研究者詳細 - 内田　明花

内田　明花（ウチダ　サヤカ）

Uchida, Sayaka

写真a

所属（所属キャンパス）: 医学部産婦人科学教室（産科）（信濃町）

職名: 専任講師

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経歴【表示／非表示】

2003年05月

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2003年09月

慶應義塾大学医学部, 産婦人科, 研修医
2003年10月

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2005年04月

慶應義塾大学病院, 産婦人科, 研修医
2005年05月

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2007年03月

慶應義塾大学医学部, 産婦人科学, 助手（専修医）
2005年06月

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2006年05月

一般財団法人神奈川県警友会けいゆう病院, 産婦人科, 医員
2006年06月

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2007年06月

大和市立病院, 産婦人科, 医員

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2003年03月

慶應義塾大学, 医学部

大学, 卒業

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博士（医学）, 慶應義塾大学, 論文, 2014年03月

Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome

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The orientation of a decellularized uterine scaffold determines the tissue topology and architecture of the regenerated uterus in rats

Miki F., Maruyama T., Miyazaki K., Takao T., Yoshimasa Y., Katakura S., Hihara H., Uchida S., Masuda H., Uchida H., Nagai T., Shibata S., Tanaka M.

Biology of Reproduction （Biology of Reproduction） 100 （ 5 ） 1215 - 1227 2019年

ISSN 00063363

　概要を見る

© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction. A decellularized uterine scaffold (DUS) prepared from rats permits recellularization and regeneration of uterine tissues when placed onto a partially excised uterus and supports pregnancy in a fashion comparable to the intact uterus. The underlying extracellular matrix (ECM) together with an acellular, perfusable vascular architecture preserved in DUS is thought to be responsible for appropriate regeneration of the uterus. To investigate this concept, we examined the effect of the orientation of the DUS-preserving ECM and the vascular architecture on uterine regeneration through placement of a DUS onto a partially defective uterine area in the reversed orientation such that the luminal face of the DUS was outside and the serosal face was inside. We characterized the tissue structure and function of the regenerated uterus, comparing the outcome to that when the DUS was placed in the correct orientation. Histological analysis revealed that aberrant structures including ectopic location of glands and an abnormal lining of smooth muscle layers were observed significantly more frequently in the reversed group than in the correct group (70% vs. 30%, P < 0.05). Despite the changes in tissue topology, the uteri regenerated with an incorrectly oriented DUS could achieve pregnancy in a way similar to uteri regenerated with a correctly oriented DUS. These results suggest that DUS-driven ECM orientation determines the regenerated uterus structure. Using DUS in the correct orientation is preferable when clinically applied. The disoriented DUS may deteriorate the tissue topology leading to structural disease of the uterus even though the fertility potential is not immediately affected.
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CD34 and CD49f Double-Positive and Lineage Marker-Negative Cells Isolated from Human Myometrium Exhibit Stem Cell-Like Properties Involved in Pregnancy-Induced Uterine Remodeling

Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T.

Biol Reprod 93 （ 2 ） 37 2015年06月

研究論文（学術雑誌）, 共著, 査読有り
- Access to Document (DOI)
Serum estradiol level during withdrawal bleeding as a predictive factor for intermittent ovarian function in women with primary ovarian insufficiency

Miyazaki K, Miki F, Uchida S, Masuda H, Uchida H, Maruyama T.

Endocr J 62 （ 1 ） 93 - 99 2014年10月

研究論文（学術雑誌）, 共著, 査読有り
- Access to Document (DOI)
Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.

Uchida S.Uchida S, Uchida H, Maruyama T, Kajitani T, Oda H, Miyazaki K, Kagami M, Yoshimura Y.

PLoS One. 8 （ 9 ） e75478 2013年09月

研究論文（学術雑誌）, 査読有り
- Access to Document (DOI)
Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis

Kajitani T, Maruyama T, Asada H, Uchida H, Oda H, Uchida S, Miyazaki K, Arase T, Ono M, Yoshimura Y.

Endocr J 60 （ 10 ） 1155 - 1164 2013年07月

研究論文（学術雑誌）, 共著, 査読有り