KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2006.04

  -

  2008.03

  okyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 初期臨床研修医

• 2008.04

  -

  2011.03

  okyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 後期臨床研修医

• 2011.04

  -

  2012.03

  Division of Thoracic Surgery, Keio University School of Medicine, 専修医

• 2012.04

  -

  2013.03

  Pathology Division, Research Center for Innovative Oncology, Department of Thoracic Surgery,National Cancer Center Hospital East, 短期がん専門研修医

• 2013.04

  -

  2013.09

  Division of Thoracic Surgery, Keio University School of Medicine, 専修医

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Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士(医学), Keio University, Dissertation, 2016.10

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 医師免許証, 2006.04

• 外科専門医, 2011.12

• がん治療認定医, 2013.04

• 呼吸器外科専門医, 2014.01

• 肺がんCT検診認定機構 肺がんCT検診認定医, 2014.10

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Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Tumor diagnostics and therapeutics (Comprehensive Genome Profiling)

• Life Science / Respiratory surgery

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Comprehensive Genome Profiling

• Percutaneous cryoablation

• Thoracic Surgery

• 胸部悪性腫瘍の集学的治療

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Lung Cancer, 

  2011.04

  -

  Present

• 胸部悪性腫瘍, 

  2011.04

  -

  Present

• がん遺伝子検査, 

  2011.04

  -

  Present

• Percutaneous cryoablation, 

  2011.04

  -

  Present

Proposed Theme of Joint Research 【 Display / hide 】

Proposed Theme of Joint Research 【 Display / hide 】

• Lung Cancer

Books 【 Display / hide 】

Books 【 Display / hide 】

• The Dokdo/Takeshima dispute : South Korea, Japan and the search for a peaceful solution

  Huth Paul K., Kim Sunwoong, Roehrig Terence, Brill Nijhoff, 2021

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Surgically resected sarcomatoid carcinoma of the lung: a nationwide retrospective study in 2010

  Kaseda, K., Asakura, K., Shintani, Y., Okami, J., Toyooka, S., Sato, Y., Watanabe, S. I., Chida, M., Suzuki, H., Miyaoka, E., Yoshino, I., Date, H. and Japanese Joint Committee of Lung Cancer, Registry

  BMC Cancer 24 ( 1 ) 938 2024.08

  Research paper (scientific journal), Joint Work, Lead author, Accepted,  ISSN  1471-2407

  　View Summary

  BACKGROUND: Sarcomatoid carcinoma of the lung is a rare histological type of non-small cell lung cancer with a poor prognosis. We aimed to investigate the clinicopathological characteristics and prognostic factors of surgically resected sarcomatoid carcinoma of the lung. METHODS: We retrospectively reviewed 14999 patients who underwent surgical resection for non-small cell lung cancer accumulated by the Japanese Joint Committee of Lung Cancer Registry in 2010. Clinicopathological characteristics and survival were compared between the sarcomatoid carcinoma and other non-small cell cancer groups. The prognostic factors in the sarcomatoid carcinoma group were identified using a multivariate Cox proportional hazard model. RESULTS: Patients with sarcomatoid carcinoma comprised 1.4% of all patients. The sarcomatoid carcinoma group demonstrated a more aggressive pathology with presentation at more advanced stages, requiring more frequent extensive surgical resections. The sarcomatoid carcinoma group had remarkably poorer overall and recurrence-free survival than the other non-small cell lung cancer group. Adjuvant chemotherapy was associated with improved survival for pathological stage II-III sarcomatoid carcinoma cases rather than for pathological stage I disease. In the multivariate analysis, larger tumor size, lymphatic permeation, and no adjuvant chemotherapy were associated with the sarcomatoid carcinoma group's overall and recurrence-free survival. CONCLUSIONS: Surgically resected sarcomatoid carcinoma of the lung has a higher aggressive and metastatic potential and a worse prognosis than other non-small cell lung cancers. Adjuvant chemotherapy, which was associated with enhanced survival in patients with pathological stage II-III of the disease, could be considered for treating patients with pathological stage II-III sarcomatoid carcinoma of the lung.

  • Access to Document (DOI)

• Loeys-Dietz syndrome associated with scoliosis progression after combined Ravitch and Nuss procedure for severe pectus excavatum: A case report

  Sugino Kosuke, Masai Kyohei, Okubo Yu, Kaseda Kaoru, Hishida Tomoyuki, Asakura Keisuke

  The Journal of the Japanese Association for Chest Surgery (The Japanese Association for Chest Surgery)  38 ( 5 ) 470 - 475 2024.07

  ISSN  09190945

  　View Summary

  <p>Loeys-Dietz syndrome (LDS) is a congenital connective tissue disorder that shares certain typical features with Marfan syndrome. Pectus excavatum is a common skeletal comorbidity in LDS. We report a case of LDS characterized by scoliosis progression following pectus excavatum repair. A 9-year-old boy, who was diagnosed with LDS by genetic tests at the age of 5, was referred to our division for severe pectus excavatum (Haller index: 9.81). He also had mild scoliosis (Cobb angle of 8.5°). The pectus deformity was repaired through a combined Ravitch and Nuss procedure, involving the insertion of two pectus bars beneath the sternum, partially resecting the costal cartilages. Post-surgery, the Haller index reduced to 3.57, but the initial lumbar scoliosis markedly progressed, with the Cobb angle increasing to 34.2°. Treatment with a brace was initiated as scoliosis progressed immediately after the surgery. Scoliosis improved markedly by the 4^th month post-surgery. In patients with pectus excavatum complicated with scoliosis, it can progress after pectus excavatum repair. In this case, due to the background of tissue fragility associated with LDS, excessive spinal deformity occurred due to pectus excavatum repair.</p>

  • Access to Document (DOI)
  • CiNii Research

• Clinicopathological predictors of postoperative long-term myasthenic status in resected thymoma with myasthenia gravis

  Suzuki T., Hishida T., Suzuki S., Okubo Y., Masai K., Kaseda K., Asakura K., Emoto K., Asamura H.

  Surgery Today (Surgery Today)  54 ( 7 ) 787 - 794 2024.07

  ISSN  09411291

  　View Summary

  Purpose: Surgical patients with thymoma and myasthenia gravis (MG) must have their MG status and oncological outcomes critically monitored. We aimed to identify clinicopathological predictors of the postoperative MG status. Methods: We conducted a retrospective review of 40 consecutive surgical patients with MG-related thymomas between 2002 and 2020. The quantitative myasthenia gravis score (QMGS) and Myasthenia Gravis Foundation of America post-intervention status (MGFA-PIS) were used to evaluate postoperative MG status. Results: All patients underwent extended total thymectomy. The most common WHO type was type B2 (32%), while 65% of patients had type B1–B3 and 35% had type A–AB thymomas. Eleven patients (28%) achieved controlled MG status in MGFA-PIS 6 months after surgery. This controlled status was observed more frequently in type A–AB than in B1–B3 (57% vs. 12%, p = 0.007). In a multivariate analysis, WHO type (A–AB or B1–B3) was an independent predictor of worsening episodes of MG based on the QMGS (Type B1–B3, hazard ratio: 3.23, 95% confidence interval: 1.12–9.25). At the last follow-up, 23 patients (58%) achieved controlled MG status. The 5-year overall survival rate of all patients was 93.7%. Conclusion: The WHO type of thymoma is an informative predictor of postoperative MG status in patients with MG-related thymoma.

  • Access to Document (DOI)

• Glomus Tumor of Intrathoracic Chest Wall: a Case Report

  Ishiguro Yuki, Masai Kyohei, Sugino Kosuke, Yano Kaito, Nomura Rui, Okubo Yu, Kaseda Kaoru, Hishida Tomoyuki, Asakura Keisuke, Kurebayashi Yutaka, Minami Yuko

  Haigan (The Japan Lung Cancer Society)  64 ( 3 ) 208 - 209 2024.06

  ISSN  03869628

  　View Summary

  <p>40歳女性．左肺尖部に5.9 cm大の腫瘤影を認め，経皮的生検を行った所，カルチノイド腫瘍が疑われ，画像上は肺尖部胸壁浸潤癌を考え，手術の方針とした．胸腔内を観察すると腫瘍は胸壁から発生しており，胸壁腫瘍を切除した．病理では類円形核と好酸性の胞体を有する異型の弱い腫瘍細胞が増生し，形態像と免疫染色所見から胸壁発生のグロムス腫瘍と診断した．胸壁発生のグロムス腫瘍の報告は極めて少なく，文献的考察を加えて報告する．</p>

  • Access to Document (DOI)
  • CiNii Research

• Quality of life, psychological states, and personality traits in patients with pectus excavatum

  Matsuda K., Fujisawa D., Masai K., Miyazaki N., Suzuki S., Okubo Y., Kaseda K., Asakura K., Hishida T., Asamura H.

  JTCVS Open (JTCVS Open)  19   355 - 369 2024.06

  　View Summary

  Objective: The quality of life (QOL) and psychological states of patients with pectus excavatum (PE) have yet to be well understood. This study aimed to evaluate the health-related QOL (HRQOL), psychological states, and personality traits of patients with PE, alongside the associations of these factors with the severity of PE. Methods: A cross-sectional evaluation was prospectively performed in patients scheduled to undergo PE repair surgery between July 2019 and April 2021. The primary outcome was the patients’ HRQOL, and the secondary outcomes were depression, social anxiety, self-efficacy, and personality traits. Results: In total, 129 patients were subjected to analyses. Patients' HRQOL had a lower role component summary score (mean ± standard deviation: 41.8 ± 12.8, P < .001) than the general population controls. Patients' HRQOL had a significantly better physical component summary (54.0 ± 10.4, P < .001) and mental component summary (53.3 ± 8.8, P < .001) than that of the general population. Fourteen patients' (10.9%) and 56 patients' (43.4%) scores indicated the presence of depression and social anxiety disorder, respectively. Patients’ self-efficacy (46.1 ± 11.4, P, .001) and level of extraversion (46.5 ± 11.8, P < .001) were lower than those of the general population. No significant correlation was found between the severity of PE and these scores. Conclusions: Our study revealed that patients with PE had decreased social-role QOL, depressive tendencies, increased social anxiety, lower self-efficacy, and introversion. No correlation between the severity of PE and the patients’ psychological outcomes leads us to conclude that surgical implications of PE should not be decided solely by a physical index.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• 病理病期I期肺腺癌において血管内微小環境が術後再発へ与える影響

  Kaseda, Kaoru

  (慶應義塾大学大学院医学研究科)  2016

• 病理病期I期肺腺癌において血管内微小環境が術後再発へ与える影響

  Kaseda, Kaoru

  (慶應義塾大学大学院医学研究科)  2016

• 病理病期I期肺腺癌において血管内微小環境が術後再発へ与える影響

  Kaseda, Kaoru

  (慶應義塾大学大学院医学研究科)  2016

• Hemoglobin vesicles ameriolate allograft airway rejection

  Kaseda, Kaoru

  科学研究費補助金研究成果報告書 2013

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 上縦隔に発生した平滑筋肉腫の1切除例

  中井 猛斗, 菱田 智之, 青木 優介, 中山 和真, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 石黒 勇輝, 矢野 海斗, 大村 征司, 大久保 祐, 政井 恭兵, 加勢田 馨, 朝倉 啓介, 林 亮介, 川井田 みほ

  肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 260 - 260 2024.06

  ISSN  0386-9628

• 気胸発症を契機として発見された混合型大細胞神経内分泌癌の1切除例

  中山 和真, 加勢田 馨, 青木 優介, 中井 猛斗, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 石黒 勇輝, 矢野 海斗, 大久保 祐, 政井 恭兵, 菱田 智之, 朝倉 啓介, 紅林 泰

  肺癌 ((NPO)日本肺癌学会)  64 ( 3 ) 255 - 256 2024.06

  ISSN  0386-9628

• 肺癌に対する肺葉切除・区域切除後における栄養状態の比較検討

  青木 輝, 大久保 祐, 青木 優介, 中井 猛斗, 中山 和真, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 石黒 勇輝, 矢野 海斗, 政井 恭兵, 加勢田 馨, 菱田 智之, 朝倉 啓介

  日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  38 ( 3 ) MO40 - 4 2024.04

  ISSN  0919-0945

• 肺分画症8手術例の臨床病理学的特徴

  青木 優介, 政井 恭兵, 中井 猛斗, 中山 和真, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 青木 輝, 石黒 勇輝, 矢野 海斗, 大久保 祐, 加勢田 馨, 菱田 智之, 三浦 瑛祐, 朝倉 啓介

  日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  38 ( 3 ) MO4 - 5 2024.04

  ISSN  0919-0945

• 気胸再発における胸郭形態の影響

  中山 和真, 政井 恭兵, 青木 優介, 中井 猛斗, 櫻田 明久, 杉野 功祐, 渡邉 真祥, 青木 輝, 石黒 勇輝, 矢野 海斗, 大久保 祐, 加勢田 馨, 菱田 智之, 朝倉 啓介

  日本呼吸器外科学会雑誌 ((一社)日本呼吸器外科学会)  38 ( 3 ) O18 - 4 2024.04

  ISSN  0919-0945

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Development of the combination therapy with cryoablation and immune checkpoint inhibitor for lung cancer

  2016.04

  -

  2019.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Kaseda Kaoru, Grant-in-Aid for Young Scientists (B), No Setting

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  Cryotherapy and cryoimmunotherapy were performed to 1.5cm femoral tumor that originated from Lewis Lung Cancer cell. Histologically, the area of nonviable tumor was significantly increased in size in cryoimmunotherapy group than cryotherapy group (Average: 88% vs 73%). Our data suggest that cryoimmunotherapy is superior than cryotherapy in local control and the most effective route is local administration. On the other hand, there was no difference in the effectiveness of local control between these three immune checkpoint inhibitors.

• Hemoglobin vesicles ameriolate allograft airway rejection

  2012.04

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  2014.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, KASEDA Kaoru, Grant-in-Aid for Young Scientists (B), No Setting

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  Acute rejection after lung transplantation is the main risk factor for the development of bronchiolitis obliterans (BO). Hemoglobin-vesicles (HbV) have been developed for use as artificial oxygen carriers and this can provide anti-inflammatory effects and may serve to limit tissue injury in airway transplant. Here, we tested the ability of HbV to prevent airway rejection. Tracheal grafts from BALB/c or C57BL/6 were transplanted to C57BL/6 recipients. Experimental groups were treated with HbV. Histopathological evaluation of luminal obliteration was blindly reviewed. Immunohistochemistry and real-time RT-PCR analyses were performed. Allografts treated with HbV revealed a reduction of thickening in epithelial and subepithelial airway layers at day 7 in orthotopic trachea transplantation model compared with allografts treated with vehicle. There was also a concordant decrease in CD3+ lymphocytes and macrophages in HbV treated allografts.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• LECTURE SERIES, SURGERY

  2024

• LECTURE SERIES, SURGERY

  2023

• INTRODUCTION TO CLINICAL CLERKSHIPS

  2023

• CLINICAL TRAINING IN DIAGNOSIS

  2023

• LECTURE SERIES, SURGERY

  2022

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本呼吸器外科学会

  　

• 日本胸部外科学会

  　

• 日本呼吸器内視鏡学会

  　

• 日本肺癌学会

  　

• 日本臨床腫瘍学会

  　

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Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2021.04

  -

  Present

  日本呼吸器内視鏡学会評議員

• 2020.10

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  Present

  日本呼吸器外科学会評議員