Hasegawa, Tomonobu

写真a

Affiliation

School of Medicine (Mita)

Position

Professor Emeritus

External Links

Career 【 Display / hide

  • 1984.05
    -
    1986.04

    慶應義塾大学医学部, 研修医(小児科)

  • 1986.05
    -
    1990.04

    慶應義塾大学医学部, 助手(専修医)(小児科学)

  • 1986.08
    -
    1995.08

    都立清瀬小児病院

  • 1990.05
    -
    1994.04

    慶應義塾大学医学部, 助手(小児科学)

  • 1992.01
    -
    1992.07

    スタンフォード大学, 小児内分泌科

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Academic Background 【 Display / hide

  • 1978.03

    東京学芸大学附属高等学校

    Graduated

  • 1978.04
    -
    1984.03

    Hirosaki University, 医学部

    University, Graduated

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, 1992.02

Licenses and Qualifications 【 Display / hide

  • 医師免許, 1984.06

  • 日本小児科学会認定医, 1990.06

  • 日本人類遺伝学会臨床遺伝学認定医, 1994.10

  • 日本人類遺伝学会臨床細胞遺伝学認定士, 1996.04

  • 日本人類遺伝学会臨床遺伝学指導医, 1996.10

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Research Areas 【 Display / hide

  • Life Science / Embryonic medicine and pediatrics (小児内分泌学、臨床遺伝学)

Research Keywords 【 Display / hide

  • 小児、内分泌、遺伝子、auxology

Research Themes 【 Display / hide

  • 小児内分泌代謝疾患の臨床遺伝学的研究, 

    2000.08
    -
    Present

  • 臨床Auxology, 

    2000.08
    -
    Present

  • 先天性骨系統疾患の分子病態解明, 

    2000.08
    -
    Present

  • 先天性内分泌疾患の分子病態解明, 

    2000.08
    -
    Present

 

Books 【 Display / hide

  • 最新主要文献とガイドラインでみる小児科学レビュー

    長谷川奉延, 加藤元博監修, 総合医学社, 2024.08

  • 最新主要文献とガイドラインでみる小児科学レビュー

    長谷川奉延監修 ; 加藤元博監修, 総合医学社, 2023.08,  Page: 268

  • からだの性 = sex characteristics

    長谷川, 奉延, 佐々木, 掌子, 国土社, 2022.06

    Contact page: p40-43

  • ターナー症候群の0.35mg/kg/週による成長ホルモン治療後の成人身長―TRC共同研究― 

    田中敏章、神崎晋、田島敏広、田中弘之、西美知、長谷川奉延、堀川玲子、横谷進、依藤亨, 日本成長学会雑誌, 2018

    Scope: 24(2) 64-69

  • 内分泌代謝専門医ガイドブック 改訂第4版 

    HASEGAWA TOMONOBU, 診断と治療社, 2016.04

    Scope: 低身長

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Papers 【 Display / hide

  • DHX37 Variant Is One of the Common Genetic Causes in Japanese Patients with Testicular Regression Syndrome/Partial Gonadal Dysgenesis without Müllerian Derivatives

    Shimura K., Ichihashi Y., Nakano S., Sato T., Hamajima T., Numasawa K., Narumi S., Hasegawa T., Ishii T.

    Hormone Research in Paediatrics 98 ( 2 ) 206 - 213 2025.04

    ISSN  16632818

     View Summary

    Introduction: The testicular regression syndrome (TRS) is a form of differences of sex development (DSD) in which the testes differentiate and function during early embryonic development, but subsequently regress. The clinical phenotype of TRS often overlaps with that of partial gonadal dysgenesis (PGD). Previous studies have demonstrated a causal association between TRS/ PGD and heterozygous missense variants of DHX37. Methods: We enrolled 11 Japanese 46,XY individuals (from 10 families) with TRS/PGD who exhibited undetected or hypoplastic testes, Müllerian duct regression, and low serum testosterone or anti- Müllerian hormone levels. The subjects underwent targeted sequencing of 36 known causative genes for DSD, PCR-based Sanger sequencing of DHX37, or whole-exome sequencing. Results: Previously described pathogenic variants or novel nonsense variants (SRY, NR5A1, and DMRT1) were observed in four out of 10 families. Additionally, we identified two heterozygous rare variants of DHX37 in four families: a previously reported pathogenic variant (c.923G>A, p.Arg308Gln) in three and a novel likely pathogenic variant (c.1882A>C, p.Thr628Pro) in one. The external genitalia of patients with the DHX37 variants varied from female-type to male-type without micropenis. Eighty percent of Japanese patients with TRS/PGD had monogenic disorders including DHX37 variant being the most commonly identified (40%). The external or internal genital phenotype of TRS/PGD overlaps between DHX37 variant carriers and others. Conclusions: DHX37 variant is one of the common genetic causes in Japanese patients with TRS/PGD without Müllerian derivatives. Genetic test is helpful in detecting DHX37- related TRS/PGD because of the phenotypic diversity of the external genitalia in this disorder.

  • Reference Values of Arm Span and Arm Span to Height Ratio of Japanese Population in Childhood and Adolescence: Comparison With Dutch and Turkish Population

    Hirano Y., Inokuchi M., Narumi S., Hasegawa T.

    American Journal of Human Biology 37 ( 4 )  2025.04

    ISSN  10420533

     View Summary

    Objectives: To establish age-specific reference values for the arm span and arm span/height ratio of the Japanese population in children and adolescence and elucidate their characteristics compared with those of other populations. Study Design: We analyzed data from a national survey on the body sizes of Japanese people conducted between 1992 and 1994 by the Research Institute of Human Engineering for Quality Life. This study was an observational cross-sectional study, including 6089 boys and 4970 girls aged between 5.5 and 18.5 years. We constructed the reference values and delineated the reference curves for the arm span and arm span/height ratio of the Japanese population in childhood and adolescence using the LMS method. The references were compared with those of the Dutch and Turkish populations using the reference curve of 0 standard deviation. Results: The arm span of the Japanese population increased throughout childhood, with a particularly large increase at the age of puberty. The arm span/height ratio also increased slowly throughout childhood. The Japanese population had a smaller arm span/height ratio than the Dutch and Turkish populations of all ages in childhood and adolescence. Moreover, the arm span/height ratio of the Japanese population reached a constant value at an earlier age than in the Dutch and Turkish populations. Conclusions: We constructed the first reference values for the arm span of Japanese children and adolescents. The Japanese population has shorter arm lengths in relation to their height, and their arm span/height ratio reaches a constant value at an earlier age, compared with the Dutch and Turkish populations.

  • Sex education to an adolescent male with Down syndrome in a single-mother family in Japan

    Saito A., Sato T., Shima H., Yamagishi H., Narumi S., Ishii T., Hasegawa T.

    Pediatrics International 67 ( 1 )  2025.01

    ISSN  13288067

  • ACVRL1 and MTHFR double variants in an adolescent with paradoxical cerebral embolism

    Sato T., Ichihashi Y., Tsuruta H., Chu P.S., Akiyama T., Hishida T., Hasegawa T.

    Pediatrics International 67 ( 1 )  2025.01

    ISSN  13288067

  • Recovery from Atrophic Autoimmune Thyroiditis in a Child: Thyroid Stimulation-Blocking Antibody as a Prognostic Marker

    Kusano C., Hori N., Hasegawa T., Narumi S.

    Hormone Research in Paediatrics  2025

    ISSN  16632818

     View Summary

    Introduction: Atrophic autoimmune thyroiditis (AAT) is a form of autoimmune hypothyroidism characterized by the absence of a goiter. Thyroid stimulation-blocking antibody (TSBAb) has been detected in a subset of pediatric AAT cases. Although the disappearance of TSBAb has been related with the recovery of thyroid function in adult AAT cases, similar outcomes have not been documented in pediatric cases. Case Presentation: A 2-year-old Japanese boy presented for evaluation of stunted growth from1 year 10 months of age. Tests for congenital hypothyroidism were negative on newborn screening, and he had no significant medical history. However, he showed symptoms of hypothyroidism (inactiveness, hair loss, dry skin), and primary hypothyroidism was confirmed by blood test (serum TSH level, 818 mU/L; serum free T4 level, <0.40 ng/ dL). The patient exhibited a unique antibody profile: positive for TSH receptor antibody (TRAb) and TSBAb and negative for anti-thyroglobulin antibody (TgAb) and antiperoxidase antibody (TPOAb). He was treated with levothyroxine, after which his growth was normalized. During the 8-year follow-up, the patient's TSBAb levels decreased, allowing for the discontinuation of levothyroxine therapy. Conclusion: We reported the case of a 2-year-old boy diagnosed with AAT who presented with a characteristic antibody profile, negative for TgAb and TPOAb, but positive for TRAb and TSBAb. During 8 years of follow-up, TSBAb seroconversion to negative was observed, leading to treatment discontinuation at age 10 years. This case suggests that monitoring of TSBAb after a diagnosis of AAT may be used to determine treatment discontinuation even in children.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

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Presentations 【 Display / hide

  • フロントラインの先生方にぜひご理解いただきたい医療安全”超”入門 

    長谷川 奉延

    第109回日本泌尿器科学会総会 卒後教育プログラム , 

    2021.12

    Oral presentation (invited, special)

  • 総排泄腔遺残症術後遠隔期における腟形成術と当院DSDセンターの取り組み

    加藤源俊、城崎浩、山岸徳子、工藤裕実、梅山知成、金森洋樹、鈴木悠史、高橋信博、内田明花、小林佑介、山田洋平、石井智弘、浅沼宏、長谷川奉延、黒田達夫

    第77回直腸肛門奇形研究会, 

    2021.10

    Oral presentation (general)

  • 副腎低形成症の新たな遺伝的病因の同定:ZNRF3遺伝子のエクソン2欠失

    天野直子、鳴海覚志、会津克哉、宮澤真理、勝又規行、石井智弘、長谷川奉延

    第54回日本小児内分泌学会学術集会, 

    2021.10

    Other

  • 完全型アンドロゲン不応症の診断後に鼠経ヘルニアを呈した一例:診断時の遺伝カウンセリングのピットフォール

    君塚優、佐藤武志、中野さつき、加藤源俊、市橋洋輔、浅沼宏、石井智弘、黒田達夫、長谷川奉延。

    第22回日本内分泌学会関東甲信越支部学術集会, 

    2021.09

    Oral presentation (general)

  • 電気化学発光免疫測定法(ECLIA)によりエストラジオール(E2)偽高値を呈した早発乳房の一例

    古澤恭平、蜂屋瑠見、柴田浩憲、内田登、石井智弘、長谷川奉延、佐々木悟郎、福島裕之

    第220回日本小児科学会千葉地方会, 

    2021.09

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 遺伝子改変マウスを用いたMIRAGE症候群における副腎機能低下症の病態解明

    2021.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • MIRAGE症候群: ゲノム編集による疾患モデルマウスの作成と病態解明

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 副腎ホルモン産生異常に関する調査研究

    2017.04
    -
    2020.03

    厚生労働省, 厚生労働省難治性疾患政策研究事業, Principal investigator

  • Model cell-line and model animals of MIRAGE syndrome

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • StARノックアウトマウスによるリポイド副腎過形成と神経ステロイドホルモンの解析

    2003.04
    -
    2005.03

    Grant-in-Aid for Scientific Research, Research grant, No Setting

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Awards 【 Display / hide

  • 平成29年度慶應義塾大学医学部 第13回 Best Teacher Award

    2018

  • 平成28年度慶應義塾大学医学部 第12回 Best Teacher Award

    2017

  • 平成27年度慶應義塾大学医学部 第11回 Best Teacher Award

    2016

  • 平成26年度慶應義塾大学医学部 第10回Best Teacher Award

    2015

  • 平成25年度慶應義塾大学医学部 第9回Best Teacher Award

    2014

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Other 【 Display / hide

  •  View Details

    慶應義塾大学医療安全管理部長

  •  View Details

    慶應義塾大学医療安全対策センター長

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    慶應義塾大学病院医療安全管理責任者

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    難病指定医

  •  View Details

    日本内分泌学会内分泌代謝科指導医(小児科)

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Courses Taught 【 Display / hide

  • LECTURE SERIES, PEDIATRICS

    2025

  • CLINICAL CLERKSHIP IN PEDIATRICS

    2025

  • BIOCHEMISTRY

    2025

  • ADVANCED CLINICAL CLERKSHIP IN PEDIATRICS

    2025

  • SYMPTOMATOLOGY

    2024

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Courses Previously Taught 【 Display / hide

  • 小児科学系統講義4コマ

    Keio University

    2019.04
    -
    2020.03

  • 大学院特別講義1コマ

    Keio University

    2015.04
    -
    2016.03

  • 旧総括講義1コマ

    Keio University

    2015.04
    -
    2016.03

  • 診断学実習2コマ

    Keio University

    2015.04
    -
    2016.03

  • 総合臨床医学2コマ

    Keio University

    2015.04
    -
    2016.03

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Social Activities 【 Display / hide

  • the International IGF Research Society

     

Memberships in Academic Societies 【 Display / hide

  • 日本生殖分泌学会, 

    2004.04
    -
    Present
  • 日本内分泌学会, 

    2004.04
    -
    Present
  • 日本人類遺伝学会, 

    2004.01
    -
    Present
  • 日本小児遺伝学会, 

    2003.04
    -
    Present
  • 日本先天代謝異常学会, 

    2003.04
    -
    Present

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Committee Experiences 【 Display / hide

  • 2019.04
    -
    Present

    理事, 日本内分泌学会

  • 2019.04
    -
    Present

    理事, 日本内分泌学会

  • 2018.04
    -
    Present

    理事, 日本ステロイドホルモン学会

  • 2018.04
    -
    Present

    理事, 日本ステロイドホルモン学会

  • 2017.10
    -
    Present

    副理事長, 日本小児内分泌学会

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