Kaseda, Kaoru

写真a

Affiliation

School of Medicine, Department of Surgery (General Thoracic Surgery) (Shinanomachi)

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Dissertation, 2016.10

Licenses and Qualifications 【 Display / hide

  • 医師免許証, 2006.04

  • 外科専門医, 2011.12

  • がん治療認定医, 2013.04

  • 呼吸器外科専門医, 2014.01

  • 肺がんCT検診認定機構 肺がんCT検診認定医, 2014.10

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Research Areas 【 Display / hide

  • Respiratory surgery

Research Keywords 【 Display / hide

  • Thoracic Surgery

Research Themes 【 Display / hide

  • Lung Cancer, 

    2011.04
    -
    Present

Proposed Theme of Joint Research 【 Display / hide

  • Lung Cancer

 

Papers 【 Display / hide

  • Four cases of completion lobectomy for locally relapsed lung cancer after segmentectomy

    Suzuki S., Asakura K., Masai K., Kaseda K., Hishida T., Asamura H.

    World Journal of Surgical Oncology (World Journal of Surgical Oncology)  19 ( 1 )  2021.12

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    Background: Although completion lobectomy is the treatment of choice for local recurrence of non-small cell lung cancer after segmentectomy, few cases have been reported. We report four patients who underwent completion lobectomies for staple line recurrence after segmentectomy for stage I non-small cell lung cancer. Case presentation: Three women aged 65, 82, and 81 years underwent completion lower lobectomy after superior segmentectomy of the same lobe for local recurrence of stage I non-small cell lung cancer. A 67-year-old man, who had a tumor recurrence on the staple line after apical segmentectomy with superior mediastinal nodal dissection for stage I non-small cell lung cancer, underwent completion right upper lobectomy. These four patients underwent segmentectomy because of comorbidities or advanced age. Local recurrence was confirmed by computed tomography-guided needle biopsy. The interval between the two operations was 37, 39, 41, and 16 months, respectively. Although minimal hilar adhesion was seen for the three completion lower lobectomies, tight adhesions after apical segmentectomy made completion right upper lobectomy quite difficult to dissect, which led to injury of the superior pulmonary vein. No recurrence was recorded after completion lobectomies for 62, 70, 67, and 72 months, respectively. Conclusions: Although completion lobectomy is one of the most difficult modes of resection, among several completion lobectomies, completion lower lobectomy after superior segmentectomy without superior mediastinal nodal dissection was relatively easy to perform because of fewer hilar adhesions.

  • Debulking surgery for malignant tumors: The current status, evidence and future perspectives

    Hishida T., Masai K., Kaseda K., Asakura K., Asamura H.

    Japanese Journal of Clinical Oncology (Japanese Journal of Clinical Oncology)  51 ( 9 ) 1349 - 1362 2021.09

    ISSN  03682811

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    Debulking surgery, also called cytoreductive surgery, is a resection of the tumor as much as possible and an intended incomplete resection for unresectable malignant tumors. Since the most important principle in surgical oncology is complete R0 resection, debulking surgery goes against the basic principle and obscures the concept of operability. However, debulking surgery has been advocated for various types of advanced malignant tumors, including gynecological cancers, urological cancers, gastrointestinal cancers, breast cancers and other malignancies, with or without adjuvant therapy. Positive data from randomized trials have been shown in subsets of ovarian cancer, renal cell carcinoma, colorectal cancer and breast cancer. However, recent trials for renal cell carcinoma, colorectal cancer and breast cancer have tended to show controversial results, mainly according to the survival improvement of nonsurgical systemic therapy alone. On the other hand, debulking surgery still has a therapeutic role for slow-growing and borderline malignant tumors, such as pseudomyxoma peritonei and thymomas. The recent understanding of tumor heterogeneity and clonal evolution responsible for malignancy and drug resistance indicates that select patients may obtain prolonged survival by the synergistic effect of debulking surgery and novel systemic therapy. This review aimed to describe the current status and evidence of debulking surgery in a cross-organ manner and to discuss future perspectives in the current era with advances in systemic therapy.

  • A case of solitary pulmonary metastasis from thymoma resected 19 years after surgery

    Suzuki M., Kaseda K., Masai K., Asakura K., Hishida T., Hayashi Y., Asamura H.

    Japanese Journal of Lung Cancer (Japanese Journal of Lung Cancer)  60 ( 5 ) 401 - 406 2020.10

    ISSN  03869628

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    © 2020 The Japan Lung Cancer Society. Background. Thymoma is a low-grade malignant epithelial tumor arising in the thymus and rarely metastasizes to distant sites after complete resection. We herein report a rare case of solitary pulmonary metastasis of type Bl thymoma. Case. A woman in her 70s underwent thymectomy with partial resection of the pericardium and right upper lobe for type Bl thymoma 19 years ago. The pathological stage was T3N0M0 Stage III with invasion to the right lung. She received postoperative radiotherapy of 50 Gy with 25 Fr and had no evidence of recurrence until the detection of a 0.8-cm solitary pulmonary nodule in the right lower lobe on follow-up computed tomography (CT) performed 13 years after surgery. The pulmonary nodule gradually grew over the next seven-year follow-up, so we performed wedge resection of the right lower lobe for the diagnosis and treatment. Pathologically, the nodule consisted of epithelial cells with slightly large nuclei and inconspicuous atypia surrounded by a lot of lymphocytes. Immunohistochemically, the epithelial cells were positive for AE1/AE3 and CK19, while the lymphocytes were positive for CD3 and TdT. These findings were similar to those shown in the initial thymoma specimen, and the diagnosis of pulmonary metastasis of type Bl thymoma was made. The patient is doing well 23 months after pulmonary metastasectomy with no evidence of re-recurrence of thymoma. Conclusion. We herein report a resected case of slow-growing pulmonary metastasis from type Bl thymoma with a review of the literature. In cases of type A-Bl thymoma, we should consider the possibility of late recurrence and perform long-term follow-up.

  • Recent and current advances in FDG-PET imaging within the field of clinical oncology in NSCLC: A review of the literature

    Kaseda K.

    Diagnostics (Diagnostics)  10 ( 8 )  2020.08

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    © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Lung cancer is the leading cause of cancer-related deaths around the world, the most common type of which is non-small-cell lung cancer (NSCLC). Computed tomography (CT) is required for patients with NSCLC, but often involves diagnostic issues and large intra- and interobserver variability. The anatomic data obtained using CT can be supplemented by the metabolic data obtained using fluorodeoxyglucose F 18 (FDG) positron emission tomography (PET); therefore, the use of FDG-PET/CT for staging NSCLC is recommended, as it provides more accuracy than either modality alone. Furthermore, FDG-PET/magnetic resonance imaging (MRI) provides useful information on metabolic activity and tumor cellularity, and has become increasingly popular. A number of studies have described FDG-PET/MRI as having a high diagnostic performance in NSCLC staging. Therefore, multidimensional functional imaging using FDG-PET/MRI is promising for evaluating the activity of the intratumoral environment. Radiomics is the quantitative extraction of imaging features from medical scans. The chief advantages of FDG-PET/CT radiomics are the ability to capture information beyond the capabilities of the human eye, non-invasiveness, the (virtually) real-time response, and full-field analysis of the lesion. This review summarizes the recent advances in FDG-PET imaging within the field of clinical oncology in NSCLC, with a focus on surgery and prognostication, and investigates the site-specific strengths and limitations of FDG-PET/CT. Overall, the goal of treatment for NSCLC is to provide the best opportunity for long-term survival; therefore, FDG-PET/CT is expected to play an increasingly important role in deciding the appropriate treatment for such patients.

  • Clinicopathological and prognostic features of operable non-small cell lung cancer patients with diabetes mellitus

    Kaseda K., Hishida T., Masai K., Asakura K., Hayashi Y., Asamura H.

    Journal of Surgical Oncology (Journal of Surgical Oncology)  123 ( 1 ) 332 - 341 2020

    ISSN  00224790

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    © 2020 Wiley Periodicals LLC Background: The aim of this study was to investigate the clinicopathological and prognostic features of operable non-small cell lung cancer (NSCLC) patients with diabetes mellitus (DM). Methods: A total of 1231 surgically resected NSCLC patients were retrospectively reviewed. Clinicopathological characteristics were compared between patients with DM (DM group, n = 139) and those without DM (non-DM group, n = 1092). The clinical factors associated with postoperative complications and prognostic factors were identified. Results: The DM group had distinct clinicopathological features. No significant differences in histological invasiveness or stage were found. The presence and control status of DM were independent predictors of postoperative complications. No significant differences in recurrence-free survival or cancer-specific survival were observed; however, the DM group had worse overall survival (OS). The DM group had a higher number of deaths from other diseases than the non-DM group, and these patients had significantly higher postoperative hemoglobin A1c levels than patients with cancer-related death. Conclusion: The presence and control status of preoperative DM are useful predictors of both postoperative complications and OS in operable NSCLC patients. Concomitant diabetes-related complications have a negative effect on long-term survival in diabetic NSCLC patients, and long-term glycemic control is important to prolong OS.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • Hemoglobin vesicles ameriolate allograft airway rejection

     

 

Courses Taught 【 Display / hide

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2021

  • CLINICAL TRAINING IN DIAGNOSIS

    2021

  • LECTURE SERIES, SURGERY

    2021

  • LECTURE SERIES, SURGERY

    2020

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2020

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Memberships in Academic Societies 【 Display / hide

  • 日本外科学会

     
  • 日本呼吸器外科学会

     
  • 日本胸部外科学会

     
  • 日本呼吸器内視鏡学会

     
  • 日本肺癌学会

     

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