Details of a Researcher - Kasuga, Yoshifumi

Kasuga, Yoshifumi

写真a

Affiliation: School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) ( Shinanomachi )

Position: Assistant Professor/Senior Assistant Professor

Scopus Paper Info

Paper Count: 87 Citation Count: 727 h-index: 15

Click to view the Scopus page. The data was downloaded from Scopus API in March 01, 2026, via http://api.elsevier.com and http://www.scopus.com .

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Career 【 Display / hide 】

2007.04

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2009.03

慶應義塾大学病院, 初期臨床研修医
2009.04

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2010.03

慶應義塾大学医学部, 産婦人科
2010.04

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2011.03

川崎市立川崎病院, 産婦人科
2011.04

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2012.03

平塚市民病院, 産婦人科
2012.04

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2017.03

慶應義塾大学医学部, 産婦人科

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Academic Background 【 Display / hide 】

2001.04

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2007.03

Nihon University, 医学部, 医学科

University, Graduated
2013.04

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2017.03

Keio University

Graduate School, Graduated, Doctoral course

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Academic Degrees 【 Display / hide 】

博士（医学）, Keio University, Dissertation, 2017.03

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

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Licenses and Qualifications 【 Display / hide 】

医師免許, 2007
日本産科婦人科学会産婦人科専門医, 2012.10
日本周産期・新生児医学会新生児蘇生法インスタラクターコース, 2013.06
日本超音波医学会超音波専門医, 2017.10
母体保護法指定医, 2017.10

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Research Areas 【 Display / hide 】

Life Science / Obstetrics and gynecology (Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD)

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Research Keywords 【 Display / hide 】

Gestational diabetes, Preterm Birth, Genome / Epigenome, Ultrasound, Pregnancy after radical trachelectomy / conization, DOHaD

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Books 【 Display / hide 】

広汎性子宮頸部摘出術後妊娠の管理

春日義史，宮越敬, 2020.01
妊娠糖尿病の遺伝情報を臨床にどう活かすか

春日義史, 宮越敬, 田嶋敦ほか, 2019.03
広汎性子宮頸部摘出術における予防的子宮頸管縫縮術の必要性は？

春日義史，田中京子，宮越敬ほか, 2018.04
腹式広汎性子宮頸部摘出術後妊娠の周産期管理

春日義史，宮越敬，田中守, 2017.07
婦人科癌の治療と妊孕性

春日義史，宮越敬，田中守, 2017.04

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Papers 【 Display / hide 】

Fetal Growth Outcomes in Early Gestational Diabetes Mellitus Managed Immediately After Diagnosis.

Nakanishi S, Miyakoshi K, Yokoyama M, Kasuga Y, Iwama N, Yamashita H, Aoki S, Yasuhi I, Sugiyama T

The journal of obstetrics and gynaecology research 52 ( 2 ) e70199 2026.02

ISSN 1341-8076
- Access to Document (DOI)
Perinatal outcomes in RhD-negative pregnant women in Japan

Takahashi K., Yoshida S., Aoki S., Tanaka S., Kawashima A., Kajiwara K., Kato N., Matsui H., Serizawa M., Tsuji S., Yamamoto T., Kinjo T., Nakamura N., Sagawa M., Sato M., Abe E., Nakanishi S., Fujimoto Y., Takahashi S., Sasaki H., Mukai Y., Hara S., Fukuta K., Kikuchi N., Hara E., Shiga T., Horiuchi C., Sado T., Matsubara Y., Akabane K., Harada A., Nagase H., Maeda K., Katagiri H., Sasahara J., Sugii H., Tamaru S., Waratani M., Tsukahara S., Shibukawa S., Kiyama T., Kasuga Y., Egawa M., Sato H., Tamamura C., Suemitsu T., Okamoto A., Samura O.

Scientific Reports 15 ( 1 ) 9921 2025.12

　View Summary

Managing RhD-negative pregnancies is vital for preventing hemolytic disease of the fetus and newborn, which occurs when RhD-negative mothers develop anti-D antibodies after exposure to RhD-positive fetal blood. This retrospective cohort study evaluated the proportion of RhD-negative pregnancies and newborns in Japan by assessing current management practices and outcomes. This study included RhD-negative pregnant women who delivered at 22 weeks or later at 47 Japanese facilities between April 2018 and March 2023. Pregnancies with unknown newborn RhD status were excluded. Data were obtained from medical records. Among the 1088 RhD-negative women, 1062 met the inclusion criteria. RhD-negative pregnancies comprised 0.71% of the total cohort, with 8.7% RhD-negative newborns. Anti-D immunoglobulin was administered in 96.5% of pregnancies, with a maternal spontaneous sensitization rate of 0.6% before 28 weeks and no sensitization detected from 28 weeks to postpartum. Sensitized RhD-negative women had higher cesarean section, preterm delivery, and neonatal hemolytic anemia rates than the non-sensitized group, leading to increased neonatal intensive care unit admissions. Despite the low incidence of RhD-negative pregnancies, this study underscores the need for tailored management strategies, suggesting that non-invasive prenatal diagnosis of fetal RhD status could prevent unnecessary anti-D immunoglobulin administration, improving outcomes and resource utilization in Japan.
- Access to Document (DOI)
Oral, Vaginal, and Placental Microbiota Profiles in Japanese Pregnancies with Preterm Birth and Chronic Abruption-Oligohydramnios Sequence (CAOS): A Cross-Sectional Study

Fukuma Y., Kasuga Y., Akita K., Tamai J., Tanaka Y., Hasegawa K., Otani T., Fukutake M., Ikenoue S., Morikawa S., Nakagawa T., Ishihara K., Tanaka M.

Medicina Lithuania 61 ( 12 ) 2025.12

ISSN 1010660X

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Background and Objectives: Preterm birth (PTB) imposes a substantial medical and economic burden on perinatal care. Recent advances in 16S rRNA gene sequencing help detailed microbiota analysis. Understanding microbiota’s contribution may help in understanding PTB pathogenesis. We aim to investigate the microbiota profiles of the oral, vaginal, and placental microbiota in pregnant Japanese women hospitalized for care of preterm labor and examine the association between them and perinatal outcomes. Materials and Methods: This cross-sectional study included 20 pregnant Japanese women admitted to a single perinatal center for preterm labor between 2022 and 2023. Oral, vaginal, and placental samples were collected aseptically during hospitalization. The patients were retrospectively categorized into: term birth (TB, n = 10), chronic abruption-oligohydramnios sequence (CAOS, n = 3), and PTB without CAOS (PTB, n = 7) perinatal outcomes. Microbiota profiles were analyzed using 16S rRNA gene sequencing, and group comparisons were performed using univariate statistical methods. Results: Alpha or beta diversity of the oral and vaginal microbiota among the three groups did not differ significantly. CAOS and PTB groups showed a trend toward altered vaginal microbial composition, but not the TB group. In the placental microbiota, beta diversity differed significantly among the TB, PTB, and CAOS groups. Ureaplasma urealyticum was more abundant in the PTB group, whereas Ureaplasma parvum was more abundant in the CAOS group. Conclusions: A potential shift in the vaginal microbiota and alterations in the placental microbiota, observed in PTB, including CAOS, suggested a possible microbial contribution.
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妊娠中に両側総頸動脈の高度狭窄を伴う高安動脈炎と診断し周産期管理を行った1例

小安公音, 秋田啓介, 池ノ上学, 梶川かおる, 高橋まりな, 田中邦生, 大谷利光, 春日義史, 山上亘, 田中守

関東連合産科婦人科学会誌 ((一社)関東連合産科婦人科学会) 62 ( 4 ) 489 - 494 2025.11

ISSN 2186-0610

　View Summary

【緒言】高安動脈炎は大動脈及びその分枝,肺動脈,冠動脈に炎症性壁肥厚をきたし,血管の狭窄,閉塞または拡張病変をきたす非特異的炎症性疾患である.今回,妊娠成立後に両側総頸動脈の高度狭窄を伴う高安動脈炎と診断し,周産期管理を行った症例を経験したので報告する.【症例】33歳.G4P1.人工授精で妊娠成立し,妊娠7週の妊婦健診で両上肢血圧が測定不能かつ,両側橈骨動脈および上腕動脈の拍動を触知しなかった.左内頸動脈に血管雑音,頸動脈超音波断層法で両側頸動脈に血管壁肥厚を認め,妊娠16週時に高安動脈炎と診断し,妊娠17週時にステロイド及びアスピリンの投与を開始した.ステロイド抵抗性であり,TNFα阻害薬及びアザチオプリンを追加し,速やかに炎症反応は低下した.妊娠36週に前期破水し,胎児機能不全のため緊急帝王切開とした.児は女児,2,100g,Apgar score 8/9点(1/5分値),明らかな外表奇形なく,母児ともに術後経過良好で術後6日目に退院とした.【結語】今回我々は妊娠成立後に高安動脈炎と診断し,周産期管理を行った症例を経験した.診断後早期にステロイド及びアスピリン投与を開始し,ステロイド抵抗性に対してTNFα阻害薬とアザチオプリンを追加投与したことにより,両側総頸動脈の高度狭窄を伴っていたが36週まで妊娠継続を可能とし,母児ともに良好な周産期転機が得られた.(著者抄録)
Intraoperative laparoscopic ultrasound during laparoscopic myomectomy for a degenerating myoma seems beneficial for improving outcomes: A case report

Kasuga Y., Watanabe J., Sakuma M., Tanaka M.

Taiwanese Journal of Obstetrics and Gynecology 64 ( 6 ) 1085 - 1086 2025.11

ISSN 10284559
- Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Vaginal microbiome analysis in pregnancy after childbearing surgery of cervical cancer

Yoshifumi, Kasuga

科学研究費補助金研究成果報告書 2023
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016
日本人女性における妊娠糖尿病関連一塩基多型解析: 症例対照研究

Kasuga, Yoshifumi

(慶應義塾大学大学院医学研究科) 2016

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Reviews, Commentaries, etc. 【 Display / hide 】

ウェアラブルデバイスによる妊娠母体概日リズムの検討

加藤恭介, 木内謙一郎, 春日義史, 池ノ上学, 勝俣良紀, 有光威志, 飛彈麻里子, 吉野純, 満倉靖恵, 伊藤裕, 林香

糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会) 25 ( 3 ) S - 108 2025.10

ISSN 1347-9172
妊娠糖尿病におけるオンライン診療の有効性、安全性についての二群無作為化試験

青山和樹, 中島裕也, 目黒周, 春日義史, 田中守, 伊藤裕, 林香

糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会) 25 ( 3 ) S - 108 2025.10

ISSN 1347-9172
妊娠糖尿病における持続血糖測定の有用性について

梶川かおる, 春日義史, 高橋まりな, 福間優花, 池ノ上学, 田中守

糖尿病と妊娠 ((一社)日本糖尿病・妊娠学会) 25 ( 3 ) S - 111 2025.10

ISSN 1347-9172
DOHaDを含めた妊娠出産に関する講義を聴講し非医療系学部大学生の反応は男女でどのように異なるか

春日義史, 石川直嗣, 緒方泰彦, 梶川かおる, 秋田啓介, 玉井順子, 福間優花, 田中雄也, 大谷利光, 福武麻里絵, 池ノ上学, 田中守

日本周産期・新生児医学会雑誌 ((一社)日本周産期・新生児医学会) 61 ( Suppl.1 ) P401 - P401 2025.06

ISSN 1348-964X
DOHaDの普及と実践-生涯健康を支えるために-　SNSを用いてDOHaDを広める　みんなに知ってもらいたい「どどメシプロジェクト」

春日義史

日本周産期・新生児医学会雑誌 ((一社)日本周産期・新生児医学会) 61 ( Suppl.1 ) P152 - P152 2025.06

ISSN 1348-964X

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

妊娠糖尿病における新生児低血糖予防を目的とした新たな管理法の検討

2025.04

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2029.03

Research grant, Principal investigator
コロナ禍における妊娠糖尿病診断基準変更が周産期予後に与えた影響に関する検討

2025

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2026.03

公益財団法人鈴木万平糖尿病財団, 若手研究者調査研究, Research grant, Principal investigator
The association between maternal glucose status during pregnancy and epigenetic changes in next generation born to mother with gestational diabetes

2023.04

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2026.03

公益財団法人今井精一記念財団, ２０２２年度（第３回）研究助成金, Research grant, Principal investigator
The clinical survey of chronic abruption oligohydramnios sequence

2023.04

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2026.03

関東連合産科婦人科学会, Research grant, Principal investigator
乳製品摂取が妊娠中および産褥期骨密度変化に与える影響

2022.04

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2023.03

一般社団法人　Jミルク, 2022年度「牛乳乳製品健康科学」学術研究, Joint research, No Setting

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Awards 【 Display / hide 】

関東連合教育活動賞銅賞

2025.10

Type of Award： Award from Japanese society, conference, symposium, etc.
令和6年度日本周産期・新生児医学会臨床研究Award

2024.06

Type of Award： Award from Japanese society, conference, symposium, etc.
第15回ロート女性健康科学研究賞

2024.04

Type of Award： Award from publisher, newspaper, foundation, etc.
日本糖尿病妊娠学会大森賞

2022.11, 日本糖尿病・妊娠学会

Type of Award： Award from Japanese society, conference, symposium, etc.
優秀演題賞

2022.10, 第9回日本DOHaD学会

Type of Award： Award from Japanese society, conference, symposium, etc.