Kaseda, Kaoru

写真a

Affiliation

School of Medicine, Department of Surgery (General Thoracic Surgery) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links
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Career 【 Display / hide 】

  • 2006.04
    -
    2008.03

    okyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 初期臨床研修医

  • 2008.04
    -
    2011.03

    okyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 後期臨床研修医

  • 2011.04
    -
    2012.03

    Division of Thoracic Surgery, Keio University School of Medicine, 専修医

  • 2012.04
    -
    2013.03

    Pathology Division, Research Center for Innovative Oncology, Department of Thoracic Surgery,National Cancer Center Hospital East, 短期がん専門研修医

  • 2013.04
    -
    2013.09

    Division of Thoracic Surgery, Keio University School of Medicine, 専修医

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Academic Degrees 【 Display / hide 】

  • 博士(医学), Keio University, Dissertation, 2016.10

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Licenses and Qualifications 【 Display / hide 】

  • 医師免許証, 2006.04

  • 外科専門医, 2011.12

  • がん治療認定医, 2013.04

  • 呼吸器外科専門医, 2014.01

  • 肺がんCT検診認定機構 肺がんCT検診認定医, 2014.10

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Research Areas 【 Display / hide 】

  • Life Science / Tumor diagnostics and therapeutics (Comprehensive Genome Profiling)

  • Life Science / Respiratory surgery

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Research Keywords 【 Display / hide 】

  • Comprehensive Genome Profiling

  • Percutaneous cryoablation

  • Thoracic Surgery

  • 胸部悪性腫瘍の集学的治療

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Research Themes 【 Display / hide 】

  • Lung Cancer, 

    2011.04
    -
    Present

  • がん遺伝子検査, 

    2011.04
    -
    Present

  • Percutaneous cryoablation, 

    2011.04
    -
    Present

  • 胸部悪性腫瘍, 

    2011.04
    -
    Present

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Proposed Theme of Joint Research 【 Display / hide 】

  • Lung Cancer

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Papers 【 Display / hide 】

  • Real-World Outcomes of Limited Resection for Tumours Greater Than 20mm in Non-Small Cell Lung Cancer

    Suzuki S., Asakura K., Masai K., Kaseda K., Hishida T., Kazama A., Shigenobu T., Hanawa R., Emoto K., Sato Y.

    European Journal of Cardio Thoracic Surgery 67 ( 10 )  2025.10

    ISSN  10107940

    　View Summary

    Sublobar resection is an established surgical option for early-stage non-small cell lung cancer. However, evidence remains limited regarding its use for tumours >20 mm in real-world settings. We evaluated characteristics and outcomes of limited resection in this context and identified predictors of local recurrence. We retrospectively analysed 165 patients with clinical stage I non-small cell lung cancer with tumours >20 mm who underwent limited resection between 2007 and 2017. Clinical, pathological, and radiological data were reviewed. The primary end-point was local recurrence, assessed using competing risk analysis. Overall survival and disease-free survival were estimated using Kaplan-Meier and Cox models. We analysed 165 patients with 13 local recurrence events. Among them, 146 (88.5%) had identifiable reasons for not undergoing lobectomy. Segmentectomy and wedge resection were performed in 59% and 41% of cases, respectively. Lymph node dissection was performed in all segmentectomies and in 20% of wedge resections. The 5-year overall and disease-free survival rates were 64.0% and 62.1%. Local recurrence occurred in 8%, more frequently after wedge resection than segmentectomy (13% vs 4%, P = .04). Solidpredominant tumours with a consolidation-to-tumour ratio greater than 0.5 accounted for 76% and were independently associated with lower disease-free survival (hazard ratio, 2.65; P = .05) and higher local recurrence (hazard ratio: infinite; P < .001). No local recurrence was observed in tumours with a ground-glass opacity-predominant pattern. Limited resection showed acceptable outcomes in lung cancers >20 mm, especially with ground-glass opacity; solidpredominant CT patterns were strongly linked to recurrence.

  • Lineage-specific transcription factor landscape of thymic neuroendocrine tumors

    Omura S., Kurebayashi Y., Hamamoto J., Terai H., Imoto T., Suzuki M., Nakagawa K., Suzuki T., Shigenobu T., Yoshizu A., Maeda C., Kaji M., Okubo Y., Suzuki S., Masai K., Kaseda K., Fukunaga K., Yasuda H., Asakura K.

    Lung Cancer 208   108731 2025.10

    ISSN  01695002

    　View Summary

    Introduction: Thymic neuroendocrine tumors (TNETs) are rare malignancies characterized by aggressive clinical behavior and limited therapeutic options. In small cell lung cancer (SCLC), molecular subtypes based on the expression of lineage-defining transcription factors (TFs)—ASCL1, NEUROD1, POU2F3, and YAP1—have been proposed. However, the TF landscape of TNETs remains poorly defined. Given the pathological similarities among neuroendocrine tumors across organs, we aimed to investigate whether the TF-based classification system used in SCLC is applicable to TNETs. Methods: Sixteen pathologically confirmed TNETs—including large cell neuroendocrine carcinoma (LCNEC), thymic small cell carcinoma (TSCC), atypical carcinoid (AC), and typical carcinoid (TC)—were retrospectively analyzed. Immunohistochemistry was performed to evaluate classical neuroendocrine (NE) markers (synaptophysin, chromogranin A, CD56) and TFs (ASCL1, NEUROD1, POU2F3, YAP1). H-scores were calculated, and tumors were categorized according to TFs expression profiles. Results: Synaptophysin was strongly expressed in all cases, while chromogranin A and CD56 showed variable expression, with reduced levels in LCNEC and TSCC. The combined NE score was significantly higher in carcinoid tumors compared to LCNEC and TSCC. For TFs, ASCL1 expression was observed in 93.8 % of cases, whereas NEUROD1 and POU2F3 were rarely or not expressed. YAP1 expression was confined to LCNEC cases, all of which co-expressed ASCL1 and YAP1. Based on H-scores, TNETs were classified into three subgroups: (1) ASCL1-positive/YAP1-negative (n = 12, 75 %), (2) ASCL1/YAP1 double-positive (n = 3, 19 %), and (3) double-negative (n = 1, 6 %). Conclusion: This study reveals molecular heterogeneity among TNETs. Notably, ASCL1 and YAP1 co-expression characterizes all LCNEC cases, making a distinct TF landscape in high-grade TNETs.

  • Clinical Application of In-House Comprehensive Genomic Profiling for Thoracic Cancer: Insights From a Japanese Hospital.

    Takaoka H, Terai H, Nakamura K, Mizuno T, Kawano R, Emoto K, Kurebayashi Y, Takada N, Hamabe K, Horie K, Ogata A, Kinoshita K, Shigematsu L, Ito F, Okada M, Fukushima T, Nukaga S, Tani T, Ohgino K, Kaseda K, Ikemura S, Yasuda H, Asakura K, Okita H, Nishihara H, Fukunaga K

    Cancer science  2025.08

    ISSN  1347-9032

  • Clinical Characteristics and Indicators of Spontaneous Hemopneumothorax Comparing With Primary Spontaneous Pneumothorax.

    Suzuki M, Kaseda K, Yano K, Omura S, Okubo Y, Masai K, Hishida T, Asakura K

    Cureus 17 ( 8 ) e90423 2025.08

    ISSN  2168-8184

  • Initial single-institutional experience with salvage surgery for stage IV non-small cell lung cancer.

    Hishida T, Oka N, Yano K, Omura S, Okubo Y, Masai K, Kaseda K, Ohgino K, Terai H, Yasuda H, Asakura K

    Interdisciplinary cardiovascular and thoracic surgery  2025.02

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Yステント留置で病状軽快が得られ,ステント抜去に至った気管・気管支縦隔瘻の1例

    中井 猛斗, 大久保 祐, 青木 優介, 中山 和真, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 矢野 海斗, 大村 征司, 政井 恭兵, 加勢田 馨, 菱田 智之, 朝倉 啓介

    気管支学 ((一社)日本呼吸器内視鏡学会)  46 ( 6 ) 460 - 460 2024.11

    ISSN  0287-2137

  • Anterior transcervical thoracic approachが有効であった胸壁デスモイド腫瘍の一例

    杉野 功祐, 政井 恭兵, 青木 優介, 中井 猛斗, 中山 和真, 櫻田 明久, 渡邉 真祥, 矢野 海斗, 大久保 祐, 加勢田 馨, 菱田 智之, 朝倉 啓介

    日本胸部外科学会関東甲信越地方会要旨集 (日本胸部外科学会-関東甲信越地方会)   ( 196回 ) 46 - 46 2024.11

  • 上縦隔に発生した平滑筋肉腫の1切除例

    中井 猛斗, 菱田 智之, 青木 優介, 中山 和真, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 石黒 勇輝, 矢野 海斗, 大村 征司, 大久保 祐, 政井 恭兵, 加勢田 馨, 朝倉 啓介, 林 亮介, 川井田 みほ

    肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 260 - 260 2024.06

    ISSN  0386-9628

  • 気胸発症を契機として発見された混合型大細胞神経内分泌癌の1切除例

    中山 和真, 加勢田 馨, 青木 優介, 中井 猛斗, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 石黒 勇輝, 矢野 海斗, 大久保 祐, 政井 恭兵, 菱田 智之, 朝倉 啓介, 紅林 泰

    肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 255 - 256 2024.06

    ISSN  0386-9628

  • 漏斗胸に起因した気道狭窄に対する胸郭挙上術の有用性について

    政井 恭兵, 大久保 祐, 加勢田 馨, 菱田 智之, 朝倉 啓介

    気管支学 ((一社)日本呼吸器内視鏡学会)  46 ( Suppl. ) S352 - S352 2024.05

    ISSN  0287-2137

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Development of the combination therapy with cryoablation and immune checkpoint inhibitor for lung cancer

    2016.04
    -
    2019.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Kaseda Kaoru, Grant-in-Aid for Young Scientists (B), No Setting

    　View Summary

    Cryotherapy and cryoimmunotherapy were performed to 1.5cm femoral tumor that originated from Lewis Lung Cancer cell. Histologically, the area of nonviable tumor was significantly increased in size in cryoimmunotherapy group than cryotherapy group (Average: 88% vs 73%). Our data suggest that cryoimmunotherapy is superior than cryotherapy in local control and the most effective route is local administration. On the other hand, there was no difference in the effectiveness of local control between these three immune checkpoint inhibitors.

  • Hemoglobin vesicles ameriolate allograft airway rejection

    2012.04
    -
    2014.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, KASEDA Kaoru, Grant-in-Aid for Young Scientists (B), No Setting

    　View Summary

    Acute rejection after lung transplantation is the main risk factor for the development of bronchiolitis obliterans (BO). Hemoglobin-vesicles (HbV) have been developed for use as artificial oxygen carriers and this can provide anti-inflammatory effects and may serve to limit tissue injury in airway transplant. Here, we tested the ability of HbV to prevent airway rejection. Tracheal grafts from BALB/c or C57BL/6 were transplanted to C57BL/6 recipients. Experimental groups were treated with HbV. Histopathological evaluation of luminal obliteration was blindly reviewed. Immunohistochemistry and real-time RT-PCR analyses were performed. Allografts treated with HbV revealed a reduction of thickening in epithelial and subepithelial airway layers at day 7 in orthotopic trachea transplantation model compared with allografts treated with vehicle. There was also a concordant decrease in CD3+ lymphocytes and macrophages in HbV treated allografts.

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, SURGERY

    2025

  • LECTURE SERIES, SURGERY

    2024

  • LECTURE SERIES, SURGERY

    2023

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2023

  • CLINICAL TRAINING IN DIAGNOSIS

    2023

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Memberships in Academic Societies 【 Display / hide 】

  • 日本外科学会

    　

  • 日本呼吸器外科学会

    　

  • 日本胸部外科学会

    　

  • 日本呼吸器内視鏡学会

    　

  • 日本肺癌学会

    　

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Committee Experiences 【 Display / hide 】

  • 2024.11
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    Present

    日本肺癌学会評議員

  • 2021.04
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    Present

    日本呼吸器内視鏡学会評議員

  • 2020.10
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    Present

    日本呼吸器外科学会評議員

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