68 singleton pregnancies delivered after 22 gestational weeks, the mean gestational duration at delivery was 25.2 ± 2.8 weeks. In patients with chronic abruption oligohydramnios sequence, the mean white blood cell count at diagnosis and mean of the maximum white blood cell count during pregnancy were 11,589 ± 2885 and 15,357 ± 4745/μL, respectively; and the mean C-reactive protein at diagnosis and mean of the maximum C-reactive protein during pregnancy were 1.0 ± 1.2 and 2.0 ± 2.1 mg/L, respectively. Chorioamnionitis was identified in 43 patients (63%). All neonates were admitted to the neonatal intensive care unit. Of the 68 singleton neonates, 5 died immediately after birth. Conclusions: Chronic abruption oligohydramnios sequence is a rare perinatal complication that is possibly associated with infections, such as chorioamnionitis, and linked to adverse perinatal and neonatal outcomes.
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Association of Cord Blood Metabolic Biomarkers (Leptin, Adiponectin, IGF-1) with Fetal Adiposity Across Gestation †

Tamai J., Ikenoue S., Akita K., Hasegawa K., Otani T., Fukutake M., Kasuga Y., Tanaka M.

International Journal of Molecular Sciences 26 ( 14 ) 2025.07

ISSN 16616596

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Childhood obesity is a substantial health problem worldwide. The origin of obesity (increased adiposity) can be partly traced back to intrauterine life. However, the determinants of fetal fat deposition remain unclear. This study investigated the association between cord blood adipocytokines related to lipid metabolism (leptin, adiponectin, and insulin-like growth factor-1 [IGF-1]) and fetal adiposity during gestation. A prospective study was conducted in a cohort of 94 singleton pregnancies. Fetal ultrasonography was performed at 24, 30, and 36 weeks of gestation. Estimated fetal adiposity (EFA) was calculated by integrating measurements of cross-sectional arm and thigh fat area percentages and anterior abdominal wall thickness. Plasma cytokine levels and C-peptide immunoreactivity (as a proxy for fetal insulin resistance) were evaluated in cord blood samples obtained at delivery. The associations of cord blood leptin, adiponectin and IGF-1 levels with EFA at 24, 30, and 36 weeks were determined by multiple linear regression, adjusted for potential covariates. The multivariate analyses indicated that leptin was significantly correlated with EFA at 30 and 36 weeks. Leptin was also positively correlated with C-peptide immunoreactivity in the umbilical cord. Cord adiponectin levels were not associated with EFA across gestation. Cord IGF-1 levels were significantly correlated with EFA and estimated fetal body weight (EFW) at 36 weeks. In conclusion, cord leptin was associated with EFA at 30 and 36 weeks, and IGF-1 was associated with EFA at 36 and EFW at 36 weeks. In Conclusion, cord leptin was associated with EFA at 30 and 36 weeks, and IGF-1 was associated with EFA and EFW at 36 weeks. Considering the effects of leptin and IGF-1 on fetal insulin resistance and lipid metabolism, increased levels of leptin and IGF-1 are potential plasma biomarkers of increased fetal adiposity, which may predispose to infant obesity and metabolic dysfunction in later life.
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Papers, etc., Registered in KOARA 【 Display / hide 】

日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016

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Reviews, Commentaries, etc. 【 Display / hide 】

妊娠糖尿病におけるオンライン診療の有効性,安全性についての二群無作為化・非盲検並行群間比較試験(TELEGLAM)

青山和樹, 中島裕也, 目黒周, 佐藤泰憲, 後藤励, 飛彈麻里子, 有光威志, 春日義史, 田中守, 伊藤裕, 林香

糖尿病 ((一社)日本糖尿病学会) 68 ( Suppl. ) S - 212 2025.04

ISSN 0021-437X
女性を「診る」　妊娠経過における母体骨密度変化とその変化に影響する因子に関する前方視的検討

春日義史, 荘慎太郎, 田中守

超音波医学 ((公社)日本超音波医学会) 52 ( Suppl. ) S279 - S279 2025.04

ISSN 1346-1176
妊娠中体重減少が周産期予後に与える影響

木村由実子, 春日義史, 秋田啓介, 玉井順子, 福間優花, 田中雄也, 大谷利光, 池ノ上学, 山上亘, 田中守

日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会) 77 ( 臨増 ) S - 619 2025.02

ISSN 0300-9165
当院における卵子提供後妊娠の後方視的検討

石川直嗣, 春日義史, 緒方泰彦, 梶川かおる, 秋田啓介, 玉井順子, 福間優花, 田中雄也, 大谷利光, 池ノ上学, 山上亘, 田中守

日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会) 77 ( 臨増 ) S - 400 2025.02

ISSN 0300-9165
胎児に構造異常を認め人工妊娠中絶あるいは子宮内胎児死亡に至った家系に対する遺伝学的アプローチ

田中雄也, 春日義史, 石川直嗣, 緒方泰彦, 梶川かおる, 秋田啓介, 玉井順子, 福間優花, 大谷利光, 池ノ上学, 山上亘, 田中守

日本産科婦人科学会雑誌 ((公社)日本産科婦人科学会) 77 ( 臨増 ) S - 464 2025.02

ISSN 0300-9165

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

妊娠糖尿病における新生児低血糖予防を目的とした新たな管理法の検討

2025.04

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2029.03

Research grant, Principal investigator
コロナ禍における妊娠糖尿病診断基準変更が周産期予後に与えた影響に関する検討

2025

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2026.03

公益財団法人鈴木万平糖尿病財団, 若手研究者調査研究, Research grant, Principal investigator
The clinical survey of chronic abruption oligohydramnios sequence

2023.04

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2026.03

関東連合産科婦人科学会, Research grant, Principal investigator
The association between maternal glucose status during pregnancy and epigenetic changes in next generation born to mother with gestational diabetes

2023.04

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2026.03

公益財団法人今井精一記念財団, ２０２２年度（第３回）研究助成金, Research grant, Principal investigator
乳製品摂取が妊娠中および産褥期骨密度変化に与える影響

2022.04

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2023.03

一般社団法人　Jミルク, 2022年度「牛乳乳製品健康科学」学術研究, Joint research, No Setting

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Awards 【 Display / hide 】

令和6年度日本周産期・新生児医学会臨床研究Award

2024.06

Type of Award： Award from Japanese society, conference, symposium, etc.
第15回ロート女性健康科学研究賞

2024.04

Type of Award： Award from publisher, newspaper, foundation, etc.
日本糖尿病妊娠学会大森賞

2022.11, 日本糖尿病・妊娠学会

Type of Award： Award from Japanese society, conference, symposium, etc.
優秀演題賞

2022.10, 第9回日本DOHaD学会

Type of Award： Award from Japanese society, conference, symposium, etc.
71st JSOG Congeress Encouragement Award

2019.04, 日本産科婦人科学会

Type of Award： Award from Japanese society, conference, symposium, etc.