Papers - Sato, Kazuki

Point of care ultrasound combined with CTS-6 to diagnose idiopathic carpal tunnel syndrome.

Kimura H, Furuhata R, Matsuo T, Suzuki T, Matsumura N, Sato K, Iwamoto T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association  2024.01

ISSN  0949-2658

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Antiviral humoral immunity against SARS-CoV-2 omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive and XBB-infected individuals.

Kosugi Y, Kaku Y, Hinay AA Jr, Guo Z, Uriu K, Kihara M, Saito F, Uwamino Y, Kuramochi J, Shirakawa K, Takaori-Kondo A, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K

The Lancet. Infectious diseases  2024.01

ISSN  1473-3099

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Recent advances in unlinked total elbow arthroplasty in Japan

Iwamoto T., Ikegami H., Tanji A., Kiyota Y., Suzuki T., Matsumura N., Sato K.

JSES International (JSES International)   2024

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Background: Total elbow arthroplasty (TEA) is a valuable therapeutic approach for improving function and relieving pain in severely deformed elbow joints. However, TEA is associated with a high incidence of complications. In Japan, the use of unlinked TEA has a long history, with the development of the Kudo prosthesis marking a significant milestone. Subsequently, various unlinked implant designs have been developed. Although favorable long-term clinical results have been reported, complications remain a concern. To further improve the outcome of unlinked TEA, attempts have been made in recent years to develop various surgical approaches and intraoperative support devices. This review focuses on the clinical outcomes and recent advances in unlinked TEA in Japan. Methods: A comprehensive review of clinical results and advancements in unlinked TEA in Japan was conducted. The analysis included trends in the number of TEA, medium-term and long-term results for unlinked TEA, surgical approaches, or preoperative planning techniques. Results: Several implant designs have been developed in Japan. Clinical studies have reported satisfactory long-term outcomes with these implants, but complications, such as infection, fractures, and dislocation, have been observed. In order to enhance the outcomes of unlinked TEA, various triceps-on approaches have been developed as alternatives to the triceps-detaching approach, which compromises the continuity between the triceps tendon and ulna, leading to inevitable complications related to the triceps tendon. Preservation or repair of the surrounding soft tissues is considered critical for preventing postoperative instability due to the absence of a radial head in the current unlinked TEA design. Computed tomography-based 3-dimensional preoperative planning has been pioneered in Japan, demonstrating its effectiveness in predicting implant size and achieving appropriate implant placement. Additionally, augmented reality–assisted surgery is being explored to accurately translate preoperative planning into the surgical procedure. Conclusion: Unlinked TEA for inflammatory arthritis has exhibited promising long-term results in Japan, with ongoing efforts to improve surgical techniques and preoperative planning. Further advancements are anticipated to prevent complications such as dislocation and peri-implant fractures.

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Prevalence of and Factors Associated with Sports Injuries in 11,000 Japanese Collegiate Athletes.

Kimura T, Mącznik AK, Kinoda A, Yamada Y, Muramoto Y, Katsumata Y, Sato K

Sports (Basel, Switzerland) 12 ( 1 )  2023.12

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Post-Traumatic Pulmonary Hematoma Presenting as Multiple Ring-shaped Spherical Nodules

Ikeda, O; Shimizu, K; Yamada, Y; Sugiura, H; Takahashi, M; Kimura, T; Suzuki, H; Sato, K; Jinzaki, M

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 208 ( 11 ) 1227 - 1230 2023.12

ISSN  1073-449X

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Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit promotes peripheral nerve regeneration in rodent sciatic nerve defect models

Takeya H., Itai S., Kimura H., Kurashina Y., Amemiya T., Nagoshi N., Iwamoto T., Sato K., Shibata S., Matsumoto M., Onoe H., Nakamura M.

Scientific Reports (Scientific Reports)  13 ( 1 )  2023.12

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Chitosan has various tissue regeneration effects. This study was designed to investigate the nerve regeneration effect of Schwann cell (SC)-encapsulated chitosan-collagen hydrogel nerve conduit (CCN) transplanted into a rat model of sciatic nerve defect. We prepared a CCN consisting of an outer layer of chitosan hydrogel and an inner layer of collagen hydrogel to encapsulate the intended cells. Rats with a 10-mm sciatic nerve defect were treated with SCs encapsulated in CCN (CCN+), CCN without SCs (CCN−), SC-encapsulated silicone tube (silicone+), and autologous nerve transplanting (auto). Behavioral and histological analyses indicated that motor functional recovery, axonal regrowth, and myelination of the CCN+ group were superior to those of the CCN− and silicone+ groups. Meanwhile, the CCN− and silicone+ groups showed no significant differences in the recovery of motor function and nerve histological restoration. In conclusion, SC-encapsulated CCN has a synergistic effect on peripheral nerve regeneration, especially axonal regrowth and remyelination of host SCs. In the early phase after transplantation, SC-encapsulated CCNs have a positive effect on recovery. Therefore, using SC-encapsulated CCNs may be a promising approach for massive peripheral nerve defects.

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Estimation of maximal lactate steady state using the sweat lactate sensor

Muramoto Y., Nakashima D., Amano T., Harita T., Sugai K., Daigo K., Iwasawa Y., Ichihara G., Okawara H., Sawada T., Kinoda A., Yamada Y., Kimura T., Sato K., Katsumata Y.

Scientific Reports (Scientific Reports)  13 ( 1 )  2023.12

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A simple, non-invasive algorithm for maximal lactate steady state (MLSS) assessment has not been developed. We examined whether MLSS can be estimated from the sweat lactate threshold (sLT) using a novel sweat lactate sensor for healthy adults, with consideration of their exercise habits. Fifteen adults representing diverse fitness levels were recruited. Participants with/without exercise habits were defined as trained/untrained, respectively. Constant-load testing for 30 min at 110%, 115%, 120%, and 125% of sLT intensity was performed to determine MLSS. The tissue oxygenation index (TOI) of the thigh was also monitored. MLSS was not fully estimated from sLT, with 110%, 115%, 120%, and 125% of sLT in one, four, three, and seven participants, respectively. The MLSS based on sLT was higher in the trained group as compared to the untrained group. A total of 80% of trained participants had an MLSS of 120% or higher, while 75% of untrained participants had an MLSS of 115% or lower based on sLT. Furthermore, compared to untrained participants, trained participants continued constant-load exercise even if their TOI decreased below the resting baseline (P < 0.01). MLSS was successfully estimated using sLT, with 120% or more in trained participants and 115% or less in untrained participants. This suggests that trained individuals can continue exercising despite decreases in oxygen saturation in lower extremity skeletal muscles.

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Anaerobic threshold using sweat lactate sensor under hypoxia

Okawara H., Iwasawa Y., Sawada T., Sugai K., Daigo K., Seki Y., Ichihara G., Nakashima D., Sano M., Nakamura M., Sato K., Fukuda K., Katsumata Y.

Scientific Reports (Scientific Reports)  13 ( 1 ) 22865 2023.12

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We aimed to investigate the reliability and validity of sweat lactate threshold (sLT) measurement based on the real-time monitoring of the transition in sweat lactate levels (sLA) under hypoxic exercise. In this cross-sectional study, 20 healthy participants who underwent exercise tests using respiratory gas analysis under hypoxia (fraction of inspired oxygen [FiO2], 15.4 ± 0.8%) in addition to normoxia (FiO2, 20.9%) were included; we simultaneously monitored sLA transition using a wearable lactate sensor. The initial significant elevation in sLA over the baseline was defined as sLT. Under hypoxia, real-time dynamic changes in sLA were successfully visualized, including a rapid, continual rise until volitionary exhaustion and a progressive reduction in the recovery phase. High intra- and inter-evaluator reliability was demonstrated for sLT’s repeat determinations (0.782 [0.607–0.898] and 0.933 [0.841–0.973]) as intraclass correlation coefficients [95% confidence interval]. sLT correlated with ventilatory threshold (VT) (r = 0.70, p < 0.01). A strong agreement was found in the Bland–Altman plot (mean difference/mean average time: − 15.5/550.8 s) under hypoxia. Our wearable device enabled continuous and real-time lactate assessment in sweat under hypoxic conditions in healthy participants with high reliability and validity, providing additional information to detect anaerobic thresholds in hypoxic conditions.

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Adult-onset idiopathic peripheral pulmonary artery stenosis.

Tamura Y, Tamura Y, Shigeta A, Hosokawa K, Taniguchi Y, Inami T, Adachi S, Tsujino I, Nakanishi N, Sato K, Sakamoto J, Tanabe N, Takama N, Nakamura K, Kubota K, Komura N, Kato S, Yamashita J, Takei M, Joho S, Ishii S, Takemura R, Sugimura K, Tatsumi K

The European respiratory journal 62 ( 6 )  2023.12

ISSN  0903-1936

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Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development.

Takada Y, Fierro L, Sato K, Sanada T, Ishii A, Yamamoto T, Kotani T

Science advances 9 ( 47 ) eadg6532 2023.11

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Large magnetocapacitance of up to 456% at room temperature in FeCo/MgAl₂O₄/FeCo(001) magnetic tunnel junctions

Shibata, Y; Sato, K; Sukegawa, H; Kaiju, H

APPLIED PHYSICS EXPRESS 16 ( 11 )  2023.11

ISSN  1882-0778

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Characteristics in patients with adult-onset idiopathic peripheral pulmonary artery stenosis

Tamura, Y; Tamura, Y; Takemura, R; Shigeta, A; Hosokawa, K; Taniguchi, Y; Inami, T; Adachi, S; Tsujita, I; Nakanishi, N; Sato, K; Sakamoto, J; Tanabe, N; Sugimura, K

EUROPEAN HEART JOURNAL 44 2023.11

ISSN  0195-668X

The prevalence and significance of the EIF2AK4 variants in the patients with pulmonary arterial hypertension

Momoi, M; Hiraide, T; Shinya, Y; Sato, K; Inami, T; Fukuda, K; Kataoka, M

EUROPEAN HEART JOURNAL 44 2023.11

ISSN  0195-668X

MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion

Ichihara G., Katsumata Y., Sugiura Y., Matsuoka Y., Maeda R., Endo J., Anzai A., Shirakawa K., Moriyama H., Kitakata H., Hiraide T., Goto S., Ko S., Iwasawa Y., Sugai K., Daigo K., Goto S., Sato K., Yamada K.I., Suematsu M., Ieda M., Sano M.

Circulation Research (Circulation Research)  133 ( 10 ) 861 - 876 2023.10

ISSN  00097330

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BACKGROUND: The membrane components of cardiomyocytes are rich in polyunsaturated fatty acids, which are easily oxidized. Thus, an efficient glutathione-based lipid redox system is essential for maintaining cellular functions. However, the relationship between disruption of the redox system during ischemia-reperfusion (IR), oxidized lipid production, and consequent cell death (ferroptosis) remains unclear. We investigated the mechanisms underlying the disruption of the glutathione-mediated reduction system related to ferroptosis during IR and developed intervention strategies to suppress ferroptosis. METHODS: In vivo fluctuations of both intra- and extracellular metabolite levels during IR were explored via microdialysis and tissue metabolome analysis. Oxidized phosphatidylcholines were assessed using liquid chromatography high-resolution mass spectrometry. The areas at risk following IR were assessed using triphenyl-tetrazolium chloride/Evans blue stain. RESULTS: Metabolomic analysis combined with microdialysis revealed a significant release of glutathione from the ischemic region into extracellular spaces during ischemia and after reperfusion. The release of glutathione into extracellular spaces and a concomitant decrease in intracellular glutathione concentrations were also observed during anoxia-reperfusion in an in vitro cardiomyocyte model. This extracellular glutathione release was prevented by chemical inhibition or genetic suppression of glutathione transporters, mainly MRP1 (multidrug resistance protein 1). Treatment with MRP1 inhibitor reduced the intracellular reactive oxygen species levels and lipid peroxidation, thereby inhibiting cell death. Subsequent in vivo evaluation of endogenously oxidized phospholipids following IR demonstrated the involvement of ferroptosis, as levels of multiple oxidized phosphatidylcholines were significantly elevated in the ischemic region 12 hours after reperfusion. Inhibition of the MRP1 transporter also alleviated intracellular glutathione depletion in vivo and significantly reduced the generation of oxidized phosphatidylcholines. Administration of MRP1 inhibitors significantly attenuated infarct size after IR injury. CONCLUSIONS: Glutathione was released continuously during IR, primarily in an MRP1-dependent manner, and induced ferroptosis. Suppression of glutathione release attenuated ferroptosis and reduced myocardial infarct size following IR.

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Nonobstructive General Angioscopy- Guided Intraventricular Tumor Biopsy Direct Visualization Improved Diagnostic Accuracy and Procedural Safety

Terauchi, T; Sato, K; Watabe, H; Ieda, M

JACC-CARDIOVASCULAR INTERVENTIONS 16 ( 20 ) 2569 - 2571 2023.10

ISSN  1936-8798

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特集 上腕骨骨折の治療戦略 高齢者の上腕骨遠位端骨折

清田 康弘, 佐藤 和毅

関節外科　基礎と臨床 (メジカルビュー社)  42 ( 10 ) 1183 - 1189 2023.10

ISSN  02865394

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Synthesis and characterization of a formal 21-electron cobaltocene derivative

Takebayashi, S; Ariai, J; Gellrich, U; Kartashov, SV; Fayzullin, RR; Kang, HB; Yamane, T; Sugisaki, K; Sato, K

NATURE COMMUNICATIONS 14 ( 1 ) 4979 2023.09

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Association Between the COVID-19 Pandemic and Early Childhood Development

Sato, K; Fukai, T; Fujisawa, KK; Nakamuro, M

JAMA PEDIATRICS 177 ( 9 ) 930 - 938 2023.09

ISSN  2168-6203

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Deep learning-based model detects atrial septal defects from electrocardiography: a cross-sectional multicenter hospital-based study

Miura K., Yagi R., Miyama H., Kimura M., Kanazawa H., Hashimoto M., Kobayashi S., Nakahara S., Ishikawa T., Taguchi I., Sano M., Sato K., Fukuda K., Deo R.C., MacRae C.A., Itabashi Y., Katsumata Y., Goto S.

eClinicalMedicine (eClinicalMedicine)  63 2023.09

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Background: Atrial septal defect (ASD) increases the risk of adverse cardiovascular outcomes. Despite the potential for risk mitigation through minimally invasive percutaneous closure, ASD remains underdiagnosed due to subtle symptoms and examination findings. To bridge this diagnostic gap, we propose a novel screening strategy aimed at early detection and enhanced diagnosis through the implementation of a convolutional neural network (CNN) to identify ASD from 12-lead electrocardiography (ECG). Methods: ECGs were collected from patients with at least one recorded echocardiogram at 3 hospitals from 2 continents (Keio University Hospital from July 2011 to December 2020, Brigham and Women's Hospital from January 2015 to December 2020, and Dokkyo Medical University Saitama Medical Center from January 2010 and December 2021). ECGs from patients with a diagnosis of ASD were labeled as positive cases while the remainder were labeled as negative. ECGs after the closure of ASD were excluded. After randomly splitting the ECGs into 3 datasets (50% derivation, 20% validation, and 30% test) with no patient overlap, a CNN-based model was trained using the derivation datasets from 2 hospitals and was tested on held-out datasets along with an external validation on the 3rd hospital. All eligible ECGs were used for derivation and validation whereas the earliest ECG for each patient was used for the test and external validation. The discrimination of ASD was assessed by the area under the receiver operating characteristic curve (AUROC). Multiple subgroups were examined to identify any heterogeneity. Findings: A total of 671,201 ECGs from 80,947 patients were collected from the 3 institutions. The AUROC for detecting ASD was 0.85–0.90 across the 3 hospitals. The subgroup analysis showed excellent performance across various characteristics Screening simulation using the model greatly increased sensitivity from 80.6% to 93.7% at specificity 33.6% when compared to using overt ECG abnormalities. Interpretation: A CNN-based model using 12-lead ECG successfully identified the presence of ASD with excellent generalizability across institutions from 2 separate continents. Funding: This work was supported by research grants from JST ( JPMJPF2101), JSR corporation, Taiju Life Social Welfare Foundation, Kondou Kinen Medical Foundation, Research fund of Mitsukoshi health and welfare foundation, Tokai University School of Medicine Project Research and Internal Medicine Project Research, Secom Science and Technology Foundation, and Grants from AMED ( JP23hma922012 and JP23ym0126813). This work was partially supported by One Brave Idea, co-funded by the American Heart Association and Verily with significant support from AstraZeneca and pillar support from Quest Diagnostics.

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Influence of Electrodiagnostic Studies on Surgery for Carpal Tunnel Syndrome: A Retrospective Analysis of Data from a Single Urban Institution

Kimura H., Matsuo T., Suzuki T., Matsumura N., Sato K., Iwamoto T.

Journal of Hand Surgery Asian-Pacific Volume (Journal of Hand Surgery Asian-Pacific Volume)  28 ( 4 ) 453 - 460 2023.08

ISSN  24248355

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Background: This study aimed to clarify the influence of preoperative electrodiagnostic (EDX) utilisation and its severity on surgically treated patients with carpal tunnel syndrome (CTS). Methods: This retrospective study analysed the data of patients who underwent CTS surgery at our facility from 2012 to 2022. Data regarding age, sex, affected side, diabetes mellitus, rheumatoid arthritis, haemodialysis and insurance type were collected, along with the following clinical information: utilisation of EDX, steroid injection, number of items of preoperative physical examination and history taking, intervals between symptom onset and the initial visit and between the initial visit and surgery, type of surgical procedure and surgery categorisation (primary or revision). EDX data (EDX severity, interval between EDX and surgery and concomitant nerve lesions) were also investigated. Univariate and multivariate analyses were conducted to assess the influence of EDX utilisation and severity on clinical parameters. Results: Of the 343 hands enrolled in our study, 304 (89%) underwent preoperative EDX assessment. EDX severity was classified as normal, mild, moderate or severe in 6 (2%), 18 (6%), 102 (34%) and 178 hands (58%), respectively. After the univariate and multivariable analyses, more items of preoperative physical examination and history taking were associated with non-EDX utilisation, whereas younger age, female sex and steroid injection were associated with milder EDX. Conclusions: Increased number of items of preoperative physical examination and history taking or steroid injection were independently associated with non-EDX utilisation or milder EDX, respectively, suggesting that when thorough clinical evaluation is conducted, hand surgeons may be less likely to request for EDX before surgery. Moreover, their treatment recommendation may be influenced by EDX severity. Level of Evidence: Level III (Diagnostic)

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Real-Time Estimation of Anaerobic Threshold during Exercise Using Electrocardiogram in Heart Failure Patients

Ryuzaki T., Shiraishi Y., Miura K., Ikura H., Seki Y., Azuma K., Sato K., Fukuda K., Katsumata Y.

Journal of Clinical Medicine (Journal of Clinical Medicine)  12 ( 16 )  2023.08

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Exercise therapy at the aerobic level is highly recommended to improve clinical outcomes in patients with heart failure, in which cardiopulmonary exercise testing (CPX) is required to determine anaerobic thresholds (ATs) but is not available everywhere. This study aimed to validate a method to estimate the AT using heart rate variability (HRV) analysis from electrocardiography data in patients with heart failure. Between 2014 and 2019, 67 patients with symptomatic heart failure underwent CPXs in a single university hospital. During the CPX, RR intervals was measured continuously and the HRV threshold (HRVT), defined as the inflection point of <5 ms2 of a high-frequency component (HFC) using the power spectrum analysis, was determined. Patients were divided into two groups according to the mean HFC at rest (high-HFC group, n = 34 and low-HFC group, n = 33). The high-HFC group showed good correlation between the VO2 at AT and HRVT (r = 0.63, p < 0.001) and strong agreement (mean difference, −0.38 mL/kg, p = 0.571). The low-HFC group also showed modest correlation (r = 0.41, p = 0.017) but poor agreement (mean differences, 3.75 mL/kg, p < 0.001). In conclusion, the HRVT obtained from electrocardiography may be a useful indicator for estimating AT in patients with heart failure.

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Influence of Electrodiagnostic Studies on Surgery for Carpal Tunnel Syndrome: A Retrospective Analysis of Data from a Single Urban Institution

Kimura, H; Matsuo, T; Suzuki, T; Matsumura, N; Sato, K; Iwamoto, T

JOURNAL OF HAND SURGERY-ASIAN-PACIFIC VOLUME 28 ( 4 )  2023.08

ISSN  2424-8355

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Influence of Electrodiagnostic Studies on Surgery for Carpal Tunnel Syndrome: A Retrospective Analysis of Data from a Single Urban Institution.

Kimura H, Matsuo T, Suzuki T, Matsumura N, Sato K, Iwamoto T

The journal of hand surgery Asian-Pacific volume 28 ( 4 ) 453 - 460 2023.08

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Influence of Electrodiagnostic Studies on Surgery for Carpal Tunnel Syndrome: A Retrospective Analysis of Data from a Single Urban Institution

Kimura, H; Matsuo, T; Suzuki, T; Matsumura, N; Sato, K; Iwamoto, T

JOURNAL OF HAND SURGERY-ASIAN-PACIFIC VOLUME 28 ( 04 ) 453 - 460 2023.08

ISSN  2424-8355

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Development of a novel drug information provision system for Kampo medicine using natural language processing technology

Maeda-Minami, A; Yoshino, T; Yumoto, T; Sato, K; Sagara, A; Inaba, K; Kominato, H; Kimura, T; Takishita, T; Watanabe, G; Nakamura, T; Mano, Y; Horiba, Y; Watanabe, K; Kamei, J

BMC MEDICAL INFORMATICS AND DECISION MAKING 23 ( 1 ) 119 2023.07

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Search for Astrophysical Electron Antineutrinos in Super-Kamiokande with 0.01% Gadolinium-loaded Water

Harada, M; Abe, K; Bronner, C; Hayato, Y; Hiraide, K; Hosokawa, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wester, T; Bian, J; Griskevich, NJ; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Lee, SH; Moon, DH; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Beauchêne, A; Drapier, O; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Choi, K; Iovine, N; Cao, S; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Langella, A; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Okazaki, R; Akutsu, R; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Bhuiyan, N; Burton, GT; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Xie, Z; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takagi, Y; Takeuchi, Y; Feng, J; Feng, L; Hu, JR; Hu, Z; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tarrant, A; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Hino, Y; Ishino, H; Kitagawa, H; Koshio, Y; Nakanishi, F; Sakai, S; Tada, T; Tano, T; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Holin, A; Nova, F; Yang, BS; Yang, JY; Yoo, J; Fannon, JEP; Kneale, L; Malek, M; McElwee, JM; Thiesse, MD; Thompson, LF; Wilson, ST; Okazawa, H; Kim, SB; Kwon, E; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Nakagiri, K; Nakajima, Y; Shima, S; Taniuchi, N; Watanabe, E; Yokoyama, M; de Perio, P; Martens, K; Tsui, KM; Vagins, MR; Xia, J; Kuze, M; Izumiyama, S; Matsumoto, R; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ommura, Y; Shigeta, N; Shinoki, M; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Gaur, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Li, X; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Boyd, SB; Edwards, R; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

ASTROPHYSICAL JOURNAL LETTERS 951 ( 2 )  2023.07

ISSN  2041-8205

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Surface Modification Strategy for Yellow-Emitting Carbon Dots in Fluoropolymer Films

Washio, K; Sato, K; Iso, Y; Isobe, T

ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY 12 ( 7 )  2023.07

ISSN  2162-8769

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Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma

Kitagawa, A; Osawa, T; Noda, M; Kobayashi, Y; Aki, S; Nakano, Y; Saito, T; Shimizu, D; Komatsu, H; Sugaya, M; Takahashi, J; Kosai, K; Takao, S; Motomura, Y; Sato, K; Hu, QJ; Fujii, A; Wakiyama, H; Tobo, T; Uchida, H; Sugimachi, K; Shibata, K; Utsunomiya, T; Kobayashi, S; Ishii, H; Hasegawa, T; Masuda, T; Matsui, Y; Niida, A; Soga, T; Suzuki, Y; Miyano, S; Aburatani, H; Doki, Y; Eguchi, H; Mori, M; Nakayama, KI; Shimamura, T; Shibata, T; Mimori, K

BRITISH JOURNAL OF CANCER 128 ( 12 ) 2206 - 2217 2023.06

ISSN  0007-0920

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Measurement of the cosmogenic neutron yield in Super-Kamiokande with gadolinium loaded water

Shinoki, M; Abe, K; Hayato, Y; Hiraide, K; Hosokawa, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Lee, SH; Moon, DH; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Beauchêne, A; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Choi, K; Cao, S; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Langella, A; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Akutsu, R; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Bhuiyan, N; Boschi, T; Burton, GT; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Taani, M; Xie, Z; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takeuchi, Y; Bronner, C; Feng, J; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tarrant, A; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Harada, M; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Nakanish, F; Sakai, S; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Holin, A; Nova, F; Yang, JY; Yang, BS; Yoo, J; Fannon, JEP; Kneale, L; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Kwon, E; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Koshiba, M; Iwamoto, K; Nakagiri, K; Nakajima, Y; Shima, S; Taniuchi, N; Yokoyama, M; Martens, K; de Perio, P; Vagins, MR; Xia, J; Kuze, M; Izumiyama, S; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ommura, Y; Shigeta, N; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Gaur, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Li, X; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Boyd, SB; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

PHYSICAL REVIEW D 107 ( 9 )  2023.05

ISSN  2470-0010

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<i>Escherichia coli</i>-derived outer-membrane vesicles induce immune activation and progression of cirrhosis in mice and humans

Natsui, K; Tsuchiya, A; Imamiya, R; Osada-Oka, M; Ishii, Y; Koseki, Y; Takeda, N; Tomiyoshi, K; Yamazaki, F; Yoshida, Y; Ohashi, R; Ling, YW; Ueda, K; Moritoki, N; Sato, K; Nakajima, T; Hasegawa, Y; Okuda, S; Shibata, S; Terai, S

LIVER INTERNATIONAL 43 ( 5 ) 1126 - 1140 2023.05

ISSN  1478-3223

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Comment on: Differential effect of anticoagulation according to cognitive function and frailty in older patients with atrial fibrillation

Kudo, M; Ito, H; Sato, K; Nagayama, H; Fujisawa, S; Yoshioka, T

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 71 ( 4 ) 1336 - 1337 2023.04

ISSN  0002-8614

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Impact of pre-diabetes, well-controlled diabetes, and poorly controlled diabetes on anastomotic leakage after esophagectomy for esophageal cancer: a two-center retrospective cohort study of 1901 patients

Hirano, Y; Fujita, T; Konishi, T; Takemura, R; Sato, K; Kurita, D; Ishiyama, K; Fujiwara, H; Oguma, J; Itano, O; Daiko, H

ESOPHAGUS 20 ( 2 ) 246 - 255 2023.04

ISSN  1612-9059

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Open system synthesis of narrow-bandwidth red-fluorescent carbon quantum dots with a function of multi-metal ion sensing

Katakami, R; Sato, K; Ogura, A; Takao, KI; Iso, Y; Isobe, T

JOURNAL OF MATERIALS CHEMISTRY C 11 ( 12 ) 4143 - 4152 2023.03

ISSN  2050-7526

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Low energy availability reduces bone mass and gonadal function in male mice

Ito E., Sato Y., Kobayashi T., Soma T., Matsumoto T., Kimura A., Miyamoto K., Matsumoto H., Matsumoto M., Nakamura M., Sato K., Miyamoto T.

Journal of Bone and Mineral Metabolism (Journal of Bone and Mineral Metabolism)  41 ( 2 ) 182 - 192 2023.03

ISSN  09148779

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Introduction: In women, the female athlete triad, marked by low energy availability, functional hypothalamic amenorrhea and osteoporosis, is a recognized risk for stress fractures. Stress injuries also occur in men, but by contrast risks and mechanisms underlying them are less characterized. Materials and methods: 5 week-old wild-type male mice were fed ad libitum (ad) or subjected to 60% food restriction (FR) for five weeks. In both groups, some mice were allowed access to an exercise wheel in cages to allow voluntary wheel running (ex) and/or treated with active vitamin D analogues. Mice were sacrificed and analyzed at 10 weeks of age. Result: Male FR mice exhibited significantly reduced testicle weight, serum testosterone levels and bone mass. Such bone losses in FR male mice were enhanced by exercise. Histological analysis revealed that both bone-resorbing and -forming activities were significantly reduced in FR or FR plus exercise (FR + ex) mice, mimicking a state of low bone turnover. Significantly reduced bone mass in FR or FR + ex male mice was significantly rescued by treatment with active vitamin D analogues, with significant restoration of osteoblastic activities. Serum levels of insulin-like growth factor I (IGF-I), which is critical for bone remodeling, were significantly lower in FR versus control male mice. Conclusions: Low energy availability puts men at risk for stress injuries as well, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men.

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Cystic fibrosis with multiple pulmonary arteriovenous malformations: A case report.

Ikeda O, Shimizu K, Yamada Y, Sugiura H, Suzuki H, Umetsu S, Sato K, Jinzaki M

Radiology case reports 18 ( 3 ) 1033 - 1036 2023.03

ISSN  1930-0433

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Factors affecting the quality of life in the chronic phase of thoracolumbar osteoporotic vertebral fracture managed conservatively with a brace

Inose, H; Kato, T; Ichimura, S; Nakamura, H; Hoshino, M; Takahashi, S; Togawa, D; Hirano, T; Tokuhashi, Y; Ohba, T; Haro, H; Tsuji, T; Sato, K; Sasao, Y; Takahata, M; Otani, K; Momoshima, S; Hirai, T; Yoshii, T; Takahashi, K; Okawa, A

SPINE JOURNAL 23 ( 3 ) 425 - 432 2023.03

ISSN  1529-9430

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Intercalation on Transition Metal Trichalcogenides via a Quasi-Amorphous Phase with 1D Order

Fujioka, M; Jeem, M; Sato, K; Tanaka, M; Morita, K; Shibuya, T; Takahashi, K; Iwasaki, S; Miura, A; Nagao, M; Demura, S; Sakata, H; Ono, M; Kaiju, H; Nishii, J

ADVANCED FUNCTIONAL MATERIALS 33 ( 10 )  2023.03

ISSN  1616-301X

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Predictors of Improvement in Exercise Tolerance After Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension

Daigo K., Katsumata Y., Esaki K., Iwasawa Y., Ichihara G., Miura K., Shirakawa K., Sato Y., Sato K., Fukuda K.

Journal of the American Heart Association (Journal of the American Heart Association)  12 ( 3 )  2023.02

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BACKGROUND: Balloon pulmonary angioplasty (BPA) improves exercise tolerance and hemodynamic parameters in patients with chronic thromboembolic pulmonary hypertension. However, it is still unclear which patient characteristics contribute to the improvement in exercise tolerance after BPA in chronic thromboembolic pulmonary hypertension. METHODS AND RESULTS: We retrospectively analyzed 126 patients with chronic thromboembolic pulmonary hypertension (aged 63±14 years; female, 65%) who underwent BPA without concomitant programmed exercise rehabilitation at Keio University between November 2012 and April 2018. Hemodynamic data and 6-minute walk distance (6MWD), as a measure of exercise tolerance, were evaluated before and 1 year after BPA. The clinical characteristics that contributed to improvement in exercise tolerance were elucidated. The 6MWD significantly increased from 372.0 m (256.5–431.3) to 462.0 m (378.8–537.0) 1 year after BPA (P<0.001). The improvement rate in the 6MWD after BPA exhibited a good correlation with age, height, mean pulmonary artery pressure, and 6MWD at baseline (Spearman rank correlation coefficients=−0.28, 0.24, −0.40, and 0.44, respectively). Additional multivariable linear regression analysis revealed that young age, tall height, high mean pulmonary artery pressure, short 6MWD at baseline, and high lung capacity at baseline were significant predictors of the improvement in 6MWD by BPA (standardized partial regression coefficient −0.39, 0.22, 0.19, −0.62, and 0.25, P<0.001, 0.007, 0.011, <0.001, and <0.001, respectively). CONCLUSIONS: BPA without concomitant programmed exercise rehabilitation significantly improves exercise tolerance. This was particularly true in young patients with high stature, high mean pulmonary artery pressure, short 6MWD, and lung capacity at the time of diagnosis.

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Prediction of hydrophilic and hydrophobic hydration structure of protein by neural network optimized using experimental data

Sato, K; Oide, M; Nakasako, M

SCIENTIFIC REPORTS 13 ( 1 ) 2183 2023.02

ISSN  2045-2322

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Dedifferentiated liposarcoma in the extremity and trunk wall: A multi-institutional study of 132 cases by the Japanese Musculoskeletal Oncology Group (JMOG)

Morii, T; Anazawa, U; Sato, C; Iwata, S; Nakagawa, M; Endo, M; Nakamura, T; Ikuta, K; Nishida, Y; Nakayama, R; Udaka, T; Kawamoto, T; Kito, M; Sato, K; Imanishi, J; Akiyama, T; Kobayashi, H; Nagano, A; Outani, H; Toki, S; Nishisho, T; Sasa, K; Suehara, Y; Kawano, H; Ueda, T; Morioka, H

EJSO 49 ( 2 ) 353 - 361 2023.02

ISSN  0748-7983

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Search for Cosmic-Ray Boosted Sub-GeV Dark Matter Using Recoil Protons at Super-Kamiokande

Abe, K; Hayato, Y; Hiraide, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Xia, J; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Choi, K; Cao, S; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Boschi, T; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Taani, M; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takeuchi, Y; Bronner, C; Feng, J; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Harada, M; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Nakanishi, F; Sakai, S; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Nova, F; Yang, JY; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Iwamoto, K; Nakagiri, K; Nakajima, Y; Taniuchi, N; Yokoyama, M; Martens, K; de Perio, P; Vagins, MR; Kuze, M; Izumiyama, S; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ommura, Y; Shigeta, N; Shinoki, M; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Akutsu, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

PHYSICAL REVIEW LETTERS 130 ( 3 ) 031802 2023.01

ISSN  0031-9007

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Excision of the hook of hamate in athletes using the carpal tunnel approach

Kimura H., Sato K., Suzuki T., Matsumura N., Iwamoto T.

Journal of Orthopaedic Science (Journal of Orthopaedic Science)  28 ( 1 ) 143 - 146 2023.01

ISSN  09492658

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Background: Hook of the hamate fractures can be managed conservatively or fixed using a screw, but excision is recommended for prompt return to activities. Although various approaches have been described, there is no gold standard. Herein, the authors have described their clinical experiences in excising the hook of the hamate using the carpal tunnel approach, in athletes. Methods: A total of 36 athletes underwent excision of the hamate hook using the carpal tunnel approach. The mean age of the patients was 23 years, and most of them were baseball players (n = 31). Results: The mean operation time was 33 min. None of the patients presented with any complications aside from transient pillar pain in five cases. All of them returned to their sports activities within an average of 27 days. Conclusions: In our study, excision of the hook of the hamate was performed safely via the carpal tunnel. The carpal tunnel approach reportedly provides superior benefits over other approaches.

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Japanese version of the Patient-rated elbow evaluation score correlates with physician-rated Japanese orthopaedic association-Japan elbow society elbow function score

Sato K., Ishigaki D., Iwabu S., Okazaki M., Koh S., Soejima O., Funakoshi T., Moriya K., Suzuki T., Ozasa Y., Sugiyama D.

Journal of Orthopaedic Science (Journal of Orthopaedic Science)   2023

ISSN  09492658

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Background: The association between Patient-Rated Elbow Evaluation: Japanese version (PREE-J) and Japanese Orthopaedic Association-Japan Elbow Society Elbow Function score (JOA-JES score) is unclear. This study evaluated the association between PREE-J and JOA-JES scores. Methods: The patients with elbow disorders were divided into two groups: Group A (conservative treatment, n = 97) and Group B (surgical treatment, n = 156). The patients were also divided into four disease subgroups according to the JOA-JES classification (rheumatoid arthritis, trauma, sports, and epicondylitis groups), and the association between PREE-J and JOA-JES scores in each disease category was examined. In group B, associations between PREE-J and JOA-JES scores were examined pre-and postoperatively. Results: In group A, there were significant associations between PREE-J and JOA-JES scores. In group B, a strong association between preoperative PREE-J and JOA-JES scores was observed in all disease categories. There was also a significant association between postoperative PREE-J and JOA-JES scores. Additionally, group B showed significant postoperative improvements in PREE-J and JOA-JES scores. Conclusions: The PREE-J score correlates well with the JOA-JES score and reflects treatment response before and after treatment.

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In-vivo kinematics of the trapeziometacarpal joint in dynamic pinch motion using four-dimensional computed tomography imaging

Inaba N., Oki S., Nagura T., Sato K., Jinzaki M., Iwamoto T., Nakamura M.

Skeletal Radiology (Skeletal Radiology)   2023

ISSN  03642348

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Objective: CT imaging precisely and quantitatively analyzes the kinematics of the carpal bones to evaluate the etiology of related osteoarthritis. Previous studies have investigated the kinematics of the trapeziometacarpal joint using static CT scans of various postures including the pinch position. This study analyzed the in-vivo kinematics of the trapeziometacarpal joint during dynamic pinch motion in young healthy volunteers using four-dimensional CT. Materials and methods: Twelve healthy young volunteers participated in this study. Each participant held the pinch meter between their thumb and index finger and pinched it with maximum force for a period of 6 s. This series of movement was recorded using a four-dimensional CT. The surface data of the trapezium and first metacarpal of all frames were reconstructed, and bone movement at the trapeziometacarpal joint was calculated using sequential three-dimensional registration. The instantaneous pinch force of each frame was measured using a pointer on a pinch meter that was reconstructed from the CT data. Results: The first metacarpal was abducted (15.9 ± 8.3°) and flexed (12.2 ± 7.1°) relative to the trapezium, and significantly translated to the volar　(0.8 ± 0.6 mm) and ulnar directions (0.9 ± 0.8 mm) with maximum pinch force. This movement consistently increased with the pinch force. Conclusion: This study successfully employed 4D-CT to precisely demonstrate changes in rotation and translation at the trapeziometacarpal joint during pinch motion for various instantaneous forces.

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[Sustaining molecular response with very low dose ponatinib and further response after hemodialysis initiation in a patient with chronic myeloid leukemia].

Sato K, Sumi M, Kobayashi M, Kataoka K, Takahashi N, Kobayashi H

[Rinsho ketsueki] The Japanese journal of clinical hematology 64 ( 10 ) 1266 - 1269 2023

ISSN  0485-1439

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Correlation between acylcarnitine/free carnitine ratio and cardiopulmonary exercise test parameters in patients with incident dialysis

Ito W., Uchiyama K., Mitsuno R., Sugita E., Nakayama T., Ryuzaki T., Takahashi R., Katsumata Y., Hayashi K., Kanda T., Washida N., Sato K., Itoh H.

Frontiers in Physiology (Frontiers in Physiology)  14 2023

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Objective: Diminished physical capacity is common and progressive in patients undergoing dialysis, who are also prone to deficiency in carnitine, which plays a pivotal role in maintaining skeletal muscle and cardiac function. The present study aimed to evaluate the association of carnitine profile with exercise parameters in patients with incident dialysis. Design and Methods: This was a single-center cross-sectional study including 87 consecutive patients aged 20–90 years who were initiated on dialysis in Keio University Hospital between December 2019 and December 2022 and fulfilled the eligibility criteria. Exercise parameters were evaluated via cardiopulmonary testing (CPX) using the electronically braked STRENGTH ERGO 8 ergometer, whereas the carnitine profile was assessed by determining serum free carnitine (FC), acylcarnitine (AC) levels and AC/FC ratio. Results: The mean cohort age was 62.1 ± 15.2 years, with male and hemodialysis predominance (70% and 73%, respectively). AC/FC was 0.46 ± 0.15, and CPX revealed peak oxygen consumption (VO2) of 13.9 ± 3.7 (mL/kg/min) with percent-predicted peak VO2 of 53.6% ± 14.7% and minute ventilation (VE)/carbon dioxide output (VCO2) slope of 35.1 ± 8.0. Fully-adjusted multivariate linear regression analysis showed that AC/FC was significantly associated with decreased peak VO2 (β, −5.43 [95% confidence interval (CI), −10.15 to −0.70]) and percent-predicted peak VO2 (β, −19.98 [95% CI, −38.43 to −1.52]) and with increased VE/VCO2 slope (β, 13.76 [95% CI, 3.78–23.75]); FC and AC did not exhibit similar associations with these parameters. Moreover, only AC/FC was associated with a decreased peak work rate (WR), percent-predicted WR, anaerobic threshold, delta VO2/delta WR, and chronotropic index. Conclusion: In patients on incident dialysis, exercise parameters, including those related to both skeletal muscle and cardiac function, were strongly associated with AC/FC, a marker of carnitine deficiency indicating altered fatty acid metabolism. Further studies are warranted to determine whether carnitine supplementation can improve exercise capacity in patients on incident dialysis.

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Genetic Testing Enables the Diagnosis of Familial Hypercholesterolemia Underdiagnosed by Clinical Criteria: Analysis of Japanese Early-Onset Coronary Artery Disease Patients

Miyama H., Katsumata Y., Momoi M., Ichihara G., Fujisawa T., Endo J., Kawakami T., Kataoka M., Yuasa S., Sano M., Sato K., Fukuda K.

Cardiology Research and Practice (Cardiology Research and Practice)  2023 2023

ISSN  20908016

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Definitive diagnosis of familial hypercholesterolemia (FH) is paramount for the risk management of patients and their relatives. The present study aimed to investigate the frequency of gene variants contributing to low-density lipoprotein cholesterol (LDL-C) metabolism and their clinical relevance in patients with early-onset coronary artery disease (EOCAD). Among 63 consecutive patients with EOCAD (men <55 years or women <65 years) who underwent percutaneous coronary intervention (PCI) from 2013 to 2019 at Keio University Hospital, 52 consented to participate in this retrospective study. Targeted sequencing of LDLR, PCSK9, APOB, and LDLRAP1 was performed. Of the 52 patients enrolled (42 men; mean age: 50 ± 6 years), one (LDLR, c.1221_1222delCGinsT) harbored a pathogenic mutation, and one (APOB, c.10591A>G) harbored variants of uncertain significance. Both the patients harboring the variants were male, showing no history of diabetes mellitus or chronic kidney disease, no family history of EOCAD, and no physical findings of FH (i.e., tendon xanthomas or Achilles tendon thickening). Patients harboring the LDLR variant had three-vessel disease, were on a statin prescription at baseline, and had stable LDL-C levels; however, the case showed a poor response to the intensification of medication after PCI. Approximately 3.8% of patients with EOCAD harbored variants of gene related to LDL-C metabolism; there were no notable indicators in the patients' background or clinical course to diagnose FH. Given the difficulty in diagnosing FH based on clinical manifestations and family history, genetic testing could enable the identification of hidden risk factors and provide early warnings to their relatives.

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RNA Secondary Structure Prediction Based on Energy Models.

Akiyama M, Sato K

Methods in molecular biology (Clifton, N.J.) 2586   89 - 105 2023

ISSN  1064-3745

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Clinical and electrophysiological characteristics of surgically treated cubital tunnel syndrome

Kimura Hiroo, Matsuo Tomoki, Suzuki Taku, Sato Kazuki, Iwamoto Takuji

Journal of Japan Elbow Society (Japan Elbow Society)  30 ( 2 ) 357 - 360 2023

ISSN  13497324

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肘部管症候群手術症例を対象に，臨床的特徴や電気生理学的所見，術後成績に及ぼす因子について検討を行った．対象は71肘で，平均年齢59歳，男性44肘，女性27肘，利き手44肘，非利き手27肘，平均BMI 25kg/m2，平均罹病期間13か月，糖尿病合併11肘，頚椎疾患合併19肘，変形性肘関節症18肘，McGowan分類はI度 9肘，II度 23肘，III度 39肘，術者5名，術式は単純除圧16肘，King変法5肘，前方移動術50肘であった．術後2年時点におけるMessina評価基準は優7肘，良28肘，可30肘，不可6肘であり，統計学的に有意な相関を認めたのは術前McGowan分類のみであった．また，電気生理学的検査では7例がインチング法のみで伝導異常を認めた．術前重症度が手術成績に影響することが示され，また，肘上下の伝導速度や振幅に異常を認めない場合にはインチング法が有用であると考えられた．

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特集 上肢のスポーツ外傷・障害Up to date introduction

佐藤 和毅

関節外科　基礎と臨床 (メジカルビュー社)  41 ( 12 ) 1293 - 1293 2022.12

ISSN  02865394

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Real-time analysis of heart rate variability during aerobic exercise in patients with cardiovascular disease

Ikura H., Katsumata Y., Seki Y., Ryuzaki T., Shiraishi Y., Miura K., Sato K., Fukuda K.

IJC Heart and Vasculature (IJC Heart and Vasculature)  43 2022.12

ISSN  23529067

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Background: Exercise therapy for cardiovascular disease (CVD) is mainly evaluated based on the heart rate (HR) or Borg scale. However, these indices can be unreliable depending on the patient's medication or their subjective decisions; thus, alternative methods are required for easier and safer implementation of aerobic exercise. Here, we examined whether real-time analysis of HR variability (HRV) can help maintain exercise intensity at the ventilatory threshold (VT) during exercise. Methods: Twenty-eight patients with CVD treated at Keio University Hospital between August 2018 and March 2020 were enrolled. Initially, oxygen uptake (VO2) and HR at the VT were determined using the cardiopulmonary exercise test. Patients then performed aerobic exercise on a stationary bicycle for 30 min while a parameter of HRV, the high-frequency (HF) component, was monitored in real time using an electrocardiograph. The work rate during exercise was adjusted every 2 min to maintain the HF range between 5 and 10. The VO2 and HR values, recorded every 2 min during exercise, were compared with those at VT. The Bland–Altman method was used to confirm similarity. Results: VO2 and HR during exercise were closely correlated with those at VT (e.g., 19 min after exercise initiation; VO2: r = 0.647, HR: r = 0.534). The Bland–Altman plot revealed no bias between the mean values (e.g., 19 min; VO2: −0.22 mL/kg/min; HR: −0.07/min). Conclusion: Real-time HRV analysis with electrocardiograph alone during exercise can provide continuous and non-invasive exercise intensity measurements at VT, promoting safer and effective exercise strategies.

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Direct Inference of Base-Pairing Probabilities with Neural Networks Improves Prediction of RNA Secondary Structures with Pseudoknots

Akiyama, M; Sakakibara, Y; Sato, K

GENES 13 ( 11 )  2022.11

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Reconstructing diets of hunted sika deer from Torihama Shell Midden site (ca. 6,000 years ago) by dental microwear texture analysis

Sato, K; Sato, T; Kubo, MO

FRONTIERS IN ECOLOGY AND EVOLUTION 10 2022.10

ISSN  2296-701X

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Search for proton decay via p → μ<SUP>+</SUP> K<SUP>0</SUP> in 0.37 megaton-years exposure of Super-Kamiokande

Matsumoto, R; Abe, K; Hayato, Y; Hiraide, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Xia, J; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Choi, K; Cao, S; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Boschi, T; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Taani, M; Xie, Z; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takeuchi, Y; Yamamoto, S; Bronner, C; Feng, J; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tsui, KM; Tarrant, A; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Harada, M; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Ma, W; Nakanishi, F; Sakai, S; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Holin, A; Nova, F; Yang, JY; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Kwon, E; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Koshiba, M; Iwamoto, K; Nakagiri, K; Nakajima, Y; Shima, S; Taniuchi, N; Yokoyama, M; Martens, K; de Perio, P; Vagins, MR; Kuze, M; Izumiyama, S; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Ommura, Y; Shigeta, N; Shinoki, M; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Akutsu, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Li, X; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Boyd, SB; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

PHYSICAL REVIEW D 106 ( 7 )  2022.10

ISSN  2470-0010

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Searching for Supernova Bursts in Super-Kamiokande IV

Mori, M; Abe, K; Hayato, Y; Hiraide, K; Ieki, K; Ikeda, M; Imaizumi, S; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nagao, Y; Nakahata, M; Nakano, Y; Nakayama, S; Noguchi, Y; Okada, T; Okamoto, K; Orii, A; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Tomiya, T; Watanabe, S; Yano, T; Yoshida, S; Han, S; Kajita, T; Okumura, K; Tashiro, T; Wang, X; Xia, J; Megias, GD; Bravo-Berguño, D; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Zsoldos, S; Pointon, BW; Blaszczyk, FDM; Kearns, E; Raaf, JL; Stone, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Mueller, TA; Paganini, P; Quilain, B; Santos, AD; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Maekawa, Y; Nishimura, Y; Fujisawa, C; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Ozaki, H; Shiozawa, T; Suzuki, AT; Takeuchi, Y; Yamamoto, S; Kotsar, Y; Ashida, Y; Bronner, C; Feng, J; Hirota, S; Kikawa, T; Nakaya, T; Wendell, RA; Yasutome, K; McCauley, N; Mehta, P; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Niwa, T; Tsukada, M; Lagoda, J; Lakshmi, SM; Mijakowski, P; Zalipska, J; Mandal, M; Prabhu, YS; Jiang, J; Jung, CK; Vilela, C; Wilking, MJ; Yanagisawa, C; Jia, M; Hagiwara, K; Harada, M; Horai, T; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Ma, W; Nakanishi, F; Piplani, N; Sakai, S; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Nova, F; Boschi, T; Gao, J; Goldsack, A; Katori, T; Di Lodovico, F; Migenda, J; Taani, M; Zsoldos, S; Yang, JY; Jenkins, SJ; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Seo, JW; Yu, I; Nishijima, K; Koshiba, M; Nakagiri, K; Nakajima, Y; Iwamoto, K; Taniuchi, N; Yokoyama, M; Martens, K; de Perio, P; Vagins, MR; Kuze, M; Izumiyama, S; Yoshida, T; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ohta, K; Ommura, Y; Shigeta, N; Shinoki, M; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Akutsu, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Walker, J; Marti, L; Minamino, A; Okamoto, K; Pintaudi, G; Sasaki, R; Sano, S; Suzuki, S; Wada, K; Cao, S; Ichikawa, A; Nakamura, KD; Tairafune, S; Choi, K

ASTROPHYSICAL JOURNAL 938 ( 1 )  2022.10

ISSN  0004-637X

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Tumor metabolic alterations after neoadjuvant chemoradiotherapy predict postoperative recurrence in patients with pancreatic cancer

Wada, Y; Okano, K; Sato, K; Sugimoto, M; Shimomura, A; Nagao, M; Matsukawa, H; Ando, Y; Suto, H; Oshima, M; Kondo, A; Asano, E; Kishino, T; Kumamoto, K; Kobara, H; Kamada, H; Masaki, T; Soga, T; Suzuki, Y

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 52 ( 8 ) 879 - 887 2022.08

ISSN  0368-2811

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Pre-supernova Alert System for Super-Kamiokande

Machado, LN; Abe, K; Hayato, Y; Hiraide, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; de Perio, P; Martens, K; Vagins, MR; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Xia, J; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Akutsu, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Prouse, NW; Kearns, E; Raaf, JL; Wan, L; Wester, T; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Cao, S; Choi, K; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Sasaki, R; Friend, M; Hasegawa, T; Ishida, T; Jakkapu, M; Kobayashi, T; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Boschi, T; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Taani, M; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takeuchi, Y; Yaamoto, S; Bronner, C; Feng, J; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Harada, M; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Ma, W; Nakanishi, F; Sakai, S; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Nova, F; Yang, JY; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Iwamoto, K; Nakagiri, K; Nakajima, Y; Taniuchi, N; Yokoyama, M; Izumiyama, S; Kuze, M; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ommura, Y; Shigeta, N; Shinoki, M; Suganuma, T; Yonenaga, M; Martin, JF; Tanaka, HA; Towstego, T; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Hadley, D; Nicholson, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

ASTROPHYSICAL JOURNAL 935 ( 1 )  2022.08

ISSN  0004-637X

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Epstein-Barr-virus-infected Plasma Cells Infiltrating Plasma Cell Mucositis of the Oral Cavity and Larynx

Sato, K; Nakaoka, K; Yabe, H; Eguchi, T; Kumagai, K; Arai, G; Ito, Y; Hamada, Y

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 34 ( 4 ) 480 - 484 2022.07

ISSN  2212-5558

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Nanoarchitectonics for conductive polymers using solid and vapor phases

Oaki, Y; Sato, K

NANOSCALE ADVANCES 4 ( 13 ) 2773 - 2781 2022.06

ISSN  2516-0230

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Surface-Modified Carbon Dots with Improved Photoluminescence Quantum Yield for Color Conversion in White-Light-Emitting Diodes

Sato, K; Katakami, R; Iso, Y; Isobe, T

ACS APPLIED NANO MATERIALS 5 ( 6 ) 7664 - 7669 2022.06

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An autopsy of a case of sporadic Creutzfeldt-Jakob disease with MM1+2C+2T

Nakayama, Y; Sano, T; Suto, Y; Adachi, T; Mizutani, M; Sato, K; Takeuchi, A; Kitamoto, T; Miyachi, T; Takao, M

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 81 ( 6 ) 483 - 483 2022.05

ISSN  0022-3069

Large magnetocapacitance beyond 420% in epitaxial magnetic tunnel junctions with an MgAl₂O₄ barrier

Sato, K; Sukegawa, H; Ogata, K; Xiao, G; Kaiju, H

SCIENTIFIC REPORTS 12 ( 1 ) 7190 2022.05

ISSN  2045-2322

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Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets

Sato, Y; Kondo, T; Uchida, A; Sato, K; Yoshino-Saito, K; Nakamura, M; Okano, H; Ushiba, J

BEHAVIOURAL BRAIN RESEARCH 425   113816 2022.05

ISSN  0166-4328

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Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness

Ando, T; Tai-Nagara, I; Sugiura, Y; Kusumoto, D; Okabayashi, K; Kido, Y; Sato, K; Saya, H; Navankasattusas, S; Li, DY; Suematsu, M; Kitagawa, Y; Seiradake, E; Yamagishi, S; Kubota, Y

JOURNAL OF CLINICAL INVESTIGATION 132 ( 6 )  2022.03

ISSN  0021-9738

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First gadolinium loading to Super-Kamiokande

Abe, K; Bronner, C; Hayato, Y; Hiraide, K; Ikeda, M; Imaizumi, S; Kameda, J; Kanemura, Y; Kataoka, Y; Miki, S; Miura, M; Moriyama, S; Nagao, Y; Nakahata, M; Nakayama, S; Okada, T; Okamoto, K; Orii, A; Pronost, G; Sekiya, H; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Xia, J; Megias, GD; Bravo-Berguño, D; Labarga, L; Marti, L; Zaldivar, B; Pointon, BW; Blaszczyk, FDM; Kearns, E; Raaf, JL; Stone, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Mine, S; Smy, MB; Sobel, HW; Takhistov, V; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Gonin, M; Mueller, TA; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Cao, S; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ospina, N; Ludovici, L; Maekawa, Y; Nishimura, Y; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Boschi, T; Gao, J; Di Lodovico, F; Migenda, J; Taani, M; Zsoldos, S; Kotsar, Y; Nakano, Y; Ozaki, H; Shiozawa, T; Suzuki, AT; Takeuchi, Y; Yamamoto, S; Ali, A; Ashida, Y; Feng, J; Hirota, S; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Fernandez, P; McCauley, N; Mehta, P; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Niwa, T; Sato, K; Tsukada, M; Lagoda, J; Lakshmi, SM; Mijakowski, P; Zalipska, J; Jiang, J; Jung, CK; Vilela, C; Wilking, MJ; Yanagisawa, C; Hagiwara, K; Harada, M; Horai, T; Ishino, H; Ito, S; Kitagawa, F; Koshio, Y; Ma, W; Piplani, N; Sakai, S; Barr, G; Barrow, D; Cook, L; Goldsack, A; Samani, S; Wark, D; Nova, F; Yang, JY; Jenkins, SJ; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, K; Nishijima, K; Koshiba, M; Iwamoto, K; Nakajima, Y; Ogawa, N; Yokoyama, M; Martens, K; Vagins, MR; Kuze, M; Izumiyama, S; Yoshida, T; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ohta, K; Shinoki, M; Suganuma, T; Martin, JF; Tanaka, HA; Towstego, T; Akutsu, R; Hartz, M; Konaka, A; de Perio, P; Prouse, NW; Chen, S; Xu, BD; Posiadala-Zezula, M; Hadley, D; O'Flaherty, M; Richards, B; Jamieson, B; Walker, J; Minamino, A; Okamoto, K; Pintaudi, G; Sano, S; Sasaki, R

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 1027 2022.03

ISSN  0168-9002

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Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures

Inose, H; Kato, T; Ichimura, S; Nakamura, H; Hoshino, M; Takahashi, S; Togawa, D; Hirano, T; Tokuhashi, Y; Ohba, T; Haro, H; Tsuji, T; Sato, K; Sasao, Y; Takahata, M; Otani, K; Momoshima, S; Hirai, T; Yoshii, T; Okawa, A

JOURNAL OF CLINICAL MEDICINE 11 ( 6 )  2022.03

ISSN  2077-0383

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Effects of Dual Task Interference on Biomechanics of the Entire Lower Extremity During the Drop Vertical Jump

Imai S., Harato K., Morishige Y., Kobayashi S., Niki Y., Sato K., Nagura T.

Journal of Human Kinetics (Journal of Human Kinetics)  81 ( 1 ) 5 - 14 2022.02

ISSN  16405544

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The dual task is an important factor affecting knee biomechanics during jump-landing tasks. Athletes often have trouble in performing two tasks concurrently and a dual task can deteriorate landing performance. However, it is still unknown whether a dual task will affect the entire lower extremity. The purpose of this study was to clarify the effects of cognitive task interference on biomechanics of hip and ankle joints as well as the knee joint during the drop vertical jump (DVJ). A total of 20 female collegiate athletes participated in the study. Athletes performed a DVJ with or without a cognitive task. The DVJ was captured using a motion analysis system. Mental arithmetic of 2-digit addition was used as a cognitive task. Maximum vertical ground reaction force (vGRF), joint angles at initial contact (IC), joint moments within 40 milliseconds (ms) after IC, and joint angles and moments at peak vGRF were assessed. The data were statistically compared between with and without a cognitive task condition using a two-tailed paired t-test or the Wilcoxon singed rank test. The peak external knee abduction moment on both limbs within 40 ms after IC during the DVJ was significantly larger in the dual task than in the single task with less knee and hip flexion at initial contact. In addition, all moments of hip and ankle joints within 40 ms after IC were significantly larger in the dual task than in the single task accompanied with greater vGRF, except for the hip internal rotation moment. Cognitive tasks during a DVJ will result in biomechanical changes of the entire lower extremity in female athletes.

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Factors that affect menarche in Japanese national-level track-and-field athletes

Tsukahara Y., Namba A., Kamada H., Torii S., Tabata S., Yamasawa F., Sato K.

American Journal of Human Biology (American Journal of Human Biology)  34 ( 2 )  2022.02

ISSN  10420533

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Objectives: The minimum body mass index (BMI) required to menarche and the relationship between the training onset age of sports and menarche is not fully understood. The aim of this study is to elucidate the minimum BMI required to attain menarche in female adolescent athletes competing at a national level, and to determine how the occurrence of menarche is associated with training onset age in track-and-field athletes. Methods: Overall, 134 sprinters and 44 long-distance (LD) runners of ninth-grade females at a national level were enrolled and an anonymous questionnaire was administered. Results: As BMI increased, the proportion of athletes who had attained menarche increased. The BMI cutoff values for menarche were 17.3 and 17.1 kg/m2 for sprinters and LD runners, respectively. Menarche had not occurred in almost 50% of the LD runners who began training at elementary school, and among LD runners, those who began training at elementary school had 18.4 higher odds of not attaining menarche until the age of 15 years as opposed to those who started training after elementary school. Conclusions: The BMI cutoff values could be an indicator for menarche in sprinters and LD runners. For LD runners, starting to compete at elementary school could be a risk factor for delayed menarche.

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Prediction of RNA secondary structure including pseudoknots for long sequences

Sato, K; Kato, Y

BRIEFINGS IN BIOINFORMATICS 23 ( 1 )  2022.01

ISSN  1467-5463

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Total elbow arthroplasty using an augmented reality–assisted surgical technique

Tanji A., Nagura T., Iwamoto T., Matsumura N., Nakamura M., Matsumoto M., Sato K.

Journal of Shoulder and Elbow Surgery (Journal of Shoulder and Elbow Surgery)  31 ( 1 ) 175 - 184 2022.01

ISSN  10582746

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Background: Precision placement of implants in total elbow arthroplasty (TEA) using conventional surgical techniques can be difficult and riddled with errors. Modern technologies such as augmented reality (AR) and 3-dimensional (3D) printing have already found useful applications in many fields of medicine. We proposed a cutting-edge surgical technique, augmented reality total elbow arthroplasty (ARTEA), that uses AR and 3D printing to provide 3D information for intuitive preoperative planning. The purpose of this study was to evaluate the accuracy of humeral and ulnar component placement using ARTEA. Methods: Twelve upper extremities from human frozen cadavers were used for experiments performed in this study. We scanned the extremities via computed tomography prior to performing TEA to plan placement sites using computer simulations. The ARTEA technique was used to perform TEA surgery on 6 of the extremities, whereas conventional (non-ARTEA) techniques were used on the other 6 extremities. Computed tomography scanning was repeated after TEA completion, and the error between the planned and actual placements of humeral and ulnar components was calculated and compared. Results: For humeral component placement, the mean positional error ± standard deviation of ARTEA vs. non-ARTEA was 1.4° ± 0.6° vs. 4.4° ± 0.9° in total rotation (P = .002) and 1.5 ± 0.6 mm vs. 8.6 ± 1.3 mm in total translation (P = .002). For ulnar component placement, the mean positional error ± standard deviation of ARTEA vs. non-ARTEA was 5.5° ± 3.1° vs. 19.5° ± 9.8° in total rotation (P = .004) and 1.5 ± 0.4 mm vs. 6.9 ± 1.6 mm in total translation (P = .002). Both rotational accuracy and translational accuracy were greater for joint components replaced using the ARTEA technique compared with the non-ARTEA technique (P < .05). Conclusion: Compared with conventional surgical techniques, ARTEA had greater accuracy in prosthetic implant placement when used to perform TEA.

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Guidelines for Reproductive Medicine in Japan

Yamada, M; Ishikawa, T; Iwasa, T; Oishi, H; Osuka, S; Oka, K; Ono, S; Ono, M; Orisaka, M; Kanasaki, H; Kawano, Y; Kawamura, K; Kishi, H; Kimura, F; Kuroda, S; Kuwahara, A; Kobayashi, H; Komiya, A; Saito, H; Sato, K; Sato, S; Shiraishi, K; Shirasawa, H; Suzuki, T; Takai, Y; Takae, S; Takahashi, T; Takiuchi, T; Tachibana, M; Tamura, I; Tamura, H; Jwa, SC; Baba, T; Harada, M; Hirata, T; Fukui, A; Fukuda, Y; Fukuhara, S; Maruyama, T; Yumura, Y; Yoshino, O; Hirota, Y; Tsujimura, A; Kuji, N; Osuga, Y

REPRODUCTIVE MEDICINE AND BIOLOGY 21 ( 1 ) e12483 2022.01

ISSN  1445-5781

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Multisystem Imaging Manifestations of Kawasaki Disease

Tsujioka, Y; Handa, A; Nishimura, G; Miura, M; Yokoyama, K; Sato, K; Handa, H; Jinzaki, M; Nosaka, S; Kono, T

RADIOGRAPHICS 42 ( 1 ) 268 - 288 2022.01

ISSN  0271-5333

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Metastatic Neuroblastoma in the Oral Cavity of a Toddler

Hiraga, CK; Suzuki, T; Yamazaki, F; Kawaida, M; Baba, A; Sato, K; Nomura, T

JOURNAL OF DENTISTRY FOR CHILDREN 89 ( 1 ) 52 - 56 2022.01

ISSN  1551-8949

Possibility for Visualizing the Muscle Microstructure by q-Space Imaging Technique

Sera Y., Nakashima D., Hata J., Okano H.J., Sato K., Nakamura M., Nagura T.

Applied Bionics and Biomechanics (Applied Bionics and Biomechanics)  2022 2022

ISSN  11762322

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In the human body, skeletal muscle microstructures have been evaluated only by biopsy. Noninvasive examination of the microstructure of muscles would be useful for research and clinical practice in sports and musculoskeletal areas. The study is aimed at determining if q-space imaging (QSI) can reveal the microstructure of muscles in humans. Forty-three Japanese subjects (controls, distance runners, powerlifting athletes, and teenage runners) were included in this cross-sectional study. Magnetic resonance imaging of the lower leg was performed. On each leg muscle, full width at half maximum (FWHM) which indicated the muscle cell diameters and pennation angle (PA) were measured and compared. FWHM showed significant positive correlations with PA, which is related to muscle strength. In addition, FWHM was higher for powerlifting, control, distance running, and teenager, in that order, suggesting that it may be directing the diameter of each muscle cell. Type 1 and type 2 fibers are enlarged by growth, so the fact that the FWHM of the control group was larger than that of the teenagers in this study may indicate that the muscle fibers were enlarged by growth. Also, FWHM has the possibility to increase with increased muscle fibers caused by training. We showed that QSI had the possibility to depict noninvasively the microstructure like muscle fiber type and subtle changes caused by growth and sports characteristics, which previously could only be assessed by biopsy.

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Volar Transfer of the Lateral Band With Transverse Retinacular Ligament for the Correction of Swan Neck Deformity

Suzuki T., Kimura H., Matsumura N., Sato K., Nakamura M., Iwamoto T.

Hand (Hand)   2022

ISSN  15589447

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Background: This retrospective study was designed to evaluate a surgical treatment for swan neck deformity of the fingers involving the volar transfer of the lateral band using the transverse retinacular ligament. Methods: Ten patients who underwent this surgical procedure for swan neck deformity treatment and were followed up for a mean of 26 months (range: 12-65 months) were included in the study. The dorsally located lateral bands were transferred toward the volar aspect of the finger, and their position was maintained using the transverse retinacular ligament. Improvement of the snapping and swan neck deformity was confirmed by intraoperative active motion of the finger. The active range of motion of the affected finger was evaluated pre- and postoperatively. Results: Extension of the proximal interphalangeal (PIP) joint averaged 30° (range: 20°-40°) preoperatively and improved to -2° (range: -5°-0°) postoperatively. Extension of the distal interphalangeal (DIP) joint averaged -30° (range: -15° to -70°) preoperatively and improved to -15° (range: 0° to -55°) postoperatively. The mean improvement in range of motion of the DIP joint was 15° (range: 10°-25°). The flexion of both the PIP and DIP joint did not significantly change in any of the patients postoperatively. Conclusions: Surgical transfer of the lateral band using the transverse retinacular ligament is effective in correcting mild swan neck deformity. Hyperextension of the PIP joint is corrected well, but the severe extension lag of the DIP joint remains uncorrected postoperatively.

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Clinical Outcomes of Medial Collateral Ligament Reconstruction of the Elbow (Itoh Method) for Baseball Players

Yamada Yuichi, Sato Kazuki, Kinoda Akira

Journal of Japan Elbow Society (Japan Elbow Society)  29 ( 2 ) 186 - 189 2022

ISSN  13497324

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【目的】われわれは，オーバヘッドアスリートの肘内側側副靱帯損傷の治療として靱帯再建術（伊藤法）を実施している．野球選手に対する本手術法の治療成績を検討した．<BR>【対象/方法】1998年8月から2019年8月に手術を施行した投手41名を対象とした．手術時平均年齢は18歳であった．競技復帰状況，投球時肘内側部痛の有無，JOA-JES scoreなどを検討した．<BR>【結果】術後平均経過観察期間は37.6か月であった．全例が野球復帰を果たし，投球再開までの期間は平均6.0か月，試合（実践）復帰までの期間は平均9.8か月であった．復帰レベルの低下を5例に認めた．JOA-JES scoreは術前平均34.1点から術後平均94.1点に改善した．<BR>【結語】野球選手に対する伊藤法の成績について報告した．5例で野球復帰レベルの低下を認めたが，全例競技復帰を果たし手術成績は概ね良好であった．

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Clinical outcome of treatment for simple elbow dislocation

Yamada Yuichi, Kusano Hiroshi, Horiuchi Yukio, Ito Yoshiyasu, Sato Kazuki

Journal of Japan Elbow Society (Japan Elbow Society)  29 ( 2 ) 74 - 77 2022

ISSN  13497324

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【目的】単純性肘関節脱臼に対する治療については未だにコンセンサスが得られていない．我々は積極的に靱帯修復術を行っており，今回その治療成績を報告する．<BR>【方法】2016年より手術を行った21肘を対象とした．術直前に全身麻酔下で肘内外反ストレステストによる不安定性評価を行い，外側: 16例，内側: 20例，両側: 15例を手術適応とした．3週間固定の後に自動運動を開始した．<BR>【結果】最終経過観察時のJOA -JES scoreは96.2点であった．平均肘関節可動域は屈曲138°，伸展-2°であった．全例肘関節不安定性は認めず，良好な治療成績が得られた．<BR>【考察】単純性肘関節脱臼に対する保存療法と手術療法の治療成績には有意差がないとする報告がある一方，保存療法では拘縮や疼痛残存が多いとする報告もある．靭帯修復術の治療成績は良好であり，適応を判断した上での手術療法は非常に有用である．

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A case of posterolateral rotatory instability with hypoplasia of ulnar coronoid process treated with iliac bone graft for reconstruction of the coronoid process

Takeya Hiroaki, Suzuki Taku, Kimura Hiroo, Sato Kazuki, Iwamoto Takuji

Journal of Japan Elbow Society (Japan Elbow Society)  29 ( 2 ) 85 - 89 2022

ISSN  13497324

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【目的】尺骨鉤状突起低形成による後外側不安定性に対して腸骨移植を用いた鉤状突起再建と外側側副靭帯縫合術を行った1例を報告する．<BR>【症例】13歳，男児．1年前より左肘可動時に違和感が持続するが近医では診断がつかず，改善がないために当院紹介受診となった．肘関節伸展時に脱臼感を認めた．画像所見では，両側尺骨鉤状突起低形成とCTや伸展位での単純X線で左肘関節後方脱臼を認めた．尺骨鉤状突起低形成による後外側不安定性と診断し，腸骨を用いた鉤状突起再建と弛緩した外側側副靭帯を縫縮した. 術後18か月の観察時に再脱臼は認めず，骨癒合も得られ良好な経過であった．<BR>【考察】鉤状突起低形成を認める症例において，腸骨移植による鉤状突起の再建ならびに外側側副靭帯縫合によって肘関節の安定性が獲得できた. また通常のX線撮影は肘関節屈曲位で施行するため, 本病態を疑った場合は, CTや伸展位のX線が有用であった．

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Preface for the special issue on Design, Concurrent Engineering and Smart Manufacturing towards Highly Digitalized Society

Morinaga, E; Inoue, M; Hino, R; Iwamura, K; Koga, T; Ogi, T; Sato, K; Ura, S; Yanagisawa, H; Ito, K; Kato, T; Nonaka, T; Okubo, M; Tanaka, T; Yamada, S; Yamada, S

JOURNAL OF ADVANCED MECHANICAL DESIGN SYSTEMS AND MANUFACTURING 16 ( 5 )  2022

ISSN  1881-3054

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Platelet-rich plasma in the treatment of medial epicondylitis

Suzuki Taku, Hayakawa Katsuhiko, Nakane Takashi, Takeya Hiroaki, Matsuo Tomoki, Kimura Hiroo, Sato Kazuki, Iwamoto Takuji

Journal of Japan Elbow Society (Japan Elbow Society)  29 ( 2 ) 222 - 224 2022

ISSN  13497324

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【目的】上腕骨内側上顆炎に対するPRP 療法の臨床成績，MRI画像成績について報告する．<BR>【対象と方法】上腕骨内側上顆炎に対してPRP療法を施行した5例を対象とした．評価はPRP療法施行前，施行後1，3，6，12ヵ月時の疼痛 （VAS），握力健側比，屈筋腱付着部のMRI像に関して調査した．MRIの評価は正常 （0），軽度 （1），中程度 （2），重度 （3）の4段階にて評価した．<BR>【結果】PRP療法施行前，施行後1，3，6，12か月における平均VAS は78→68→50→35→20，平均握力健側比も75→83→89→93→95%と経時的に低下し，MRI評価も1.6→1.0→0.4→0.2→0.2と治療前と比べて改善した．<BR>【考察】上腕骨内側上顆炎に対するPRP療法は臨床成績、画像成績共に良好であった．

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Treadmill Training for Common Marmoset to Strengthen Corticospinal Connections After Thoracic Contusion Spinal Cord Injury.

Kondo T, Saito R, Sato Y, Sato K, Uchida A, Yoshino-Saito K, Shinozaki M, Tashiro S, Nagoshi N, Nakamura M, Ushiba J, Okano H

Frontiers in cellular neuroscience 16   858562 2022

ISSN  1662-5102

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Diffuse supernova neutrino background search at Super-Kamiokande

Abe, K; Bronner, C; Hayato, Y; Hiraide, K; Ikeda, M; Imaizumi, S; Kameda, J; Kanemura, Y; Kataoka, Y; Miki, S; Miura, M; Moriyama, S; Nagao, Y; Nakahata, M; Nakayama, S; Okada, T; Okamoto, K; Orii, A; Pronost, G; Sekiya, H; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Xia, J; Megias, GD; Bravo-Berguño, D; Labarga, L; Marti, L; Zaldivar, B; Pointon, BW; Blaszczyk, FDM; Kearns, E; Raaf, JL; Stone, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Mine, S; Smy, MB; Sobel, HW; Takhistov, V; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Cao, S; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Gonin, M; Mueller, TA; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ospina, N; Ludovici, L; Maekawa, Y; Nishimura, Y; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Kotsar, Y; Nakano, Y; Ozaki, H; Shiozawa, T; Suzuki, AT; Takeuchi, Y; Yamamoto, S; Ali, A; Ashida, Y; Feng, J; Hirota, S; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Fernandez, P; McCauley, N; Mehta, P; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Niwa, T; Sato, K; Tsukada, M; Lagoda, J; Lakshmi, SM; Mijakowski, P; Zalipska, J; Jiang, J; Jung, CK; Vilela, C; Wilking, MJ; Yanagisawa, C; Hagiwara, K; Harada, M; Horai, T; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Ma, W; Piplani, N; Sakai, S; Barr, G; Barrow, D; Cook, L; Goldsack, A; Samani, S; Wark, D; Nova, F; Boschi, T; Di Lodovico, F; Gao, J; Migenda, J; Taani, M; Zsoldos, S; Yang, JY; Jenkins, SJ; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Seo, JW; Yu, I; Nishijima, K; Koshiba, M; Iwamoto, K; Nakagiri, K; Nakajima, Y; Ogawa, N; Yokoyama, M; Martens, K; Vagins, MR; Kuze, M; Izumiyama, S; Yoshida, T; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ohta, K; Shinoki, M; Suganuma, T; Ichikawa, AK; Nakamura, K; Martin, JF; Tanaka, HA; Towstego, T; Akutsu, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; de Perio, P; Prouse, NW; Chen, S; Xu, BD; Zhang, Y; Posiadala-Zezula, M; Hadley, D; O'Flaherty, M; Richards, B; Jamieson, B; Walker, J; Minamino, A; Okamoto, K; Pintaudi, G; Sano, S; Sasaki, R

PHYSICAL REVIEW D 104 ( 12 )  2021.12

ISSN  2470-0010

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Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring

Ito E., Sato Y., Kobayashi T., Soma T., Matsumoto T., Kimura A., Miyamoto K., Matsumoto H., Matsumoto M., Nakamura M., Sato K., Miyamoto T.

Bone (Bone)  153 2021.12

ISSN  87563282

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Changes in bone metabolism occur in mothers during pregnancy or lactation that may decrease bone mass and result in fragility fractures after partum. However, use of drugs during pregnancy or lactation to counteract these effects is often prohibited or strongly discouraged. Therefore, approaches to protect mothers from fragility fractures have not been established. Here we show that bone mineral density was significantly lower in female mice after partum than in age-matched female mice without partum. We also show that temporary administration of the bisphosphonate alendronate, either just before or just after pregnancy, to female mice was protective against bone loss due to pregnancy or lactation and had no adverse effects on offspring, such as growth retardation. Furthermore, we show that alendronate administration to female mice during lactation was effective in increasing bone mass in mothers without promoting bone abnormalities or growth retardation in offspring. Calcium levels in milk from female mice administered alendronate during lactation were equivalent to those in milk from mothers not treated with alendronate. Overall, we propose that alendronate administration to mothers could prevent bone loss and fragility fractures during pregnancy and lactation.

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A novel device for detecting anaerobic threshold using sweat lactate during exercise

Seki Y., Nakashima D., Shiraishi Y., Ryuzaki T., Ikura H., Miura K., Suzuki M., Watanabe T., Nagura T., Matsumato M., Nakamura M., Sato K., Fukuda K., Katsumata Y.

Scientific Reports (Scientific Reports)  11 ( 1 )  2021.12

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The lactate threshold (LT1), which is defined as the first rise in lactate concentration during incremental exercise, has not been non-invasively and conveniently determined in a clinical setting. We aimed to visualize changes in lactate concentration in sweat during exercise using our wearable lactate sensor and investigate the relationship between the lactate threshold (LT1) and ventilatory threshold (VT1). Twenty-three healthy subjects and 42 patients with cardiovascular diseases (CVDs) were enrolled. During exercise, the dynamic changes in lactate values in sweat were visualized in real-time with a sharp continuous increase up to volitional exhaustion and a gradual decrease during the recovery period. The LT1 in sweat was well correlated with the LT1 in blood and the VT1 (r = 0.92 and 0.71, respectively). In addition, the Bland–Altman plot described no bias between the mean values (mean differences: − 4.5 and 2.5 W, respectively). Continuous monitoring of lactate concentrations during exercise can provide additional information for detecting the VT1.

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Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury With Preexisting Cervical Stenosis A Randomized Clinical Trial

Chikuda, H; Koyama, Y; Matsubayashi, Y; Ogata, T; Ohtsu, H; Sugita, S; Sumitani, M; Kadono, Y; Miura, T; Tanaka, S; Akiyama, T; Ando, K; Anno, M; Azuma, S; Endo, K; Endo, T; Fujiyoshi, T; Furuya, T; Hayashi, H; Higashikawa, A; Hiyama, A; Horii, C; Iimoto, S; Iizuka, Y; Ikuma, H; Imagama, S; Inokuchi, K; Inoue, H; Inoue, T; Ishii, K; Ishii, M; Ito, T; Itoi, A; Iwamoto, K; Iwasaki, M; Kaito, T; Kato, T; Katoh, H; Kawaguchi, Y; Kawano, O; Kimura, A; Kobayashi, K; Koda, M; Komatsu, M; Kumagai, G; Maeda, T; Makino, T; Mannoji, C; Masuda, K; Masuda, K; Matsumoto, K; Matsumoto, M; Matsunaga, S; Matsuyama, Y; Mieda, T; Miyoshi, K; Mochida, J; Moridaira, H; Motegi, H; Nakagawa, Y; Nohara, Y; Oae, K; Ogawa, S; Okazaki, R; Okuda, A; Onishi, E; Ono, A; Oshima, M; Oshita, Y; Saita, K; Sasao, Y; Sato, K; Sawakami, K; Seichi, A; Seki, S; Shigematsu, H; Suda, K; Takagi, Y; Takahashi, M; Takahashi, R; Takasawa, E; Takenaka, S; Takeshita, K; Takeshita, Y; Tokioka, T; Tokuhashi, Y; Tonosu, J; Uei, H; Wada, K; Watanabe, M; Yahata, T; Yamada, K; Yasuda, T; Yasui, K; Yoshii, T

JAMA NETWORK OPEN 4 ( 11 ) e2133604 2021.11

ISSN  2574-3805

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Laminar flow ventilation system to prevent airborne infection during exercise in the COVID-19 crisis: A single-center observational study

Katsumata Y., Sano M., Okawara H., Sawada T., Nakashima D., Ichihara G., Fukuda K., Sato K., Kobayashi E.

PLoS ONE (PLoS ONE)  16 ( 11 November )  2021.11

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Particulate generation occurs during exercise-induced exhalation, and research on this topic is scarce. Moreover, infection-control measures are inadequately implemented to avoid particulate generation. A laminar airflow ventilation system (LFVS) was developed to remove respiratory droplets released during treadmill exercise. This study aimed to investigate the relationship between the number of aerosols during training on a treadmill and exercise intensity and to elucidate the effect of the LFVS on aerosol removal during anaerobic exercise. In this single-center observational study, the exercise tests were performed on a treadmill at Running Science Lab in Japan on 20 healthy subjects (age: 29±12 years, men: 80%). The subjects had a broad spectrum of aerobic capacities and fitness levels, including athletes, and had no comorbidities. All of them received no medication. The exercise intensity was increased by 1-km/h increments until the heart rate reached 85% of the expected maximum rate and then maintained for 10 min. The first 10 subjects were analyzed to examine whether exercise increased the concentration of airborne particulates in the exhaled air. For the remaining 10 subjects, the LFVS was activated during constant-load exercise to compare the number of respiratory droplets before and after LFVS use. During exercise, a steady amount of particulates before the lactate threshold (LT) was followed by a significant and gradual increase in respiratory droplets after the LT, particularly during anaerobic exercise. Furthermore, respiratory droplets ≥0.3 μm significantly decreased after using LFVS (2120800±759700 vs. 560 ± 170, p<0.001). The amount of respiratory droplets significantly increased after LT. The LFVS enabled a significant decrease in respiratory droplets during anaerobic exercise in healthy subjects. This study's findings will aid in exercising safely during this pandemic.

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Effects of peripheral tears of the triangular fibrocartilage complex on distal radioulnar joint stability: A biomechanical study

Fukuoka M., Nakamura T., Nishiwaki M., Toyama Y., Matsumoto M., Nakamura M., Sato K.

Journal of Orthopaedic Science (Journal of Orthopaedic Science)  26 ( 6 ) 1008 - 1013 2021.11

ISSN  09492658

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Background: Peripheral triangular fibrocartilage complex (TFCC) tears may induce instability of the distal radioulnar joint (DRUJ). In this biomechanical study, simulated peripheral tears of the TFCC were examined on the stability of the DRUJ. Restabilization effect of the DRUJ by ulnar shortening and direct repair of those injuries were sequentially examined. Method: The DRUJ stiffness was measured in intact, simulated two types of peripheral tears (ulnar and extended ulnodorsal) at three forearm positions: neutral, 60° pronation and 60° supination in 8 fresh frozen cadaver specimens. After the tears were sutured with stitches or after simulated ulnar shortening of 3 mm, the DRUJ stiffness was again measured. Results: The ulnar and ulnodorsal TFCC tears decreased the DRUJ stiffness significantly compared with the intact in all forearm positions. When ulnar shortening was done for the ulnar tear, the DRUJ stiffness increased significantly in the neutral and 60° pronated positions. When the ulnar TFCC tear was repaired, the DRUJ stiffness increased significantly in all forearm positions. DRUJ stiffness did not increase either with ulnar shortening or repair in ulnodorsal tear of the TFCC, however. Conclusion: The simulated TFCC tears indicated significant loss of DRUJ stiffness. Direct repair or ulnar shortening was effective only on treatment of the ulnar tear of the TFCC in this study.

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A Max-Margin Model for Predicting Residue-Base Contacts in Protein-RNA Interactions

Kashiwagi, S; Sato, K; Sakakibara, Y

LIFE-BASEL 11 ( 11 )  2021.11

ISSN  2075-1729

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Two-Dimensional Terahertz Beam Steering Based on Trajectory Deflection of Leaky-Mode

Sato, K; Monnai, Y

IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY 11 ( 6 ) 676 - 683 2021.11

ISSN  2156-342X

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Search for tens of MeV neutrinos associated with gamma-ray bursts in Super-Kamiokande

Abe, K; Bronner, C; Hayato, Y; Ikeda, M; Imaizumi, S; Ito, H; Kameda, J; Kataoka, Y; Kato, Y; Kishimoto, Y; Miura, M; Moriyama, S; Mochizuki, T; Nagao, Y; Nakahata, M; Nakajima, Y; Nakayama, S; Okada, T; Okamoto, K; Pronost, G; Sekiya, H; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Wang, R; Xia, J; Megias, GD; Bravo-Berguño, D; Labarga, L; Marti, L; Zaldivar, B; Blaszczyk, FDM; Kearns, E; Raaf, JL; Stone, JL; Wan, L; Wester, T; Pointon, BW; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Mine, S; Smy, MB; Sobel, HW; Takhistov, V; Weatherly, P; Ganezer, KS; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Gonin, M; Mueller, TA; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Matsuno, S; Anthony, LHV; Litchfield, RP; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Ospina, N; Ludovici, L; Nishimura, Y; Cao, S; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Boschi, T; Di Lodovico, F; Sedgwick, SM; Taani, M; Zsoldos, S; Hasegawa, M; Isobe, Y; Miyabe, H; Nakano, Y; Shiozawa, T; Sugimoto, T; Suzuki, AT; Takeuchi, Y; Yamamoto, S; Ali, A; Ashida, Y; Feng, J; Hirota, S; Jiang, M; Ichikawa, AK; Kikawa, T; Mori, M; Nakamura, KE; Nakaya, T; Wendell, RA; Yasutome, K; Fernandez, P; McCauley, N; Mehta, P; Pritchard, A; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Niwa, T; Sato, K; Tsukada, M; Mijakowski, P; Frankiewicz, K; Jung, CK; Vilela, C; Wilking, MJ; Yanagisawa, C; Fukuda, D; Harada, M; Hagiwara, K; Horai, T; Ishino, H; Ito, S; Koshio, Y; Ma, W; Piplani, N; Sakai, S; Sakuda, M; Takahira, Y; Xu, C; Kuno, Y; Barr, G; Barrow, D; Cook, L; Goldsack, A; Samani, S; Simpson, C; Wark, D; Nova, F; Yang, JY; Jenkins, SJ; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Choi, Y; Kim, SB; Yu, I; Nishijima, K; Koshiba, M; Iwamoto, K; Ogawa, N; Yokoyama, M; Martens, K; Vagins, MR; Izumiyama, S; Kuze, M; Tanaka, M; Yoshida, T; Inomoto, M; Ishitsuka, M; Matsumoto, R; Ohta, K; Shinoki, M; Martin, JF; Nantais, CM; Tanaka, HA; Towstego, T; Akutsu, R; Hartz, M; Konaka, A; de Perio, P; Prouse, NW; Chen, S; Xu, BD; Posiadala-Zezula, M; Richards, B; Jamieson, B; Walker, J; Minamino, A; Okamoto, K; Pintaudi, G; Sasaki, R

PROGRESS OF THEORETICAL AND EXPERIMENTAL PHYSICS 2021 ( 10 )  2021.10

ISSN  2050-3911

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A Case of Coronal Intra-articular and Epiphyseal Fractures of the Metacarpal Head in Early Adolescence

Kato T., Iwamoto T., Suzuki T., Matsumura N., Nakamura M., Matsumoto M., Sato K.

Journal of Hand and Microsurgery (Journal of Hand and Microsurgery)  13 ( 4 ) 247 - 251 2021.10

ISSN  09743227

　View Summary

Intra-articular metacarpal head fracture is relatively rare. We report a case of coronal intra-articular and epiphyseal fractures of Salter-Harris type IV injury in the metacarpal head of the index finger. Surgery was performed by a dorsal approach. The volar fragment that was displaced proximally was gently reduced while bending the metacarpophalangeal (MP) joint, and it was fixed with cortical screws inserted proximal to the articular cartilage facilitating early rehabilitation. We consider the mechanism of injury to be a force applied from the distal phalanx that was transmitted unevenly to the volar side when the MP joint was slightly flexed. A three-dimensional computed tomography scan was useful in making the precise diagnosis, confirming the fracture pattern and planning fixation of the fracture.

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Preliminary Effect and Acceptability of an Intervention to Improve End-of-Life Care in Long-Term-Care Facilities: A Feasibility Study

Yamagata, C; Matsumoto, S; Miyashita, M; Kanno, Y; Taguchi, A; Sato, K; Fukahori, H

HEALTHCARE 9 ( 9 )  2021.09

ISSN  2227-9032

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Search for Neutrinos in Coincidence with Gravitational Wave Events from the LIGO-Virgo O3a Observing Run with the Super-Kamiokande Detector

Abe, K; Bronner, C; Hayato, Y; Ikeda, M; Imaizumi, S; Kameda, J; Kanemura, Y; Kataoka, Y; Miki, S; Miura, M; Moriyama, S; Nagao, Y; Nakahata, M; Nakayama, S; Okada, T; Okamoto, K; Orii, A; Pronost, G; Sekiya, H; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Wang, R; Xia, J; Megias, GD; Bravo-Berguño, D; Labarga, L; Marti, L; Zaldivar, B; Pointon, BW; Blaszczyk, FD; Kearns, E; Raaf, JL; Stone, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Mine, S; Smy, MB; Sobel, HW; Takhistov, V; Weatherly, P; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Gonin, M; Mueller, TA; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Anthony, LHV; Martin, DGR; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Ospina, N; Ludovici, L; Maekawa, Y; Nishimura, Y; Cao, S; Friend, M; Hasegawa, T; Ishida, T; Jakkapu, M; Kobayashi, T; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Kotsar, Y; Nakano, Y; Ozaki, H; Shiozawa, T; Suzuki, AT; Takeuchi, Y; Yamamoto, S; Ali, A; Ashida, Y; Feng, J; Hirota, S; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Fernandez, P; McCauley, N; Mehta, P; Pritchard, A; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Niwa, T; Sato, K; Tsukada, M; Mijakowski, P; Jiang, J; Jung, CK; Vilela, C; Wilking, MJ; Yanagisawa, C; Hagiwara, K; Harada, M; Horai, T; Ishino, H; Ito, S; Koshio, Y; Kitagawa, H; Ma, W; Piplani, N; Sakai, S; Kuno, Y; Barr, G; Barrow, D; Cook, L; Goldsack, A; Samani, S; Simpson, C; Wark, D; Nova, F; Boschi, T; Di Lodovico, F; Migenda, J; Sedgwick, SM; Taani, M; Zsoldos, S; Yang, JY; Jenkins, SJ; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Yu, I; Nishijima, K; Koshiba, M; Iwamoto, K; Nakajima, Y; Ogawa, N; Yokoyama, M; Martens, K; Vagins, MR; Izumiyama, S; Kuze, M; Tanaka, M; Yoshida, T; Inomoto, M; Ishitsuka, M; Ito, H; Matsumoto, R; Ohta, K; Shinoki, M; Martin, JF; Tanaka, HA; Towstego, T; Akutsu, R; Hartz, M; Konaka, A; de Perio, P; Prouse, NW; Chen, S; Xu, BD; Posiadala-Zezula, M; Hadley, D; Richards, B; Jamieson, B; Walker, J; Minamino, A; Okamoto, K; Pintaudi, G; Sano, S; Sasaki, R; Ichikawa, AK; Nakamura, K

ASTROPHYSICAL JOURNAL 918 ( 2 )  2021.09

ISSN  0004-637X

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Risk factors for subsequent vertebral fracture after acute osteoporotic vertebral fractures

Inose, H; Kato, T; Ichimura, S; Nakamura, H; Hoshino, M; Togawa, D; Hirano, T; Tokuhashi, Y; Ohba, T; Haro, H; Tsuji, T; Sato, K; Sasao, Y; Takahata, M; Otani, K; Momoshima, S; Takahashi, K; Yuasa, M; Hirai, T; Yoshii, T; Okawa, A

EUROPEAN SPINE JOURNAL 30 ( 9 ) 2698 - 2707 2021.09

ISSN  0940-6719

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Restricted Wrist Rotation after an Ulnar Head Fracture: A Report of Two Cases

Kato, T; Abe, K; Sato, K; Nakamura, T

JOURNAL OF WRIST SURGERY 10 ( 04 ) 341 - 346 2021.08

ISSN  2163-3916

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Normal values and ranges of the lateral capitello-humeral angle in healthy children

Kiyota Y., Suzuki T., Inaba N., Nishiwaki M., Kimura H., Matsumura N., Sato K., Nakamura M., Matsumoto M., Iwamoto T.

Journal of Pediatric Orthopaedics Part B (Journal of Pediatric Orthopaedics Part B)  30 ( 4 ) 381 - 384 2021.07

ISSN  1060152X

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The lateral capitello-humeral angle (LCHA), which is an index of sagittal alignment of the elbow, has gradually been adopted for the postoperative assessment of radiographic results. However, the normal values and ranges of the LCHA remain unclear. A retrospective cohort study was performed to evaluate the normal values and ranges of the LCHA in a sample of healthy children with even distributions of age, sex and laterality. A total of 168 radiographs of the elbows of healthy children (age range, 0–11 years) with even distributions of age, sex and laterality were reviewed. The primary aim was to analyze the normal values and ranges of the LCHA categorized by age, sex and laterality. The secondary aim was to assess the association of the LCHA with increasing age. The LCHA between sex or laterality in each age category was also compared. The mean LCHA of the 168 patients was 47.1º(range, 27º–63º). There was a weak association between the LCHA and increasing age (r = 0.41). The mean LCHA in females (49.1º) was significantly larger than that in males (45.1º). Significant sex-related differences were observed in age categories between 2 and 7 years. Results of this study will be useful in the postoperative radiographic assessment of sagittal alignment of the elbow in children.

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Evaluation of Dynamic Carpal Arch Stability following Carpal Tunnel Release Using Four-Dimensional Computed Tomography

Kimura H., Sato K., Matsumura N., Suzuki T., Iwamoto T., Ohori K., Yamada Y., Matsumoto M., Nakamura M., Jinzaki M., Nagura T.

Journal of Hand and Microsurgery (Journal of Hand and Microsurgery)  13 ( 3 ) 138 - 142 2021.07

ISSN  09743227

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Introduction This study aimed to assess the carpal arch dynamics during active finger and wrist motion following carpal tunnel release using four-dimensional computed tomography (4D-CT). Materials and Methods Four patients who diagnosed with bilateral carpal tunnel syndrome and underwent unilateral carpal tunnel release were prospectively included. 4D-CT of the bilateral wrists during active finger and wrist motion was performed for 10 seconds at five frames per second. The distances between the tip of tuberosity of the scaphoid and the volar ridge of the pisiform (S-P distance) and volar ridge of trapezium and the tip of hook of hamate (T-H distance) were measured at each position and the values of S-P and T-H distances were compared between the postoperative and contralateral wrists. Results During finger motion, the S-P and T-H distances were not different at any position between the postoperative side and contralateral side. Conversely, S-P and T-H distances gradually increased in the postoperative wrists. The differences between the sides of S-P distance were significant, with >0 degrees of wrist extension, and differences of T-H distance were significant with >15 degrees of wrist extension. Conclusion This study demonstrated the carpal arch dynamics using 4D-CT and revealed that the carpal arch was widened with the wrist in extension after carpal tunnel release. This study suggests that the transverse carpal ligament plays an important role in maintaining carpal arch stability.

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Motion of the distal radioulnar joint in extension and flexion of the wrist using axial CT imaging of healthy volunteers

Suzuki T., Hayakawa K., Nakane T., Inaba N., Matsumura N., Sato K., Iwamoto T.

Journal of Orthopaedic Science (Journal of Orthopaedic Science)  26 ( 4 ) 610 - 615 2021.07

ISSN  09492658

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Background: The midcarpal joint and the radiocarpal joint contribute to the extension and flexion of the wrist. Little is known about the contribution of the distal radioulnar joint (DRUJ) to the extension and flexion of the wrist. This study evaluated the ulnar motion in extension and flexion of the wrist using computed tomography (CT) imaging. Methods: A total of 30 wrists of healthy volunteers were enrolled. CT images of the axial sections of the DRUJ were obtained with 3 different positions of the wrist: 0° of extension (straight position), maximum active extension, and maximum active flexion. Each wrist motion was performed with 3 different forearm positions: neutral, pronation, and supination. Ulnar position at the DRUJ level was measured and ulnar position with the wrist in straight position was defined as baseline. The ulnar position was recorded as positive value when the position of the ulnar head was volar side and negative value when the position of the ulnar head was dorsal side. The difference from baseline in a position of maximum extension and flexion was evaluated. Results: In forearm neutral position and pronation, a value of ulnar position in maximum wrist flexion is significantly negative compared to that in the wrist straight position: the ulnar head moved dorsally from the wrist straight position to wrist flexion. In forearm supination, a value of ulnar position in maximum wrist extension is significantly positive compared to that in the wrist straight position: the ulnar head moved to the volar side from the wrist straight position to wrist extension. Conclusions: The ulnar head moves during extension and flexion of the wrist. The direction of the ulnar motion was different according to the wrist and forearm position.

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Exercise tolerance and quality of life in hemodynamically partially improved patients with chronic thromboembolic pulmonary hypertension treated with balloon pulmonary angioplasty

Miura K., Katsumata Y., Kawakami T., Ikura H., Ryuzaki T., Shiraishi Y., Fukui S., Kawakami M., Kohno T., Sato K., Fukuda K.

PLoS ONE (PLoS ONE)  16 ( July )  2021.07

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The efficacy of extensive balloon pulmonary angioplasty (BPA) beyond hemodynamic improvement in chronic thromboembolic pulmonary hypertension (CTEPH) patients has been verified. However, the relationship between extensive BPA in CTEPH patients after partial hemodynamic improvement and exercise tolerance or quality of life (QOL) remains unclear. We prospectively enrolled 22 CTEPH patients (66±10 years, females: 59%) when their mean pulmonary artery pressure initially decreased to <30 mmHg during BPA sessions. Hemodynamic and echocardiographic data, cardiopulmonary exercise testing, and QOL scores using the 36-item short form questionnaire (SF-36) were evaluated at enrollment (entry), just after the final BPA session (finish), and at the 6-month follow-up (followup). We analyzed whether extensive BPA improves exercise capacity and QOL scores over time. Moreover, the clinical characteristics leading to improvement were elucidated. The peak oxygen uptake (VO2) showed significant improvement at entry, finish, and follow-up (17.3±5.5, 18.4±5.9, and 18.9±5.3 mL/kg/min, respectively; P<0.001). Regarding the QOL, the physical component summary (PCS) scores significantly improved (32±11, 38±13, and 43±13, respectively; P<0.001), but the mental component summary scores remained unchanged. Linear regression analysis revealed that age and a low peak VO2 at entry were predictors of improvement in peak VO2, while low PCS scores and low TAPSE at entry were predictors of improvement in PCS scores. In conclusion, extensive BPA led to improved exercise tolerance and physical QOL scores, even in CTEPH patients with partially improved hemodynamics.

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Range of Motion after the Sauve-Kapandji and Darrach Procedures without Extensor Tendon Rupture

Kato, T; Suzuki, T; Kameyama, M; Okazaki, M; Morisawa, Y; Nishiwaki, M; Nakamura, T; Sato, K; Iwamoto, T

JOURNAL OF WRIST SURGERY 10 ( 03 ) 190 - 195 2021.06

ISSN  2163-3916

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Seabird Biologging System with Compact Waterproof Airflow Sensor

Takahashi, H; Naruoka, M; Inada, Y; Sato, K

JOURNAL OF ROBOTICS AND MECHATRONICS 33 ( 3 ) 466 - 474 2021.06

ISSN  0915-3942

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Predictors of residual low back pain after acute osteoporotic compression fracture

Inose, H; Kato, T; Ichimura, S; Nakamura, H; Hoshino, M; Togawa, D; Hirano, T; Tokuhashi, Y; Ohba, T; Haro, H; Tsuji, T; Sato, K; Sasao, Y; Takahata, M; Otani, K; Momoshima, S; Yuasa, M; Hirai, T; Yoshii, T; Okawa, A

JOURNAL OF ORTHOPAEDIC SCIENCE 26 ( 3 ) 453 - 458 2021.05

ISSN  0949-2658

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Causes of Procedural Failures of Closed Reductions using an Extension-Block Pin for Bony Mallet Finger

Suzuki T., Iwamoto T., Matsumura N., Kimura H., Nakamura M., Matsumoto M., Sato K.

Journal of Hand and Microsurgery (Journal of Hand and Microsurgery)  13 ( 2 ) 69 - 74 2021.04

ISSN  09743227

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This retrospective study evaluated procedural failures of closed reductions using an extension-block Kirschner wire (K-wire) for bony mallet finger. A total of 132 patients who underwent a closed reduction for bony mallet finger in a procedure using an extension-block K-wire were radiographically assessed. Radiographs were used to evaluate (1) postoperative displacement of the reduction before or after K-wire removal and (2) inaccurate reduction of the fragment immediately after surgery. The causes of procedural failure and bone union were evaluated using radiographs and medical records of the intraoperative findings. Out of 132 patients, 17 with procedural failure were enrolled. Displacement of the reduction before and after K-wire removal occurred in seven and six cases, respectively. Inaccurate reduction immediately after surgery occurred in four cases. The most common cause of procedural failure was inaccurate insertion of the K-wire to fix the distal interphalangeal joint (eight cases) followed by inaccurate insertion of the extension-block pin (five cases). All patients had bone union regardless of the displacement of the reduction or inaccurate reduction of the fragment. Caution should be exercised during the reduction and fixation when an extension-block K-wire is used in a closed reduction procedure.

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Development of a microsurgery-assisted robot for high-precision thread traction and tension control, and confirmation of its applicability

Hangai S., Nozaki T., Soma T., Miyashita H., Asoda S., Yazawa M., Sato K., Kawana H., Ohnishi K., Kobayashi E.

International Journal of Medical Robotics and Computer Assisted Surgery (International Journal of Medical Robotics and Computer Assisted Surgery)  17 ( 2 )  2021.04

ISSN  14785951

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Background: Microsurgery requires high skills for suturing using fragile threads, often within narrow surgical fields. Precise tension is required for good healing and to avoid the risk of thread breakage. Methods: To meet the demands, we developed a novel assist robot utilizing high-precision sensorless haptic technology. The robot adopts a cable-driven mechanism to maintain a distance from the surgical area and enhances compatibility with surgical equipment such as microscopes. The robot performance was verified through in vitro and in vivo experiments using a rat model. Results: The realization of precise tension control was confirmed in both experiments. In particular, in the in vivo experiments, the developed robot succeeded to produce a knot with an accurate tension of 0.66% error. Conclusions: The developed robot can realize to control traction force precisely. This technology might open up the window for a full assist robot for microsurgery with haptic feeling.

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Defining a good death for people with dementia: A scoping review

Takahashi, Z; Yamakawa, M; Nakanishi, M; Fukahori, H; Igarashi, N; Aoyama, M; Sato, K; Sakai, S; Nagae, H; Miyashita, M

JAPAN JOURNAL OF NURSING SCIENCE 18 ( 2 ) e12402 2021.04

ISSN  1742-7932

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Personal View つれづれの時

佐藤 和毅

整形・災害外科 (金原出版)  64 ( 3 ) 245 - 245 2021.03

ISSN  03874095

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Risk Factors Contributing to Early Implant Fracture in Silicone Metacarpophalangeal Joint Arthroplasty for Patients With Rheumatoid Arthritis

Iwamoto T., Ishii K., Suzuki T., Kimura H., Matsumura N., Sato K.

Journal of Hand Surgery (Journal of Hand Surgery)  46 ( 3 ) 243.e1 - 243.e7 2021.03

ISSN  03635023

　View Summary

Purpose: To identify the risk factors associated with early implant fracture of silicone metacarpophalangeal (MCP) joint arthroplasty using the volar hinge silicone implant for patients with rheumatoid arthritis. Methods: We retrospectively reviewed 113 fingers of 31 hands that underwent MCP joint arthroplasty between 2008 and 2014, with a minimum follow-up of 3 years,. An implant fracture within 3 years after surgery was regarded as an early implant fracture. Patient records were reviewed for potential risk factors of age, affected fingers, ulnar drift angle, and range of motion of the MCP joint before surgery and 1 year after surgery. Candidate risk factors were compared at the level of the digit and at the patient level. Results: With fracture of the implants as the end point, Kaplan–Meier estimated survival rate was 74.3% at 3 years and 67.9% at 5 years. Early implant fracture was detected in 29 fingers. Bivariate analyses showed significant associations between early implant fracture and MCP joint arc of motion before surgery, MCP joint flexion range 1 year after surgery, and MCP joint arc of motion 1 year after surgery. Multiple logistic regression analysis showed that increased MCP joint flexion range 1 year after surgery was an independent risk factor for early implant fracture. Conclusions: Increasing MCP joint flexion range was associated with increased fractures of the implants. We propose that the MCP joint flexion range should be restricted to less than 60° in postoperative rehabilitation; it is necessary to educate the patient to permanently avoid excessive flexion of the MCP joint. Type of study/level of evidence: Therapeutic IV.

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A Web Server for Designing Molecular Switches Composed of Two Interacting RNAs

Taneda, A; Sato, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 ( 5 )  2021.03

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Treatment with an active vitamin D analogue blocks hypothalamic dysfunction-induced bone loss in mice

Ito E., Sato Y., Kobayashi T., Nakamura S., Kaneko Y., Soma T., Matsumoto T., Kimura A., Miyamoto K., Matsumoto H., Matsumoto M., Nakamura M., Sato K., Miyamoto T.

Biochemical and Biophysical Research Communications (Biochemical and Biophysical Research Communications)  542   48 - 53 2021.02

ISSN  0006291X

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Estrogen deficiency can be caused by ovarian dysfunction in females. Mechanisms underlying osteoporosis in this condition have been characterized in animal models, such as ovariectomized mice and rats, although it remains unclear how hypothalamic dysfunction promotes osteoporosis. Here, we show that administration of a gonadotropin-releasing hormone antagonist (GnRHa) significantly decreases uterine weight, a manifestation of hypothalamic dysfunction, and promotes both cortical and trabecular bone loss in female mice in vivo. We also report that osteoclast number significantly increased in mice administered GnRHa, and that the transcription factor hypoxia inducible factor 1 alpha (HIF1α) accumulated in those osteoclasts. We previously reported that treatment of mice with the active vitamin D analogue ED71, also known as eldecalcitol, inhibited HIF1α accumulation in osteoclasts. We show here that in mice, co-administration of ED71 with GnRHa significantly rescued the reduced cortical and trabecular bone mass promoted by GnRHa administration alone. GnRHa-dependent HIF1α accumulation in osteoclasts was also blocked by co-administration of ED71. We conclude that hypothalamic dysfunction promotes HIF1α accumulation in osteoclasts and likely results in reduced bone mass. We conclude that treatment with ED71 could serve as a therapeutic option to counter osteoporotic conditions in humans.

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RNA secondary structure prediction using deep learning with thermodynamic integration

Sato, K; Akiyama, M; Sakakibara, Y

NATURE COMMUNICATIONS 12 ( 1 ) 941 2021.02

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Experimental evaluation of the GE Discovery 870 CZT clinical SPECT system equipped with WEHR and MEHRS collimator

Ito, T; Matsusaka, Y; Onoguchi, M; Ichikawa, H; Okuda, K; Shibutani, T; Shishido, M; Sato, K

JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS 22 ( 2 ) 165 - 177 2021.02

ISSN  1526-9914

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A hypomorphic variant in <i>EYS</i> detected by genome-wide association study contributes toward retinitis pigmentosa

Nishiguchi, KM; Miya, F; Mori, Y; Fujita, K; Akiyama, M; Kamatani, T; Koyanagi, Y; Sato, K; Takigawa, T; Ueno, S; Tsugita, M; Kunikata, H; Cisarova, K; Nishino, J; Murakami, A; Abe, T; Momozawa, Y; Terasaki, H; Wada, Y; Sonoda, KH; Rivolta, C; Tsunoda, T; Tsujikawa, M; Ikeda, Y; Nakazawa, T

COMMUNICATIONS BIOLOGY 4 ( 1 ) 140 2021.01

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Neutron-antineutron oscillation search using a 0.37 megaton-years exposure of Super-Kamiokande

Abe, K; Bronner, C; Hayato, Y; Ikeda, M; Imaizumi, S; Ito, H; Kameda, J; Kataoka, Y; Miura, M; Moriyama, S; Nagao, Y; Nakahata, M; Nakajima, Y; Nakayama, S; Okada, T; Okamoto, K; Orii, A; Pronost, G; Sekiya, H; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Yano, T; Akutsu, R; Han, S; Kajita, T; Okumura, K; Tashiro, T; Wang, R; Xia, J; Bravo-Berguño, D; Labarga, L; Marti, LL; Zaldivar, B; Blaszczyk, FDM; Kearns, E; Gustafson, JD; Raaf, JL; Stone, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Mine, S; Smy, MB; Sobel, HW; Takhistov, V; Weatherly, P; Hill, J; Kim, JY; Lim, IT; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Gonin, M; Mueller, TA; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Anthony, LHV; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Ospina, N; Ludovici, L; Nishimura, Y; Cao, S; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Matsubara, T; Nakadaira, T; Jakkapu, M; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Nakano, Y; Shiozawa, T; Suzuki, AT; Takeuchi, Y; Yamamoto, S; Ali, A; Ashida, Y; Feng, J; Hirota, S; Ichikawa, AK; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Fernandez, P; McCauley, N; Mehta, P; Pritchard, A; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Niwa, T; Sato, K; Tsukada, M; Mijakowski, P; Posiadala-Zezula, M; Jung, CK; Vilela, C; Wilking, MJ; Yanagisawa, C; Harada, M; Hagiwara, K; Horai, T; Ishino, H; Ito, S; Koshio, Y; Ma, W; Piplani, N; Sakai, S; Kuno, Y; Barr, G; Barrow, D; Cook, L; Goldsack, A; Samani, S; Simpson, C; Wark, D; Nova, F; Boschi, T; Di Lodovico, F; Sedgwick, SM; Taani, M; Zsoldos, S; Yang, JY; Jenkins, SJ; McElwee, JM; Thiesse, MD; Thompson, LF; Malek, M; Stone, O; Okazawa, H; Kim, SB; Yu, I; Nishijima, K; Koshiba, M; Ogawa, N; Iwamoto, K; Yokoyama, M; Martens, K; Vagins, MR; Kuze, M; Izumiyama, S; Tanaka, M; Yoshida, T; Inomoto, M; Ishitsuka, M; Matsumoto, R; Ohta, K; Shinoki, M; Martin, JF; Tanaka, HA; Towstego, T; Hartz, M; Konaka, A; de Perio, P; Prouse, NW; Pointon, BW; Chen, S; Xu, BD; Richards, B; Jamieson, B; Walker, J; Minamino, A; Okamoto, K; Pintaudi, G; Sasaki, R

PHYSICAL REVIEW D 103 ( 1 )  2021.01

ISSN  2470-0010

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Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice

Ito E., Sato Y., Kobayashi T., Nakamura S., Kaneko Y., Soma T., Matsumoto T., Kimura A., Miyamoto K., Matsumoto H., Matsumoto M., Nakamura M., Sato K., Miyamoto T.

Biochemical and Biophysical Research Communications (Biochemical and Biophysical Research Communications)  534   165 - 171 2021.01

ISSN  0006291X

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Low energy availability in female athletes often causes hypothalamic amenorrhea and osteoporosis, in turn promoting stress fractures. Mechanisms underlying these conditions remain unclear. Here we show that model mice subjected to food restriction (FR) or FR-plus-voluntary running exercise exhibit significantly reduced bone mineral density, cortical bone parameters and uterine weight than do control mice, and that these parameters worsen in the FR-plus-exercise group. Relative to controls, FR and FR-plus-exercise groups showed significantly lower mineral apposition rate and osteoclast number and significantly reduced serum insulin-like growth factor-1 (IGF1) levels. Outcomes were rescued by ED71 or 1.25(OH)2D3 treatment. Thus, we conclude that administration of active vitamin D analogues represents a possible treatment to prevent these conditions.

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Occupational exposure limits for acetaldehyde, 2-bromopropane, glyphosate, manganese and inorganic manganese compounds, and zinc oxide nanoparticle, and the biological exposure indices for cadmium and cadmium compounds and ethylbenzene, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications

Araki, A; Azuma, K; Endo, G; Endo, Y; Fukushima, T; Hara, K; Harada, K; Hori, H; Horie, S; Horiguchi, H; Ichiba, M; Ichihara, G; Ishitake, T; Ito, A; Ito, Y; Iwasawa, S; Kakamu, T; Kamijima, M; Karita, K; Kawai, T; Kawamoto, T; Kishi, R; Kumagai, S; Matsumoto, A; Miyagawa, M; Miyauchi, H; Morimoto, Y; Nagano, K; Naito, H; Nakajima, T; Nakano, M; Nomiyama, T; Okuda, H; Okuda, M; Omae, K; Sato, K; Sobue, T; Suwazono, Y; Takebayashi, T; Takeshita, T; Takeuchi, A; Takeuchi, A; Tanaka, S; Tsuji, M; Tsukahara, T; Ueno, S; Ueyama, J; Umeda, Y; Yamamoto, K; Yamano, Y; Yamauchi, T; Yano, E

JOURNAL OF OCCUPATIONAL HEALTH 63 ( 1 )  2021.01

ISSN  1341-9145

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Predictors for quality of life improvement after acute osteoporotic vertebral fracture: results of post hoc analysis of a prospective randomized study

Inose, H; Kato, T; Nakamura, H; Hoshino, M; Togawa, D; Hirano, T; Tokuhashi, Y; Ohba, T; Haro, H; Tsuji, T; Sato, K; Sasao, Y; Takahata, M; Otani, K; Momoshima, S; Takahashi, K; Yuasa, M; Hirai, T; Yoshii, T; Okawa, A

QUALITY OF LIFE RESEARCH 30 ( 1 ) 129 - 135 2021.01

ISSN  0962-9343

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A Channel Selection Algorithm Using Reinforcement Learning for Mobile Devices in Massive IoT System

Furukawa, H; Li, AH; Shoji, Y; Watanabe, Y; Kim, SJ; Sato, K; Andreopoulos, Y; Hasegawa, M

2021 IEEE 18TH ANNUAL CONSUMER COMMUNICATIONS & NETWORKING CONFERENCE (CCNC)  2021

ISSN  2331-9852

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Clinical results of open surgery for medial epicondylitis

Suzuki Taku, Hayakawa Katsuhiko, Nakane Takashi, Takeya Hiroaki, Kimura Hiroo, Sato Kazuki, Iwamoto Takuji

Journal of Japan Elbow Society (Japan Elbow Society)  28 ( 2 ) 148 - 149 2021

ISSN  13497324

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目的：上腕骨内側上顆炎に対する直視下手術の成績について報告する．<BR>対象と方法：保存加療に抵抗性の上腕骨内側上顆炎に対して直視下手術を施行した7例（男性5例，女性2例，平均年齢54歳）を対象とした．術前に尺骨神経の症状を呈していた症例は5例であった．手術は，全例，屈筋共同腱のデブリドマン，尺骨神経剥離，内側上顆部分切除，内側上顆のドリリングを施行した．評価は，術前，術後1年における疼痛（VAS），握力健側比に関して調査した．<BR>結果：平均VASは術前81（55-100）であったのに対して，術後1年では15（0-40）と有意に低下した．平均握力健側比も術前で 64（26-71）%であったのに対して，最終観察時には 95（84-100）%と有意に改善した．<BR>考察：上腕骨内側上顆炎に対する直視下手術は，有用であった．

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Rupture of the lateral collateral ligament of the elbow associated with steroid injection for humeral lateral epicondylitis

Takeya Hiroaki, Suzuki Taku, Kimura Hiroo, Sato Kazuki, Iwamoto Takuji

Journal of Japan Elbow Society (Japan Elbow Society)  28 ( 2 ) 69 - 71 2021

ISSN  13497324

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目的：上腕骨外側上顆炎へのステロイド局所注射が原因であると考えられる外側側副靭帯損傷の症例に対して長掌筋腱を用いた靭帯再建術を行い，良好な結果を得たために報告する．<BR>方法：上腕骨外側上顆炎に対してステロイド局所注射後に，外側側副靭帯損傷を生じた3症例（平均年齢52歳，男性3例）を対象とした．評価は，術前注射回数，術後疼痛，不安定性の有無，肘関節自動運動可動域について調査した．<BR>結果：術前注射回数は平均5.3（3～5）回であった．全例で術前に認めていた肘関節外側部痛や不安定性は術後に消失し，可動域制限も認めなかった．<BR>考察：上腕骨外側上顆炎へのステロイド局所注射による外側側副靭帯損傷は注射回数が3回以上を損傷リスクとする報告もある．上腕骨外側上顆炎に対しての多数回のステロイド局所注射は，外側側副靭帯断裂の原因となる可能性があることに留意が必要である．

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Effect of volar angulation of extra-articular distal radius fractures on distal radioulnar joint stability

Bessho Y., Nakamura T., Nagura T., Nishiwaki M., Sato K., Toyama Y.

Journal of Hand Surgery: European Volume 40 ( 8 ) 775 - 782 2015.10

ISSN  1753-1934

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<p>The relationship between increased volar tilt of the distal radius and distal radioulnar joint stability was examined. Distal radioulnar joint stiffness was recorded at 10° intervals from 10° dorsal angulation to 20° of volar angulation from the anatomical position of the radius. Tests were performed with the intact radioulnar ligament and repeated after partial and then complete sectioning of the radioulnar ligament at the ulnar fovea. With the intact radioulnar ligament, distal radioulnar joint stiffness increased significantly at 10° and 20° of volar angulation. Partial sectioning of the radioulnar ligament resulted in an approximate 10% decrease of distal radioulnar joint stiffness compared with the intact state, but distal radioulnar joint stiffness still increased significantly with greater volar tilt. Complete sectioning of the radioulnar ligament significantly decreased distal radioulnar joint stiffness, and increasing the volar tilt did not result in increased distal radioulnar joint stiffness. These results suggest that volar angulation deformities of the distal radius should be corrected to 10° of volar tilt when the triangular fibrocartilage complex is intact.</p>

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Shoulder position increases ulnar nerve strain at the elbow of patients with cubital tunnel syndrome

Ochi Kensuke, Horiuchi Yukio, Horiuchi Koichi, Iwamoto Takuji, Morisawa Yasushi, Sato Kazuki

Journal of Shoulder and Elbow Surgery 24 ( 9 ) 1380 - 1385 2015.09

ISSN  1058-2746

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<p>Background: Previous studies have shown that the shoulder internal rotation elbow flexion (SIREF) test, which is a modified elbow flexion (EF) test, has significantly higher sensitivity than the EF test in patients with cubital tunnel syndrome (CubTS). Here, we hypothesized that this increase in sensitivity was due to increase in the ulnar nerve strain around the elbow introduced by the additional shoulder position. Methods: Ulnar nerve strain at the elbow was intraoperatively measured at both the EF test and SIREF test positions in 20 patients with CubTS before simple decompression. Statistical analysis was performed with the Wilcoxon signed rank test at a confidence level of 99% (. P &lt; .001). Results: Mean ulnar nerve strain in the EF test position was 18.9% ± 12.1%, whereas that in the SIREF test position was 24.7% ± 14.0%. Ulnar nerve strain was higher in the SIREF than in the EF test position in all cases, and the difference was significant (mean, 5.8% ± 0.9%; 95% confidence interval, 3.90%-7.73%). Conclusion: This study indicated that increased sensitivity in the SIREF test compared with the EF test was due to the increase in ulnar nerve strain around the elbow. To the best of our knowledge, this is the first study showing that shoulder position changes the ulnar nerve strain around the elbow in living patients with CubTS.</p>

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Comparison of surgical treatments for triple extensor tendon ruptures in rheumatoid hands

Suzuki Taku, Iwamoto Takuji, Ikegami Hiroyasu, Sakuma Y., Ikari Katsunori, Matsumura Noboru, Ochi Kensuke, Sato Kazuki, Nakamura Masaya, Matsumoto Morio, Momohara Shigeki

Modern Rheumatology  2015.08

ISSN  1439-7595

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<p>Objective. This retrospective study was designed to evaluate the outcomes of four different surgical reconstructions for extensor tendon ruptures in ulnar three fingers in 48 patients with rheumatoid arthritis. Methods. The following four techniques were performed; palmaris longus tendon grafting (PL group; n = 9), extensor indicis proprius (EIP) tendon transfers (EIP group; n = 8), end-to-side transfers with tension-reduced early mobilization (End-to-side group; n = 16), and a combination of end-to-side and EIP transfers (Combination group; n = 15). Loss of extension was evaluated to determine the mean postoperative range of motion of the metacarpophalangeal (MP) joint and clinical outcomes were categorized using modified Geldmacher criteria. Results. Combination group demonstrated the best mean MP joint extension (− 3°), followed by End-to-side group (− 12°), EIP group (− 16°), and PL group (− 21°). Combination group yielded the best clinical outcomes with all cases showing good results. Conclusions. The combination of end-to-side and EIP transfer was an effective surgical reconstruction procedure for triple fingers extension loss.</p>

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Radial deviation of the finger caused by an occult intramuscular ganglion in a patient with rheumatoid arthritis

Kato Tomoyuki, Iwamoto Takuji, Matsumura Noboru, Sato Kazuki, Nakamura Toshiyasu, Toyama Yoshiaki

Modern Rheumatology  2015.06

ISSN  1439-7595

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<p>Ulnar deviation is a common complication in patients with rheumatoid arthritis (RA). We report a case of an unusual radial deviation of the middle finger caused by an occult intramuscular ganglion of the second interosseous muscle (IOM) in a patient with RA. The resection of the ganglion did not resolve the problem, and the full range of motion of the metacarpophalangeal (MP) joint was achieved through dissection of the tendon of the second dorsal IOM.</p>

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Time course of osteonecrosis in rabbit articular intercalated bone

Obara Yukihiko, Nakamura Toshiyasu, Shinmoto Hiroshi, Osada Natsuya, Yamabe Eiko, Sato Kazuki, Toyama Yoshiaki

Magnetic Resonance in Medical Sciences 14 ( 1 ) 57 - 64 2014.12

ISSN  1347-3182

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<p>Purpose: Magnetic resonance (MR) imaging offers the highest sensitivity for detecting bone necrosis. We evaluated osteonecrosis in rabbit models by calculating the percentage of fat to (fat + water) [F/(F+W)] on MR spectroscopy (MRS) and compared MR spectroscopy and imaging findings with corresponding histological results. Methods: To model the natural course of articular osteonecrosis, we removed the fourth tarsal bone in 45 rabbits, froze it for 5 min in liquid nitrogen to produce complete cellular necrosis, and then replaced the bone into the knee joint. We performed Carr-Purcell- Meiboom-Gill proton spectroscopic imaging to assess necrotic bone at 3 days and one, 2, 3, 4, 8, 12, 16, and 20 weeks after osteonecrosis and calculated the percentage of F/ (F+W) of each bone. We also performed conventional T1- and T2-weighted imaging and compared all data to histological findings to analyze the natural course of necrosis. Results: T1-weighted MR imaging demonstrated obvious low signal intensity at 2 to 8 weeks and recovery at 12 to 20 weeks, whereas T2-weighted imaging demonstrated inconsistent intensities throughout the period. The postoperative percentage of F/(F+W) measured using line scan MRS decreased to 8.88% at 3 weeks, 6.22% at 8 weeks, and 34.40% at 20 weeks results that were mostly consistent with MR imaging findings. Histological findings demonstrated complete absence of osteocyte nuclei and loss of osteoid-osteogenesis at 3 to 8 weeks. Recovery of bone marrow was identified as an increase in the area of fat after 12 weeks. Conclusion: Osteonecrosis delineated by T1-weighted MR imaging demonstrated fat content in the bone marrow that correlated with histology. The present MRS modality can be used to calculate the percentage of F/(F+W) of osteonecrosis to enable objective assessment of recovery and quantification of osteonecrosis to provide a numerical value for osteonecrosis.</p>

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How Does Ulnar Shortening Osteotomy Influence Morphologic Changes in the Triangular Fibrocartilage Complex?

Yamanaka Yoshiaki, Nakamura Toshiyasu, Sato Kazuki, Toyama Yoshiaki

Clinical Orthopaedics and Related Research 472 ( 11 ) 3489 - 3494 2014.10

ISSN  0009-921X

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<p>Background: Ulnar shortening osteotomy often is indicated for treatment of injuries to the triangular fibrocartilage complex (TFCC). However, the effect of ulnar shortening osteotomy on the changes in shape of the TFCC is unclear. In our study, quantitative evaluations were performed using MRI to clarify the effect of ulnar shortening on triangular fibrocartilage (TFC) thickness attributable to disc regeneration of the TFC and TFC angle attributable to the suspension effect of ulnar shortening on the TFC.</p><p>Questions/purposes: The purposes of this study were (1) to compare preoperative and postoperative TFC thickness and TFC angle on MR images to quantitatively evaluate the effect of ulnar shortening osteotomy on disc regeneration and the suspension effect on the TFC; and (2) to assess whether changes in TFC thickness and TFC angle correlated with the Mayo wrist score.</p><p>Methods: Between 1995 and 2008, 256 patients underwent ulnar shortening osteotomy for TFCC injuries. The minimum followup was 24 months (mean, 51 months; range, 24–210 months). A total of 79 patients (31%) with complete followup including preoperative and postoperative MR images and the Mayo wrist score was included in this retrospective study. Evaluation of the postoperative MR images and the Mayo wrist score were performed at the final followup. The remaining 177 patients did not undergo postoperative MRI, or they had a previous fracture, large tears of the disc proper, or were lost to followup. Two orthopaedists, one of whom performed the surgeries, measured the TFC thickness and the TFC angle on coronal MR images before and after surgery for each patient. Correlations of the percent change in the TFC thickness and the magnitude of TFC angle change with age, sex, postoperative MR images, extent of ulnar shortening, preoperative ulnar variance, and postoperative Mayo wrist score were assessed.</p><p>Results: Stepwise regression analysis showed a correlation between the percent change in TFC thickness and preoperative ulnar variance (R² = 0.21; β = −0.33; 95% CI, −0.11 to 0.01; p = 0.01) and between the magnitude of change in the TFC angle and the extent of ulnar shortening (R² = 0.18; β = −0.29; 95% CI, −5.8 to 0.29; p = 0.03). The Mayo wrist score was not correlated with the percent change in TFC thickness or the magnitude of change in the TFC angle.</p><p>Conclusions: These results suggest that, in patients with TFCC injury with a smaller preoperative ulnar variance, a high residual potential for regeneration in the disc proper was seen after ulnar shortening osteotomy, and correlated with the extent of ulnar shortening and the suspension effect on TFC. However, there was no correlation between disc regeneration or the suspension effect on TFC and the Mayo wrist score.</p><p>Level of Evidence: Level IV, therapeutic study. See the Instructions for Authors for a complete description of levels of evidence.</p>

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Associations between ulnar nerve strain and accompanying conditions in patients with cubital tunnel syndrome

Ochi Kensuke, Horiuchi Yukio, Nakamura Toshiyasu, Sato Kazuki, Morita Kozo, Horiuchi Koichi

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 19 ( 3 ) 329 - 333 2014

ISSN  0218-8104

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<p>Pathophysiology of cubital tunnel syndrome (CubTS) is still controversial. Ulnar nerve strain at the elbow was measured intraoperatively in 13 patients with CubTS before simple decompression. The patients were divided into three groups according to their accompanying conditions: compression/adhesion, idiopathic, and relaxation groups. The mean ulnar nerve strain was 43.5 ± 30.0%, 25.5 ± 14.8%, and 9.0 ± 5.0% in the compression/adhesion, idiopathic, and relaxation groups respectively. The mean ulnar nerve strains in patients with McGowan's classification grades I, II, and III were 18.0 ± 4.2%, 27.1 ± 22.7%, and 33.7 ± 24.7%, respectively. The Jonckheere-Terpstra test showed that there were significant reductions in the ulnar nerve strain among the first three groups, but not in the three groups according to McGowan's classification. Our results suggest that the pathophysiology, not disease severity, of CubTS may be explained at least in part by the presence of ulnar nerve strain. </p>

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Reply to the Letter to the Editor

Yamanaka Yoshiaki, Nakamura Toshiyasu, Sato Kazuki, Toyama Yoshiaki

Clinical Orthopaedics and Related Research 473 ( 1 ) 399 - 400 2014

ISSN  0009-921X

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Slow progression predicts poor prognoses in patients with spontaneous posterior interosseous nerve palsy

Ochi Kensuke, Horiuchi Yukio, Tazaki Kenichi, Takayama Shinichiro, Nakamura Toshiyasu, Sato Kazuki

Journal of Plastic Surgery and Hand Surgery 47 ( 6 ) 493 - 497 2013.12

ISSN  2000-656X

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<p>There are still no factors that predict the prognoses of patients with spontaneous posterior interosseous nerve palsies who are in an early phase of the illness. This paper reviewed 39 patients with this type of palsy. Seventeen patients who requested surgery for possible earlier recovery underwent interfascicular neurolysis because no signs of recovery were seen more than 3 months after onset. A Medical Research Council muscle power grade over 4 at their final visit was considered a good result, while a power less than grade 4 was considered a poor result. The clinical outcomes were significantly worse for the patients who had palsies with slow progressions (for more than 1 month) compared with those who had palsies with rapid progressions (completed within 1 month), regardless of their treatment. No significant difference was seen between the prognoses of patients with complete and incomplete palsies. We, therefore, recommend that interfascicular neurolysis is performed together with tendon transfer as the primary surgical procedures for patients with palsies with slow progression. © 2013 Informa Healthcare.</p>

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An obliquely placed headless compression screw for distal interphalangeal joint arthrodesis

Iwamoto Takuji, Matsumura Noboru, Sato Kazuki, Momohara Shigeki, Toyama Yoshiaki, Nakamura Toshiyasu

Journal of Hand Surgery 38 ( 12 ) 2360 - 2364 2013.12

ISSN  0363-5023

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<p>Purpose To assess the outcomes of our technique involving oblique headless compression screw for arthrodesis of the thumb interphalangeal joint and the distal interphalangeal joints of the other digits. Methods A total of 28 joints (19 thumb interphalangeal and 9 distal interphalangeal) in 23 patients with a mean age of 65 years (range, 58-74 y) were retrospectively analyzed. All operations were performed with the Acutrak2 micro-screw. After the resection of synovium and joint cartilage by a dorsal approach, a 0.88-mm diameter guide wire was inserted at the ulnar side of the proximal phalanx in the thumb and radial side of the middle phalanx in the other digits from proximal to distal to fix the joint obliquely. We verified its position under fluoroscopic control and placed the cannulated screw from proximal to distal over the guide wire. Results Intraoperative rigid fixation was obtained except for 1 case, which required additional K-wire fixation. The overall union rate was 96%. Average time to fusion was 11 weeks (range, 8-30 wk), with 76% achieving union within 3 months. There were 2 complications, 1 nonunion and 1 late infection. Other complications such as dorsal skin necrosis, nail deformity, and paresthesia did not occur. Conclusions Efforts to avoid invasion of the nailbed can be technically demanding. We believe that our proximal to distal technique with oblique placement of the headless compression screw is a straightforward and effective method with a relatively low risk of complication. Type of study/level of evidence Therapeutic IV. © 2013 by the American Society for Surgery of the Hand. All rights reserved.</p>

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The effects of dorsally angulated distal radius fractures on distal radioulnar joint stability

Saito T., Nakamura T., Nagura T., Nishiwaki M., Sato K., Toyama Y.

Journal of Hand Surgery: European Volume 38 ( 7 ) 739 - 745 2013.09

ISSN  1753-1934

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<p>Relationship between dorsal tilt of the distal radius and distal radioulnar joint stability was examined. Stiffness in dorsopalmar displacement of the radius (distal radioulnar joint stiffness) was recorded at 10° intervals until 30° of dorsal angulation from 10° of palmar tilt. Tests were repeated after partial sectioning of the radioulnar ligament, then after complete sectioning of the radioulnar ligament. All data were compared with control (intact triangular fibrocartilage complex, 10° of palmar tilt). The distal radioulnar joint stiffness in dorsal translation decreased significantly with dorsal tilt 10° and 20° in pronation. Partial sectioning of the radioulnar ligament indicated a decrease of the distal radioulnar joint stiffness in the dorsal translation at neutral tilt to 20° of dorsal tilt in the neutral position and in pronation. Distal radioulnar joint stiffness decreased significantly in both dorsal and palmar translations in all forearm positions at 10° and 20° of dorsal tilt. From these findings, the dorsal angulation of the radius should be corrected to less than 10° of dorsal tilt. © 2013 The Author(s).</p>

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Ulnar nerve strain at the elbow in patients with cubital tunnel syndrome

Ochi K., Horiuchi Y., Nakamura T., Sato K., Arino H., Koyanagi T.

Journal of Hand Surgery: European Volume 38 ( 5 ) 474 - 480 2013.06

ISSN  1753-1934

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<p>Simple decompression of the ulnar nerve at the elbow has not been shown to reduce nerve strain in cadavers. In this study, ulnar nerve strain at the elbow was measured intraoperatively in 11 patients with cubital tunnel syndrome, before and after simple decompression. Statistical analysis was performed using a paired Student's t-test. Mean ulnar nerve strain before and after simple decompression was 30.5% (range 9% to 69%) and 5.5% (range -2% to 11%), respectively; this difference was statistically significant (p &lt; 0.01) with a statistical power of 96%. Simple decompression reduced ulnar nerve strain in all patients by an average of 24.5%. Our results suggest that the pathophysiology of cubital tunnel syndrome may be multifactorial, being neither a simple compression neuropathy nor a simple traction neuropathy, and simple decompression may be a favourable surgical procedure for cubital tunnel syndrome in terms of decompression and reduction of strain in the ulnar nerve. © The Author(s) 2012.</p>

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Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

Saito Kenta, Horiuchi Keisuke, Kimura Tokuhiro, Mizuno Sakiko, Yoda Masaki, Morioka Hideo, Akiyama Haruhiko, Threadgill David, Okada Yasunori, Toyama Yoshiaki, Sato Kazuki

PLoS ONE 8 ( 1 )  2013.01

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<p>TNFα-converting enzyme (TACE) is a membrane-bound proteolytic enzyme with essential roles in the functional regulation of TNFα and epidermal growth factor receptor (EGFR) ligands. Previous studies have demonstrated critical roles for TACE in vivo, including epidermal development, immune response, and pathological neoangiogenesis, among others. However, the potential contribution of TACE to skeletal development is still unclear. In the present study, we generated a Tace mutant mouse in which Tace is conditionally disrupted in chondrocytes under the control of the Col2a1 promoter. These mutant mice were fertile and viable but all exhibited long bones that were approximately 10% shorter compared to those of wild-type animals. Histological analyses revealed that Tace mutant mice exhibited a longer hypertrophic zone in the growth plate, and there were fewer osteoclasts at the chondro-osseous junction in the Tace mutant mice than in their wild-type littermates. Of note, we found an increase in osteoprotegerin transcripts and a reduction in Rankl and Mmp-13 transcripts in the TACE-deficient cartilage, indicating that dysregulation of these genes is causally related to the skeletal defects in the Tace mutant mice. Furthermore, we also found that phosphorylation of EGFR was significantly reduced in the cartilage tissue lacking TACE, and that suppression of EGFR signaling increases osteoprotegerin transcripts and reduces Rankl and Mmp-13 transcripts in primary chondrocytes. In accordance, chondrocyte-specific abrogation of Egfr in vivo resulted in skeletal defects nearly identical to those observed in the Tace mutant mice. Taken together, these data suggest that TACE-EGFR signaling in chondrocytes is involved in the turnover of the growth plate during postnatal development via the transcriptional regulation of osteoprotegerin, Rankl, and Mmp-13. © 2013 Saito et al.</p>

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An experimental study on costal osteochondral graft

Sato K., Moy O. J., Peimer C. A., Nakamura T., Howard C., Ko S. H., Lee T. C., Nishiwaki Y.

Osteoarthritis and Cartilage 20 ( 2 ) 172 - 183 2012.02

ISSN  1063-4584

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<p>Objective: To investigate usefulness of osteochondral grafting from the costo-osteochondral junction as a repair technique for articular cartilage defects histologic and biochemical analysis of grafted cartilage in rabbit knees was evaluated up to 48. weeks after transplantation. Methods: Twenty New Zealand White rabbits were used. A costal osteochondral plug was harvested from a middle rib. After trimming, it was transplanted into a cylindrical osteochondral 2.5. mm diameter and 5. mm deep defect created in the knee. The animals were sacrificed at 6, 12, 24, and 48. weeks after transplantation. Defect sites were inspected macroscopically, and then by light microscopy. Samples were evaluated for cell viability using a fluorescent. in situ double-staining protocol with confocal laser microscopic analysis. Samples were also processed to assess type I and II collagen and aggrecan mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR). Results: Histologically, bone union was achieved in all plugs. Confocal microscopic analysis revealed chondrocyte viability in the 48-week grafts; the distribution of chondrocytes was similar to surrounding articular cartilage. The expression of type II collagen and aggrecan mRNA in the grafted cartilage was consistent with normal articular cartilage and normal costal cartilage. These results were observed over 6-48. weeks. Conclusions: Our study revealed that chondrocytes in the grafted cartilage were viable at least up to 48. weeks and that mRNA expression of type II collagen and aggrecan was also similar to that of normal articular cartilage. These results suggest that costal osteochondral grafting can be a useful alternative in the treatment of osteochondral defects. © 2011 Osteoarthritis Research Society International.</p>

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Radial and volar perilunate trans-scaphoid fracture dislocation

Nishiyama Yuichiro, Sato Kazuki, Nakamura Toshiyasu, Okazaki Masato, Toyama Yoshiaki, Ikegami Hiroyasu

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 17 ( 1 ) 93 - 97 2012

ISSN  0218-8104

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<p>A case of radial and volar perilunate trans-scaphoid fracture dislocation in which the proximal fragment of the scaphoid was dislocated dorsally is presented.</p>

Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis

Isshiki Honoka, Sato Kazuki, Horiuchi Keisuke, Tsutsumi Shuichi, Kano Makoto, Ikegami Hiroyasu, Abe Hitoshi, Umezawa Akihiro, Aburatani Hiroyuki, Toyama Yoshiaki

Journal of Orthopaedic Science 16 ( 5 ) 670 - 672 2011.09

ISSN  0949-2658

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Vertical locking of the metacarpophalangeal joint in young adults

Tajima Kosuke, Sato Kazuki, Sasaki Takashi, Peimer Clayton A.

Journal of Hand Surgery 36 ( 9 ) 1482 - 1485 2011.09

ISSN  0363-5023

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<p>Locking of the metacarpophalangeal joints has been occasionally reported in older adults, but reports of this problem are rare in younger individuals. We report 8 young adult patients with a metacarpophalangeal joint locked in 90° flexion after minor trauma. The cases included 6 little fingers and 2 thumbs in 1 male and 7 female patients aged 16 to 39 years. All were easily reduced closed. We postulate the mechanism of injury. Type of study/level of evidence: Therapeutic IV. © 2011 American Society for Surgery of the Hand.</p>

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Repair of foveal detachment of the triangular fibrocartilage complex

Nakamura Toshiyasu, Sato Kazuki, Okazaki Masato, Toyama Yoshiaki, Ikegami Hiroyasu

Hand Clinics 27 ( 3 ) 281 - 290 2011.08

ISSN  0749-0712

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<p>Because the radioulnar ligament attaches to the ulnar fovea and base of the ulnar styloid, foveal detachment of the triangular fibrocartilage complex (TFCC) induces severe distal radioulnar joint instability. This article describes both an arthroscopic and open repair technique to reattach the TFCC to the fovea. Both techniques reanchor the detached TFCC to the fovea. Both techniques are reliable and promising techniques in the repair of a foveal detachment of the TFCC. © 2011 Elsevier Inc.</p>

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Steroid-induced osteonecrosis of bilateral distal humerus treated by arthroplasty using costal osteochondral graft

Watanabe Ryuichi, Sato Kazuki, Nakamura Toshiyasu, Obara Yukihiko, Toyama Yoshiaki, Ikegami Hiroyasu

Journal of Hand Surgery 36 ( 5 ) 816 - 819 2011.05

ISSN  0363-5023

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<p>We report the case of a 43-year-old man with steroid-induced osteonecrosis of the distal humerus in both arms. Costal osteochondral autografts were used to restore both joints with satisfactory outcomes. © 2011 American Society for Surgery of the Hand.</p>

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Costo-osteochondral graft for post-traumatic osteonecrosis of the radial head in an adolescent boy

Iwai S., Sato K., Nakamura T., Okazaki M., Itoh Y., Toyama Y., Ikegami H.

Journal of Bone and Joint Surgery - Series B 93 B ( 1 ) 111 - 114 2011.01

ISSN  0301-620X

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<p>We present a case of post-traumatic osteonecrosis of the radial head in a 13-year-old boy which was treated with costo-osteochondral grafts. A satisfactory outcome was seen at a follow-up of two years and ten months. Although costo-osteochondral grafting has been used in the treatment of defects in articular cartilage, especially in the hand and the elbow, the extension of the technique to manage post-traumatic osteonecrosis of the radial head in a child has not previously been reported in the English language literature. Complete relief of pain was obtained and an improvement in the range of movement was observed. The long-term results remain uncertain. ©2011 British Editorial Society of Bone and Joint Surgery.</p>

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Avulsion of flexor digitorum profundus secondary to recurrent enchondroma.

Nomura T., Nakamura T., Sato K., Toyama Y., Ikegami H.

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 16 ( 2 ) 205 - 206 2011

ISSN  0218-8104

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<p>We report a case of avulsion of the flexor digitorum profundus secondary to recurrent enchondroma. The tumor was curetted with bone grafting of cancellous bone from the distal radius, and the fragment avulsed by the flexor digitorum profundus tendon was fixed to its original site using a pullout suture through the distal phalanx to the nail. The lesion healed and function recovered 6 years after surgery.</p>

Erratum

Okazaki M., Tazaki K., Nakamura T., Toyama Y., Sato K.

Journal of Hand Surgery: European Volume 35 ( 7 ) 601 2010.09

ISSN  1753-1934

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The "docking" method for periprosthetic humeral fracture after total elbow arthroplasty

Kawano Yusuke, Okazaki Masato, Ikegami Hiroyasu, Sato Kazuki, Nakamura Toshiyasu, Toyama Yoshiaki

Journal of Bone and Joint Surgery - Series A 92 ( 10 ) 1988 - 1991 2010.08

ISSN  0021-9355

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Corrective Osteotomy for Volarly Malunited Distal Radius Fracture

Sato Kazuki, Nakamura Toshiyasu, Iwamoto Takuji, Toyama Yoshiaki, Ikegami Hiroyasu, Takayama Shinichiro

Journal of Hand Surgery 34 ( 1 )  2009.01

ISSN  0363-5023

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<p>Purpose: To retrospectively analyze consecutive cases with opening wedge corrective osteotomy of the volarly malunited distal radius with iliac bone graft, including preoperative and postoperative comparison of symptoms, visual analog scale (VAS), Japanese Society for Surgery of the Hand version of the Disabilities of the Arm, Shoulder, and Hand (DASH-JSSH) questionnaires, radiographic indices, clinical results as evaluated by modified Mayo wrist score, and complications. Methods: Subjects were 28 patients with volarly malunited distal radius fracture treated by transverse opening wedge osteotomy with oblique iliac bone graft. Preoperative symptoms included wrist deformity, weakness of grip strength, and marked restriction of supination range. Postoperative symptoms, radiographic parameters, clinical results, and complications were analyzed at an average of 25 months of follow-up. We also analyzed the union period of the radius in younger patients (≤45 years old) and older patients (&gt;45 years old). Results: Mean preoperative visual analog scale was 45, improving significantly to 3 postoperatively. Range of wrist motion improved in all 28 patients, with supination range improving from 16° preoperatively to 80° postoperatively. Mean preoperative DASH-JSSH score was 55, improving to 9 postoperatively. Radiography revealed that volar tilt improved from 32° preoperatively to 10° postoperatively, and radial inclination increased from 17° to 21°. Preoperative ulnar variance of +5.9 mm was corrected to -0.1 mm postoperatively. All 28 wrists demonstrated bony union at the osteotomy site after an average of 52 days (younger patients, 51 days; older patients, 54 days). No complications, significant radiographic correction loss, or nonunion were seen after at least 2 years of follow-up. Modified Mayo wrist score was excellent in 16 patients, good in 10 patients, and fair in 2 patients. Conclusions: Opening wedge osteotomy for volarly malunited distal radius fracture restored bony configuration of the distal radius, decreased pain, and improved grip strength and range of wrist motion, particularly for forearm supination. No complications or noteworthy correction loss were noted after surgery, even in older patients. Type of study/level of evidence: Therapeutic IV. © 2009 American Society for Surgery of the Hand.</p>

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Tendon entrapment in distal radius fractures

Okazaki Masato, TazakiA K., Nakamura T., Toyama Y., Sato K.

Journal of Hand Surgery: European Volume 34 ( 4 ) 479 - 482 2009

ISSN  1753-1934

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<p>We retrospectively defined the rate and clinical features of tendon entrapment in 693 consecutive patients with 701 distal radius fractures treated in a single hospital. Eight extensor tendons and one flexor tendon were entrapped. All fractures with extensor tendon entrapment were palmarly displaced (Smith type) or epiphyseal. Flexor tendon entrapment was seen in dorsally angulated (Colles type) epiphyseal fracture. The rate of tendon entrapment in acute distal radius fractures was 1.3%. Extensor tendon entrapment in palmarly displaced fractures is more common. © 2009 The British Society for Surgery of the Hand. Published by SAGE. All rights reserved.</p>

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Re

Okuyama N., Sato Kazuki, Nakamura T., Ikegami H.

Journal of Hand Surgery: European Volume 34 ( 1 ) 132 - 133 2009

ISSN  1753-1934

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Nicotine acts on growth plate chondrocytes to delay skeletal growth through the α7 neuronal nicotinic acetylcholine receptor

Kawakita Atsuo, Sato Kazuki, Makino Hatsune, Ikegami Hiroyasu, Takayama Shinichiro, Toyama Yoshiaki, Umezawa Akihiro

PLoS ONE 3 ( 12 )  2008.12

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<p>Background: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced delayed skeletal growth. However, the possible mechanism of delayed skeletal growth caused by nicotine remains unclarified. In the last decade, localization of neuronal nicotinic acetylcholine receptor (nAChR), a specific receptor of nicotine, has been widely detected in non-excitable cells. Therefore, we hypothesized that nicotine affect growth plate chondrocytes directly and specifically through nAChR to delay skeletal growth. Methodology/Principal Findings: We investigated the effect of nicotine on human growth plate chondrocytes, a major component of endochondral ossification. The chondrocytes were derived from extra human fingers. Nicotine inhibited matrix synthesis and hypertrophic differentiation in human growth plate chondrocytes in suspension culture in a concentration-dependent manner. Both human and murine growth plate chondrocytes expressed alpha7 nAChR, which constitutes functional homopentameric receptors. Methyllycaconitine (MLA), a specific antagonist of alpha7 nAChR, reversed the inhibition of matrix synthesis and functional calcium signal by nicotine in human growth plate chondrocytes in vitro. To study the effect of nicotine on growth plate in vivo, ovulation-controlled pregnant alpha7 nAChR +/- mice were given drinking water with or without nicotine during pregnancy, and skeletal growth of their fetuses was observed. Maternal nicotine exposure resulted in delayed skeletal growth of alpha7 nAChR +/+ fetuses but not in alpha7 nAChR -/- fetuses, implying that skeletal growth retardation by nicotine is specifically mediated via fetal alpha7 nAChR. Conclusions/Significance: These results suggest that nicotine, from cigarette smoking, acts directly on growth plate chondrocytes to decrease matrix synthesis, suppress hypertrophic differentiation via alpha7 nAChR, leading to delayed skeletal growth. © 2008 Kawakita et al.</p>

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Finger joint reconstruction with costal osteochondral graft

Sato Kazuki, Nakamura Toshiyasu, Nakamichi Noriaki, Okuyama Noriko, Toyama Yoshiaki, Ikegami Hiroyasu

Techniques in Hand and Upper Extremity Surgery 12 ( 3 ) 150 - 155 2008.09

ISSN  1089-3393

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<p>Cartilage disorders of the finger joint may influence hand function. Loss of integrity of the finger joint may severely compromise its stability and may lead to degenerative arthritis. Anatomical reduction of the finger cartilage should be as precise as possible in treating cartilage defects due to trauma and other causes. We have repaired cartilage defects in finger joints by arthroplasty with costal osteochondral grafting in 29 patients (30joints) since 1997. Three patients underwent total joint reconstruction using costal osteochondral grafting for complete bony ankylosis (1 metacarpophalangeal joint and 2 proximal interphalangeal joints). The purpose of this study was to describe the history, indications, and surgical techniques of the costal osteochondral graft for cartilage disorders or defects in the metacarpophalangeal and proximal interphalangeal joints. © 2008 Lippincott Williams &amp; Wilkins, Inc.</p>

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MCL reconstruction using patellar tendon-bone graft for severe valgus instability of the elbow after excessive resection of the medial epicondyle of the humerus

Sato Kazuki, Nakamura Toshiyasu, Kawakita Atsuo, Shimizu Kuniaki, Toyama Yoshiaki, Ikegami Hiroyasu

Journal of Orthopaedic Science 13 ( 5 ) 469 - 471 2008.09

ISSN  0949-2658

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Isolated dorsal fracture-dislocation of the scaphoid

Wanajo S., Sato Kazuki, Nakamura T., Ikegami H., Tanino Y., Toyama Y.

Journal of Hand Surgery: European Volume 33 ( 3 ) 311 - 313 2008.06

ISSN  1753-1934

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<p>This paper reports an isolated dorsal fracture-dislocation of the scaphoid at its waist with the proximal fragment dislocated dorsally. Such a fracture-dislocation is extremely rare. We believe the pathomechanics of this injury to have been a flexion and radial deviation with an axial force on the wrist. © 2008 The British Society for Surgery of the Hand. Published by SAGE. All rights reserved.</p>

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Costal osteochondral grafts for osteochondritis dissecans of the capitulum humeri

Sato Kazuki, Nakamura Toshiyasu, Toyama Yoshiaki, Ikegami Hiroyasu

Techniques in Hand and Upper Extremity Surgery 12 ( 2 ) 85 - 91 2008.06

ISSN  1089-3393

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<p>The objective of the treatment for osteochondritis dissecans of the humeral capitulum is to prevent the occurrence of osteoarthritis and to allow the patients to return to throwing activities. In repairing osteochondral defects in advanced osteochondritis dissecans of the humeral capitulum after free body removal, we have performed block-shaped costal osteochondral grafting in 18 elbows since 1997. A block-shaped graft harvested from the transitional area between the rib and its associated cartilage was implanted to the osteochondral defect. This method allows the osteochondral defect to be repaired with uniform hyaline cartilaginous articular surface without any effect to other joints. Donor site no longer causes pain at 2 or 3 days after surgery. The purpose of this study is to describe the history, indications, and the surgical techniques of costal osteochondral grafting for advanced osteochondritis dissecans of the capitulum. © 2008 Lippincott Williams &amp; Wilkins.</p>

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Clinical Outcome and Histologic Findings of Costal Osteochondral Grafts for Cartilage Defects in Finger Joints

Sato Kazuki, Sasaki Takashi, Nakamura Toshiyasu, Toyama Yoshiaki, Ikegami Hiroyasu

Journal of Hand Surgery 33 ( 4 ) 511 - 515 2008.04

ISSN  0363-5023

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<p>Purpose: For the purpose of achieving anatomical reduction as precisely as possible, we performed osteochondral grafting from the costo-osteochondral junction in 16 patients (17 joints) with posttraumatic articular cartilage injury or avascular necrosis in finger joints. The purpose of this study was to review our series of costal osteochondral grafts in order to determine the practicality, effectiveness, and functionality of this grafting technique in a clinical setting. Methods: Patients were followed for at least 18 months postoperatively (18-57 months; average, 28 months). The injured joints included 3 metacarpophalangeal, 9 proximal interphalangeal, 3 distal interphalangeal, and 2 thumb interphalangeal joints. The defect accounted for 50% to 100% of the articular surface (average, 63%). Results: The average time until bone union of the graft was 58 days. The mean arc of motion was 13° before surgery versus 58° after surgery, with a mean increase of 45°. In 7 patients (8 joints), an extremely small portion (approximately 1 × 1 mm in size and thinner than 0.1 mm) of the implanted cartilage was obtained via biopsy using a scalpel with the consent of the patient at the time of screw removal and was used to prepare histologic specimens, which revealed scattered chondrocytes within the matrix without differences from normal hyaline cartilage in any. The chondrocytes in the grafts appeared viable, and the reconstruction of the joint surface could be confirmed histologically. Conclusions: Osteochondral grafting from the costo-osteochondral junction achieves excellent reconstruction of the injured joint without affecting other joints. This technique is particularly beneficial in cases where it is difficult to obtain allograft donors, as is often the case in Japan. Despite these encouraging findings in this small series, we believe that it is necessary to conduct further studies of this method over a longer period. Type of study/level of evidence: Therapeutic IV. © 2008 American Society for Surgery of the Hand.</p>

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Radial perilunate trans-styloid trans-triquetrum fracture dislocation

Suzuki Taku, Sato Kazuki, Nakamura Toshiyasu, Toyama Yoshiaki, Ikegami Hiroyasu

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 13 ( 1 ) 41 - 44 2008

ISSN  0218-8104

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<p>We present a rare case of radial perilunate trans-styloid fracture dislocation, in which the scaphoid invaginated radially into the fractured radial styloid.</p>

Dorsal dislocations of the second to fifth carpometacarpal joints

Mito Kazuaki, Nakamura Toshiyasu, Sato Kazuki, Toyama Yoshiaki, Ikegami Hiroyasu

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 13 ( 2 ) 129 - 132 2008

ISSN  0218-8104

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<p>Dislocations involving the four ulnar carpometacarpal joints are rare. These complex dislocations are considered to be due to the application of a hyperflexion force on the metacarpal heads. In the present case, an indirect hyperextension force on the metacarpal bones created a lever-arm effect resulting in rupture of the firm ligament complex of the carpometacarpal joints, inducing complete dislocations of the second to fifth carpometacarpal joints.</p>

Flexion contracture of the elbow due to phlebosclerosis induced by anti-cancer drug infusion.

Fujimaki Ryoji, Nakamura Toshiyasu, Sato Kaziki, Toyama Yoshiaki, Ikegami Hiroyasu

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 13 ( 2 ) 107 - 110 2008

ISSN  0218-8104

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<p>This case report describes a patient with elbow contracture due to phlebosclerosis induced by anti-cancer drug infusion. Limitation of elbow extension was completely relieved by surgical excision of the sclerotic vein.</p>

Idiopathic calcinosis cutis in fingertip treated with occlusive dressing using aluminum foil

Sato Kazuki, Nakamura Toshiyasu, Toyama Yoshiaki, Ikegami Hiroyasu, Kameyama Kaori, Takayama Shinichiro

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 12 ( 3 ) 149 - 154 2007

ISSN  0218-8104

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<p>Calcium deposition in the skin, known as calcinosis cutis, is an uncommon disorder caused by an abnormal deposit of calcium phosphate in the skin. We report a case of idiopathic calcinosis cutis in fingertip treated with surgical excision followed by the occlusive dressing using aluminum foil, and obtained significant pain relief and round-shaped fingertip which looked normal.</p>

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Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture

Vacanti Victor, Kong Elton, Suzuki Gen, Sato Kazuki, Canty John M., Lee Techung

Journal of Cellular Physiology 205 ( 2 ) 194 - 201 2005.11

ISSN  0021-9541

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<p>The in vitro culture of porcine bone marrow-derived mesenchymal stem cells (MSCs) was used for the investigation of adult stem cell biology. Isolated porcine MSCs possessed the ability to proliferate extensively in an antioxidants-rich medium containing 5% fetal bovine serum (FBS). Greater than 40 serial MSC passages and 100 cell population doublings have been recorded for some MSC batches. Early and late passage MSCs were defined here as those cultures receiving less than 5 trypsin passages and more than 15 trypsin passages, respectively. Consistent with their robust ability to proliferate, both the early and late passage MSCs expressed the cell-cycle promoting enzyme p34cdc2 kinase. Late MSCs, however, exhibited certain features reminiscent of cellular aging such as actin accumulation, reduced substrate adherence, and increased activity of lysosomal acid β-galactosidase. Early MSCs retained the multipotentiality capable of chondrogenic, osteogenic, and adipogenic differentiation upon induction in vitro. In contrast, late MSCs were only capable of adipogenic differentiation, which was greatly enhanced at the expense of the osteochondrogenic potential. Along with these changes in multipotentiality, late MSCs expressed decreased levels of the bone morphogenic protein (BMP-7) and reduced activity of alkaline phosphatase. Late MSCs also exhibited attenuated synthesis of the hematopoietic cytokines granulocyte colony-stimulating factor (G-CSF), leukemia inhibitory factor (LIF), and stem cell factor (SCF). The long-term porcine MSC culture, thus, provides a model system to study the molecular interplay between multiple MSC differentiation cascades in the context of cellular aging. © 2005 Wiley-Liss, Inc.</p>

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Open repair of the ulnar disruption of the triangular fibrocartilage complex with double three-dimensional mattress suturing technique

Nakamura Toshiyasu, Nakao Yasushi, Ikegami Hiroyasu, Sato Kazuki, Takayama Shinichiro

Techniques in Hand and Upper Extremity Surgery 8 ( 2 ) 116 - 123 2004.06

ISSN  1089-3393

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<p>Open repair technique of the ulnar disruption of the triangular fibrocartilage complex is described. This technique is indicated for a fresh or a relatively fresh (less than 1 year after the initial injury) ulnar foveal detachment tear, horizontal tear, and proximal slit tear of the triangular fibrocartilage complex, all of which are accompanied by severe dorsal, palmar, or multidirectional instability of the distal radioulnar joint. A chronic tear greater than 1 year from initial injury and a fresh triangular fibrocartilage complex tear without distal radioulnar joint instability, such as central slit tear, are excluded from our indications. A dorsal C-shaped skin incision, a longitudinal incision of the radial edge of the extensor carpi ulnaris subsheath and the dorsal distal radioulnar joint capsule, exposes the distal radioulnar joint. A small, 5-mm longitudinal incision at the origin of the radioulnar ligament exposes its fovea detachment and/or the proximal slit tear of the triangular fibrocartilage complex. The disrupted radioulnar ligament is sutured in a pullout fashion to the ulna with a 3-dimensional double mattress technique through 2 bone tunnels that is precisely made at the central portion of the fovea with 1.2-mm K-wire. An additional horizontal mattress suture is used for closure of the small incision made at the radioulnar ligament, then the extensor carpi ulnaris is repaired. This open-repair technique is complex and requires precise technical skills; however, early results hav been more rewarding than the conservative treatment. © 2004 Lippincott Williams &amp; Wilkins, Philadelphia.</p>

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Two cases with osteochondritis dissecans of the capitulum humeri treated with costal osteochondral graft transplantation

Sato Kazuki, Mio Futoshi, Hosoya Toshihiko, Ito Yoshiyasu

Journal of Shoulder and Elbow Surgery 12 ( 4 ) 403 - 407 2003.07

ISSN  1058-2746

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指尖部損傷に対するアルミニウムホイル被覆療法

SATOU KAZUKI

Monthly Book Orthopaedics, 17(2): 6-13, 2003  2003

Research paper (scientific journal), Single Work

Two cases with osteochondritis dissecans of the capitulum humeri treated with costal osteochondral graft transplantation.

SATOU KAZUKI

J Sholder Elbow Surg, 12: 403-407, 2003  ( 12 )  2003

Research paper (scientific journal), Single Work

開放療法による指尖損傷の治療

Satou Kazuki, Sasaki Takashi, Takayama Shinichirou

Monthly book orthopaedics 15 ( 1 ) 1-9 2002.01

Research paper (scientific journal), Joint Work

尺骨茎状突起基部骨折を伴ったGaleazzi骨折の検討

Kikuchi Yoshito，Horiuchi Yukio，Nakamura Toshiyasu，Tazaki Kenichi，Satou Kazuki

日本手の外科学会雑誌 17 ( 1 ) 94-98 2000.08

Research paper (scientific journal), Joint Work

指尖損傷のアルミホイル法に関する考察―医療経済の観点から―

Satou Kazuki, Sasaki Takashi, Horiuchi Yukio, Takayama Shinichirou, Ookushi Kazuhiko

日本手の外科学会雑誌 15 ( 1 ) 195-197 1998.08

Research paper (scientific journal), Joint Work

指骨軟部組織欠損に対するアルミニウムホイル被覆法の治療経験 --指尖部以外への適応--

Satou Kazuki, Sasaki Takashi, Itou Yoshiyasu, Horiuchi Yukio, Takayama Shinichirou

日手の外科会誌 14   151-155 1997

Research paper (scientific journal), Joint Work

指尖切断のOCCLUSIVE　DRESSING法に関する実験的研究--再生神経の分布について--

Sato Kazuki, Sasaki Takashi, Takayama Shinichiro, Horiuchi Yukio, Yabe Yutaka

日手会誌 13 ( 3 ) 568-572 1996.11

Research paper (scientific journal), Joint Work