研究者詳細 - 堀口　崇

論文 - 堀口　崇

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Marfan症候群の患者に生じたくも膜下出血に対し開頭クリッピングを施行した1例─症例報告と文献的考察─

高橋里史, 堀越知, 金澤徳典, 秋山武紀, 堀口崇, 吉田一成

脳卒中の外科（一般社団法人日本脳卒中の外科学会） 44 （ 4 ） 307 - 310 2016年

ISSN 09145508

We report a case of subarachnoid hemorrhage due to a rupture of an aneurysm at the right internal carotid artery-posterior communicating artery in a patient with Marfan syndrome. Since the patient had a history of aortic dissection that was treated conservatively, we selected clipping rather than coil embolization as the surgical strategy for the patient. She was surgically treated successfully, and discharged from our hospital without neurological sequelae 18 days postoperatively. From the findings of the present case in combination with a review of the literature, cerebral aneurysms in patients with Marfan syndrome may be developed due to the fragility of elastic membranes of major cerebral arteries, and we emphasize the importance of developing surgical strategy based on the fragility of elastic membranes.

経過観察となった5mm未満の未破裂脳動脈瘤に対する治療方針─治療介入を決定する因子と時期について─

堀口崇, 秋山武紀, 高橋里史, 吉田一成

脳卒中の外科（一般社団法人日本脳卒中の外科学会） 44 （ 4 ） 276 - 282 2016年

ISSN 09145508

To clarify the optimal timing of surgical or endovascular treatment for patients with small-sized (<5 mm) unruptured intracranial aneurysms (UIA) with conventional follow-up, we retrospectively evaluated the characteristics of UIA that ruptured or enlarged during observation. From 1999 to 2014, 316 UIA (271 cases) were initially treated without surgical or endovascular intervention. Four ruptured and 17 grown UIAs were treated with clipping or coil embolization. In these cases, the ratio of the internal carotid to the posterior communicating artery and that of the anterior cerebral artery to the anterior communicating artery was 71%. Intraoperative findings revealed that the bleb formed during follow-up was observed as a very thin wall. Ruptured UIAs are prone to rapid growth. We conclude that location, growth rate, and bleb formation are useful to estimate the risk of rupture of smallsized UIAs during follow-up.

The early histomorphological changes of neurovascular unit after subarachnoid hemorrhage in mice model

Mizutani, K; Takahashi, S; Akiyama, T; Horiguchi, T; Yoshida, K

CEREBROVASCULAR DISEASES 41 204 - 204 2016年

ISSN 1015-9770

The process of change in hemodynamics after revascularization in the ischemic brain

Shidoh, Satoka, Akiyama, Takenori, Horiguchi, Takashi, Ohira, Takayuki, Yoshida, Kazunari

NEUROREPORT 26 （ 11 ） 629 - 633 2015年08月

研究論文（学術雑誌）, ISSN 0959-4965

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Gruber's ligament as a useful landmark for the abducens nerve in the transnasal approach

堀口崇

JOURNAL OF NEUROSURGERY 122 （ 3 ） 499 - 503 2015年03月

研究論文（学術雑誌）, ISSN 0022-3085

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CEAとCASの選択

堀口崇

診断と治療 103 65 - 69 2015年

A case of basilar artery aneurysm rupture from 1836

Demetriades Andreas K., Horiguchi Takashi, Goodrich James T., Kawase Takeshi

World Neurosurgery 82 （ 5 ） 902 - 905 2014年11月

ISSN 1878-8750

<p>Although credit is given to Sir William Gull for highlighting the clinical picture of subarachnoid hemorrhage in 1859, we discuss a case presented by Mr. Egerton A. Jennings, Fellow of the Linnaean Society, published 23 years earlier in the 1836 edition of the Transactions of the Provincial Medical and Surgical Association. This case, probably the first reported in the English language of a basilar aneurysm rupture, is of medico-historical interest. Jennings provided a remarkably accurate and detailed description of the patient, who experienced coma as a result of the severity of subarachnoid hemorrhage. The detailed clinical observations on initial assessment and the description of the patient's deterioration to the time of death are a succinct representation of the natural history of this disease. The author's discussion provides evidence of a philosophy committed to medical education and progress at the time based on principles of rational observation, meticulous clinical acumen, insight into experimental physiology, and the awareness of ethical boundaries. In provincial 1836 England, similar to most of Europe, cerebral localization was elementary. Nonetheless, this case report highlights the attempt at linking structure to function by means of observation on the effects of lesioning. It provides evidence of an established thought process already in progress in England in the 19th century. It is characteristic that this thought process came from a surgical practitioner. The cultivation of practical observation in British surgical culture would allow the late 19th century surgeon scientists to match the contributions of British neurologists with landmark steps in the development and establishment of neurosurgery.</p>

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Systematic review of complications for proper informed consent (6) surgery for sphenoid ridge/parasellar meningiomas

Horiguchi Takashi, Yoshida Kazunari

Neurological Surgery 41 （ 2 ） 163 - 184 2013年02月

ISSN 0301-2603

合併症のシステマティック・レビュー　適切なInformed Consentのために　髄膜腫手術　sphenoid ridge, parasellarの髄膜腫

堀口崇, 吉田一成

Neurological Surgery （(株)医学書院） 41 （ 2 ） 163 - 184 2013年02月

ISSN 0301-2603

蝶形骨縁及び傍鞍部髄膜腫に関連する論文総数は68編(英文66編、和文2編)であり、髄膜腫発生部位ごとではclinoid:12編、sphenoorbital:8編、sphenoid wing:9編、parasellar:6編、tuberculum:24編、olfactory groove:9編であった。手術総数は2829例、全摘率は平均73.5%、再発率は平均9.02%、合併症発生率は平均37.2%、永続する合併症発生率は平均10.1%、手術関連死亡率は平均1.74%、傍鞍部髄膜腫の術後の視機能悪化率は平均10.4%であった。合併症としては、1)傍鞍部に存在する脳神経、動静脈、間脳下垂体に関わる合併症、2)脳損傷による合併症、3)脳脊髄液に関わる合併症、4)手術部位感染症、5)手術による後遺症状、6)周術期の全身性合併症に分類された。手術関連死では頭蓋内合併症より周術期の全身性合併症が多く、特に肺塞栓症が最多であり、死亡に至らない肺塞栓を含めて平均4.2%の発生率であった。

髄膜種

堀口　崇、坂本　茜、吉田一成

BRAIN NURSING 29 74 - 77 2013年

共著

Recanalisation of spontaneously occluded vertebral artery dissection after subarachnoid haemorrhage

堀口崇

NEUROSURGICAL REVIEW 35 （ 4 ） 615 - 619 2012年10月

研究論文（学術雑誌）, ISSN 0344-5607

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Nontraumatic acute subdural hematoma associated with the myelodysplastic/myeloproliferative neoplasms

Ichimura Shinya, Horiguchi Takashi, Inoue Satoshi, Yoshida Kazunari

Journal of Neurosciences in Rural Practice 3 （ 1 ） 98 - 99 2012年01月

ISSN 0976-3147

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Importance of Preserved Periosteum Around Jugular Foramen Neurinomas for Functional Outcome of Lower Cranial Nerves: Anatomic and Clinical Studies

堀口崇

NEUROSURGERY 69 230 - 240 2011年12月

研究論文（学術雑誌）, ISSN 0148-396X

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Untitled Reply

Ohba Shigeo, Onozuka Satoshi, Horiguchi Takashi, Kawase Takeshi, Yoshida Kazunari

NEUROLOGIA MEDICO-CHIRURGICA 51 （ 7 ） 547 - 547 2011年07月

ISSN 0470-8105

Long-term surgical outcome and biological prognostic factors in patients with skull base meningiomas

堀口崇

JOURNAL OF NEUROSURGERY 114 （ 5 ） 1278 - 1287 2011年05月

研究論文（学術雑誌）, ISSN 0022-3085

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Perimedullary Arteriovenous Fistula at the Craniocervical Junction-Case Report

堀口崇

NEUROLOGIA MEDICO-CHIRURGICA 51 （ 4 ） 299 - 301 2011年04月

研究論文（学術雑誌）, ISSN 0470-8105

Perimedullary arteriovenous fistula at the craniocervical junction

Ohba S., Onozuka S., Horiguchi T., Kawase T., Yoshida K.

Neurologia Medico-Chirurgica 51 （ 4 ） 299 - 301 2011年04月

ISSN 04708105

Perimedullary arteriovenous fistulas (AVFs) at the craniocervical junction are uncommon, and are often fed by the anterior spinal artery, with only a few cases fed by the intradural vertebral artery (VA). A 55-year-old man presented with a case of perimedullary AVF fed by the VA at the craniocervical junction manifesting as subarachnoid hemorrhage. Left vertebral angiography demonstrated an AVF supplied by branches from the VA. Three-dimensional computed tomography angiography (3D-CTA) revealed that the feeding arteries originated from the VA at the intradural position. Two feeding arteries were coagulated and dissected, followed by coagulation of a small feeder. The draining veins became discolored and shrank. 3D-CTA performed 2 months after the operation revealed disappearance of the AVF. Open surgery was successfully performed for the almost perimedullary AVF at the craniocervical junction, and is considered to be preferable for the treatment of this disease.