Ihara, Naho

写真a

Affiliation

School of Medicine, Department of Anesthesiology (Shinanomachi)

Position

Instructor

E-mail Address

E-mail address

Career 【 Display / hide

  • 2013.04
    -
    Present

    慶應義塾大学医学部 , 麻酔学教室, 助教

Academic Background 【 Display / hide

  • 2001.04
    -
    2007.03

    慶應義塾大学, 医学部, 医学科

    University, Graduated

 

Books 【 Display / hide

  • 複合性局所疼痛症候群(CRPS)をもっと知ろう-病態・診断・治療から後遺障害診断まで-

    Ihara Naho,Tsuzaki Koichi, 全日本病院出版会, 2015.10

    Scope: CRPSのペインクリニックにおける治療-早期治療と慢性疼痛対策

Papers 【 Display / hide

  • Altered functional connectivity associated with time discounting in chronic pain

    Wakaizumi K., Jabakhanji R., Ihara N., Kosugi S., Terasawa Y., Morisaki H., Ogaki M., Baliki M.N.

    Scientific Reports (Scientific Reports)  9 ( 1 )  2019.12

     View Summary

    Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.

  • Effects of prophylactic dexamethasone on postoperative nausea and vomiting in scoliosis correction surgery: a double-blind, randomized, placebo-controlled clinical trial

    Wakamiya R., Seki H., Ideno S., Ihara N., Minoshima R., Watanabe K., Sato Y., Morisaki H.

    Scientific Reports (Scientific Reports)  9 ( 1 )  2019.12

     View Summary

    Dexamethasone is widely used for postoperative nausea and vomiting (PONV) prophylaxis, but its effect on PONV prevention in paediatric patients is validated only in short minor surgical procedures. In this study, we aimed to determine whether a single dose of dexamethasone reduces PONV in highly invasive surgeries that require opioid-based postoperative analgesia. One hundred adolescents undergoing scoliosis correction surgery were randomized to receive intravenous dexamethasone 0.15 mg/kg (dexamethasone group) or saline (control group) at induction of anaesthesia. The primary outcome was the incidence of PONV in the 72 h postoperatively. Data for 98 patients were available for analysis. The 72-h incidence of PONV was significantly lower in the dexamethasone group than in the control group (62.5% vs 84.0%; RR 0.74, 95% CI 0.58–0.96, P = 0.02). During the first and second 24-h postoperative intervals, fewer patients in the dexamethasone group received rescue antiemetics. Visual analogue scale scores for nausea and pain were lower in the dexamethasone group than in the control group during the first 24 h postoperatively. Dexamethasone did not increase the number of adverse events. The results of this study showed that a single dose of dexamethasone was effective for reducing PONV after paediatric scoliosis correction surgery.

  • Aberrant resting-state functional connectivity of the dorsolateral prefrontal cortex to the anterior insula and its association with fear avoidance belief in chronic neck pain patients

    Ihara N., Wakaizumi K., Nishimura D., Kato J., Yamada T., Suzuki T., Hashiguchi S., Terasawa Y., Kosugi S., Morisaki H.

    PLoS ONE (PLoS ONE)  14 ( 8 )  2019.08

     View Summary

    Chronic neck pain (CNP), a global health problem, involves a large amount of psychological and socioeconomic burdens. Not only physical causes but also behavioral disorders such as a fear-avoidance belief (FAB) can associate with the chronicity of neck pain. However, functional brain mechanisms underlying CNP and its related behavioral disorders remain unknown. The aim of the current resting-state functional magnetic resonance imaging (fMRI) study was to explore how the functional brain networks differed between CNP patients and age- and sex-matched healthy, pain-free controls (HCs). We also investigated whether these possible brain network changes in CNP patients were associated with fear avoidance belief (FAB) and the intensity of pain. We analyzed the resting-state fMRI data of 20 CNP patients and 20 HCs. FAB and the intensity of pain were assessed by Tampa Scale for Kinesiophobia (TSK) and Visual Analog Scale (VAS) of pain. The whole brain analysis showed that CNP patients had significant different functional connectivity (FC) compared with HCs, and the right dorsolateral prefrontal cortex (DLPFC) was a core hub of these altered functional networks. Furthermore, general linear model analyses showed that, in CNP patients, the increased FC between the right DLPFC and the right anterior insular cortex (aIC) significantly associated with increased TSK (p = 0.01, statistical significance after Bonferroni correction: p<0.025), and the FC between the right DLPFC and dorsal posterior cingulate cortex had a trend of inverse association with VAS (p = 0.04). Our findings suggest that aberrant FCs between the right DLPFC and aIC associated with CNP and its related FAB.

  • らくらくイメージ!呼吸レクチャー

    Ihara Naho

    オペナーシング 34   8 - 48 2019

    Single Work

  • がん患者の痛みの管理

    Ihara Naho

    耳喉頭頸 90   564 - 571 2018.06

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Presentations 【 Display / hide

  • 慢性頸肩腕痛患者における恐怖回避思考が安静時脳機能的結合に及ぼす影響についての検討―患者対照比較試験

    Ihara Naho

    第65回日本麻酔科学会学術集会, 2018.05, Oral Presentation(general)

  • プロリン水酸化酵素(PHD)阻害剤はキヌレニン経路の活性化を介してエンドトキシンショックを軽減する

    Ihara Naho

    第65回日本麻酔科学会学術集会, 2018.05, Oral Presentation(general)

  • Psychological factors and cervicobrachial syndrome. A Comparative study of healthy volunteers and patients with chronic cervicobrachial pain.

    Ihara Naho

    日本ペインクリニック学会第51回大会 (岐阜) , 2017.07, Poster (general)

  • Efficacy and safety of equianalgesic opioid conversion-based postoperative pain management in patients with chronic opioid use

    Ihara Naho

    International Association for the Study of Pain 16th Woeld Conress on Pain, 2016.09, Poster (general)

  • 術前オピオイド使用患者の術後痛管理についての前向き観察研究

    Ihara Naho

    日本ペインクリニック学会第50会大会 (横浜) , 2016.07, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 低酸素応答の活性化を介した新たな敗血症性心筋症治療戦略の検討

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 伊原 奈帆, Grant-in-Aid for Young Scientists (B), Principal Investigator

 

Courses Previously Taught 【 Display / hide

  • 麻酔科

    Keio University, 2015, Full academic year, Laboratory work/practical work/exercise

 

Memberships in Academic Societies 【 Display / hide

  • Japanese Society for Palliative Medecine, 

    2009.04
    -
    Present
  • Japanese Society of Anesthesiologists, 

    2009.04
    -
    Present
  • Japan Society of Pain Clinicians, 

    2009.04
    -
    Present