KEIO RESEARCHERS INFORMATION SYSTEM

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1998.03

  Keio University, Faculty of Medicine

  University, Graduated

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, Keio University, Dissertation, 2008.09

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Neurosurgery (Cerebral Neurosurgery)

• Life Science / Neurosurgery (Cerebral Neurosurgery)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• interventional neuroradiology

• cerebrovascular disease

• functional neurosurgery

• spinal vascular diseases

• cerebrovascular disease

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• 脳脊髄血管障害に対する診断・治療法の開発, 

  2011.04

  -

  Present

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• A Case of Aneurysmal SAH and Stanford Type A Acute Aortic Dissection: A Case Report

  ENOMOTO Takuya, MIZUTANI Katsuhiro, KARATSU Kousuke, IWAMA Takashi, TAMURA Ryota, AKIYAMA Takenori, ITO Tsutomu, TODA Masahiro

  NMC Case Report Journal (The Japan Neurosurgical Society)  12 ( 0 ) 459 - 464 2025.12

  ISSN  2188-4226

  　View Summary

  <p>We report a concurrent case of aneurysmal subarachnoid hemorrhage and acute aortic dissection. A 47-year-old woman presented to our hospital unconscious. Subarachnoid hemorrhage was diagnosed by brain computed tomography on arrival. Computed tomography angiography revealed 2 aneurysms in the right internal carotid artery. Computed tomography angiography from the cervical to thoracic regions, which was initially performed to inspect the access route for interventional radiology, demonstrated the presence of Stanford type A acute aortic dissection. Neck clipping and total aortic arch replacement were performed for the 2 aneurysms and the acute aortic dissection, respectively. Only a few reports have described the coexistence of acute aortic dissection and subarachnoid hemorrhage. Managing these 2 pathologies requires a thorough evaluation of each therapeutic strategy and careful management of the patient's systemic and neurological conditions. We believe our case report enhances the understanding of this specific pathological condition and will provide valuable insights for treating future patients with similar conditions.</p>

  • Access to Document (DOI)
  • CiNii Research

• Comprehensive Genetic Analysis of NF2 in Sporadic Vestibular Schwannoma

  Wakabayashi T., Wasano K., Nakamura K., Hosoya M., Kawano R., Takamatsu R., Ueno M., Shimanuki M.N., Tsuzuki N., Nishiyama T., Akiyama T., Toda M., Nishihara H., Ozawa H., Oishi N.

  Laryngoscope Investigative Otolaryngology 10 ( 5 ) e70265 2025.10

  ISSN  2378-8038

  　View Summary

  Objective: To elucidate the genetic etiology of sporadic vestibular schwannomas (VSs) and investigate the correlation between NF2 inactivation mechanisms and preoperative clinical characteristics, including hearing function and tumor growth. Methods: Nineteen patients who underwent VS resection at our otorhinolaryngology or neurosurgery department between June 2020 and March 2022 were included in this study. Whole-exome sequencing (WES) was performed to detect somatic changes in NF2. Additionally, NF2 promoter methylation status and copy number changes were evaluated using methylation analysis and multiple ligation-dependent probe amplification (MLPA). Preoperative clinical data, including pure tone audiometry, speech discrimination scores, and tumor growth rates, were collected and analyzed for correlations with genetic findings. Results: WES identified somatic alterations in both NF2 alleles in 16 cases (84.2%). The addition of methylation analysis and MLPA confirmed biallelic NF2 inactivation in all cases. NF2 promoter methylation was suggested to be associated with hearing loss and tumor progression. A weak correlation between NF2 expression levels and tumor growth rate was observed (r = 0.21), while no significant correlation was found between NF2 expression and pure tone audiometry or speech discrimination scores. Conclusion: Comprehensive genetic analyses, including WES, methylation analysis, and MLPA, are essential for identifying NF2 inactivation mechanisms in sporadic VSs. The findings suggest that NF2 methylation may contribute to variations in clinical presentation. Further studies with larger cohorts are necessary to clarify the role of epigenetic modifications in disease progression and their potential impact on patient management strategies. Level of Evidence: 4.

  • Access to Document (DOI)

• A Cautionary Note on the Indication for Deep Brain Stimulation in Parkinsonism Patients With <i>SLC9A6 </i>Gene Mutations

  Okusa, S; Tezuka, T; Kosugi, K; Yamamoto, Y; Takahata, K; Higuchi, M; Akiyama, T; Kobayashi, M; Toda, M; Ito, D; Nakahara, J; Seki, M

  JOURNAL OF MOVEMENT DISORDERS 18 ( 3 ) 268 - 270 2025.07

  ISSN  2005-940X

  • Access to Document (DOI)

• 特集 他科の視点・診療連携の観点でみる　母斑・母斑症Ⅰ 疾患別の概説--診療連携の視点を含めて ６.オスラー病

  秋山 武紀

  小児科 (金原出版)  66 ( 3 ) 268 - 275 2025.03

  ISSN  00374121

  • Access to Document (DOI)
  • CiNii Research

• <i>ACVRL1</i> and <i>MTHFR</i> double variants in an adolescent with paradoxical cerebral embolism

  Sato, T; Ichihashi, Y; Tsuruta, H; Chu, PS; Akiyama, T; Hishida, T; Hasegawa, T

  PEDIATRICS INTERNATIONAL 67 ( 1 ) e70025 2025.01

  ISSN  1328-8067

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• microRNA expression profiling in serum of patients with subarachnoid hemorrhage

  akiyama takenori

  科学研究費補助金研究成果報告書 2017

• Investigation of the resultant changes in corticospinal excitability by syllogistic reasoning

  Akiyama, Takenori

  CARLS series of advanced study of logic and sensibility (Centre for Advanced Research on Logic and Sensibility The Global Centers of Excellence Program, Keio University)  2   127 - 133 2008

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 【他科の視点・診療連携の観点でみる　母斑・母斑症I】疾患別の概説　診療連携の視点を含めて　オスラー病

  秋山 武紀

  小児科 (金原出版(株))  66 ( 3 ) 268 - 275 2025.03

  ISSN  0037-4121

  　View Summary

  ＜文献概要＞オスラー病は,遺伝性出血性毛細血管拡張症(HHT)の通称で,鼻出血と口唇・手指などの毛細血管拡張,および肺・脳など臓器の血管奇形を特徴とする遺伝疾患である.本疾患の認知度はいまだ十分でなく,多くの患者が未診断のまま適切な対応がなされていない現状がある.小児期には,鼻出血や毛細血管拡張といった典型的なHHTの症候を示さないことも多く,臨床症状による診断は容易ではない.しかし,HHTの診断が不十分な場合に脳出血・脳梗塞など重篤な症候を呈する可能性があり,本疾患に対する適切な知識とその対応は重要である.本稿では,オスラー病の疾患概念とその臨床症状を概説し,小児診療における注意点について述べる.

• 淡蒼球内節脳深部刺激療法を施行した非定型的なパーキンソニズムを呈するヘテロ接合性SLC9A6遺伝子変異患者の1例

  大草 翔平, 佐柳 太一, 小杉 健三, 秋山 武紀, 小林 正人, 伊東 大介, 戸田 正博, 中原 仁, 関 守信

  日本定位・機能神経外科学会プログラム・抄録集 ((一社)日本定位・機能神経外科学会)  64回   142 - 142 2025.01

• 体位が外頸静脈・板間静脈に与える影響　座位CTを用いた解析

  水谷 克洋, 宮内 翼, 山田 祥岳, 山田 稔, 横山 陽一, 小杉 健三, 吉田 啓佑, 秋山 武紀, 戸田 正博, 陣崎 雅弘

  日本脳神経血管内治療学会学術集会抄録集 ((一社)日本脳神経血管内治療学会)  40回   422 - 422 2024.11

• CASにおける全身麻酔と局所麻酔のアウトカム比較

  勝又 雅裕, 秋山 武紀, 水谷 克洋, 高橋 里史, 中原 仁, 戸田 正博

  日本脳神経血管内治療学会学術集会抄録集 ((一社)日本脳神経血管内治療学会)  40回   574 - 574 2024.11

• 頭頸部脈管奇形のIVR

  井上 政則, 塚田 実郎, 山本 洋輔, 荒牧 典子, 秋山 武紀

  日本脳神経血管内治療学会学術集会抄録集 ((一社)日本脳神経血管内治療学会)  40回   262 - 262 2024.11

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 慢性閉塞性脳血管病変の治療前後における機能活動時の大脳皮質酸素代謝-多チャンネルfNIRSを用いた検討-

  'AKIYAMA TAKENORI, Ohira Takayuki, Kawase Takeshi, Kato Toshinori'

  [Domestic presentation]  第15回日本脳循環代謝学会総会 (大阪) , 

  2003.10

  , 

  Poster presentation

• 脳虚血疾患で運動負荷によって引き起こされた一次運動野の低酸素賦活反応—機能的NIRSを用いた検討—

  'AKIYAMA TAKENORI, Ohira Takayuki, Fukunaga Atsushi, Kawase Takeshi, Kato Toshinori'

  [Domestic presentation]  第33回日本臨床神経生理学会・学術大会 (旭川) , 

  2003.10

  , 

  Poster presentation

• 視床下核へのDBS電極留置術後に一過性にdyskinesiaが消失したParkinson病の一例

  'AKIYAMA TAKENORI, Ohira Takayuki, Hiraga Kenji, Ochiai Masato, Kawase Takeshi'

  [Domestic presentation]  第42回日本定位・機能神経外科学会 (仙台) , 

  2003.09

  , 

  Oral presentation (general)

• Analysis of Hb concentration change detected by TMS mapping oriented NIRS in the activated cerebral cortex during motor task

  'AKIYAMA TAKENORI, Takayuki Ohira, Kenji Hiraga, Maki Niimi, Atsushi Fukunaga, Takeshi Kawase, Toshinori Kato '

  [International presentation]  Human Brain Mapping 2003 ('New York, USA') , 

  2003.06

  , 

  Poster presentation

• 近赤外線トポグラフィーによる大脳皮質顔面一次運動野描出の試みと問題点

  AKIYAMA TAKENORI

  [Domestic presentation]  第26回日本顔面神経研究会 (東京) , 

  2003.06

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 末梢血中マイクロRNAスクリーニングおよび発現解析による硬膜動静脈瘻の病期診断および新たな治療戦略の構築

  2015.02

  -

  2017.03

  日本脳神経血管内治療学会, 日本脳神経血管内治療学会助成研究, 秋山 武紀, 高橋 里史, Research grant, Principal investigator

• microRNA expression profiling in serum of patients with subarachnoid hemorrhage

  2015

  -

  2017

  高橋 里史, 秋山 武紀, Research grant, Coinvestigator(s)

• 高分解能近赤外光イメージング法の開発と高次脳機能計測への応用

  2004.04

  -

  2006.04

  平成16年度慶應医師会医学研究助成金, 秋山 武紀, Research grant, Principal investigator

  　View Summary

  近赤外光イメージング法により脳血流変化から脳機能計測を行う手法を確立、脳血管障害患者で有用性を証明した。

• Development of a new method for measuring higher brain function - integrated measuring system by fMRI and MEG -

  2003

  -

  2005

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, OHIRA Takayuki, KAWASE Takeshi, FUKUNAGA Atsushi, GADO Hisashi, OGAWA Seiji, Grant-in-Aid for Scientific Research (C), No Setting

  　View Summary

  The aim of this study is to establish a new integrated measuring system by fMRI, MEG and NIRS for evaluation of higher brain function. First, activated BOLD signals were observed during electrostimulation on bilateral median nerves by fMRI. Distributions of activated BOLD signals were evaluated in the three conditions, no delay, 30 msec delay and 100 msec delay. As a result, the smallest activated area was observed at the primary sensory area in the 30 msec delay condition. A MEG study revealed that no waves at 76 msec were observed in the 30 msec delay condition. Second, it was evaluated how the brain functions during loss-resulting or tie-resulting pursuant paper-rock-scissors with the dominant or non-dominant hands, using a 3-tesla functional MRI in normal right-handed subjects. Interestingly, the right SMA was activated more strongly during tie-resulting pursuant paper-rock-scissors with the left hand, while the left SMA was activated more strongly during loss-resulting pursuant paper-rock-scissors with the left hand. These findings suggest that the left SMA might be associated with inhibition of stereotypical performance and monitoring of conflict in the subject's mind. Last, we evaluated changes in blood concentration of hemoglobin by NIRS in the patients with severe carotid arterial stenosis before and after surgery. Before surgery, an evident elevation of blood concentration of hemoglobin was observed at the periprimary hand motor area during hand grasp task, although it disappeared after surgery. Our study revealed that further investigation is required to clarify more detailed higher brain functions, and for the achievement of this goal, it was especially important to compare the distributions of activated brain area by between fMRI and MEG during electrostimulation on bilateral median nerves.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• LECTURE SERIES, NEUROSURGERY

  2025

• LECTURE SERIES, NEUROSURGERY

  2024

• LECTURE SERIES, NEUROSURGERY

  2023

• INTRODUCTION TO CLINICAL CLERKSHIPS

  2023

• CLINICAL TRAINING IN DIAGNOSIS

  2023

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2021.10

  -

  Present

  総務委員会　委員, 日本脳神経外科学会

• 2021.10

  -

  Present

  定款・規則等対応委員会　委員, 日本脳神経外科学会

• 2021.10

  -

  Present

  定款・規則等対応委員会 委員, 日本脳神経外科学会

• 2021.10

  -

  Present

  総務委員会 委員, 日本脳神経外科学会

• 2021.10

  -

  Present

  総務委員会 委員, 日本脳神経外科学会

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