Papers - Toda, Masahiro

A simple combined approach using anterior transpetrosal and retrosigmoid approach: A case report.

Tamura R, Ueda R, Karatsu K, Sayanagi T, Takahara K, Hino U, Iwama T, Nogawa H, Nakaya M, Horiguchi T, Toda M

Front. Surg (FRONTIERS MEDIA SA)  10 2023.02

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Safety, feasibility, and efficacy of additional extraventricular anterior commissurotomy with　corpus callosotomy.

Kosugi K, Yoshitomi M, Takayama Y, Iijima K, Kimura Y, Kaneko Y, Toda M, Iwasaki M

Oper Neurosurg ( LIPPINCOTT WILLIAMS & WILKINS)  24 ( 2 ) e68 - e74 2023.02

Joint Work

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Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Surgically Resected Schwannomas.

Takahara K, Tamura R, Kuranari Y, Karatsu K, Akiyama T, Toda M

Frontiers in Oncology (FRONTIERS MEDIA SA)   2023

Joint Work

Volumetric measurement of paranasal sinuses and its clinical significance in pituitary neuroendocrine tumors operated using an endoscopic endonasal approach.

Nakaya M, Tamura R, Takahara K, Senuma T, Yoshida K, Kitamura Y, Ueda R, Toda M

Front Neurol (Frontiers Media SA)   2023

Joint Work

Clinical, histopathological and molecular risk factors for recurrence　of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence.

Tamura R, Iwatani A, Ohara K, Nishimoto M, Pareira ES, Miwa T, Tsuzaki N, Morimoto Y, Toda M, Okano H, Nakamura M, Yoshida K, Sasaki H

Brain Tumor Pathol (SPRINGER JAPAN KK)   2023

Joint Work

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Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death.

Yamada H, Kase Y, Okano Y, Kim D, Goto M, Takahashi S, Okano H, Toda M

Inflammation and Regeneration (BMC)     42 - 61 2022.12

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The role of optimal cut-off diagnosis in 11C-methionine PET for differentiation of intracranial brain tumor from non-neoplastic lesions before treatment

Tomohiro Yamaki, Yoshinori Higuchi, Yasuo Iwadate, Tomoo Matsutani, Seiichiro Hirono, Hikaru Sasaki, Masahiro Toda, Shinji Onodera, Nobuo Oka, Shigeki Kobayashi

Clinical Imaging (Elsevier Science Inc.)  92   124 - 130 2022.12

Joint Work

Gene therapy using genome-edited iPS cells for targeting malignant glioma

Tamura R, Miyoshi H, Imaizumi K, Yo M, Kase Y, Sato T, Sato M, Morimoto Y, Sampetrean O, Kohyama J, Shinozaki M, Miyawaki A, Yoshida K, Saya H, Okano H, Toda M

Bioengineering & Translational Medicine (Wiley)     e10406 2022.09

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Surgical Planning and Simulation of Endonasal Endoscopic Surgery for Pituitary Adenoma with Cavenous Sinus Invasion

Tamura R,Oda H,Kosugi K,Toda M

Operative　Neurosurgery 23 ( 4 ) e276 - e282 2022.07

Joint Work, Corresponding author, Accepted

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Role of endovascular treatment for ruptured aneurysms involving the anterior spinal artery at the craniocervical junction

Mizutani K , Akiyama T, Tomita H, Toda M

J Neuroradiol (Amer Soc Neuroradiology)  50 ( 1 ) 44 - 49 2022.04

Joint Work, Accepted

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Imaging of the venous plexus of Rektorzik using CT-digital subtraction venography:a retrospective study

Ryota Imai,Katsuhiro Mizutani,Takenori Akiyama,Takashi Horiguchi,Yoshifumi Takatsume,Masahiro Toda

Neuroradiology (Spriger)  64 ( 10 ) 1961 - 1968 2022.04

Research paper (scientific journal), Joint Work

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Stepwise improvement in limb shaking achieved by staged angioplasty for severe carotid stenosis.

Takahara K, Akiyama T, Yoshida K, Yamada H, Oishi Y, Kuranari Y, Katsumata M, Toda M

Neuroradiol J (Sage Publications inc.)  35 ( 2 ) 260 - 263 2022.04

Joint Work

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治療前の非腫瘍性病変からの頭蓋内脳腫瘍の鑑別のための11C-メチオニンPETにおける最適なカットオフ診断の役割

山木 智宏, 樋口 義則, 岩立 康夫, 松谷 智生, 広野 誠一郎 , 佐々木 光, 戸田 正博 , 小野寺 真二 , 岡 信夫 , 小林 茂樹

臨床イメージング (エルゼビア・サイエンス・パブリッシング・カンパニー)   2022

Accepted

Cone-beam computed tomography fusion technique for vascular assessment of skull base meningiomas

Yoshida K, Akiyama T, Takahashi S, Miwa T, Horiguchi T, Sasaki H, Toda M

World Neurosurg (Elsevier Science Inc.)  S1878-8750 ( 21 ) 61 - 69 2021.04

Research paper (scientific journal), Joint Work

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A novel histopathological classification of meningiomas based on dural invasion

Murase M, Tamura R, Kuranari Y, Sato M, Ohara K, Morimoto Y, Yoshida K, Toda M

J Clin Path 74 ( 4 ) 238 - 243 2021.04

Research paper (scientific journal), Joint Work, Accepted

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Aims Histological invasion into the adjacent brain parenchyma is frequently investigated in meningioma because it is an important morphological criterion for grade II meningioma according to the 2016 WHO classification. However, few studies have focused on dural invasion of meningiomas. Herein, we propose a novel histopathological classification based on dural invasion of meningiomas. Methods Forty-nine cases with WHO grade I meningiomas who underwent Simpson grade I removal were collected. After the meningeal layer (ML) and periosteal layer (PL) of dura mater were visualised by Masson's trichrome stain, we evaluated the depth (to the ML and PL) and the patterns (1, expanding; 2, infiltrating) of dural invasion of meningiomas using serial paraffin sections. Invasion-associated markers, including Ki-67, matrix metalloproteinase (MMP)-1, MMP-9 and MMP-13, aquaporin 1 and Na-K-2Cl cotransporter, were quantitatively analysed by immunohistochemistry. Results Thirty-five cases (71.4%) showed the dural invasion. In 27 of these 35 cases (77.1%), dural invasion was localised in ML. Type 1 (expanding type) and type 2 (infiltrating type) invasions were observed in 23 and 12 cases, respectively. The recurrence rate in cases with type 2 invasion was significantly higher than that in cases with type 1 invasion. The percentage of MMP-1-positive tumour cells was also significantly higher in cases with dural invasion than those without, suggesting involvement of MMP-1 in dural invasion. Conclusions We quantitatively evaluated the depth and patterns of dural invasion in meningiomas. The patterns of dural invasion were associated with meningioma recurrence.

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Angio-anatomical study of the pterygovaginal artery based on cone-beam computed tomography

Yoshida K, Akiyama T, Raz E, Kamamoto D, Ozawa H, Toda M

Neruoradiology (Neuroradiology)   2021.02

Research paper (scientific journal), Joint Work, Accepted,  ISSN  00283940

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Purpose: To investigate the anatomical characteristics and clinical implications of the pterygovaginal artery (PtVA), a recurrent branch from the distal internal maxillary artery (IMA), which courses through the pterygovaginal canal that connects the pterygopalatine fossa and nasopharynx. Methods: Eighty-two patients with 90 sides of cone-beam computed tomography (CBCT) reconstructed from rotational angiography of the external or common carotid artery with a field of view covering the pterygopalatine fossa were retrospectively reviewed. The origin from the IMA, branching type, distribution, and anastomoses was evaluated. The underlying lesions were 36 hypervascular lesions with possible supply from PtVA (17 cavernous sinus arteriovenous fistulas (AVFs), 6 anterior condylar AVFs, and 13 nasopharyngeal, parasellar, or paraclival tumors) and 46 other diseases. Results: PtVA was identified in 75 sides (83%). It originated from the pterygopalatine segment of the IMA in 45 sides (60%) and from the pterygoid segment in 30 sides (40%). It arose independently (77%), sharing the common trunk with the Vidian artery (15%) or with other branches. It ran posteromedially through the pterygovaginal canal to supply the mucosa over the nasopharyngeal roof, the choanae, and the pharyngeal ostium of the eustachian tube. It anastomosed with the ascending pharyngeal artery (n=37), the accessory meningeal artery (n=7), and the mandibular artery from the petrous internal carotid artery (n=2). It served as a feeder of osseous AVFs and skull base tumors. Conclusion: PtVA was often identified by CBCT even in normal anatomy. Its detailed angio-anatomy could be evaluated in the presence of parasellar or paraclival hypervascular lesions.

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Recent progress in the research of suicide gene therapy for malignant glioma

Tamura R., Miyoshi H., Yoshida K., Okano H., Toda M.

Neurosurgical Review (Neurosurgical Review)  44 ( 1 ) 29 - 49 2021.02

ISSN  03445607

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Malignant glioma, which is characterized by diffuse infiltration into the normal brain parenchyma, is the most aggressive primary brain tumor with dismal prognosis. Over the past 40 years, the median survival has only slightly improved. Therefore, new therapeutic modalities must be developed. In the 1990s, suicide gene therapy began attracting attention for the treatment of malignant glioma. Some clinical trials used a viral vector for suicide gene transduction; however, it was found that viral vectors cannot cover the large invaded area of glioma cells. Interest in this therapy was recently revived because some types of stem cells possess a tumor-tropic migratory capacity, which can be used as cellular delivery vehicles. Immortalized, clonal neural stem cell (NSC) line has been used for patients with recurrent high-grade glioma, which showed safety and efficacy. Embryonic and induced pluripotent stem cells may be considered as sources of NSC because NSC is difficult to harvest, and ethical issues have been raised. Mesenchymal stem cells are alternative candidates for cellular vehicle and are easily harvested from the bone marrow. In addition, a new type of nonlytic, amphotropic retroviral replicating vector encoding suicide gene has shown efficacy in patients with recurrent high-grade glioma in a clinical trial. This replicating viral capacity is another possible candidate as delivery vehicle to tackle gliomas. Herein, we review the concept of suicide gene therapy, as well as recent progress in preclinical and clinical studies in this field.

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Effect of Gravity on Brain Structure as Indicated on Upright Computed Tomography

Yokoyama Y, Yamada Y, Kosugi K, Yamda M, Narita K, Nakahara T, Fujiwara H, Toda M, Jinzaki M

Scientific Reports (Scientific Reports)  11 ( 1 ) 392 2021.01

Research paper (scientific journal), Joint Work, Accepted

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We aimed to use upright computed tomography (CT) to depict posture-related changes in the brain tissue under normal gravity. Thirty-two asymptomatic volunteers underwent upright CT in the sitting position and conventional CT in the supine position on the same day. We compared the shift of the pineal body, cerebellar tonsil, the length of pituitary stalk, optic nerve sheath area and perimeter (ONSA and ONSP, respectively), and lateral ventricular volume between the supine and sitting positions. We also compared shape changes of the cerebrospinal fluid (CSF) spaces at different sites between both positions. In the sitting position, the pineal body shifted 0.68 ± 0.27 mm in the ventral direction and 0.76 ± 0.24 mm in the caudal direction, the length of pituitary stalk decreased by 1.23 ± 0.71 mm, the cerebellar tonsil descended by 2.10 ± 0.86 mm, the right ONSA decreased by 15.21 ± 6.54%, the left ONSA decreased by 15.30 ± 7.37%, the right ONSP decreased by 8.52 ± 3.91%, the left ONSP decreased by 8.20 ± 4.38%, and the lateral ventricular volume decreased by 5.07 ± 3.24% (all P < 0.001). We also observed changes in the shape of CSF spaces with changes in posture. We concluded that the intracranial structure of healthy subjects and volume of ventricles changed according to posture on Earth.

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Cystic Dumbbell-shaped C1 Schwannoma with intracranial extension and hydrocephalus: a case report

Matsui Y, Fukumura M, Toda M

World Neurosurg 148   24 - 28 2021.01

Research paper (scientific journal), Joint Work

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Background: Schwannomas at the craniocervical junction commonly originate from the lower cranial nerves or C1 and C2 nerves. To date, very few cases of C1 schwannomas have been described in the literature, and the majority involve either the intra- or the extradural compartment, but not both. To our knowledge, this report documents the first case of a dumbbell-shaped C1 schwannoma that encompassed both intra- and extradural compartments and was accompanied by hydrocephalus. Case Description: The patient was admitted to our hospital, where magnetic resonance imaging revealed a tumor at the craniocervical junction, extending from the C1 level of the right first cervical vertebra into the cerebellopontine angle with 2 giant cysts. We removed the tumor by performing a midline posterior craniectomy and cervical laminectomy. Intraoperatively, the tumor was found to originate from the right C1 posterior root. The pathological diagnosis was of a schwannoma. The patient was subsequently discharged without any neurologic deficits. Conclusions: To our knowledge, we present the first case of a dumbbell-shaped C1 schwannoma with intracranial extensions and accompanying hydrocephalus. The tumor had spread inside and outside the dura, but was safely removed. Our findings in this case emphasize that to achieve safe resection, detailed case-specific preoperative consideration is essential.

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Orthostatic Enlargement of a Supracerebellar　Arachnoid Cyst with Cerebellar Descent Visualized by Upright Computed Tomography

Yoshida K, Toda M, Yamada Y, Yamada M, Yokoyama Y, Fujiwara H, Kosugi K, Sasaki H, Jinzaki M

World Neurosurgery (World Neurosurgery)  145   256 - 259 2021.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  18788750

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Background: Posterior fossa arachnoid cysts are often asymptomatic, but can rarely cause postural headache, the mechanism of which remains unknown. Case Description: We present a 40-year-old woman with an asymptomatic supracerebellar arachnoid cyst. Upright computed tomography (CT) showed enlargement of the arachnoid cyst and caudal descent of the cerebellum compared with supine CT with narrowing of the craniocervical junction cerebrospinal fluid space. Conclusions: This finding aids in understanding the association of posterior fossa arachnoid cysts with orthostatic headache. Clinicians should be aware of possible posture-related changes in intracranial structures.

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