Morisaki, Hiroshi

写真a

Affiliation

School of Medicine (Mita)

Position

Professor Emeritus

External Links
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Profile 【 Display / hide 】

  • Dr. Hiroshi Morisaki is currently Professor and Chair of the Department of Anesthesiology at Keio University School of Medicine, Tokyo, Japan. He also serves as the Director of the General Intensive Care Unit, Keio University Hospital. Dr. Morisaki graduated from Keio University School of Medicine in 1983, and obtained his Doctorate of Medicine by performing basic research in the Department of Biochemistry, Keio University School of Medicine, in 1990. After obtaining clinical training at Keio University Hospital and its affiliated hospitals, he became board certified by the Japanese Societies of Anesthesiology and Intensive Care Medicine. At present, Dr. Morisaki’s research interests include all aspects of gut immune function, and organ dysfunction in patients with sepsis and/or other types of critical illness. He has investigated several protective approaches to prevent and/or treat multiple organ dysfunction in critically ill patients. Dr. Morisaki has been the Deputy Editor of the Journal of Intensive Care.

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Career 【 Display / hide 】

  • 1990.07
    -
    1992.12

    University of Western Ontario Program in Critical Care, Research fellow

  • 1994.01
    -
    1996.09

    慶應義塾大学医学部麻酔学教室, 助教

  • 1996.10
    -
    2004.03

    Keio University School of Medicine, Department of Anesthesiology, Assistant Professor

  • 2004.04
    -
    2012.09

    Keio University School of Medicine, Department of Anesthesiology, Associate Professor

  • 2012.10
    -
    Present

    Keio University School of Medicine, Anetsheisology, Professor

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Academic Background 【 Display / hide 】

  • 1977.04
    -
    1983.03

    Keio University, School of Medicne

    University, Graduated

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Academic Degrees 【 Display / hide 】

  • 医学博士, 慶應義塾大学

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Licenses and Qualifications 【 Display / hide 】

  • Medical Doctor, 1983.06

  • 日本麻酔科学会　麻酔指導医, 1990.02

  • 日本集中治療医学会　集中治療専門医, 1995.04

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Research Areas 【 Display / hide 】

  • Life Science / Anesthesiology

  • Life Science / Emergency medicine

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Research Keywords 【 Display / hide 】

  • gut immune function

  • multiple orga failure

  • epidural anesthesia

  • volatile anesthetics

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Research Themes 【 Display / hide 】

  • neutrophil-derived glycoprotein and gut immune function, 

    2010.04
    -
    Present

  • gut immune function in criticall ill, 

    1996.04
    -
    Present

  • protective effects of epidural anesthesia on organ function, 

    1994.04
    -
    Present

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Books 【 Display / hide 】

  • 標準麻酔科学「第7版」

    MORISAKI HIROSHI, 医学書院, 2018

    Scope: 集中治療

  • ICUとCCU

    山田高成、上田朝美、鈴木武志、森崎浩, 医学図書出版, 2015

    Scope: esCCO Estimated continuous cardiac output. 特集「最近の各種モニターのICUにおける有用性と問題点」

  • Yearbook of Intensive Care and Emergency Medicine

    Sibbald WJ, Bloos F, Morisaki H, Springer-Verlag, 1996

    Scope: Sepsis, anemia, and tissue O2 availability

  • Clinical Trials for the Treatment of Sepsis

    Sibbald WJ, Doig G, Morisaki H, Springer-Verlag, 1995

    Scope: Roles of RBC Transfusion Therapy in Sepsis

  • Yearbook of Intensive Care and Emergency Medicine

    Morisaki H, Sibbald W, Springer-Verlag, Berlin, 1993.06

    Scope: Issues in Colloid and Transfusion Therapies of Sepsis

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Papers 【 Display / hide 】

  • Life-threatening rocuronium-induced anaphylactic shock without cutaneous manifestations successfully reversed with sugammadex: a case report

    Takise Yoshiaki, Kato Jungo, Suhara Tomohiro, Yamada Takashige, Funakoshi Takeru, Takahashi Hayato, Amagai Masayuki, Morisaki Hiroshi

    JA CLINICAL REPORTS 6 ( 1 )  2020.12

    ISSN  2363-9024

  • Safety and efficacy of remimazolam in induction and maintenance of general anesthesia in high-risk surgical patients (ASA Class III): results of a multicenter, randomized, double-blind, parallel-group comparative trial

    Doi M., Hirata N., Suzuki T., Morisaki H., Morimatsu H., Sakamoto A.

    Journal of Anesthesia (Journal of Anesthesia)  34 ( 4 ) 491 - 501 2020.08

    ISSN  09138668

    　View Summary

    © 2020, Japanese Society of Anesthesiologists. Purpose: Remimazolam, an ultra-short-acting benzodiazepine sedative is equally effective as propofol in induction and maintenance of general anesthesia with improved hemodynamic stability in American Society of Anesthesiologists (ASA) Class I and II patients. This trial investigated remimazolam’s efficacy and safety in vulnerable patients (ASA Class III) undergoing elective general surgery. Methods: A multicenter, randomized, double-blind, parallel-group trial in 67 adult surgical patients undergoing general anesthesia with two remimazolam induction doses (6 mg kg−1 h−1—group A and 12 mg kg−1 h−1—group B) has been conducted in 6 trials sites in Japan. Remimazolam was infused up to 2 mg kg−1 h−1 for maintenance of anesthesia in both groups. Results: The functional anesthetic capability of the investigated drug was 100% in both arms. The mean time to loss of consciousness (LoC) was significantly shorter in group B (81.7 s) compared to group A (97.2 s), p = 0.0139. The mean bispectral index (BIS) value during maintenance of anesthesia ranged from 46.0 to 68.0 and from 44.7 to 67.5 in group A and B, respectively. There was no statistically significant difference between the remimazolam arms concerning the incidence of blood pressure (BP) decrease (67.7% in group B vs. 54.8% in group A), recovery profile or the incidence or severity of adverse events (AEs) or adverse drug reactions (ADRs). Conclusion: Both induction regimens (6 and 12 mg kg−1 h−1) were equally efficacious and safe in surgical patients ASA Class III. A significantly shorter time to LoC was observed with the higher remimazolam dosage. Clinical trial registration This trial is registered with the Japan Pharmaceutical Information Center—Clinical Trials Information (JapicCTI). JapicCTI number: 121977.

  • Abrupt Exacerbation of Atrial Functional Mitral Regurgitation During Emergence From General Anesthesia Following Transcatheter Aortic Valve Replacement

    Sato Masaaki, Kato Jungo, Toya Ryo, Ueda Tomomi, Igarashi Toru, Yamada Takashige, Tsuruta Hikaru, Hayashida Kentaro, Morisaki Hiroshi

    A & A PRACTICE 14 ( 9 )  2020.07

    ISSN  2325-7237

  • Ringer’s ethyl pyruvate solution attenuates hypoperfusion and renal injury after multivisceral ischemia–reperfusion in rabbits

    Yamada T., Nishimura D., Inoue K., Kato J., Morisaki H., Kotake Y.

    Journal of Anesthesia (Journal of Anesthesia)  34 ( 2 ) 303 - 307 2020.04

    ISSN  09138668

    　View Summary

    © 2020, Japanese Society of Anesthesiologists. Ringer's ethyl pyruvate solution (REPS) has been protective against experimental renal, intestinal, and spinal ischemia and may be useful for organ protection in major vascular surgery. The purpose of this study was to investigate whether REPS attenuates organ injury in a rabbit model of supraceliac aortic cross-clamp that simulates thoracoabdominal aortic surgery. Following the Institutional Animal Care and Use Committee’s approval, 20 rabbits were undergone cross-clamping of the supraceliac thoracic aorta for 30 min, and observed for 180 min after reperfusion. Either REPS (33 mg/kg/h of ethyl pyruvate) or Ringer's lactate solution were infused throughout the study period. Arterial pressure and aortic blood flow were continuously monitored. Blood lactate concentration, serum transaminase levels, neutrophil activation, and urinary N-acetyl-beta-glucosaminidase (NAG) activity were evaluated. After reperfusion, supraceliac aortic blood flow was significantly higher, and urinary NAG was significantly lower in animals that received REPS, while the other parameters were not significantly different. In conclusion, REPS attenuated the reduction of aortic blood flow and urinary NAG elevation after the cross-clamp of supraceliac aorta.

  • Effects of prophylactic dexamethasone on postoperative nausea and vomiting in scoliosis correction surgery: a double-blind, randomized, placebo-controlled clinical trial

    Wakamiya R., Seki H., Ideno S., Ihara N., Minoshima R., Watanabe K., Sato Y., Morisaki H.

    Scientific Reports (Scientific Reports)  9 ( 1 )  2019.12

    ISSN  2045-2322

    　View Summary

    © 2019, The Author(s). Dexamethasone is widely used for postoperative nausea and vomiting (PONV) prophylaxis, but its effect on PONV prevention in paediatric patients is validated only in short minor surgical procedures. In this study, we aimed to determine whether a single dose of dexamethasone reduces PONV in highly invasive surgeries that require opioid-based postoperative analgesia. One hundred adolescents undergoing scoliosis correction surgery were randomized to receive intravenous dexamethasone 0.15 mg/kg (dexamethasone group) or saline (control group) at induction of anaesthesia. The primary outcome was the incidence of PONV in the 72 h postoperatively. Data for 98 patients were available for analysis. The 72-h incidence of PONV was significantly lower in the dexamethasone group than in the control group (62.5% vs 84.0%; RR 0.74, 95% CI 0.58–0.96, P = 0.02). During the first and second 24-h postoperative intervals, fewer patients in the dexamethasone group received rescue antiemetics. Visual analogue scale scores for nausea and pain were lower in the dexamethasone group than in the control group during the first 24 h postoperatively. Dexamethasone did not increase the number of adverse events. The results of this study showed that a single dose of dexamethasone was effective for reducing PONV after paediatric scoliosis correction surgery.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 家兎人工呼吸惹起性肺損傷モデルにおける気管支肺胞洗浄液中のエラスターゼ活性の検討

    Takagi Airin Naomi, Ishizaka Akitoshi, Yamamoto Shinichi, Fukushima Junko, Morisaki Hiroshi, Takeda Junzou

    第43回日本呼吸器学会, 

    2003.03
    , 

    Poster presentation

  • 硬膜外麻酔は内毒素惹起性腸管粘膜内アシドーシス進行を抑える

    Kosugi Shizuko, Satou Tomoyuki, Ai Kimiaki, Serita Ryouhei, Kotake Yoshifumi, Morisaki Hiroshi, Takeda Junzou

    第30回日本集中治療医学会, 

    2003.02
    , 

    Oral presentation (general)

  • Pseudo-vein appearance様所見を呈し，大血管損傷を疑われた胸部外傷の一例

    You Kikuo, Aoki Katsunori, Kurihara Tomohiro, Yamamoto Jun, Miyatake Satoru, Yamasaki Motoyasu, Ishikawa Hideki, Kimura Hiroyuki, Takuma Kiyotsugu, Namiki Jun, Fujishima Seitarou, Hori Shingo, Morisaki Hiroshi, Aikawa Naoki

    第53回日本救急医学会関東地方会, 

    2003.02
    , 

    Oral presentation (general)

  • Pseudo-vein appearance様所見を呈し，大血管損傷を疑われた胸部外傷の一例

    You Kikuo, Aoki Katsunori, Kurihara Tomohiro, Yamamoto Jun, Miyatake Satoru, Yamasaki Motoyasu, Ishikawa Hideki, Kimura Hiroyuki, Takuma Kiyotsugu, Namiki Jun, Fujishima Seitarou, Hori Shingo, Morisaki Hiroshi, Aikawa Naoki

    第53回日本救急医学会関東地方会, 

    2003.02
    , 

    Oral presentation (general)

  • 集中治療における臨床工学士の役割—透析からICUへローテートして

    Komori Masaki, Shibano Toyohiko, Morita Masanori, Jinnai Makoto, Hashimoto Hiroaki, Oshitari Yukio, Matayoshi Tooru, Morisaki Hiroshi, Ochiai Ryouichi, Takeda Junzou

    第30回日本集中治療医学会, 

    2003.02
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 敗血症における至適ヘモグロビン値と腸管壁防御機構―ストレス応答酵素の役割

    2002.04
    -
    2005.03

    Research grant, Principal investigator

  • βブロッカーは敗血症患者の救命率を高めるー擬似ラットモデルでの検討

    2008.04
    -
    2010.03

    Principal investigator

  • 脳下垂体ホルモンであるオキシトシンが敗血症の心筋および血管系におよぼす影響

    2008.04
    -
    2012.03

    日本学術振興会, Research grant, Coinvestigator(s)

  • Hyperglycemia-induced alteration of gut flora in a model of critically ill

    2009.04
    -
    2013.03

    Japan Society for the Promotion of Science, Hiroshi Morisaki, Research grant, Principal investigator

  • Catecholamine-induced alterations of gut immune function: effects of intestinal flora

    2013.04
    -
    2016.03

    Japan Society for the Promotion of Science, Hiroshi Morisaki, Research grant, Principal investigator

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Awards 【 Display / hide 】

  • The Fellow Award In-Training

    Morisaki H, Bloos F, Keys J, Martin C, Sibbald WJ, 1992.05, The Society of Critical Care Medicine, Colloid infusion preserves microvascular integrity better than crystalloid in hyperdynamic sepsis.

    Country： United States

  • Kitajima Award

    1998.06, Keio University School of Mediicne, Sanshikai, Inflammatory tissue injury and countermeasures during perioperative period

  • 日本集中治療医学会　優秀論文賞

    2003.02, Japanese Society of Intensive Care Medicine, Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms.

  • 優秀論文賞

    Morisaki H, Katayama T, Kotake Y, Ito M, Handa M, Ikeda Y, Takeda J, Suematsu M., 2003, 日本集中治療医学会, Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 北島賞

    1998.06, 慶應義塾大学医学部三四会, 周術期における炎症性組織障害と対策

    Type of Award： Keio commendation etc.

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, ANESTHESIOLOGY AND PALLIATIVE CARE

    2024

  • PAIN CONTROL: SEMINAR

    2023

  • PAIN CONTROL: PRACTICE

    2023

  • LECTURE SERIES, ANESTHESIOLOGY AND PALLIATIVE CARE

    2023

  • CLINICAL ANESTHESIOLOGY

    2023

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Courses Previously Taught 【 Display / hide 】

  • 麻酔学概論

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, 40people

  • 集中治療医学概論

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 40people

  • 麻酔科学概論

    Keio University

    2017.04
    -
    2018.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 40people

  • 集中治療医学概論

    Keio University

    2017.04
    -
    2018.03
    , 

    Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty, 40people

  • Anesthesiology & Intensive Care Medicine

    Keio University

    2015.04
    -
    2016.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 50people

    Intensive Care Medicine

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Educational Activities and Special Notes 【 Display / hide 】

  • Lecture of Anesthesia

    1994.01
    -
    Present

    , Device of Educational Contents

  • Lecture of Intensive Care Medicine

    1994.04
    -
    Present

    , Device of Educational Contents

  • Standards fof Anesthesiology

    2015.04

    , Development of Textbook and Teaching Material

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Social Activities 【 Display / hide 】

  • 国立大学教育研究評価委員会専門委員

    2015.04
    -
    Present

  • 厚生労働科学研究費補助金特別研究事業　「プロポフォールの小児集中治療領域における使用の必要性及び適切な使用のための研究」研究分担者

    2015.04
    -
    2016.03
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Memberships in Academic Societies 【 Display / hide 】

  • 日本麻酔科学会, 

    1983.05
    -
    Present

  • Japanese Society of Intensive Care Medicine, 

    1989.06
    -
    Present

  • 日本ペインクリニック学会

    　

  • 日本産科麻酔学会

    　

  • 日本医療ガス学会

    　

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Committee Experiences 【 Display / hide 】

  • 2017.05
    -
    Present

    総務委員会, 公益社団法人日本麻酔科学会

  • 2013.05
    -
    2017.05

    財務委員会, 公益社団法人日本麻酔科学会

  • 2012.03
    -
    Present

    英文機関誌作成委員会, 日本集中治療医学会

  • 2008.02
    -
    Present

    社会保険対策委員会, 日本集中治療医学会

  • 2006
    -
    2012

    機関誌編集委員会, 日本集中治療医学会

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