Asakura, Keisuke

写真a

Affiliation

School of Medicine, Department of Surgery (General Thoracic Surgery) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

 

Papers 【 Display / hide

  • Histological and prognostic data on surgically resected early-stage lung adenocarcinoma.

    Yotsukura M, Asamura H, Suzuki S, Asakura K, Yoshida Y, Nakagawa K, Sakurai H, Watanabe SI, Motoi N

    Data in brief 31   105785 2020.08

    Research paper (scientific journal), Joint Work, Accepted

  • Prognostic impact of cancer-associated active fibroblasts and invasive architectural patterns on early-stage lung adenocarcinoma.

    Yotsukura M, Asamura H, Suzuki S, Asakura K, Yoshida Y, Nakagawa K, Sakurai H, Watanabe SI, Motoi N

    Lung cancer (Amsterdam, Netherlands) 145   158 - 166 2020.07

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0169-5002

  • Salvage surgery after chemotherapy and/or radiotherapy including SBRT and proton therapy: A consecutive analysis of 38 patients.

    Kobayashi AK, Horinouchi H, Nakayama Y, Ohe Y, Yotsukura M, Uchida S, Asakura K, Yoshida Y, Nakagawa K, Watanabe SI

    Lung cancer (Amsterdam, Netherlands) 145   105 - 110 2020.07

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0169-5002

  • A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy.

    Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, Sakamoto H, Kato K, Watanabe SI, Ochiya T

    Communications biology 3 ( 1 ) 134 2020.03

    Research paper (scientific journal), Joint Work, Accepted

  • Prognostic Impact of Tumor Doubling Time in Patients with Metachronous Lung Cancer

    Asakura K., Yoshida Y., Sakurai H., Nakagawa K., Motoi N., Watanabe S.

    World Journal of Surgery (World Journal of Surgery)  43 ( 12 ) 3259 - 3266 2019.12

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  03642313

     View Summary

    © 2019, Société Internationale de Chirurgie. Background: Good prognosis following surgery for metachronous lung cancer has been reported. However, prognostic factors have not been fully investigated. The purpose of this study was to identify the preoperative predictor of survival in metachronous lung cancer. Methods: Patients who underwent a second pulmonary resection for metachronous lung cancer at our institution between 2000 and 2014 were analyzed. Results: A retrospective chart review identified 86 eligible patients (of 6213; 1.4%). The 5-year overall survival was 77%. All 86 cancers met Martini and Melamed’s criteria for second primary cancer. However, on pathological examination based on morphological concordance between the initial and metachronous cancer, 73 (85%) cases were diagnosed as second primary cancer and 13 (15%) as a possible recurrent tumor. The 5-year overall survivals were 82% for second primary cancers and 52% for possible recurrent tumors. Tumor doubling time > 180 days (p < 0.001), pathological diagnosis of second primary cancer (p = 0.013), pathological stage IA (p = 0.016), interval between resections > 2 years (p = 0.040), and consolidation/tumor diameter ratio ≤ 0.5 (p = 0.045) were associated with superior overall survival. Multivariate Cox regression analysis identified tumor doubling time > 180 days as the only independent predictor of overall survival (hazard ratio 3.600, 95% confidence interval 1.226–10.338; p = 0.0196). Conclusions: Surgical resection for metachronous lung cancer is effective and feasible. Particularly, a tumor doubling time > 180 days is associated with superior survival in patients with metachronous lung cancer.

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Papers, etc., Registered in KOARA 【 Display / hide

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Presentations 【 Display / hide

  • 限局性悪性胸膜中皮腫の1例

    前田 智早, 菱田 智之, 加勢田 馨, 政井 恭兵, 朝倉 啓介, 淺村 尚生, 江本 桂, 林 雄一郎

    肺癌, 2020.04, Oral Presentation(general), (NPO)日本肺癌学会

  • 当院における椎体浸潤を伴う局所進行肺癌切除症例の検討

    松田 康平, 加勢田 馨, 政井 恭兵, 朝倉 啓介, 菱田 智之, 江本 桂, 林 雄一郎, 石井 賢, 淺村 尚生

    肺癌, 2019.11, Oral Presentation(general), (NPO)日本肺癌学会

  • 臨床病期I期肺癌疑いの病変に術前病理診断は必要か 治療転帰からの検討

    中込 貴博, 加勢田 馨, 鈴木 嵩弘, 前田 智早, 松田 康平, 大村 征司, 鈴木 幹人, 政井 恭兵, 朝倉 啓介, 菱田 智之, 淺村 尚生

    肺癌, 2019.11, Oral Presentation(general), (NPO)日本肺癌学会

  • 当院における原発性肺癌に対する解剖学的肺切除の治療成績 レジデント教育の視点から

    加勢田 馨, 政井 恭兵, 朝倉 啓介, 菱田 智之, 淺村 尚生

    肺癌, 2019.11, Oral Presentation(general), (NPO)日本肺癌学会

  • 当院における成熟奇形腫切除例の治療成績 腫瘍穿破が術後経過に及ぼす影響

    鈴木 嵩弘, 加勢田 馨, 政井 恭兵, 朝倉 啓介, 菱田 智之, 江本 桂, 林 雄一郎, 淺村 尚生

    肺癌, 2019.11, Oral Presentation(general), (NPO)日本肺癌学会

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • The cytostatic effects of zoledronic acid on ACC-MESO-1 cells

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 朝倉 啓介, Grant-in-Aid for Scientific Research (C), Principal Investigator

     View Summary

    Malignant pleural mesothelioma is widely resistant to therapies, and new treatment starategies are needed. We clarified that zoledronic acid reduces cell viavility and cell migration of human malignant pleural mesothelioma cells in vitro, and that induction of autophagic changes may at least in part be involved in this process.

 

Courses Taught 【 Display / hide

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2021

  • LECTURE SERIES, SURGERY

    2021

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2020

  • LECTURE SERIES, SURGERY

    2020

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2019