慶應義塾研究者情報データベース

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• 脊椎脊髄外科を専門にしており、脊髄損傷の再生医療に関わる基礎研究にも携わっています。脊髄損傷に対する細胞移植治療の実現を目指して、日夜臨床と研究を続けています。

経歴 【 表示 ／ 非表示 】

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• 2016年01月

  -

  継続中

  慶應義塾大学医学部, 整形外科, 助教

• 2014年01月

  -

  2016年01月

  トロント西部病院, Division of Genetics and Development, Post-doctoral fellow

• 2013年07月

  -

  2013年12月

  北海道中央労災病院せき損センター, 整形外科, 医長

• 2009年04月

  -

  2013年06月

  村山医療センター, 整形外科, 医員

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• 2005年04月

  -

  2009年03月

  慶應義塾大学, 医学研究科, 整形外科

  大学院, 卒業, 博士

• 1996年04月

  -

  2002年03月

  慶應義塾大学, 医学部

  大学, 卒業, その他

学位 【 表示 ／ 非表示 】

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• 医学博士, 慶應義塾大学, 論文, 2009年03月

免許・資格 【 表示 ／ 非表示 】

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• 日本医師会認定産業医

• 医師免許, 2002年05月

• 日本脊椎脊髄病学会認定指導医, 2014年

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• ライフサイエンス / 整形外科学

研究キーワード 【 表示 ／ 非表示 】

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• 脊髄損傷

• 頚髄症

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• 頚髄症, 

  2014年01月

  -

  継続中

• 脊髄損傷と細胞移植, 

  2005年04月

  -

  継続中

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• Neural Crest Stem Cells –Breakthroughs and Applications

  Narihito NagoshiHideyuki Okano, World Scientific, 2011年

論文 【 表示 ／ 非表示 】

論文 【 表示 ／ 非表示 】

• The Impact of Depression and Bipolar Disorders on Functional and Quality of Life Outcomes in Patients Undergoing Surgery for Degenerative Cervical Myelopathy: Analysis of a Combined Prospective Dataset

  Tetreault, L., Nagoshi, N., Nakashima, H., Singh, A., Kopjar, B., Arnold, P. and Fehlings, M. G.

  Spine (Phila Pa 1976) 2016年07月

  ISSN  1528-1159

  　概要を見る

  STUDY DESIGN: Analysis of a combined prospective dataset. OBJECTIVE: To compare clinical outcomes in patients with and without preexisting depression or bipolar disorder undergoing surgery for degenerative cervical myelopathy (DCM). SUMMARY OF BACKGROUND DATA: Psychiatric co-morbidities, including depression, have been associated with worse clinical outcomes following lumbar spine surgery; however, it is unclear whether these psychiatric disorders are also predictive of outcomes in patients undergoing surgery for the treatment of DCM. METHODS: Four hundred and one patients with symptomatic DCM were enrolled in the prospective AOSpine International or North America study at twelve North American sites. Patients were evaluated preoperatively and at 6-, 12- and 24-months using the modified Japanese Orthopedic Association scale (mJOA), Nurick score, Neck Disability Index (NDI), and Short- Form 36v2 (SF-36) Health Survey. A mixed model analytic approach was used to evaluate differences in outcomes at 24-months between patients with and without psychiatric disorders, while controlling for relevant baseline characteristics and surgical factors. RESULTS: Ninety-seven patients (24.19%) were diagnosed with preexisting depression or bipolar disorder. There were more females (65.98%) with these psychiatric disorders than males (34.02%) (p < 0.0001). Patients with psychiatric co-morbidities were more likely to have cardiovascular (p = 0.0177), respiratory (p < 0.0001), gastrointestinal (p < 0.0001), rheumatologic (p = 0.0109) and neurologic (p = 0.0309) disorders. At 24-months following surgery, patients in both groups demonstrated significant improvements on the mJOA, Nurick, NDI and SF-36 Physical Component Score (PCS). Patients with depression or bipolar disorder, however, did not exhibit a significant or clinically important change on the SF-36 Mental Component Score (MCS). There were no differences in mJOA and Nurick scores at 24-months between patients in each group. Improvement in NDI, SF-36 PCS and MCS, however, were smaller in patients with depression or bipolar disorder than those without. CONCLUSIONS: Patients with depression or bipolar disorder have smaller functional and quality of life improvements following surgery compared to patients without psychiatric co-morbidities.

  • Access to Document (DOI)

• Does age affect surgical outcomes in patients with degenerative cervical myelopathy? Results from the prospective multicenter AOSpine International study on 479 patients

  Nakashima, H., Tetreault, L. A., Nagoshi, N., Nouri, A., Kopjar, B., Arnold, P. M., Bartels, R., Defino, H., Kale, S., Zhou, Q. and Fehlings, M. G.

  J Neurol Neurosurg Psychiatry 87 （ 7 ） 734 - 40 2016年07月

  ISSN  1468-330X

  　概要を見る

  BACKGROUND: In general, older patients with degenerative cervical myelopathy (DCM) are felt to have lower recovery potential following surgery due to increased degenerative pathology, comorbidities, reduced physiological reserves and age-related changes to the spinal cord. This study aims to determine whether age truly is an independent predictor of surgical outcome and to provide evidence to guide practice and decision-making. METHODS: A total of 479 patients with DCM were prospectively enrolled in the CSM-International study at 16 centres. Our sample was divided into a younger group (<65 years) and an elderly (>/=65 years) group. A mixed model analytic approach was used to evaluate differences in the modified Japanese Orthopaedic Association (mJOA), Nurick, Short Form-36 (SF-36) and Neck Disability Index (NDI) scores between groups. We first created an unadjusted model between age and surgical outcome and then developed two adjusted models that accounted for variations in (1) baseline characteristics and (2) both baseline and surgical factors. RESULTS: Of the 479 patients, 360 (75.16%) were <65 years and 119 (24.84%) were >/=65 years. Elderly patients had a worse preoperative health status (p<0.0001) and were functionally more severe (p<0.0001). The majority of younger patients (64.96%) underwent anterior surgery, whereas the preferred approach in the elderly group was posterior (58.62%, p<0.0001). Elderly patients had a greater number of decompressed levels than younger patients (p<0.0001). At 24 months after surgery, younger patients achieved a higher postoperative mJOA (p<0.0001) and a lower Nurick score (p<0.0001) than elderly patients. After adjustments for patient and surgical characteristics, these differences in postoperative outcome scores decreased but remained significant. CONCLUSIONS: Older age is an independent predictor of functional status in patients with DCM. However, patients over 65 with DCM still achieve functionally significant improvement after surgical decompression.

  • Access to Document (DOI)

• Do Caucasians and East Asians have Different Outcomes Following Surgery for the Treatment of Degenerative Cervical Myelopathy? Results from the Prospective Multicenter AOSpine International Study

  Nagoshi, N., Tetreault, L. A., Nakashima, H., Nouri, A., Arnold, P., Zileli, M., Tan, G., Kopjar, B. and Fehlings, M. G.

  Spine (Phila Pa 1976) 2016年03月

  ISSN  1528-1159

  　概要を見る

  STUDY DESIGN: Prospective multicenter cohort study. OBJECTIVE: To compare outcomes of surgery for the treatment for DCM between Caucasians and East Asians. SUMMARY OF BACKGROUND DATA: Numerous studies have indicated that race can influence both disease prevalence and clinical prognosis in a variety of medical conditions; however, none have evaluated the impact of race on surgical outcomes in patients with degenerative cervical myelopathy (DCM). METHODS: Four hundred and seventy-nine patients with symptomatic DCM were enrolled in the prospective AOSpine CSM-International study at 16 global sites. Preoperatively and at each follow-up, patients were evaluated using the modified Japanese Orthopedic Association scale (mJOA), the Nurick score, the Neck Disability Index (NDI), and the Short- Form 36 (SF-36) Health Survey. A mixed model analytic approach was used to evaluate differences in outcomes between races at 24 months postoperatively, while controlling for relevant baseline characteristics and surgical factors. RESULTS: Three hundred and twenty-four (67.64%) patients were Caucasian and 106 (22.13%) were East Asian. There was no difference in the incidence of ossification of the posterior longitudinal ligament (OPLL) between the two races; however a greater percentage of Caucasians in India (46.15%) and Turkey (41.38%) displayed evidence of OPLL than Caucasians in other regions (p < 0.001). The frequency of spondylosis was significantly higher in Caucasians (p < 0.001). Caucasians had a longer duration of symptoms (27.33 +/- 34.47 months) than East Asians (23.11 +/- 35.68 months) (p < 0.001), and a lower preoperative score on the SF-36 Physical Component Score (33.85 +/- 9.04) compared to East Asians (37.47 +/- 8.67) (p < 0.001). At 24-months after surgery, there were no differences in functional status or QOL between East Asians and Caucasians, after adjusting for baseline characteristics, surgical preferences and disease causation. Rates of perioperative complications were not significantly different between the races (p = 0.261). CONCLUSIONS: Decompressive surgery for DCM results in comparable functional gains and is equally safe in Caucasians and East Asians. LEVEL OF EVIDENCE: 2.

  • Access to Document (DOI)

• Comparison of Outcomes of Surgical Treatment for Ossification of the Posterior Longitudinal Ligament Versus Other Forms of Degenerative Cervical Myelopathy: Results from the Prospective, Multicenter AOSpine CSM-International Study of 479 Patients

  Nakashima, H., Tetreault, L., Nagoshi, N., Nouri, A., Arnold, P., Yukawa, Y., Toyone, T., Tanaka, M., Zhou, Q. and Fehlings, M. G.

  J Bone Joint Surg Am 98 （ 5 ） 370 - 8 2016年03月

  ISSN  1535-1386

  　概要を見る

  BACKGROUND: Degenerative cervical myelopathy (DCM) is an all-encompassing term that includes cervical spondylotic myelopathy (CSM), ossification of the posterior longitudinal ligament (OPLL), and other spinal abnormalities that cause cervical cord compression. It is unclear whether surgery is equally effective and safe for patients with OPLL as it is for those with other forms of DCM. The purpose of this study was to compare surgical outcomes of patients with OPLL and those with other forms of DCM. METHODS: Four hundred and seventy-nine patients with symptomatic DCM were prospectively enrolled in the CSM-International study at sixteen sites. Patients' functional status was evaluated using the modified Japanese Orthopaedic Association scale (mJOA) and the Nurick score. Quality of life was assessed using patient-reported outcome measures, including the Neck Disability Index (NDI) and the Short Form (SF)-36. Postoperative functional and quality-of-life outcomes were assessed at two years of follow-up, and scores were compared between patients with and without OPLL. RESULTS: Of 479 patients, 135 (28.2%) had radiographic evidence of OPLL, and 344 (71.8%) had other forms of DCM. The two groups did not differ significantly in demographics, surgical approach, or baseline myelopathy severity. Patients with OPLL achieved similar functional outcomes by two years following surgery compared with patients with other forms of DCM. With respect to quality of life, the NDI and most of the subscales of the SF-36 were not different between the two diagnostic groups. There was a higher risk of perioperative complications in the OPLL group (p = 0.054), although this relationship did not reach statistical significance. Rates of neurological complications did not differ significantly between diagnostic groups. CONCLUSIONS: Surgical decompression for the treatment of OPLL resulted in improvements in functional status and quality of life comparable to those seen in patients with other forms of DCM. Patients with OPLL were at a higher risk of perioperative complications than patients with other forms of DCM.

  • Access to Document (DOI)

• Commentary: Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord

  Nagoshi, N., Nakashima, H. and Fehlings, M. G.

  Neurosurgery 78 （ 2 ） E309 2016年02月

  ISSN  1524-4040

  • Access to Document (DOI)

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• 末梢神経再生に向けたヒトiPS細胞を用いたハイブリッド型人工神経の開発

  名越, 慈人

  科学研究費補助金研究成果報告書 2020年

• 脊髄損傷に対する脊髄領域iPS細胞由来神経幹細胞移植と化学遺伝学による機能的解明

  名越, 慈人

  福澤諭吉記念慶應義塾学事振興基金事業報告集 （福澤基金運営委員会)  2020年

• 脊髄損傷後の神経幹細胞移植に対する免疫抑制剤の効果 : C5aアンタゴニストの有用性

  名越, 慈人

  科学研究費補助金研究成果報告書 2019年

• 慢性疼痛に関わる感覚神経のネットワーク形成メカニズムの解明と治療法開発

  名越, 慈人

  科学研究費補助金研究成果報告書 2012年

• 脊髄損傷における自己修復機構の解明 : 内在性シュワン細胞の寄与

  名越, 慈人

  科学研究費補助金研究成果報告書 2011年

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競争的研究費の研究課題 【 表示 ／ 非表示 】

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• 脊髄損傷のiPS細胞由来神経幹細胞移植における化学遺伝学を用いた神経機能の解明

  2022年04月

  -

  2025年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 名越 慈人, 基盤研究(B), 補助金,  研究代表者

• 脊髄損傷後の神経幹細胞移植に対する免疫抑制剤の効果-C5aアンタゴニストの有用性

  2017年04月

  -

  2020年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 名越　慈人, 基盤研究(B), 補助金,  研究代表者

• 再生医療実用化研究事業　再生医療等安全性確保法に従って実施する臨床研究

  2016年09月

  -

  2019年03月

  中村雅也, 補助金,  研究分担者

• 日本損保協会　交通事故医療に関する一般助成

  2016年

  -

  2017年

  補助金,  研究代表者

• 日本学術振興会　海外特別研究員

  2014年01月

  -

  2016年01月

  補助金,  研究代表者

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• North American Spine Society Research Traveling Fellowship Award

  2015年10月, 北米脊椎学会, Human direct reprogramming neural precursor cells - a novel source for cell replacement therapy in spinal cord injury

  受賞区分： 国内外の国際的学術賞,  受賞国： アメリカ合衆国

• Best Paper Award

  2011年04月, Cervical Spine Research Society (Asian Pacific Section), Schwann cell plasticity shown by neural crest lineage tracing

  受賞区分： 国内外の国際的学術賞

• 日本整形外科学会奨励賞

  2010年05月, Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad

  受賞区分： 国内学会・会議・シンポジウム等の賞

• Young Investigator's Award優秀賞

  2010年03月, Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing

  受賞区分： 国内学会・会議・シンポジウム等の賞

• 東京都医師会賞

  2010年, Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad

  受賞区分： 国内学会・会議・シンポジウム等の賞

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• 整形外科学講義

  2024年度

• 先端医療技術

  2024年度

• 整形外科学講義

  2023年度

• 先端医療技術

  2023年度

• 整形外科学講義

  2022年度

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