Uchida, Sayaka



School of Medicine, Department of Obstetrics and Gynecology (Obstetrics) (Shinanomachi)


Assistant Professor/Senior Assistant Professor

Career 【 Display / hide

  • 2003.05

    慶應義塾大学医学部, 産婦人科, 研修医

  • 2003.10

    慶應義塾大学病院, 産婦人科, 研修医

  • 2005.05

    慶應義塾大学医学部, 産婦人科学, 助手(専修医)

  • 2005.06

    一般財団法人神奈川県警友会 けいゆう病院, 産婦人科, 医員

  • 2006.06

    大和市立病院, 産婦人科, 医員

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Academic Background 【 Display / hide

  • 2003.03

    Keio University, School of Medicine

    University, Graduated

Academic Degrees 【 Display / hide

  • 博士(医学), 慶應義塾大学, Dissertation, 2014.03

    Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome


Papers 【 Display / hide

  • The orientation of a decellularized uterine scaffold determines the tissue topology and architecture of the regenerated uterus in rats

    Miki F., Maruyama T., Miyazaki K., Takao T., Yoshimasa Y., Katakura S., Hihara H., Uchida S., Masuda H., Uchida H., Nagai T., Shibata S., Tanaka M.

    Biology of Reproduction (Biology of Reproduction)  100 ( 5 ) 1215 - 1227 2019

    ISSN  00063363

     View Summary

    © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction. A decellularized uterine scaffold (DUS) prepared from rats permits recellularization and regeneration of uterine tissues when placed onto a partially excised uterus and supports pregnancy in a fashion comparable to the intact uterus. The underlying extracellular matrix (ECM) together with an acellular, perfusable vascular architecture preserved in DUS is thought to be responsible for appropriate regeneration of the uterus. To investigate this concept, we examined the effect of the orientation of the DUS-preserving ECM and the vascular architecture on uterine regeneration through placement of a DUS onto a partially defective uterine area in the reversed orientation such that the luminal face of the DUS was outside and the serosal face was inside. We characterized the tissue structure and function of the regenerated uterus, comparing the outcome to that when the DUS was placed in the correct orientation. Histological analysis revealed that aberrant structures including ectopic location of glands and an abnormal lining of smooth muscle layers were observed significantly more frequently in the reversed group than in the correct group (70% vs. 30%, P < 0.05). Despite the changes in tissue topology, the uteri regenerated with an incorrectly oriented DUS could achieve pregnancy in a way similar to uteri regenerated with a correctly oriented DUS. These results suggest that DUS-driven ECM orientation determines the regenerated uterus structure. Using DUS in the correct orientation is preferable when clinically applied. The disoriented DUS may deteriorate the tissue topology leading to structural disease of the uterus even though the fertility potential is not immediately affected.

  • CD34 and CD49f Double-Positive and Lineage Marker-Negative Cells Isolated from Human Myometrium Exhibit Stem Cell-Like Properties Involved in Pregnancy-Induced Uterine Remodeling

    Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T.

    Biol Reprod 93 ( 2 ) 37 2015.06

    Research paper (scientific journal), Joint Work, Accepted

  • Serum estradiol level during withdrawal bleeding as a predictive factor for intermittent ovarian function in women with primary ovarian insufficiency

    Miyazaki K, Miki F, Uchida S, Masuda H, Uchida H, Maruyama T.

    Endocr J 62 ( 1 ) 93 - 99 2014.10

    Research paper (scientific journal), Joint Work, Accepted

  • Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.

    Uchida S.Uchida S, Uchida H, Maruyama T, Kajitani T, Oda H, Miyazaki K, Kagami M, Yoshimura Y.

    PLoS One. 8 ( 9 ) e75478 2013.09

    Research paper (scientific journal), Accepted

  • Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis

    Kajitani T, Maruyama T, Asada H, Uchida H, Oda H, Uchida S, Miyazaki K, Arase T, Ono M, Yoshimura Y.

    Endocr J 60 ( 10 ) 1155 - 1164 2013.07

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 着床面における子宮内膜細胞局所的細胞死の合目的副次効果の解明


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator


Courses Taught 【 Display / hide











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