中山 タラント ロバート (ナカヤマ タラント ロバート)

Nakayama, Turrent robert

写真a

所属(所属キャンパス)

医学部 整形外科学教室 (信濃町)

職名

専任講師

外部リンク

学歴 【 表示 / 非表示

  • 1995年04月
    -
    2001年03月

    慶應義塾大学, 医学部, 医学科

    大学, 卒業

  • 2004年04月
    -
    2008年03月

    慶應義塾大学, 医学部, 医学科

    大学院, 卒業, 博士

学位 【 表示 / 非表示

  • 医学博士, 慶應義塾大学, 2008年01月

免許・資格 【 表示 / 非表示

  • 医師免許, 2001年05月

 

研究分野 【 表示 / 非表示

  • 整形外科学

研究キーワード 【 表示 / 非表示

  • 骨・軟部腫瘍

 

論文 【 表示 / 非表示

  • SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters

    R. T. Nakayama, J. L. Pulice, A. M. Valencia, M. J. McBride, Z. M. McKenzie, M. A. Gillespie, W. L. Ku, M. Teng, K. Cui, R. T. Williams, S. H. Cassel, H. Qing, C. J. Widmer, G. D. Demetri, R. A. Irizarry, K. Zhao, J. A. Ranish and C. Kadoch

    Nat Genet 2017年09月

    ISSN  1546-1718

     概要を見る

    Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) complexes contribute to more than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor, an aggressive pediatric cancer characterized by biallelic inactivation of the core BAF complex subunit SMARCB1 (BAF47). However, the mechanism by which this alteration contributes to tumorigenesis remains poorly understood. We find that BAF47 loss destabilizes BAF complexes on chromatin, absent significant changes in complex assembly or integrity. Rescue of BAF47 in BAF47-deficient sarcoma cell lines results in increased genome-wide BAF complex occupancy, facilitating widespread enhancer activation and opposition of Polycomb-mediated repression at bivalent promoters. We demonstrate differential regulation by two distinct mSWI/SNF assemblies, BAF and PBAF complexes, enhancers and promoters, respectively, suggesting that each complex has distinct functions that are perturbed upon BAF47 loss. Our results demonstrate collaborative mechanisms of mSWI/SNF-mediated gene activation, identifying functions that are co-opted or abated to drive human cancers and developmental disorders.

  • Metastasis of Renal Cell Carcinoma to the Trapezium

    R. Nakagawa, M. Susa, R. Nakayama, I. Watanabe, K. Horiuchi, Y. Toyama, M. Nakamura, M. Matsumoto and H. Morioka

    J Hand Surg Asian Pac Vol 22 ( 2 ) 262 - 265 2017年06月

    ISSN  2424-8363

     概要を見る

    Solitary metastasis of a carcinoma to carpal bone is extremely rare. Metastases of renal cell carcinoma (RCC) usually occur in a multiple fashion and there has been no report to date of a solitary metastasis to trapezium from RCC. The tumor was excised and reconstructed with iliac bone transplantation. 2 years and 6 months after surgery, there is no local recurrence with minimal functional loss.

  • Extraskeletal Chondroma of the Index Finger: A Case Report

    M. Saito, K. Nishimoto, R. Nakayama, K. Kikuta, M. Nakamura, M. Matsumoto and H. Morioka

    Case Rep Oncol 10 ( 2 ) 479 - 484 2017年05月

    ISSN  1662-6575

     概要を見る

    Extraskeletal chondroma is defined as a rare, benign, cartilaginous tumor arising from soft tissues such as tendons, tendon sheath synovia, and joint capsules with no continuity to the periosteum or bone cortex. In histopathologic findings, the tumor exhibits many lobular structures and some parts similar to hyaline cartilage. Therefore, it is sometimes difficult to differentiate this tumor from low-grade chondrosarcoma because of their similar histopathologic findings. In order to prevent recurrence, it is necessary to remove the tumor as a whole, including the capsule, so as not to leave any remnants of the tumor. In this article, we report our treatment experience with a case of extraskeletal chondroma in the index finger of a 63-year-old patient.

  • A histological positive margin after surgery is correlated with high local re-recurrence rate in patients with recurrent myxofibrosarcoma

    K. Kikuta, R. Nakayama, A. Yoshida, A. Sasaki, K. Kameyama, H. Chuman, A. Kawai, M. Nakamura, M. Matsumoto and H. Morioka

    Jpn J Clin Oncol 47 ( 4 ) 334 - 341 2017年04月

    ISSN  1465-3621

     概要を見る

    Objective: Myxofibrosarcoma has high frequency of local recurrence after surgery. To determine an optimal treatment for recurrent tumors, clinical features of recurrent cases should be characterized. Methods: We performed a retrospective analysis of 30 patients with recurrent myxofibrosarcoma who underwent surgery between 1999 and 2008. Results: A negative margin after surgery was achieved in only 12 patients (40.0%). The 5-year re-recurrence free-survival rate was 31.7%. The 5-year re-recurrence free survival for those with positive histological margin and those with negative margin were 9.8% and 62.3%, respectively, which indicated that a positive margin was the significant predictor of poor prognosis (P = 0.006). In 21 patients with recurrent myxofibrosarcoma in the extremities, 10 patients (47.6%) ultimately underwent amputation in the follow-up period and the 5-year amputation-free survival rate was 62.5%. The 5-year metastasis-free survival rates and the 5-year overall survival rates were 84.8% and 83.6%, respectively. Conclusions: In this study, the majority of recurrent cases could not achieve negative margins; notably, a positive margin is a significant poor prognostic indicator of local re-recurrence in patients with recurrent myxofibrosarcoma. To control local recurrence of myxofibrosarcoma was extremely difficult and amputation is often needed in the extremity cases.

  • Computed tomography-guided percutaneous cryoablation for recurrent sacral chordoma following carbon ion radiotherapy: A case report

    N. Inaba, R. Nakayama, T. Mori, S. Hosaka, M. Susa, H. Yabe, M. Inoue, S. Nakatsuka, M. Nakamura, M. Matsumoto, Y. Toyama and H. Morioka

    J Orthop Sci 2016年11月

    ISSN  1436-2023

全件表示 >>

KOARA(リポジトリ)収録論文等 【 表示 / 非表示

競争的資金等の研究課題 【 表示 / 非表示

  • 滑膜肉腫における変異SWI/SNFクロマチン制御複合体の機能解析

    2017年04月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 中山 タラント ロバート, 基盤研究(C), 補助金,  代表

 

担当授業科目 【 表示 / 非表示

  • 整形外科学講義

    2019年度