Akiyama, Takenori

写真a

Affiliation

School of Medicine, Department of Neurosurgery ( Shinanomachi )

Position

Associate Professor

External Links

Academic Background 【 Display / hide 】

  • 1998.03

    Keio University, Faculty of Medicine

    University, Graduated

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Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, Dissertation, 2008.09

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Research Areas 【 Display / hide 】

  • Life Science / Neurosurgery (Neurosurgery)

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Research Keywords 【 Display / hide 】

  • interventional neuroradiology

  • cerebrovascular disease

  • functional neurosurgery

  • spinal vascular diseases

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Research Themes 【 Display / hide 】

  • 脳脊髄血管障害に対する診断・治療法の開発, 

    2011.04
    -
    Present

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Papers 【 Display / hide 】

  • A Case of Aneurysmal SAH and Stanford Type A Acute Aortic Dissection: A Case Report

    ENOMOTO Takuya, MIZUTANI Katsuhiro, KARATSU Kousuke, IWAMA Takashi, TAMURA Ryota, AKIYAMA Takenori, ITO Tsutomu, TODA Masahiro

    NMC Case Report Journal (The Japan Neurosurgical Society)  12 ( 0 ) 459 - 464 2025.12

    Accepted,  ISSN  2188-4226

    　View Summary

    <p>We report a concurrent case of aneurysmal subarachnoid hemorrhage and acute aortic dissection. A 47-year-old woman presented to our hospital unconscious. Subarachnoid hemorrhage was diagnosed by brain computed tomography on arrival. Computed tomography angiography revealed 2 aneurysms in the right internal carotid artery. Computed tomography angiography from the cervical to thoracic regions, which was initially performed to inspect the access route for interventional radiology, demonstrated the presence of Stanford type A acute aortic dissection. Neck clipping and total aortic arch replacement were performed for the 2 aneurysms and the acute aortic dissection, respectively. Only a few reports have described the coexistence of acute aortic dissection and subarachnoid hemorrhage. Managing these 2 pathologies requires a thorough evaluation of each therapeutic strategy and careful management of the patient's systemic and neurological conditions. We believe our case report enhances the understanding of this specific pathological condition and will provide valuable insights for treating future patients with similar conditions.</p>

  • Comprehensive Genetic Analysis of NF2 in Sporadic Vestibular Schwannoma

    Wakabayashi T., Wasano K., Nakamura K., Hosoya M., Kawano R., Takamatsu R., Ueno M., Shimanuki M.N., Tsuzuki N., Nishiyama T., Akiyama T., Toda M., Nishihara H., Ozawa H., Oishi N.

    Laryngoscope Investigative Otolaryngology 10 ( 5 ) e70265 2025.10

    Accepted,  ISSN  2378-8038

    　View Summary

    Objective: To elucidate the genetic etiology of sporadic vestibular schwannomas (VSs) and investigate the correlation between NF2 inactivation mechanisms and preoperative clinical characteristics, including hearing function and tumor growth. Methods: Nineteen patients who underwent VS resection at our otorhinolaryngology or neurosurgery department between June 2020 and March 2022 were included in this study. Whole-exome sequencing (WES) was performed to detect somatic changes in NF2. Additionally, NF2 promoter methylation status and copy number changes were evaluated using methylation analysis and multiple ligation-dependent probe amplification (MLPA). Preoperative clinical data, including pure tone audiometry, speech discrimination scores, and tumor growth rates, were collected and analyzed for correlations with genetic findings. Results: WES identified somatic alterations in both NF2 alleles in 16 cases (84.2%). The addition of methylation analysis and MLPA confirmed biallelic NF2 inactivation in all cases. NF2 promoter methylation was suggested to be associated with hearing loss and tumor progression. A weak correlation between NF2 expression levels and tumor growth rate was observed (r = 0.21), while no significant correlation was found between NF2 expression and pure tone audiometry or speech discrimination scores. Conclusion: Comprehensive genetic analyses, including WES, methylation analysis, and MLPA, are essential for identifying NF2 inactivation mechanisms in sporadic VSs. The findings suggest that NF2 methylation may contribute to variations in clinical presentation. Further studies with larger cohorts are necessary to clarify the role of epigenetic modifications in disease progression and their potential impact on patient management strategies. Level of Evidence: 4.

  • A Cautionary Note on the Indication for Deep Brain Stimulation in Parkinsonism Patients With <i>SLC9A6 </i>Gene Mutations

    Okusa, S; Tezuka, T; Kosugi, K; Yamamoto, Y; Takahata, K; Higuchi, M; Akiyama, T; Kobayashi, M; Toda, M; Ito, D; Nakahara, J; Seki, M

    JOURNAL OF MOVEMENT DISORDERS 18 ( 3 ) 268 - 270 2025.07

    ISSN  2005-940X

  • <i>ACVRL1</i> and <i>MTHFR</i> double variants in an adolescent with paradoxical cerebral embolism

    Sato, T., Ichihashi, Y., Tsuruta, H., Chu, PS, Akiyama, T., Hishida, T., Hasegawa, T.

    PEDIATRICS INTERNATIONAL 67 ( 1 ) e70025 2025.01

    Accepted,  ISSN  1328-8067

  • Angiographical Investigation of Vagal and Carotid Body Paragangliomas

    Yamamoto Kosei, Akiyama Takenori, Mizutani Katsuhiro, Ozawa Hiroyuki, Toda Masahiro

    Journal of Neuroendovascular Therapy (The Japanese Society for Neuroendovascular Therapy)  19 ( 1 ) n/a 2025

    Corresponding author,  ISSN  18824072

    　View Summary

    <p><b>Objective:</b> Although vagal paragangliomas (VPs) and carotid body paragangliomas (CBPs) are both neck paragangliomas, they have different surgical risks and clinical courses. In this report, we investigated the feeding arteries of VPs compared with CBPs, with an aim to better differentiate these tumors and improve our understanding of their angioarchitecture.</p><p><b>Methods</b>: We conducted a retrospective analysis of angiography data from 3 cases of VPs and 10 tumors from 9 cases of CBP. For each case, we evaluated the level of the vertebral body corresponding to the upper margin of the tumor, the tumor size, the arterial supply of the tumor, the topological relationship between the external carotid artery and internal carotid artery and the tumor, the details of preoperative embolization, and the incidence of postoperative neurological deficits.</p><p><b>Results</b>: In all 3 cases of VPs, the blood supply originated from the occipital, vertebral, and ascending pharyngeal arteries. By contrast, among the 10 CBP tumors, 3 were supplied by the occipital artery, 1 was supplied by the vertebral artery, and all 10 were fed by the ascending pharyngeal artery. VPs, when compared to CBPs, exhibited larger tumor sizes, a higher positioning of the upper margin of the tumor, and a lack of splaying of the internal and external carotid arteries, compressing both forward. Additionally, preoperative embolization was frequently performed in cases of VPs. Furthermore, the postoperative occurrence of complications such as hoarseness and vocal cord paralysis was also higher.</p><p><b>Conclusion</b>: VPs originate from the inferior ganglion of the vagus nerve, which is chiefly nourished by the vertebral artery. This original arterial distribution may explain the angioarchitecture observed in this study. This study may facilitate the better understanding of the VP angioarchitecture and safe and efficient embolization for them.</p>

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 【他科の視点・診療連携の観点でみる 母斑・母斑症I】疾患別の概説 診療連携の視点を含めて オスラー病

    秋山 武紀

    小児科 (金原出版(株))  66 ( 3 ) 268 - 275 2025.03

    ISSN  0037-4121

    　View Summary

    ＜文献概要＞オスラー病は,遺伝性出血性毛細血管拡張症(HHT)の通称で,鼻出血と口唇・手指などの毛細血管拡張,および肺・脳など臓器の血管奇形を特徴とする遺伝疾患である.本疾患の認知度はいまだ十分でなく,多くの患者が未診断のまま適切な対応がなされていない現状がある.小児期には,鼻出血や毛細血管拡張といった典型的なHHTの症候を示さないことも多く,臨床症状による診断は容易ではない.しかし,HHTの診断が不十分な場合に脳出血・脳梗塞など重篤な症候を呈する可能性があり,本疾患に対する適切な知識とその対応は重要である.本稿では,オスラー病の疾患概念とその臨床症状を概説し,小児診療における注意点について述べる.

  • 【脊椎脊髄疾患のインターベンショナルラジオロジー(IVR)】脊髄血管奇形の血管内治療(硬膜内)

    水谷 克洋, 秋山 武紀

    脊椎脊髄ジャーナル ((株)三輪書店)  36 ( 11 ) 777 - 786 2023.12

    ISSN  0914-4412

    　View Summary

    ＜文献概要＞はじめに 脊髄血管奇形は中枢神経に発生する種々の血管奇形の中でもきわめてまれな疾患である.脊髄は中枢神経の中でも非常に狭い領域に重要な神経路が集中しており,脊髄の横断面全体がeloquentともいえるため,その領域の血管奇形の治療においては解剖や血管奇形の血管構築に対する十分な知識と熟練した技術が必要になる.本稿では,脊髄血管奇形の中でも硬膜内に発生する血管奇形について取り上げ,その診断・治療に必要な解剖学的知識,病態,血管内治療について紹介する.

  • 【二刀流術者のための脳血管障害手術テキスト】(Chapter 5)二刀流術者のチーム運営について知る 慶応義塾大学のチーム運営

    秋山 武紀

    脳神経外科速報 ((株)メディカ出版)   ( 2023増刊 ) 156 - 158 2023.10

    ISSN  0917-1495

  • 【輸液管理のすべて-研修医からの質問257-】急性期病態編 くも膜下出血患者の輸液管理

    宮内 翼, 秋山 武紀

    救急・集中治療 ((株)総合医学社)  35 ( 2 ) 459 - 466 2023.08

    ISSN  1346-0935

    　View Summary

    ＜ここがポイント!＞▼くも膜下出血(SAH)の患者では脳血流のautoregulationが破綻しているので,細やかな管理によって脳血流量(CBF)を維持する必要がある.▼SAHでは神経原性肺水腫やたこつぼ心筋症などの全身合併症をきたすことも多いため,過剰輸液とならないよう留意する.▼スパズム期は脱水を避けて,euvolemiaを目標に管理を行う.意図的な血圧上昇,volume負荷や,血液希釈は弊害も多く,推奨されない.▼スパズム期には低Na血症に注意する.▼新規に承認された抗スパズム薬であるクラゾセンタンには体液貯留の副作用があるため,日々の胸部X線などでうっ血を評価するとともに,水分出納に留意する.(著者抄録)

  • 【どんな手術が、どんな手順で、どんな風に行われているかがとことんわかる!手術動画つき 必要な術後看護がみえてくる 脳神経外科の手術】(1章)脳神経外科の手術を理解するうえで知っておきたいこと 手術治療を行う脳神経疾患の病態生理 頸動脈狭窄症

    秋山 武紀

    Brain Nursing ((株)メディカ出版)  39 ( 1 ) 56 - 57 2023.01

    ISSN  0910-8459

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Presentations 【 Display / hide 】

  • HHTに関連した臓器別AVM HHT JAPAN全国調査の結果報告

    西田 武生, 秋山 武紀

    日本脳神経血管内治療学会学術集会抄録集, 

    2024.11
    , 

    (一社)日本脳神経血管内治療学会

  • Pial AVF 成人頭蓋内Pial AVFの概念と分類

    秋山 武紀, 山田 浩貴

    日本脳神経血管内治療学会学術集会抄録集, 

    2024.11
    , 

    (一社)日本脳神経血管内治療学会

  • Pial AVF 成人軟膜AVFの特徴 全国調査(Characteristics of Adult Pial AVF: A nationwide study)

    賀耒 泰之, 秋山 武紀, 清末 一路

    日本脳神経血管内治療学会学術集会抄録集, 

    2024.11
    , 

    (一社)日本脳神経血管内治療学会

  • HHTのbrain AVMに対するSRSの効果

    秋山 武紀

    脳血管内治療, 

    2023.11
    , 

    (一社)日本脳神経血管内治療学会

  • 慢性閉塞性脳血管病変の治療前後における機能活動時の大脳皮質酸素代謝-多チャンネルfNIRSを用いた検討-

    'AKIYAMA TAKENORI, Ohira Takayuki, Kawase Takeshi, Kato Toshinori'

    [Domestic presentation]  第15回日本脳循環代謝学会総会 (大阪) , 

    2003.10
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 末梢血中マイクロRNAスクリーニングおよび発現解析による硬膜動静脈瘻の病期診断および新たな治療戦略の構築

    2015.02
    -
    2017.03

    日本脳神経血管内治療学会, 日本脳神経血管内治療学会助成研究, 秋山 武紀, 高橋 里史, Research grant, Principal investigator

  • microRNA expression profiling in serum of patients with subarachnoid hemorrhage

    2015
    -
    2017

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 高橋 里史, 秋山 武紀, Grant-in-Aid for Scientific Research (C), Research grant, Coinvestigator(s)

    　View Summary

    49 microRNAs those express in SAH patients’ sera lower than 1/4 and other 27 microRNAs those expressed more than twice compared to those in control sera were identified. Degeneration of basal membrane, and peeling of endofeet of astrocyte from basal membrane was identified in hippocampus of mouse SAH model 1 day after procedure (duration of ICP elevation in the model was as long as 5 s). Three days after procedure, GFAP positive cell was decreased at the same site but no quantitative nor morphological change in neuron was observed. From the current result, we speculate degeneration of NVU starts abound microvasculature after SAH, and emerges to surrounding astrocyte that leads to neurological deterioration.

  • 高分解能近赤外光イメージング法の開発と高次脳機能計測への応用

    2004.04
    -
    2006.04

    平成16年度慶應医師会医学研究助成金, 秋山 武紀, Research grant, Principal investigator

    　View Summary

    近赤外光イメージング法により脳血流変化から脳機能計測を行う手法を確立、脳血管障害患者で有用性を証明した。

  • Development of a new method for measuring higher brain function - integrated measuring system by fMRI and MEG -

    2003
    -
    2005

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, OHIRA Takayuki, KAWASE Takeshi, FUKUNAGA Atsushi, GADO Hisashi, OGAWA Seiji, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    The aim of this study is to establish a new integrated measuring system by fMRI, MEG and NIRS for evaluation of higher brain function. First, activated BOLD signals were observed during electrostimulation on bilateral median nerves by fMRI. Distributions of activated BOLD signals were evaluated in the three conditions, no delay, 30 msec delay and 100 msec delay. As a result, the smallest activated area was observed at the primary sensory area in the 30 msec delay condition. A MEG study revealed that no waves at 76 msec were observed in the 30 msec delay condition. Second, it was evaluated how the brain functions during loss-resulting or tie-resulting pursuant paper-rock-scissors with the dominant or non-dominant hands, using a 3-tesla functional MRI in normal right-handed subjects. Interestingly, the right SMA was activated more strongly during tie-resulting pursuant paper-rock-scissors with the left hand, while the left SMA was activated more strongly during loss-resulting pursuant paper-rock-scissors with the left hand. These findings suggest that the left SMA might be associated with inhibition of stereotypical performance and monitoring of conflict in the subject's mind. Last, we evaluated changes in blood concentration of hemoglobin by NIRS in the patients with severe carotid arterial stenosis before and after surgery. Before surgery, an evident elevation of blood concentration of hemoglobin was observed at the periprimary hand motor area during hand grasp task, although it disappeared after surgery. Our study revealed that further investigation is required to clarify more detailed higher brain functions, and for the achievement of this goal, it was especially important to compare the distributions of activated brain area by between fMRI and MEG during electrostimulation on bilateral median nerves.

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, NEUROSURGERY

    2025

  • LECTURE SERIES, NEUROSURGERY

    2024

  • LECTURE SERIES, NEUROSURGERY

    2023

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2023

  • CLINICAL TRAINING IN DIAGNOSIS

    2023

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Committee Experiences 【 Display / hide 】

  • 2024.11
    -
    Present

    薬事社会保険委員会　委員長, 日本脳神経血管内治療学会

  • 2021.10
    -
    Present

    総務委員会　委員, 日本脳神経外科学会

  • 2021.10
    -
    Present

    定款・規則等対応委員会　委員, 日本脳神経外科学会

  • 2025.10
    -
    Present

    保険診療委員会　委員, 日本脳神経外科学会

  • 2025.10
    -
    Present

    保険診療委員会 委員, 日本脳神経外科学会

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