Takahashi, Satoshi



School of Medicine, Department of Neurosurgery (Shinanomachi)


Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links

Academic Background 【 Display / hide

  • 2002.03

    Keio University, Faculty of Medicine, 医学部

    University, Graduated

  • 2007.04

    Keio University, Graduate school of Medicine, Graduate school of Medicine, Surgery

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士 (医学), 慶應義塾大学, Coursework, 2011.03

    Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells


Research Areas 【 Display / hide

  • Life Science / Neurosurgery (Cerebral Neurosurgery)

Research Keywords 【 Display / hide

  • CT perfusion

  • selective neuronal loss

  • subarachnoid hemorrhage

  • moyamoya disease

  • cerebral aneurysm

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Books 【 Display / hide

  • Comparison of Navigated Transcranial Magnetic Stimulation to Direct Electrical Stimulation for Mapping the Motor Cortex Prior to Brain Tumor Resection

    Satoshi Takahashi, Thomas Picht, 2014,  Page: 16

  • 神経皮膚症候群

    高橋 里史, 吉田 一成 , シュプリンガー・ジャパン, 2010.07

  • Longstanding Overt Ventriculomegaly in Adult (LOVA)

    Shizuo Oi, Satoshi Takahashi,  informa healthcare, 2010,  Page: 11

Papers 【 Display / hide

  • Usefulness of Intraoperative Imaging in a Patient with a Ruptured Aneurysm of the M4 Segment of the Middle Cerebral Artery

    Sasao R., Takahashi S., Nishimoto M., Yoshida K.

    World Neurosurgery (World Neurosurgery)  120   90 - 95 2018.12

    ISSN  18788750

     View Summary

    © 2018 Elsevier Inc. Background: Treating cerebral aneurysms in the M4 segment of the middle cerebral artery (MCA) is challenging because they are small and are buried in the brain parenchyma. Case Description: A right-handed Asian woman in her 80s was referred to our hospital with a chief complaint of altered level of consciousness. On admission, her consciousness level on the Glasgow Coma Scale was 7 (E1V1M5), and a computed tomography (CT) scan showed subarachnoid hemorrhage with intracerebral hematoma in the left temporal lobe. Subsequent 3-dimensional CT angiography showed an aneurysm in the M4 segment of the left MCA. The aneurysm of the patient was clipped safely and effectively because of the navigation system in combination with intraoperative angiography. The navigation system was especially useful for estimating the proximal part of the parent artery at the brain surface, whereas intraoperative angiography was especially useful for confirming that the proximal portion of the parent artery identified by the navigation system was correct. Conclusions: We emphasize the importance of choosing the modality of intraoperative imaging according to each characteristic when treating M4 segment aneurysms.

  • Combined Endoscopic Endonasal and Video-microscopic Transcranial Approach with Preoperative Embolization for a Posterior Pituitary Tumor

    Yoshida K., Toda M., Akiyama T., Takahashi S., Nishimoto M., Ozawa H., Ikari Y., Yoshida K.

    World Neurosurgery (World Neurosurgery)  119   201 - 208 2018.11

    ISSN  18788750

     View Summary

    © 2018 Elsevier Inc. Background: Posterior pituitary tumor is rare, and its optimal surgical strategy is undetermined. Surgical removal of posterior pituitary tumors is often complicated by their hypervascularity. Prevention and preparation for excessive hemorrhage is crucial for safe resection. Case Description: A 69-year-old woman presented with bitemporal hemianopsia and was found to have a sellar tumor with suprasellar extension, resembling a pituitary adenoma. Microscopic transsphenoidal resection was attempted but was interrupted by a massive intraoperative hemorrhage. Pathologic diagnosis was a spindle cell oncocytoma, and she was referred to our institution. She underwent preoperative embolization to decrease tumor vascularity, and resection was performed using a combined endoscopic endonasal and video-microscopic transcranial approach, using a 4K three-dimensional (3D) video microscope. The final diagnosis was a posterior pituitary tumor with immunopositivity for thyroid transcription factor-1, with preferred interpretation as a pituicytoma. Conclusions: A combined endonasal and transcranial approach with preoperative embolization is a useful strategy for hypervascular posterior pituitary tumors. A 4K 3D video microscope is compact, and it provides high-resolution images, contributing larger surgical space and facilitating a multi-team surgery.

  • Pros and cons of using ORBEYE™ for microneurosurgery

    Takahashi S., Toda M., Nishimoto M., Ishihara E., Miwa T., Akiyama T., Horiguchi T., Sasaki H., Yoshida K.

    Clinical Neurology and Neurosurgery (Clinical Neurology and Neurosurgery)  174   57 - 62 2018.11

    ISSN  03038467

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    © 2018 Elsevier B.V. Objective: To evaluate the pros and cons of using a newly developed microscope, ORBEYE™, during microneurosurgery. Patients and methods: ORBEYE™ use in 14 microneurosurgical procedures was retrospectively assessed by nine neurosurgeons after the procedure. A questionnaire comprising 20 questions was designed and used for evaluation. Results: Compared with the current gold standard, the binocular microscope, ease of setting up the equipment was scored the highest, whereas ease of conducting surgery in a position of an assistant was scored the lowest. Among characteristics of ORBEYE™ itself, the space-saving feature was scored the highest and was followed by the ability to perform procedures in a comfortable position. The only characteristic that was rated below average was ease of operation in a position of an assistant. Neurosurgeons with greater experience (more than five procedures using ORBEYE™) provided significantly higher scores (p = 0.0196) for characteristics of ORBEYE™ itself compared with neurosurgeon with fewer ORBEYE™ experience. Conclusions: The main benefits of the ORBEYETM are its compact size and freedom from focusing through the eye lens of a conventional binocular microscope. However, it appears to be disadvantageous for operating in a position of an assistant because the surgical field has a rotated view on the monitor from a position of an assistant. Nonetheless, because of certain advantages, we believe the ORBEYE™ could be of additional help to use of conventional binocular microscope at the moment and will facilitate microneurosurgery in the future.

  • Preoperative Assessment of Pathologic Subtypes of Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma Using Dynamic Computed Tomography: A Clinical Research Study

    Arai N., Mizutani K., Takahashi S., Morimoto Y., Akiyama T., Horiguchi T., Mami H., Yoshida K.

    World Neurosurgery (World Neurosurgery)  115   e676 - e680 2018.07

    ISSN  18788750

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    © 2018 Elsevier Inc. Background: Solitary fibrous tumors (SFTs)/hemangiopericytomas (HPCs) are highly vascularized tumors well known for malignant, invasive, and highly vascular features. To date, several studies have reported the preoperative imaging findings of SFTs/HPCs. In this study, computed tomography (CT) tumor values acquired from dynamic CT scan were selected to determine the tumor pathology of highly vascular tumors, such as SFTs/HPCs. Methods: We conducted a retrospective study on patients with pathologically diagnosed meningiomas and SFTs/HPCs who had undergone a dynamic contrast CT scan. We assessed and compared the CT values of these tumors according to the pathology. Results: From a total of 34 patients, 30 patients with meningiomas and 4 patients with HPCs were included. The mean CT values of SFTs/HPCs and angiomatous meningioma were statistically significantly higher than those of the other meningioma subtypes (P = 0.003). We also performed receiver operating characteristic curve analyses to detect an appropriate cutoff point for the CT value to differentiate tumor pathology, and the calculated threshold was 161 Hounsfield units (HU) (sensitivity, 100%; specificity, 75%; area under the curve, 0.87; 95%, CI 0.75–0.99). Conclusions: This study showed that obtaining a CT value is useful in determining highly vascular tumor pathology preoperatively. When considering neurosurgical extra-axial tumor removal, and when the CT value of tumors is >161 HU, then highly vascular tumors such as SFTs/HPCs or angiomatous meningiomas are likely, and this should be considered prior to surgical intervention and for risk assessment.

  • Advantages of Staged Angioplasty in a Patient with Internal Carotid Artery Pseudo-Occlusion Besides Prevention of Cerebral Hyperperfusion Syndrome

    Takahashi S., Akiyama T., Nakahara J., Yoshizaki T., Suzuki N., Yoshida K.

    World Neurosurgery (World Neurosurgery)  109   409 - 412 2018.01

    ISSN  18788750

     View Summary

    © 2017 Elsevier Inc. Background Staged angioplasty for carotid artery stenosis has been reported to be effective in preventing postoperative cerebral hyperperfusion syndrome (CHS) in patients with severe carotid stenosis; thus, it is also recommended for patients with internal carotid artery (ICA) pseudo-occlusion, the treatment strategy for which is controversial. Case Description This study reports the case of an Asian man in his 50s who had motor aphasia and right-side weakness caused by pseudo-occlusion of the left ICA. After medical treatment, he underwent a staged angioplasty. After the first stage of percutaneous transluminal angioplasty, anterograde blood flow to the left ICA increased but the distal ICA remained partially collapsed. Initially, the second stage of carotid artery stenting (CAS) was planned for 2 weeks after the first stage; however, hemorrhagic infarction was observed the day before the CAS, and it was postponed by 2 weeks, after adjustment of antiplatelet therapy. At the time of the CAS, the diameter of the initially collapsed left distal ICA was remodeled and it was fully dilated; thus, we used a balloon-type embolic protection device and conducted CAS successfully without apparent embolic complications. The postoperative course was uneventful. The patient did not develop CHS. Conclusions Besides preventing CHS, staged angioplasty has advantages when used for treating patients with ICA pseudo-occlusions in that the extent of dilation of the distal ICA after percutaneous transluminal angioplasty can be confirmed and the development of a possible hemorrhagic infarction can be assessed before stent placement.

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • chordomaとchondrosarcomaに対する頭蓋底手術及び重粒子線治療併用療法

    Takahashi Satoshi

    第67回社団法人日本脳神経外科学会総会 (盛岡) , 


    Poster presentation

  • Clinoid Meningioma の摘出により軽快したFocal Hand Dystoniaの1例

    Takahashi Satoshi

    第106回日本脳神経外科学会 関東支部学術集会 (等強) , 


    Oral presentation (general)

  • Parasagittal solitary fibrous tumorの一例

    志藤里香, 吉田一成, 高橋里史, 三上修治, 向井万起男, 河瀬斌

    第26回日本脳腫瘍病理学会 (東京) , 


    Oral presentation (general), 日本脳腫瘍病理学会

  • Combined treatment by skull base surgery and carbon ion radiotherapy for clival chordomas 〜斜台脊索腫への頭蓋底手術と重粒子線併用療法〜

    Takahashi Satoshi

    第11回KNC脳疾患研究会 (富士吉田) , 


    Oral presentation (general)

  • Expression and function analysis of a new glioma antigen for immune-therapy.

    Takahashi Satoshi, Toda Masahiro, Kawase Takeshi

    Keio University International Symposium 2007 (Tokyo) , 


    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Identification of endothelial cell origin microRNA as a clinical marker and therapeutic target of EBI after SAH


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • microRNA expression profiling in serum of patients with subarachnoid hemorrhage


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 膠芽腫及びその幹細胞の浸潤機構解明と臨床応用


    Grant-in-Aid for Scientific Research, Research grant, No Setting

  • 膠芽腫及びその幹細胞の浸潤機構解明と臨床応用


    Grant-in-Aid for Scientific Research, Research grant, No Setting


Courses Taught 【 Display / hide