慶應義塾研究者情報データベース

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• 2002年03月

  慶應義塾大学, 医学部, 医学部

  大学, 卒業

• 2007年04月

  -

  2011年03月

  慶應義塾大学大学院, 医学研究科, 外科学

  大学院, 修了, 博士

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• 博士 (医学), 慶應義塾大学, 課程, 2011年03月

  Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells

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• ライフサイエンス / 脳神経外科学 （Cerebral Neurosurgery）

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• CT灌流画像

• selective neuronal loss

• くも膜下出血

• もやもや病

• 脳動脈瘤

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• Comparison of Navigated Transcranial Magnetic Stimulation to Direct Electrical Stimulation for Mapping the Motor Cortex Prior to Brain Tumor Resection

  Satoshi Takahashi, Thomas Picht, 2014年,  ページ数： 16

• 神経皮膚症候群

  高橋　里史, 吉田　一成 , シュプリンガー・ジャパン, 2010年07月

• Longstanding Overt Ventriculomegaly in Adult (LOVA)

  Shizuo Oi, Satoshi Takahashi,  informa healthcare, 2010年,  ページ数： 11

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• Usefulness of Intraoperative Imaging in a Patient with a Ruptured Aneurysm of the M4 Segment of the Middle Cerebral Artery

  Sasao R., Takahashi S., Nishimoto M., Yoshida K.

  World Neurosurgery （World Neurosurgery）  120   90 - 95 2018年12月

  ISSN  18788750

  　概要を見る

  © 2018 Elsevier Inc. Background: Treating cerebral aneurysms in the M4 segment of the middle cerebral artery (MCA) is challenging because they are small and are buried in the brain parenchyma. Case Description: A right-handed Asian woman in her 80s was referred to our hospital with a chief complaint of altered level of consciousness. On admission, her consciousness level on the Glasgow Coma Scale was 7 (E1V1M5), and a computed tomography (CT) scan showed subarachnoid hemorrhage with intracerebral hematoma in the left temporal lobe. Subsequent 3-dimensional CT angiography showed an aneurysm in the M4 segment of the left MCA. The aneurysm of the patient was clipped safely and effectively because of the navigation system in combination with intraoperative angiography. The navigation system was especially useful for estimating the proximal part of the parent artery at the brain surface, whereas intraoperative angiography was especially useful for confirming that the proximal portion of the parent artery identified by the navigation system was correct. Conclusions: We emphasize the importance of choosing the modality of intraoperative imaging according to each characteristic when treating M4 segment aneurysms.

  • Access to Document (DOI)

• Combined Endoscopic Endonasal and Video-microscopic Transcranial Approach with Preoperative Embolization for a Posterior Pituitary Tumor

  Yoshida K., Toda M., Akiyama T., Takahashi S., Nishimoto M., Ozawa H., Ikari Y., Yoshida K.

  World Neurosurgery （World Neurosurgery）  119   201 - 208 2018年11月

  ISSN  18788750

  　概要を見る

  © 2018 Elsevier Inc. Background: Posterior pituitary tumor is rare, and its optimal surgical strategy is undetermined. Surgical removal of posterior pituitary tumors is often complicated by their hypervascularity. Prevention and preparation for excessive hemorrhage is crucial for safe resection. Case Description: A 69-year-old woman presented with bitemporal hemianopsia and was found to have a sellar tumor with suprasellar extension, resembling a pituitary adenoma. Microscopic transsphenoidal resection was attempted but was interrupted by a massive intraoperative hemorrhage. Pathologic diagnosis was a spindle cell oncocytoma, and she was referred to our institution. She underwent preoperative embolization to decrease tumor vascularity, and resection was performed using a combined endoscopic endonasal and video-microscopic transcranial approach, using a 4K three-dimensional (3D) video microscope. The final diagnosis was a posterior pituitary tumor with immunopositivity for thyroid transcription factor-1, with preferred interpretation as a pituicytoma. Conclusions: A combined endonasal and transcranial approach with preoperative embolization is a useful strategy for hypervascular posterior pituitary tumors. A 4K 3D video microscope is compact, and it provides high-resolution images, contributing larger surgical space and facilitating a multi-team surgery.

  • Access to Document (DOI)

• Pros and cons of using ORBEYE™ for microneurosurgery

  Takahashi S., Toda M., Nishimoto M., Ishihara E., Miwa T., Akiyama T., Horiguchi T., Sasaki H., Yoshida K.

  Clinical Neurology and Neurosurgery （Clinical Neurology and Neurosurgery）  174   57 - 62 2018年11月

  ISSN  03038467

  　概要を見る

  © 2018 Elsevier B.V. Objective: To evaluate the pros and cons of using a newly developed microscope, ORBEYE™, during microneurosurgery. Patients and methods: ORBEYE™ use in 14 microneurosurgical procedures was retrospectively assessed by nine neurosurgeons after the procedure. A questionnaire comprising 20 questions was designed and used for evaluation. Results: Compared with the current gold standard, the binocular microscope, ease of setting up the equipment was scored the highest, whereas ease of conducting surgery in a position of an assistant was scored the lowest. Among characteristics of ORBEYE™ itself, the space-saving feature was scored the highest and was followed by the ability to perform procedures in a comfortable position. The only characteristic that was rated below average was ease of operation in a position of an assistant. Neurosurgeons with greater experience (more than five procedures using ORBEYE™) provided significantly higher scores (p = 0.0196) for characteristics of ORBEYE™ itself compared with neurosurgeon with fewer ORBEYE™ experience. Conclusions: The main benefits of the ORBEYETM are its compact size and freedom from focusing through the eye lens of a conventional binocular microscope. However, it appears to be disadvantageous for operating in a position of an assistant because the surgical field has a rotated view on the monitor from a position of an assistant. Nonetheless, because of certain advantages, we believe the ORBEYE™ could be of additional help to use of conventional binocular microscope at the moment and will facilitate microneurosurgery in the future.

  • Access to Document (DOI)

• Preoperative Assessment of Pathologic Subtypes of Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma Using Dynamic Computed Tomography: A Clinical Research Study

  Arai N., Mizutani K., Takahashi S., Morimoto Y., Akiyama T., Horiguchi T., Mami H., Yoshida K.

  World Neurosurgery （World Neurosurgery）  115   e676 - e680 2018年07月

  ISSN  18788750

  　概要を見る

  © 2018 Elsevier Inc. Background: Solitary fibrous tumors (SFTs)/hemangiopericytomas (HPCs) are highly vascularized tumors well known for malignant, invasive, and highly vascular features. To date, several studies have reported the preoperative imaging findings of SFTs/HPCs. In this study, computed tomography (CT) tumor values acquired from dynamic CT scan were selected to determine the tumor pathology of highly vascular tumors, such as SFTs/HPCs. Methods: We conducted a retrospective study on patients with pathologically diagnosed meningiomas and SFTs/HPCs who had undergone a dynamic contrast CT scan. We assessed and compared the CT values of these tumors according to the pathology. Results: From a total of 34 patients, 30 patients with meningiomas and 4 patients with HPCs were included. The mean CT values of SFTs/HPCs and angiomatous meningioma were statistically significantly higher than those of the other meningioma subtypes (P = 0.003). We also performed receiver operating characteristic curve analyses to detect an appropriate cutoff point for the CT value to differentiate tumor pathology, and the calculated threshold was 161 Hounsfield units (HU) (sensitivity, 100%; specificity, 75%; area under the curve, 0.87; 95%, CI 0.75–0.99). Conclusions: This study showed that obtaining a CT value is useful in determining highly vascular tumor pathology preoperatively. When considering neurosurgical extra-axial tumor removal, and when the CT value of tumors is >161 HU, then highly vascular tumors such as SFTs/HPCs or angiomatous meningiomas are likely, and this should be considered prior to surgical intervention and for risk assessment.

  • Access to Document (DOI)

• Advantages of Staged Angioplasty in a Patient with Internal Carotid Artery Pseudo-Occlusion Besides Prevention of Cerebral Hyperperfusion Syndrome

  Takahashi S., Akiyama T., Nakahara J., Yoshizaki T., Suzuki N., Yoshida K.

  World Neurosurgery （World Neurosurgery）  109   409 - 412 2018年01月

  ISSN  18788750

  　概要を見る

  © 2017 Elsevier Inc. Background Staged angioplasty for carotid artery stenosis has been reported to be effective in preventing postoperative cerebral hyperperfusion syndrome (CHS) in patients with severe carotid stenosis; thus, it is also recommended for patients with internal carotid artery (ICA) pseudo-occlusion, the treatment strategy for which is controversial. Case Description This study reports the case of an Asian man in his 50s who had motor aphasia and right-side weakness caused by pseudo-occlusion of the left ICA. After medical treatment, he underwent a staged angioplasty. After the first stage of percutaneous transluminal angioplasty, anterograde blood flow to the left ICA increased but the distal ICA remained partially collapsed. Initially, the second stage of carotid artery stenting (CAS) was planned for 2 weeks after the first stage; however, hemorrhagic infarction was observed the day before the CAS, and it was postponed by 2 weeks, after adjustment of antiplatelet therapy. At the time of the CAS, the diameter of the initially collapsed left distal ICA was remodeled and it was fully dilated; thus, we used a balloon-type embolic protection device and conducted CAS successfully without apparent embolic complications. The postoperative course was uneventful. The patient did not develop CHS. Conclusions Besides preventing CHS, staged angioplasty has advantages when used for treating patients with ICA pseudo-occlusions in that the extent of dilation of the distal ICA after percutaneous transluminal angioplasty can be confirmed and the development of a possible hemorrhagic infarction can be assessed before stent placement.

  • Access to Document (DOI)

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• くも膜下出血後早期脳損傷治療標的としての大脳皮質毛細血管内皮細胞由来遺伝子の検討

  高橋, 里史

  学事振興資金研究成果実績報告書 （慶應義塾大学）  2021年

• 未破裂脳動脈瘤破裂予測のマーカー及び破裂予防の治療標的としてのマイクロRNA解析

  高橋, 里史

  学事振興資金研究成果実績報告書 （慶應義塾大学）  2018年

• くも膜下出血後遅発性脳虚血のマーカー及び治療標的としてのmiRNAスクリーニング

  高橋, 里史

  科学研究費補助金研究成果報告書 2017年

• 新規グリオーマ幹細胞増殖因子の同定

  高橋, 里史

  科学研究費補助金研究成果報告書 2010年

• 膠芽腫及びその幹細胞の浸潤機構解明と臨床応用

  高橋, 里史

  科学研究費補助金研究成果報告書 2008年

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• chordomaとchondrosarcomaに対する頭蓋底手術及び重粒子線治療併用療法

  高橋 里史, 河瀬 斌, 吉田 一成, 長谷川安都佐, 溝江純悦

  第67回社団法人日本脳神経外科学会総会 （盛岡） , 

  2008年10月

  , 

  ポスター発表

• Clinoid Meningioma の摘出により軽快したFocal Hand Dystoniaの1例

  高橋 里史, 志藤 里香, 河瀬 斌

  第106回日本脳神経外科学会 関東支部学術集会 （等強） , 

  2008年09月

  , 

  口頭発表（一般）

• Parasagittal solitary fibrous tumorの一例

  志藤里香, 吉田一成, 高橋里史, 三上修治, 向井万起男, 河瀬斌

  第２６回日本脳腫瘍病理学会 （東京） , 

  2008年05月

  , 

  口頭発表（一般）, 日本脳腫瘍病理学会

• Combined treatment by skull base surgery and carbon ion radiotherapy for clival chordomas 〜斜台脊索腫への頭蓋底手術と重粒子線併用療法〜

  高橋 里史、河瀬 斌、吉田 一成、長谷川 安都佐、溝江 純悦

  第11回KNC脳疾患研究会 （富士吉田） , 

  2007年11月

  , 

  口頭発表（一般）

• Expression and function analysis of a new glioma antigen for immune-therapy.

  高橋 里史

  Keio University International Symposium 2007 （Tokyo） , 

  2007年10月

  , 

  ポスター発表

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競争的研究費の研究課題 【 表示 ／ 非表示 】

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• SAH後早期脳損傷マーカー及び治療標的としての内皮細胞由来マイクロRNAの同定

  2019年04月

  -

  2022年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 高橋　里史, 基盤研究（Ｃ）, 補助金,  研究代表者

• くも膜下出血後遅発性脳虚血のマーカー及び治療標的としてのmiRNAスクリーニング

  2015年04月

  -

  2018年03月

  文部科学省・日本学術振興会, 科学研究費助成事業, 高橋　里史, 基盤研究(C), 補助金,  研究代表者

• 膠芽腫及びその幹細胞の浸潤機構解明と臨床応用

  　

  科学研究費補助金(文部科学省・日本学術振興会）, 補助金,  未設定

• 膠芽腫及びその幹細胞の浸潤機構解明と臨床応用

  　

  科学研究費補助金(文部科学省・日本学術振興会）, 補助金,  未設定

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• 脳神経外科学講義

  2024年度

• 脳神経外科学講義

  2023年度

• 脳神経外科学講義

  2022年度

• 脳神経外科学講義

  2021年度

• 脳神経外科学講義

  2020年度

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