貴志　和生 （キシ　カズオ）

Kishi, Kazuo

写真a

所属（所属キャンパス）

医学部 形成外科学教室 （信濃町）

職名

教授

外部リンク
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    慶應義塾大学

    大学

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  • 日本形成外科学会専門医

  • 医師免許

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  • ライフサイエンス / 形成外科学

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  • 皮膚再生

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  • Influence of Flap Thickness on Nipple Projection After Nipple Reconstruction Using a Modified Star Flap

    貴志 和生

    AESTHETIC PLASTIC SURGERY 42 （ 4 ） 964 - 970 2018年08月

    研究論文（学術雑誌）,  ISSN  0364-216X

  • Surgical Simulation and Custom-Made Implant for Cranial Fibrous Dysplasia

    Sakamoto Yoshiaki, Miwa Tomoru, Yoshida Kazunari, Kishi Kazuo

    Journal of Craniofacial Surgery 29 （ 5 ） 1352 - 1353 2018年07月

    ISSN  1049-2275

    　概要を見る

    <p>Background: The management of fronto-orbital fibrous dysplasia involves total excision of the dysplastic bone and bone reconstruction using implants. Custom-made implants are used to achieve good contouring. However, the remnant defect after excising the lesion often does not match the implant. Methods: To design the craniotomy line, a template was prepared by preoperative computed surgical simulation. The template was overlaid on the preoperative cranium, such that its inner surface fits exactly with the cranial surface. After excising the lesion by performing osteotomy, the implant was placed in the defect and fixed. Both template and implant were made of hydroxyapatite. Results: The authors treated 4 patients, with fibrous dysplasia involving the fronto-facial region by using the template. Intraoperative trimming of the implant or bone defect was not required in 2 patients, while the third patient required mild trimming. They did not have any complications and obtained good contouring. Conclusion: The hydroxyapatite templates reduced the surgical time by determining the precise craniotomy line preoperatively, thus avoiding needless trimming of the implant and bone defect. Therefore, they can enhance the efficacy of treatment for fronto-orbital fibrous dysplasia lesion.</p>

  • A simple calculation for the preoperative estimation of transverse rectus abdominis myocutaneous free flap volume in 2-stage breast reconstruction using a tissue expander

    Kono Hikaru, Ishii Naohiro, Takayama Masayoshi, Takemaru Masashi, Kishi Kazuo

    Archives of Plastic Surgery 45 （ 4 ） 333 - 339 2018年07月

    ISSN  2234-6163

    　概要を見る

    <p>Background Flap volume is an important factor for obtaining satisfactory symmetry in breast reconstruction with a transverse rectus abdominis myocutaneous (TRAM) free flap. We aimed to develop an easy and simple method to estimate flap volume. Methods We performed a preoperative estimation of the TRAM flap volume in five patients with breast cancer who underwent 2-stage breast reconstruction following an immediate tissue expander operation after a simple mastectomy. We measured the height and width of each flap zone using a ruler and measured the tissue thickness by ultrasound. The volume of each zone, approximated as a triangular or square prism, was then calculated. The zone volumes were summed to obtain the total calculated volume of the TRAM flap. We then determined the width of zone II, so that the calculated flap volume was equal to the required flap volume (1.2×1.05× the weight of the resected mastectomy tissue). The TRAM flap was transferred vertically so that zone III was located on the upper side, and zone II was trimmed in the sitting position after vascular anastomosis. We compared the estimated flap width of zone II (=X) with the actual flap width of zone II. Results X was similar to the actual measured width. Accurate volume replacement with the TRAM flap resulted in good symmetry in all cases. Conclusions The volume of a free TRAM flap can be straightforwardly estimated preopera-tively using the method presented here, with ultrasound, ruler, and simple calculations, and this technique may help reduced the time required for precise flap tailoring.</p>

  • Influence of backscatter radiation on cranial bone fixation devices

    Sakamoto Yoshiaki, Koike Naoyoshi, Takei Hideyuki, Ohno Mari, Shigematsu Naoyuki, Kishi Kazuo

    Journal of Craniofacial Surgery 29 （ 4 ） 1094 - 1096 2018年06月

    ISSN  1049-2275

    　概要を見る

    <p>Postoperative radiation can cause ulcer formation, leading to the denudation of skin over alloplastic materials. The influence of backscatter radiation from fixation devices has not been investigated. The aim of this study is to evaluate backscatter dose variations for different cranial bone fixation devices in an experimental model designed to simulate postoperative radiotherapy. The authors assessed the radiation backscatter doses associated with resorbable (PLLA-PGA) and titanium plates. The samples were irradiated with 6 and 10 MV photon beams from a linear accelerator. Measurements were obtained using an ionization chamber and radiochromic films cut from the same batch. As a result, the backscatter radiation of water and PLLA-PGA proportionally decreased as the depth increased. However, the backscatter radiation of the titanium plate increased just above the plate. This depth lies in the region of the scalp. Each material showed a dose of radioactivity that was higher at 10 MV than that at 6 MV. These devices showed a significant difference, which suggested that these materials amplified the dose compared with water at 6 MV. In conclusion, it is supposed that PLLA-PGA should be used to fix the cranium to decrease the potential for radiation ulcers.</p>

  • Influence of Flap Thickness on Nipple Projection After Nipple Reconstruction Using a Modified Star Flap

    Ishii Naohiro, Ando Jiro, Harao Michiko, Takemae Masaru, Kishi Kazuo

    Aesthetic Plastic Surgery    1 - 7 2018年05月

    ISSN  0364-216X

    　概要を見る

    <p>Background: In nipple reconstruction, the width, length, and thickness of modified star flaps are concerns for long-term reconstructed nipple projection. However, the flap’s projection has not been analyzed, based on its thickness. The aim of the present study was to investigate how flap thickness in a modified star flap influences the resulting reconstructed nipple and achieves an appropriate flap width in design. Methods: Sixty-three patients who underwent nipple reconstruction using a modified star flap following implant-based breast reconstruction between August 2014 and July 2016 were included in this case-controlled study. The length of laterally diverging flaps was 1.5 times their width. The thickness of each flap was measured using ultrasonography, and the average thickness was defined as the flap thickness. We investigated the correlation between the resulting reconstructed nipple and flap thickness, and the difference of the change in the reconstructed nipple projection after using a thin or thick flap. Results: The average flap thickness was 3.8 ± 1.7 (range 2.5–6.0) mm. There was a significant, linear correlation between the flap thickness and resulting reconstructed nipple projection (β = 0.853, p &lt; 0.01). Furthermore, the difference between the thin and thick flaps in the resulting reconstructed nipple projection was significant (p &lt; 0.01). Conclusion: Measuring the flap thickness preoperatively may allow surgeons to achieve an appropriate flap width; otherwise, alternative methods for higher projection might be used. Level of Evidence IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.</p>

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研究発表 【 表示 ／ 非表示 】

  • C2C12 differentiate in three dimensional collagen gel

    Tanaka Takara, Kishi Kazuo, Satoh Hiroko, Nakajima Hideo, Nakajima Tatsuo

    International Tissue Engineering Society, 

    2002年12月
    , 

    口頭発表（一般）

  • Endothelial lumen formed in type I collagen gel actually incorporate blood in them

    Satoh Hiroko, Kishi Kazuo, Nakajima Tatsuo

    International Tissue Engineering Society, 

    2002年12月
    , 

    口頭発表（一般）

  • Co-culture system of skeletal muscle cells, endothelial cells, and anterior horn cells in collagen gel

    Kishi Kazuo, Satoh Hiroko, Tanaka Takara, Nakajima Hideo, Nakajima Tatsuo

    International Tissue Engineering Society, 

    2002年12月
    , 

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  • 3次元培養下C2C12の動態の変化#UR

    田中宝，貴志和生，佐藤博子，中嶋英雄，中島龍夫

    第11回日本形成外科学会基礎学術集会, 

    2002年10月
    , 

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  • メラノサイトと母斑細胞のE-cadherin　発現の差異

    松田就人，貴志和生，中島龍夫

    第11回日本形成外科学会基礎学術集会, 

    2002年10月
    , 

    口頭発表（一般）

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  • SASP 細胞除去によるヒト皮膚若返り

    2022年06月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 貴志 和生, 挑戦的研究（萌芽）, 補助金,  研究代表者

  • シングルセル解析を用いたマウス胎仔皮膚再生メカニズムの解明

    2022年04月
    -
    2025年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 貴志 和生, 基盤研究(B), 補助金,  研究代表者

  • コンディショナルノックアウトマウスを用いたマウス胎仔皮膚再生メカニズムの解析

    2019年04月
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    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 貴志　和生, 基盤研究（Ｂ）, 補助金,  研究代表者

  • 遺伝子改変マウスを用いたマウス胎仔皮膚再生の解明

    2016年04月
    -
    2019年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 貴志　和生, 基盤研究(B), 補助金,  研究代表者

  • 線維芽細胞の未分化性獲得の際のエピジェネティックス変化

    2015年04月
    -
    2017年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 貴志　和生, 挑戦的萌芽研究, 補助金,  研究代表者

    　研究概要を見る

    本研究では、線維芽細胞を用いて、２次元培養および非接着培養による細胞凝集塊を行い、２者の接着・非接着以外の条件を限りなく合わせた上で、２者のDNAメチル化の比較を、網羅的に検討した。その結果、２次元接着培養で３次元培養に比較して増強しているmRNAプロモーター領域が、数多く確認できた。細胞凝集塊形成による未分化能獲得はエピジェネティックな変化によるものである可能性が考えられた。

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  • 形成外科学演習

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