Details of a Researcher - Kosugi, Shizuko

痛みにチームでアプローチ！運動器慢性痛ケースカンファレンス.

牛田享宏 , 福井聖 , 川﨑元敬, 小杉志都子, メディカルビュー社. , 2020.03
慢性疼痛治療ガイドライン

Kosugi Shizuko, 真興交易医書出版部, 2018.04
神経障害疼痛薬物療法ガイドライン改定第2版

Kosugi Shizuko, 真興交易医書出版部, 2016.06
-For Professional Anesthesiologist-静脈麻酔

Kosugi Shizuko, 克誠堂出版, 2014

Scope: 患者自己調節鎮痛法
ペインクリニック　診断・治療ガイド第4版

Kosugi Shizuko, 日本医事新報社, 2013

Scope: 各論Ⅸ　疼痛以外の疾患６赤面症.

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Papers 【 Display / hide 】

Effectiveness of duloxetine for post-surgical chronic neuropathic disorders after spine and spinal cord surgery.

1. Tsuji O, Kosugi S, Suzuki S, Nori S, M, Nagoshi N, Okada E, Fujita N, Yagi M, Nakamura M, Matsumoto M, Watanabe K.

Asian Spine Journal 15 2021

Research paper (scientific journal), Joint Work, Accepted
Prediction of Postoperative Pain and Opioid Requirement in Patients Chronically Using Opioids

2. Ihara N, Kosugi S, Wakaizumi K, Nishimura D, Fukuda Y, Nagata H, Yamada T, Hashiguchi S, Morisaki H.

Journal of clinical anesthesia 60 14 - 15 2020

Research paper (scientific journal), Joint Work, Accepted
Altered functional connectivity associated with time discounting in chronic pain

Wakaizumi K., Jabakhanji R., Ihara N., Kosugi S., Terasawa Y., Morisaki H., Ogaki M., Baliki M.

Scientific Reports (Scientific Reports) 9 ( 1 ) 2019.12

Research paper (scientific journal), Joint Work, Accepted

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© 2019, The Author(s). Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.
- Access to Document (DOI)
Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients

Ihara N., Wakaizumi K., Nishimura D., Kato J., Yamada T., Suzuki T., Hashiguchi S., Terasawa Y., Kosugi S., Morisaki H.

PLoS ONE (PLoS ONE) 14 ( 8 ) 2019.08

Research paper (scientific journal), Joint Work, Accepted

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© 2019 Ihara et al. Chronic neck pain (CNP), a global health problem, involves a large amount of psychological and socioeconomic burdens. Not only physical causes but also behavioral disorders such as a fear-avoidance belief (FAB) can associate with the chronicity of neck pain. However, functional brain mechanisms underlying CNP and its related behavioral disorders remain unknown. The aim of the current resting-state functional magnetic resonance imaging (fMRI) study was to explore how the functional brain networks differed between CNP patients and age- and sex-matched healthy, pain-free controls (HCs). We also investigated whether these possible brain network changes in CNP patients were associated with fear avoidance belief (FAB) and the intensity of pain. We analyzed the resting-state fMRI data of 20 CNP patients and 20 HCs. FAB and the intensity of pain were assessed by Tampa Scale for Kinesiophobia (TSK) and Visual Analog Scale (VAS) of pain. The whole brain analysis showed that CNP patients had significant different functional connectivity (FC) compared with HCs, and the right dorsolateral prefrontal cortex (DLPFC) was a core hub of these altered functional networks. Furthermore, general linear model analyses showed that, in CNP patients, the increased FC between the right DLPFC and the right anterior insular cortex (aIC) significantly associated with increased TSK (p = 0.01, statistical significance after Bonferroni correction: p<0.025), and the FC between the right DLPFC and dorsal posterior cingulate cortex had a trend of inverse association with VAS (p = 0.04). Our findings suggest that aberrant FCs between the right DLPFC and aIC associated with CNP and its related FAB.
- Access to Document (DOI)
Breathing hydrogen sulfide prevents delayed paraplegia in mice

Kakinohana M., Marutani E., Tokuda K., Kida K., Kosugi S., Kasamatsu S., Magliocca A., Ikeda K., Kai S., Sakaguchi M., Hirai S., Xian M., Kaneki M., Ichinose F.

Free Radical Biology and Medicine (Free Radical Biology and Medicine) 131 243 - 250 2019.02

ISSN 08915849

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© 2018 Elsevier Inc. Delayed paraplegia complicates the recovery from spinal cord ischemia or traumatic spinal cord injury. While delayed motor neuron apoptosis is implicated in the pathogenesis, no effective treatment or preventive measures is available for delayed paraplegia. Hydrogen sulfide exerts anti-apoptotic effects. Here, we examined effects of hydrogen sulfide breathing on the recovery from transient spinal cord ischemia. Breathing hydrogen sulfide starting 23 h after reperfusion for 5 h prevented delayed paraplegia after 5 min of spinal cord ischemia. Beneficial effects of hydrogen sulfide were mediated by upregulation of anti-apoptotic Bcl-XL and abolished by nitric oxide synthase 2 deficiency. S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. These results uncover the molecular mechanism of the anti-apoptotic effects of sulfide based on the interaction between nitric oxide and sulfide. Exploitation of the anti-apoptotic effects of delayed hydrogen sulfide breathing may provide a new therapeutic approach for delayed paraplegia.
- Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Neuroeconomic research in chronic pain. : a fMRI-based whole brain analysis of impulsivity and fear avoidance belief

Kosugi, Shizuko

学事振興資金研究成果実績報告書 (慶應義塾大学) 2017
Epidural Analgesia Prevents Endotoxin-lnduced Gut Mucosal Injury in Rabbits

Kosugi, Shizuko

Journal of the Keio Medical Society (慶應医学会) 83 ( 1 ) 14 2006.03

ISSN 03685179

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Reviews, Commentaries, etc. 【 Display / hide 】

高齢者の疼痛管理と緩和ケア

小杉志都子

日本老年医学会雑誌 56 2020

Article, review, commentary, editorial, etc. (scientific journal), Single Work
脊椎低侵襲手術の最近の話題-FBSSへのSpinal cord stimulation

小杉志都子

Bone Joint Nerve 35 2019

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work
整形外科・知ってるつもり.慢性疼痛治療に対する脊髄刺激法.

Kosugi Shizuko

臨床整形外科 53 428 - 430 2018

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work
特集　痛みの評価票と痛み診療：痛み診療における特殊な尺度の評価

Kosugi Shizuko

ペインクリニック (真興交易医書出版部) 39 607 - 612 2018

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work
オキシコドン経口剤から注射製剤への剤型変更で円滑に周術期管理を行えた1症例.

Kosugi Shizuko

日本ペインクリニック学会誌 1 25 - 28 2016

Rapid communication, short report, research note, etc. (scientific journal)

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Presentations 【 Display / hide 】

シンポジウム2「手術・侵襲的治療の効果と問題点」-脊髄刺激療法の適応とその効果-.

小杉志都子

第13回日本運動器疼痛学会オンライン集会.,

2020.12
,
Symposium, workshop panel (nominated)
慢性疼痛患者における運動療法が及ぼすPDASの改善とその関連因子について.

篠原佑太,石川愛子, 川上途行, 田中智里, 星野麗子, 小杉志都子.

第13回運動器疼痛学会.web開催,

2020.12
,
Poster presentation
慢性痛の学際的治療におけるマインドフルネス認知療法と運動療法の併用.

田中智里、藤澤大介、篠原佑太、石川愛子、小杉志都子、川上途行.

第13回運動器疼痛学会.,

2020.12
,
Oral presentation (general)
パネルディスカッション３：「脳機能画像による慢性痛の評価：どこまで分かったか」-安静時ｆMRIから慢性痛の指標を読み解く-.

小杉志都子

第54回日本ペインクリニック学会オンライン集会.,

2020.11
,
Symposium, workshop panel (nominated)
人工膝関節置換術術後の遷延痛および疼痛関連障害度と術前の心理社会的因子および中枢炎症との関連(優秀演題).

村瀬玲子、小杉志都子、加藤純悟、西村大輔、伊原奈帆、星野麗子、本田あやか、森崎浩.

第54回日本ペインクリニック学会. web開催,

2020.11
,
Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

一次性慢性痛に対するインターネット支援型認知行動療法の効果と機序の検証研究

2024.04

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2028.03

基盤研究(B), Principal investigator
非がん性疼痛に対するインターネット支援型認知行動療法の開発と脳科学的機序の検討

2021.04

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2024.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator
慢性疼痛診療体制構築モデル事業

2020.04

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2021.03

厚生労働科学研究費補助金（慢性の痛み対策研究事業）, Research grant, Coinvestigator(s)
Exploratory research for biomarkers of neuropathic pain via global miRNA expression analysis

2020.04

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2021.03

AMED, Commissioned ｒesearch, Coinvestigator(s)
慢性疼痛診療システムの均てん化と痛みセンター診療データベースの活用による医療向上を目指す研究

2019.04

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2021.03

厚生労働科学研究費補助金（慢性の痛み対策研究事業）, Research grant, Coinvestigator(s)