Hida, Mariko

写真a

Affiliation

School of Medicine, Department of Pediatrics （Shinanomachi）

Position

Associate Professor
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Papers 【 Display / hide 】

  • Tubular dysfunction in extremely low birth weight survivors

    Matsumura K., Matsuzaki Y., Hida M., Ikeda K., Awazu M.

    Clinical and Experimental Nephrology （Clinical and Experimental Nephrology)  23 （ 3 ） 395 - 401 2019.03

    ISSN  13421751

    　View Summary

    © 2018, Japanese Society of Nephrology. Background: Extremely low birth weight (ELBW) survivors may develop glomerulosclerosis due to low nephron number, whereas their tubular function remains unknown except for hypercalciuria and phosphaturia. Methods: Fifty-three subjects (30 boys and 23 girls, aged 7 months-19 years, median 36 months) were studied retrospectively. The median gestational age and birth weight were 26 weeks (range 22–32) and 745 g (range 316–999), respectively. Urine calcium-to-creatinine ratio (Ca/Cr), N-acetyl-β-d-glucosaminidase-to-creatinine ratio (NAG/Cr), β2 microglobulin-to-creatinine ratio (β2m/Cr), uric acid-to-creatinine ratio (UA/Cr), glucose-to-creatinine ratio (glu/Cr), and microalbumin-to-creatinine ratio (malb/Cr) were examined. We also assessed the association between urine parameters and current age, gestational age, birth weight, and predictors of renal injury. Follow-up data were analyzed in 43 subjects 4–6 years later. Results: Ninety percent of subjects had at least one tubular dysfunction. Frequency of elevated values was NAG/Cr 77.5%, UA/Cr 54.1%, β2m/Cr 38.2%, malb/Cr 30.4%, Ca/Cr 21.5%, and glu/Cr 20.5%. There were significant negative correlations between the current age and Ca/Cr, NAG/Cr, glu/Cr, and UA/Cr, suggesting tubular function maturation. Urine β2M/Cr and glu/Cr were negatively correlated with the gestational age. There were significant associations between elevated glu/Cr and asphyxia or neonatal acute kidney injury, and elevated NAG/Cr and indomethacin use, although these were not confirmed by multivariate analysis. At follow-up, the frequency of elevated NAG/Cr, glu/Cr, UA/Cr, and malb/Cr was reduced but that of elevated Ca/Cr, IgG/Cr, and β2m/Cr remained similar or increased. Conclusion: Tubular dysfunction is common in ELBW survivors. Some abnormalities resolved with age while some remained persistent or even increased.

  • 培養尿細管細胞周期的伸展刺激によるp38MAPキナーゼの活性化

    Fujita Naoyo, Osada Michio, Kanamoto Katsuyoshi, Fukuda Keiichi, Oomori Sayu, Hida Mariko, Awazu Midori

    日本小児腎臓病学会雑誌 16 （ 1 ） 29-33 2003.01

    Research paper (scientific journal), Joint Work

  • 培養尿管芽細胞周期的伸展刺激によるp38 MAPキナーゼの活性化

    Fujita Hisayo, Nagata Michio, Kanemoto Katsuyoshi, Fukuda Keiichi, Oomori Sayu, Hida Mariko, Awazu Midori

    小児腎臓病学会誌 16   29-34 2003

    Research paper (scientific journal), Joint Work

  • MAP kinase in renal development

    Awazu Midori, Omori Sayu, Hida Mariko

    Nephrology dialysis transplantation 17 （ [Suppl9] ） 5-7 2002.09

    Research paper (scientific journal), Joint Work

  • The herbal medicine Sairei　to inhibits proliferation of rat mesangial cells

    Awazu Midori, Fujita Hisayo, Omori Sayu, Hida Mariko

    Nephron 92 （ 3 ） 652-659 2002.07

    Research paper (scientific journal), Joint Work

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 妊娠前から出産後まで継続的に関わりをもった思春期妊娠の1症例

    Sekiguchi Shinichirou, Hida Mariko, Watanabe Hisako, Takahashi Takao

    第507回日本小児科学会東京都地方会講話会, 

    2002.12
    , 

    Oral presentation (general)

  • Cyclic stretch stimulates proliferation and Pax2 expression via p38 mitogen-activated protein kinase in a ureteric bud cell line

    Fujita Hisayo, Nagata Michio, Kanemoto Katsuyoshi, Fukuda Keiichi, Omori Sayu, Hida Mariko, Awazu Midori

    Annual Meeting, 

    2002.11
    , 

    Poster presentation

  • Gene expression profiling in rat model of tubulointerstitial fibrosis

    Awazu Midori, Fujita Hisayo, Hida Mariko, Omori Sayu

    Annual Meeting, 

    2002.11
    , 

    Poster presentation

  • Expression and role of RhoA/ROCK in renal development

    Hida Mariko, Fujita Hisayo, Omori Sayu, Awazu Midori

    Annual Meeting, 

    2002.11
    , 

    Poster presentation

  • Expression of mitogen-activated protein kinases in obstructed uropathy in fetal lambs

    Omori Sayu, Kitagawa Hiroaki, Koike Junki, Fujita Hisayo, Hida Mariko, Pringle Kevin C, Awazu Midori

    American Society of Nephrology, 

    2002.11
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Analysis of the role of HIF in early termination of nephrogenesis due to prematurity and development of treatment.

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Courses Taught 【 Display / hide 】

  • NURSE-MIDWIFERY PRACTICUM

    2024

  • MIDWIFERY CARE2(HIGH RISK MATERNITY CARE)

    2024

  • LECTURE SERIES, PEDIATRICS

    2024

  • CLINICAL ENGINEERING AND SAFETY CONTROL IN HEALTH CARE

    2024

  • NURSE-MIDWIFERY PRACTICUM

    2023

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