Kishi, Kazuo

写真a

Affiliation

School of Medicine, Department of Plastic and Reconstructive Surgery （Shinanomachi）

Position

Professor

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Academic Background 【 Display / hide 】

  • 　

    Keio University

    University

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Licenses and Qualifications 【 Display / hide 】

  • 日本形成外科学会専門医

  • 医師免許

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Research Areas 【 Display / hide 】

  • Life Science / Plastic and reconstructive surgery

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Research Keywords 【 Display / hide 】

  • 皮膚再生

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Papers 【 Display / hide 】

  • Influence of Flap Thickness on Nipple Projection After Nipple Reconstruction Using a Modified Star Flap

    Ishii, Naohiro, Ando, Jiro, Harao, Michiko, Takemae, Masaru, Kishi, Kazuo

    AESTHETIC PLASTIC SURGERY 42 （ 4 ） 964 - 970 2018.08

    Research paper (scientific journal),  ISSN  0364-216X

  • Surgical Simulation and Custom-Made Implant for Cranial Fibrous Dysplasia

    Sakamoto Yoshiaki, Miwa Tomoru, Yoshida Kazunari, Kishi Kazuo

    Journal of Craniofacial Surgery 29 （ 5 ） 1352 - 1353 2018.07

    ISSN  1049-2275

    　View Summary

    <p>Background: The management of fronto-orbital fibrous dysplasia involves total excision of the dysplastic bone and bone reconstruction using implants. Custom-made implants are used to achieve good contouring. However, the remnant defect after excising the lesion often does not match the implant. Methods: To design the craniotomy line, a template was prepared by preoperative computed surgical simulation. The template was overlaid on the preoperative cranium, such that its inner surface fits exactly with the cranial surface. After excising the lesion by performing osteotomy, the implant was placed in the defect and fixed. Both template and implant were made of hydroxyapatite. Results: The authors treated 4 patients, with fibrous dysplasia involving the fronto-facial region by using the template. Intraoperative trimming of the implant or bone defect was not required in 2 patients, while the third patient required mild trimming. They did not have any complications and obtained good contouring. Conclusion: The hydroxyapatite templates reduced the surgical time by determining the precise craniotomy line preoperatively, thus avoiding needless trimming of the implant and bone defect. Therefore, they can enhance the efficacy of treatment for fronto-orbital fibrous dysplasia lesion.</p>

  • A simple calculation for the preoperative estimation of transverse rectus abdominis myocutaneous free flap volume in 2-stage breast reconstruction using a tissue expander

    Kono Hikaru, Ishii Naohiro, Takayama Masayoshi, Takemaru Masashi, Kishi Kazuo

    Archives of Plastic Surgery 45 （ 4 ） 333 - 339 2018.07

    ISSN  2234-6163

    　View Summary

    <p>Background Flap volume is an important factor for obtaining satisfactory symmetry in breast reconstruction with a transverse rectus abdominis myocutaneous (TRAM) free flap. We aimed to develop an easy and simple method to estimate flap volume. Methods We performed a preoperative estimation of the TRAM flap volume in five patients with breast cancer who underwent 2-stage breast reconstruction following an immediate tissue expander operation after a simple mastectomy. We measured the height and width of each flap zone using a ruler and measured the tissue thickness by ultrasound. The volume of each zone, approximated as a triangular or square prism, was then calculated. The zone volumes were summed to obtain the total calculated volume of the TRAM flap. We then determined the width of zone II, so that the calculated flap volume was equal to the required flap volume (1.2×1.05× the weight of the resected mastectomy tissue). The TRAM flap was transferred vertically so that zone III was located on the upper side, and zone II was trimmed in the sitting position after vascular anastomosis. We compared the estimated flap width of zone II (=X) with the actual flap width of zone II. Results X was similar to the actual measured width. Accurate volume replacement with the TRAM flap resulted in good symmetry in all cases. Conclusions The volume of a free TRAM flap can be straightforwardly estimated preopera-tively using the method presented here, with ultrasound, ruler, and simple calculations, and this technique may help reduced the time required for precise flap tailoring.</p>

  • Influence of backscatter radiation on cranial bone fixation devices

    Sakamoto Yoshiaki, Koike Naoyoshi, Takei Hideyuki, Ohno Mari, Shigematsu Naoyuki, Kishi Kazuo

    Journal of Craniofacial Surgery 29 （ 4 ） 1094 - 1096 2018.06

    ISSN  1049-2275

    　View Summary

    <p>Postoperative radiation can cause ulcer formation, leading to the denudation of skin over alloplastic materials. The influence of backscatter radiation from fixation devices has not been investigated. The aim of this study is to evaluate backscatter dose variations for different cranial bone fixation devices in an experimental model designed to simulate postoperative radiotherapy. The authors assessed the radiation backscatter doses associated with resorbable (PLLA-PGA) and titanium plates. The samples were irradiated with 6 and 10 MV photon beams from a linear accelerator. Measurements were obtained using an ionization chamber and radiochromic films cut from the same batch. As a result, the backscatter radiation of water and PLLA-PGA proportionally decreased as the depth increased. However, the backscatter radiation of the titanium plate increased just above the plate. This depth lies in the region of the scalp. Each material showed a dose of radioactivity that was higher at 10 MV than that at 6 MV. These devices showed a significant difference, which suggested that these materials amplified the dose compared with water at 6 MV. In conclusion, it is supposed that PLLA-PGA should be used to fix the cranium to decrease the potential for radiation ulcers.</p>

  • Influence of Flap Thickness on Nipple Projection After Nipple Reconstruction Using a Modified Star Flap

    Ishii Naohiro, Ando Jiro, Harao Michiko, Takemae Masaru, Kishi Kazuo

    Aesthetic Plastic Surgery    1 - 7 2018.05

    ISSN  0364-216X

    　View Summary

    <p>Background: In nipple reconstruction, the width, length, and thickness of modified star flaps are concerns for long-term reconstructed nipple projection. However, the flap’s projection has not been analyzed, based on its thickness. The aim of the present study was to investigate how flap thickness in a modified star flap influences the resulting reconstructed nipple and achieves an appropriate flap width in design. Methods: Sixty-three patients who underwent nipple reconstruction using a modified star flap following implant-based breast reconstruction between August 2014 and July 2016 were included in this case-controlled study. The length of laterally diverging flaps was 1.5 times their width. The thickness of each flap was measured using ultrasonography, and the average thickness was defined as the flap thickness. We investigated the correlation between the resulting reconstructed nipple and flap thickness, and the difference of the change in the reconstructed nipple projection after using a thin or thick flap. Results: The average flap thickness was 3.8 ± 1.7 (range 2.5–6.0) mm. There was a significant, linear correlation between the flap thickness and resulting reconstructed nipple projection (β = 0.853, p &lt; 0.01). Furthermore, the difference between the thin and thick flaps in the resulting reconstructed nipple projection was significant (p &lt; 0.01). Conclusion: Measuring the flap thickness preoperatively may allow surgeons to achieve an appropriate flap width; otherwise, alternative methods for higher projection might be used. Level of Evidence IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.</p>

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Presentations 【 Display / hide 】

  • C2C12 differentiate in three dimensional collagen gel

    Tanaka Takara, Kishi Kazuo, Satoh Hiroko, Nakajima Hideo, Nakajima Tatsuo

    International Tissue Engineering Society, 

    2002.12
    , 

    Oral presentation (general)

  • Endothelial lumen formed in type I collagen gel actually incorporate blood in them

    Satoh Hiroko, Kishi Kazuo, Nakajima Tatsuo

    International Tissue Engineering Society, 

    2002.12
    , 

    Oral presentation (general)

  • Co-culture system of skeletal muscle cells, endothelial cells, and anterior horn cells in collagen gel

    Kishi Kazuo, Satoh Hiroko, Tanaka Takara, Nakajima Hideo, Nakajima Tatsuo

    International Tissue Engineering Society, 

    2002.12
    , 

    Oral presentation (general)

  • 3次元培養下C2C12の動態の変化#UR

    Tanaka Takara, Kishi Kazuo,

    第11回日本形成外科学会基礎学術集会, 

    2002.10
    , 

    Oral presentation (general)

  • メラノサイトと母斑細胞のE-cadherin　発現の差異

    Matsuda Naruhito, Kishi Kazuo, Nakajima Tatsuo

    第11回日本形成外科学会基礎学術集会, 

    2002.10
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • SASP 細胞除去によるヒト皮膚若返り

    2022.06
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 挑戦的研究（萌芽）, Principal investigator

  • シングルセル解析を用いたマウス胎仔皮膚再生メカニズムの解明

    2022.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(B), Principal investigator

  • コンディショナルノックアウトマウスを用いたマウス胎仔皮膚再生メカニズムの解析

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Mechanism of fetal skin regeneration

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Epigenetic change when fibroblasts become undifferenciated

    2015.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Principal investigator

    　View Summary

    By using fibroblasts, we cultured in adhesive condition using ordinary 2D culture and non-adhesive 3D condition using non-adhesive culture dishes. After the conditions except for adhesion and non-adhesion were adjusted together, we comprehensively observed the differences in DNA methylation of the two condition. As a results, we found various DNA methylated sites in two dimensional culture. From these results, it was supposed that the change into undifferentuated state by culturing on non-adhesive dish comes from epigenetic changes.

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Courses Taught 【 Display / hide 】

  • PLASTIC, RECONSTRUCTIVE AND AESTHETIC SURGERY: SEMINAR

    2024

  • PLASTIC, RECONSTRUCTIVE AND AESTHETIC SURGERY: PRACTICE

    2024

  • PLASTIC SURGERY

    2024

  • LECTURE SERIES, PLASTIC AND RECONSTRUCTIVE SURGERY

    2024

  • CLINICAL CLERKSHIP IN PLASTIC AND RECONSTRUCTIVE SURGERY

    2024

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