伊原 奈帆 (イハラ ナホ)

Ihara, Naho

写真a

所属(所属キャンパス)

医学部 麻酔学教室 (信濃町)

職名

助教(有期)

経歴 【 表示 / 非表示

  • 2013年04月
    -
    継続中

    慶應義塾大学医学部 , 麻酔学教室, 助教

学歴 【 表示 / 非表示

  • 2001年04月
    -
    2007年03月

    慶應義塾大学, 医学部, 医学科

    大学, 卒業

 

著書 【 表示 / 非表示

  • 複合性局所疼痛症候群(CRPS)をもっと知ろう-病態・診断・治療から後遺障害診断まで-

    伊原 奈帆、津崎 晃一, 全日本病院出版会, 2015年10月

    担当範囲: CRPSのペインクリニックにおける治療-早期治療と慢性疼痛対策

論文 【 表示 / 非表示

  • Altered functional connectivity associated with time discounting in chronic pain

    Wakaizumi K., Jabakhanji R., Ihara N., Kosugi S., Terasawa Y., Morisaki H., Ogaki M., Baliki M.N.

    Scientific Reports (Scientific Reports)  9 ( 1 )  2019年12月

     概要を見る

    Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.

  • Effects of prophylactic dexamethasone on postoperative nausea and vomiting in scoliosis correction surgery: a double-blind, randomized, placebo-controlled clinical trial

    Wakamiya R., Seki H., Ideno S., Ihara N., Minoshima R., Watanabe K., Sato Y., Morisaki H.

    Scientific Reports (Scientific Reports)  9 ( 1 )  2019年12月

     概要を見る

    Dexamethasone is widely used for postoperative nausea and vomiting (PONV) prophylaxis, but its effect on PONV prevention in paediatric patients is validated only in short minor surgical procedures. In this study, we aimed to determine whether a single dose of dexamethasone reduces PONV in highly invasive surgeries that require opioid-based postoperative analgesia. One hundred adolescents undergoing scoliosis correction surgery were randomized to receive intravenous dexamethasone 0.15 mg/kg (dexamethasone group) or saline (control group) at induction of anaesthesia. The primary outcome was the incidence of PONV in the 72 h postoperatively. Data for 98 patients were available for analysis. The 72-h incidence of PONV was significantly lower in the dexamethasone group than in the control group (62.5% vs 84.0%; RR 0.74, 95% CI 0.58–0.96, P = 0.02). During the first and second 24-h postoperative intervals, fewer patients in the dexamethasone group received rescue antiemetics. Visual analogue scale scores for nausea and pain were lower in the dexamethasone group than in the control group during the first 24 h postoperatively. Dexamethasone did not increase the number of adverse events. The results of this study showed that a single dose of dexamethasone was effective for reducing PONV after paediatric scoliosis correction surgery.

  • Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients

    Ihara N., Wakaizumi K., Nishimura D., Kato J., Yamada T., Suzuki T., Hashiguchi S., Terasawa Y., Kosugi S., Morisaki H.

    PLoS ONE (PLoS ONE)  14 ( 8 )  2019年08月

     概要を見る

    Chronic neck pain (CNP), a global health problem, involves a large amount of psychological and socioeconomic burdens. Not only physical causes but also behavioral disorders such as a fear-avoidance belief (FAB) can associate with the chronicity of neck pain. However, functional brain mechanisms underlying CNP and its related behavioral disorders remain unknown. The aim of the current resting-state functional magnetic resonance imaging (fMRI) study was to explore how the functional brain networks differed between CNP patients and age- and sex-matched healthy, pain-free controls (HCs). We also investigated whether these possible brain network changes in CNP patients were associated with fear avoidance belief (FAB) and the intensity of pain. We analyzed the resting-state fMRI data of 20 CNP patients and 20 HCs. FAB and the intensity of pain were assessed by Tampa Scale for Kinesiophobia (TSK) and Visual Analog Scale (VAS) of pain. The whole brain analysis showed that CNP patients had significant different functional connectivity (FC) compared with HCs, and the right dorsolateral prefrontal cortex (DLPFC) was a core hub of these altered functional networks. Furthermore, general linear model analyses showed that, in CNP patients, the increased FC between the right DLPFC and the right anterior insular cortex (aIC) significantly associated with increased TSK (p = 0.01, statistical significance after Bonferroni correction: p<0.025), and the FC between the right DLPFC and dorsal posterior cingulate cortex had a trend of inverse association with VAS (p = 0.04). Our findings suggest that aberrant FCs between the right DLPFC and aIC associated with CNP and its related FAB.

  • らくらくイメージ!呼吸レクチャー

    伊原 奈帆

    オペナーシング 34   8 - 48 2019年

    単著

  • がん患者の痛みの管理

    伊原 奈帆

    耳喉頭頸 90   564 - 571 2018年06月

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

総説・解説等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • 慢性頸肩腕痛患者における恐怖回避思考が安静時脳機能的結合に及ぼす影響についての検討―患者対照比較試験

    伊原 奈帆

    第65回日本麻酔科学会学術集会, 

    2018年05月

    口頭発表(一般)

  • プロリン水酸化酵素(PHD)阻害剤はキヌレニン経路の活性化を介してエンドトキシンショックを軽減する

    伊原 奈帆

    第65回日本麻酔科学会学術集会, 

    2018年05月

    口頭発表(一般)

  • 頸肩腕痛患者における心理的要因についての検討―患者対照比較試験

    伊原 奈帆

    日本ペインクリニック学会第51回大会 (岐阜) , 

    2017年07月

    ポスター発表

  • Efficacy and safety of equianalgesic opioid conversion-based postoperative pain management in patients with chronic opioid use

    伊原 奈帆

    International Association for the Study of Pain 16th Woeld Conress on Pain, 

    2016年09月

    ポスター発表

  • 術前オピオイド使用患者の術後痛管理についての前向き観察研究

    伊原 奈帆

    日本ペインクリニック学会第50会大会 (横浜) , 

    2016年07月

    ポスター発表

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競争的研究費の研究課題 【 表示 / 非表示

  • 低酸素応答の活性化を介した新たな敗血症性心筋症治療戦略の検討

    2016年04月
    -
    2019年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 伊原 奈帆, 若手研究(B), 補助金,  研究代表者

 

担当授業科目 【 表示 / 非表示

  • 終末期病態学

    2022年度

担当経験のある授業科目 【 表示 / 非表示

  • 麻酔科

    慶應義塾

    2015年04月
    -
    2016年03月

    通年, 実習・実験

 

所属学協会 【 表示 / 非表示

  • 日本緩和医療学会, 

    2009年04月
    -
    継続中
  • 日本麻酔科学会, 

    2009年04月
    -
    継続中
  • 日本ペインクリニック学会, 

    2009年04月
    -
    継続中