Papers - Nakamura, Masaya

腰椎変性すべり症に対する後方除圧術の成績—固定・非固定例の分析

Matsumoto Morio, Nishizawa Takashi, Nakamura Masaya, Maruiwa Hirofumi, Chiba Kazuhiro, Toyama Yoshiaki

臨床整形外科 38 ( 3 ) 271-277 2003.03

Research paper (scientific journal), Joint Work

再生医療の現状と将来展望；＜臓器再生＞中枢神経系の再生医療

Kaneko Shinnjirou, Iwanami Akio, Nakamura Masaya, Ogawa Yuuto, Toyama Yoshiaki, Okano Hiroyuki

日本医師会雑誌 129 ( 3 ) 355-359 2003.02

Research paper (scientific journal), Joint Work

中枢神経系の再生医療

Kaneko Shinjirou, Iwanami Akio, Nakamura Masaya, Ogawa Yuuto, Toyama Yoshiaki, Okano Hideyuki

日本医師会雑誌 129 ( 3 ) 355-359 2003.02

Research paper (scientific journal), Joint Work

脊髄損傷に対する再生医療 / 神経幹細胞移植を中心として

Kaneko Shinjirou, Nakamura Masaya, Iwanami Akio, Ogawa Yuuto, Toyama Yoshiaki, Okano Hideyuki

脊椎脊髄ジャーナル 16 ( 2 ) 123-129 2003.02

Research paper (scientific journal), Joint Work

脊髄損傷に対する再生医療—神経幹細胞移植を中心として

Kaneko Shinjirou, Nakamura Masaya, Iwanami Akio, Ogawa Yuuto, Okano Hiroyuki, Toyama Yoshiaki

脊椎脊髄ジャーナル 16 ( 2 ) 123-129 2003.02

Research paper (scientific journal), Joint Work

脊椎脊髄外科のすべて- この10年何が進歩したか - 髄内腫瘍の診断と治療

NAKAMURA MASAYA

整形外科・災害外科 46 ( 5 ) 689-696 2003

Research paper (scientific journal), Single Work

脊椎脊髄外科のすべて—この10年何が進歩したか—髄内腫瘍の診断と治療

Nakamura Masaya, Chiba Kazuhiro, Toyama Yoshiaki

整形外科・災害外科 46 ( 5 ) 689-696 2003

Research paper (scientific journal), Joint Work

Transplantation of neural stem cells into the spinal cord after injury

Okano Hideyuki, Ogawa Yuto, Nakamura Masaya, Kaneko Shinjiro, Iwanami Akio, Toyama Yoshiaki

Seminars in cells & developmental biology 379   39455 2003

Research paper (scientific journal), Joint Work

Transplantation of neural stem cells into spinal cord after injury

Nakamura Masaya, Toyama Yoshiaki

Nippon rinsho. Japanese journal of clinical medicine 61 ( 3 ) 463 - 468 2003

ISSN  0047-1852

　View Summary

<p>Recovery from central nervous system damage in adult mammals is hindered by their limited ability to replace lost cells and damaged myelin, and reestablish functional neural connections. However, recent progresses in stem cell biology are making it feasible to induce the regeneration of injured axons after spinal cord injury. Transplantation of in vitro expanded neural stem cells into rat spinal cord 9 days after contusion injury induced their differentiation into neurons and oligodendrocytes, and the functional recovery of skilled forelimb movement. It was partly because the microenvironment within the injured spinal cord at 9 days after injury was more favorable for grafted neural stem cells in terms of their survival and differentiation.</p>

神経幹細胞と損傷脊髄の再生

Iwanami Akio, Ogawa Yuuto, Nakamura Masaya, Kaneko Shinjirou, Toyama Yoshiaki, Okano Hideyuki

日本整形外科学会雑誌 76 ( 12 ) 579-589 2002.12

Research paper (scientific journal), Joint Work

中枢神経系の再生医療

Kaneko Shinjirou, Iwanami Akio, Nakamura Masaya, Ogawa Yuuto, Toyama Yoshiaki, Okano Hideyuki

日本小児科学会雑誌 106 ( 12 ) 1736-1743 2002.12

Research paper (scientific journal), Joint Work

教育研修講座―神経幹細胞と損傷脊髄の再生

Iwanami Akio, Nakamura Masaya, Ogawa Yuuto, Kaneko Shinjirou, Toyama Yoshiaki, Okano Hiroyuki

日本整形外科学会誌 76 ( 12 ) 579-591 2002.12

Research paper (scientific journal), Joint Work

小児科領域における最先端医療＜再生医療の最近の進歩＞―中枢神経系の再生医療

Kaneko Shinjirou, Iwanami Akio, Nakamura Masaya, Ogawa Yuuto, Toyama Yoshiaki, Okano Hiroyuki

日本小児科学会雑誌 106 ( 12 ) 1736-1743 2002.12

Research paper (scientific journal), Joint Work

脊柱後弯による遅発性脊髄麻痺に関する実験的研究（第1報）―実験動物モデルの作成―

Shimizu Kentarou, Nishikawa Yuuji, Hijikata Sadahisa, Nakamura Masaya, Chiba Kazuhiro, Toyama Yoshiaki

脊柱変形 17 ( 1 ) 7-13 2002.12

Research paper (scientific journal), Joint Work

髄内外にわたるendodermal cyst 再発の1治験例

Ikegami Ken, Chiba Kazuhiro, Nishizawa Takashi, Nakamura Masaya, Maruiwa Hirofumi．matsumoto Morio, Toyama Yoshiaki, Mukai Makio

関東整形災害外科学会誌 33 ( 5 ) 311-315 2002.10

Research paper (scientific journal), Joint Work

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

Ogawa Y., Sawamoto K., Miyata T., Miyao S., Watanabe M., Nakamura M., Bregman B. S., Koike M., Uchiyama Y., Toyama Y., Okano H.

Journal of Neuroscience Research 69 ( 6 ) 925 - 933 2002.09

ISSN  0360-4012

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<p>Neural progenitor cells, including neural stem cells, are a potential expandable source of graft material for transplantation aimed at repairing the damaged CNS. Here we present the first evidence that in vitro-expanded fetus-derived neurosphere cells were able to generate neurons in vivo and improve motor function upon transplantation into an adult rat spinal-cord-contusion injury model. As the source of graft material, we used a neural stem cell-enriched population that was derived from rat embryonic spinal cord (E14.5) and expanded in vitro by neurosphere formation. Nine days after contusion injury, these neurosphere cells were transplanted into adult rat spinal cord at the injury site. Histological analysis 5 weeks after the transplantation showed that mitotic neurogenesis occurred from the transplanted donor progenitor cells within the adult rat spinal cord, a nonneurogenic region; that these donor-derived neurons extended their processes into the host tissues; and that the neurites formed synaptic structures. Furthermore, analysis of motor behavior using a skilled reaching task indicated that the treated rats showed functional recovery. These results indicate that in vitro-expanded neurosphere cells derived from the fetal spinal cord are a potential source for transplantable material for treatment of spinal cord injury. © 2002 Wiley-Liss, Inc.</p>

• Access to Document (DOI)

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenisis and fuctional recovery after spinal cord contusion injury in adult rats

Ogawa Yuto, Sawamoto Kazunobu, T Miyata, S Miyano, Watanabe Masahiko, Nakamura Masaya, Brebman BS, M Koike, Uchiyama Y, Toyama Yoshiaki, Okano H

Journal of neuroscience research 69 ( 6 ) 925-933 2002.09

Research paper (scientific journal), Joint Work

特集―脊椎・脊髄画像診断マニュアル；脊髄疾患―髄外腫瘍

Nakamura Masaya, Chiba Kazuhiro, Toyama Yoshiaki

Monthly book orthopaedics 15 ( 9 ) 164-170 2002.09

Research paper (scientific journal), Joint Work

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

Ogawa Yuto, Sawamoto Kazunobu, Miyata Takuki, Miyao Sachiyo, Watanabe M, Toyama Yoshiaki, Nakamura Masaya, Bregman BS, Koike M, Uchiyama Yasuo, Okano Hideyuki

Jounal of neuroscience research 69 ( 6 ) 925-933 2002.09

Research paper (scientific journal), Joint Work

硬膜内に発生した傍神経節腫の1例

Ichihara Daisuke, Nishizawa Takashi, Watanabe Masahiko, Nakamura Masaya, Maruiwa Hirofumi, Matsumoto Morio, Chiba Kazuhiro, Toyama Yoshiaki

臨床整形外科 37 ( 8 ) 971-974 2002.08

Research paper (scientific journal), Joint Work