Kaseda, Kaoru

写真a

Affiliation

School of Medicine, Department of Surgery (General Thoracic Surgery) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links
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Career 【 Display / hide 】

  • 2006.04
    -
    2008.03

    okyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 初期臨床研修医

  • 2008.04
    -
    2011.03

    okyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 後期臨床研修医

  • 2011.04
    -
    2012.03

    Division of Thoracic Surgery, Keio University School of Medicine, 専修医

  • 2012.04
    -
    2013.03

    Pathology Division, Research Center for Innovative Oncology, Department of Thoracic Surgery,National Cancer Center Hospital East, 短期がん専門研修医

  • 2013.04
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    2013.09

    Division of Thoracic Surgery, Keio University School of Medicine, 専修医

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Academic Degrees 【 Display / hide 】

  • 博士(医学), Keio University, Dissertation, 2016.10

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Licenses and Qualifications 【 Display / hide 】

  • 医師免許証, 2006.04

  • 外科専門医, 2011.12

  • がん治療認定医, 2013.04

  • 呼吸器外科専門医, 2014.01

  • 肺がんCT検診認定機構 肺がんCT検診認定医, 2014.10

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Research Areas 【 Display / hide 】

  • Life Science / Tumor diagnostics and therapeutics (Comprehensive Genome Profiling)

  • Life Science / Respiratory surgery

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Research Keywords 【 Display / hide 】

  • Comprehensive Genome Profiling

  • Percutaneous cryoablation

  • Thoracic Surgery

  • 胸部悪性腫瘍の集学的治療

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Research Themes 【 Display / hide 】

  • Lung Cancer, 

    2011.04
    -
    Present

  • 胸部悪性腫瘍, 

    2011.04
    -
    Present

  • がん遺伝子検査, 

    2011.04
    -
    Present

  • Percutaneous cryoablation, 

    2011.04
    -
    Present

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Proposed Theme of Joint Research 【 Display / hide 】

  • Lung Cancer

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Papers 【 Display / hide 】

  • Initial single-institutional experience with salvage surgery for stage IV non-small cell lung cancer.

    Hishida T, Oka N, Yano K, Omura S, Okubo Y, Masai K, Kaseda K, Ohgino K, Terai H, Yasuda H, Asakura K

    Interdisciplinary cardiovascular and thoracic surgery  2025.02

  • Thoracic posture-related morphological changes in patients with pectus excavatum versus healthy controls

    Suzuki T., Asakura K., Yamada Y., Masai K., Yamada M., Yokoyama Y., Okubo Y., Kaseda K., Hishida T., Jinzaki M.

    European Journal of Cardio-thoracic Surgery 66 ( 5 )  2024.11

    ISSN  10107940

    　View Summary

    OBJECTIVES. Cases of severe pectus excavatum presenting with worsening cardiopulmonary symptoms in the upright position have been reported. However, the underlying mechanism remains unclear. We evaluated posture-related morphological changes of the thorax in patients with pectus excavatum. METHODS. Chest morphology was evaluated preoperatively using upright and supine computed tomography in 21 patients with pectus excavatum and 35 healthy volunteers. The minimum anterior–posterior thoracic diameter, depression depth, and Haller index on horizontal sections, as well as the T6-12 plumb line distance on sagittal sections, were compared between the 2 positions. RESULTS. In patients with pectus excavatum (median age, 22 years; 18 males and 3 females), the minimum anterior–posterior diameter was smaller (4.5 vs 5.1 cm, P < 0.001) and the Haller index was greater (10.1 vs 6.4, P < 0.001) in the upright position than in the supine position. The T6-T12 plumb line distance was longer in the upright position (2.4 vs 0.8 cm, P < 0.001), while the depression depth showed no significant difference. Healthy volunteers exhibited similar changes. The degree of spinal curvature increased in the upright position due to the anterior shift of the lower thoracic vertebrae, resulting in a shorter anterior–posterior diameter, irrespective of chest wall deformity. One patient with dyspnoea only in the upright position exhibited compression of the right inferior pulmonary vein only on upright computed tomography. CONCLUSIONS. The minimum anterior–posterior diameter is shorter in the upright position. This may explain the worsening of cardiopulmonary symptoms in patients with severe pectus excavatum when in an upright position.

  • Clinical impact of multiple pectus bars on surgical outcomes following pectus excavatum repair

    Oka N., Masai K., Okubo Y., Kaseda K., Hishida T., Asakura K.

    Interdisciplinary Cardiovascular and Thoracic Surgery 39 ( 4 )  2024.10

    　View Summary

    OBJECTIVES: The Nuss procedure, a minimally invasive surgery for pectus excavatum, has undergone various improvements. However, the impact of using multiple bars on thoracic shape changes and surgical outcomes remains unclear. METHODS: We retrospectively evaluated patients who underwent the Nuss procedure for pectus excavatum between August 2014 and September 2021. We divided the patients into 2 groups based on the number of bars placed and identified differences in surgical outcomes and morphological characteristics. RESULTS: A total of 225 patients were evaluated, of whom 132 were classified into the ≤2 bar group (using 1 or 2 bars) and 93 into the ≥3 bar group (using 3 or more bars). There was no difference in the preoperative Haller index [median (interquartile range), 4.59 (3.67–6.16) vs 4.67 (4.12–6.14), P ¼ 0.227], and asymmetric excavatum was more frequently observed in the ≥3 bar group (81% vs 51%, P < 0.001). The preoperative sternal torsion angle was larger in the ≥3 bar group, but no difference was found between the 2 groups postoperatively. The incidence of postoperative complications (≥grade 3) was comparable between groups (10% vs 17%, P ¼ 0.105); however, postoperative pleurisy was more frequently observed in the ≥3 bar group (12% vs 4%, P ¼ 0.021). In univariable and multivariable analyses, ≥3 bar placement was the only risk factor for postoperative pleurisy. CONCLUSIONS: The placement of multiple bars (≥3 bars) is useful for the correction of asymmetric pectus excavatum, but attention should be paid to the potential risk of postoperative pleurisy.

  • Validity of Simple Thymomectomy for Clinical Stage I Thymoma without Myasthenia Gravis: A Propensity Score-Matched Analysis

    Hishida, T; Suzuki, T; Omura, S; Okubo, Y; Masai, K; Kaseda, K; Asakura, K

    JOURNAL OF THORACIC ONCOLOGY 19 ( 10 ) S274 - S274 2024.10

    ISSN  1556-0864

  • Multiple Lung Resections for Metastases from Pheochromocytoma to Reduce Catecholamine Production.

    Yano K, Okubo Y, Ishiguro Y, Masai K, Kaseda K, Emoto K, Miyashita K, Hisihida T, Asakura K

    Annals of thoracic surgery short reports 2 ( 3 ) 488 - 491 2024.09

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Yステント留置で病状軽快が得られ,ステント抜去に至った気管・気管支縦隔瘻の1例

    中井 猛斗, 大久保 祐, 青木 優介, 中山 和真, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 矢野 海斗, 大村 征司, 政井 恭兵, 加勢田 馨, 菱田 智之, 朝倉 啓介

    気管支学 ((一社)日本呼吸器内視鏡学会)  46 ( 6 ) 460 - 460 2024.11

    ISSN  0287-2137

  • Anterior transcervical thoracic approachが有効であった胸壁デスモイド腫瘍の一例

    杉野 功祐, 政井 恭兵, 青木 優介, 中井 猛斗, 中山 和真, 櫻田 明久, 渡邉 真祥, 矢野 海斗, 大久保 祐, 加勢田 馨, 菱田 智之, 朝倉 啓介

    日本胸部外科学会関東甲信越地方会要旨集 (日本胸部外科学会-関東甲信越地方会)   ( 196回 ) 46 - 46 2024.11

  • 上縦隔に発生した平滑筋肉腫の1切除例

    中井 猛斗, 菱田 智之, 青木 優介, 中山 和真, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 石黒 勇輝, 矢野 海斗, 大村 征司, 大久保 祐, 政井 恭兵, 加勢田 馨, 朝倉 啓介, 林 亮介, 川井田 みほ

    肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 260 - 260 2024.06

    ISSN  0386-9628

  • 気胸発症を契機として発見された混合型大細胞神経内分泌癌の1切除例

    中山 和真, 加勢田 馨, 青木 優介, 中井 猛斗, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 石黒 勇輝, 矢野 海斗, 大久保 祐, 政井 恭兵, 菱田 智之, 朝倉 啓介, 紅林 泰

    肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 255 - 256 2024.06

    ISSN  0386-9628

  • 漏斗胸に起因した気道狭窄に対する胸郭挙上術の有用性について

    政井 恭兵, 大久保 祐, 加勢田 馨, 菱田 智之, 朝倉 啓介

    気管支学 ((一社)日本呼吸器内視鏡学会)  46 ( Suppl. ) S352 - S352 2024.05

    ISSN  0287-2137

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Development of the combination therapy with cryoablation and immune checkpoint inhibitor for lung cancer

    2016.04
    -
    2019.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Kaseda Kaoru, Grant-in-Aid for Young Scientists (B), No Setting

    　View Summary

    Cryotherapy and cryoimmunotherapy were performed to 1.5cm femoral tumor that originated from Lewis Lung Cancer cell. Histologically, the area of nonviable tumor was significantly increased in size in cryoimmunotherapy group than cryotherapy group (Average: 88% vs 73%). Our data suggest that cryoimmunotherapy is superior than cryotherapy in local control and the most effective route is local administration. On the other hand, there was no difference in the effectiveness of local control between these three immune checkpoint inhibitors.

  • Hemoglobin vesicles ameriolate allograft airway rejection

    2012.04
    -
    2014.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, KASEDA Kaoru, Grant-in-Aid for Young Scientists (B), No Setting

    　View Summary

    Acute rejection after lung transplantation is the main risk factor for the development of bronchiolitis obliterans (BO). Hemoglobin-vesicles (HbV) have been developed for use as artificial oxygen carriers and this can provide anti-inflammatory effects and may serve to limit tissue injury in airway transplant. Here, we tested the ability of HbV to prevent airway rejection. Tracheal grafts from BALB/c or C57BL/6 were transplanted to C57BL/6 recipients. Experimental groups were treated with HbV. Histopathological evaluation of luminal obliteration was blindly reviewed. Immunohistochemistry and real-time RT-PCR analyses were performed. Allografts treated with HbV revealed a reduction of thickening in epithelial and subepithelial airway layers at day 7 in orthotopic trachea transplantation model compared with allografts treated with vehicle. There was also a concordant decrease in CD3+ lymphocytes and macrophages in HbV treated allografts.

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, SURGERY

    2024

  • LECTURE SERIES, SURGERY

    2023

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2023

  • CLINICAL TRAINING IN DIAGNOSIS

    2023

  • CLINICAL TRAINING IN DIAGNOSIS

    2022

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Memberships in Academic Societies 【 Display / hide 】

  • 日本呼吸器外科学会

    　

  • 日本胸部外科学会

    　

  • 日本呼吸器内視鏡学会

    　

  • 日本肺癌学会

    　

  • 日本臨床腫瘍学会

    　

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Committee Experiences 【 Display / hide 】

  • 2024.11
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    Present

    日本肺癌学会評議員

  • 2021.04
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    Present

    日本呼吸器内視鏡学会評議員

  • 2020.10
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    Present

    日本呼吸器外科学会評議員

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