Fujino, Akihiro

写真a

Affiliation

School of Medicine, Department of Surgery (Pediatric Surgery) (Shinanomachi)

Position

Professor

External Links

Profile 【 Display / hide

  • Pediatric surgeon. General, digestive surgery and thoracic surgery in children. In particular, committed to clinical and basic research of lymphatic disease, mainly lymphangioma (lymphatic malformations).

Career 【 Display / hide

  • 2012.04
    -
    Present

    National Center for Child Health and Development, Department of Pediatric Surgery, 非常勤医師

  • 2007.10
    -
    Present

    National Center for Child Health and Development, Reproductive Cell Biology, 共同研究員

  • 2007.07
    -
    2012.03

    National Center for Child Health and Development, Department of Pediatric Surgery, 常勤医師

  • 2005.04
    -
    2007.06

    Massachusetts General Hospital, Pediatric Surgical Research Laboratories, Researcher

  • 2012.04
    -
    Present

    川崎市立川崎病院, 外科, 非常勤医師

Academic Background 【 Display / hide

  • 1990.04
    -
    1996.03

    Keio University, School of Medicine

    University, Graduated

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Dissertation, 2011.09

    Cell migration and activated PI3K/AKT-directed elongation in the developing rat Müllerian duct

Licenses and Qualifications 【 Display / hide

  • 医師免許, 1996.07

  • 日本小児外科学会指導医, 2012.04

  • 日本小児外科学会専門医, 2012.04

  • 日本外科学会外科専門医, 2009.12

  • 日本がん治療認定医機構がん治療認定医, 2013.04

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Research Areas 【 Display / hide

  • Life Science / General surgery and pediatric surgery

  • Life Science / Experimental pathology

  • Life Science / Anatomy

Research Keywords 【 Display / hide

  • lymphangioma

  • lymphatic malformation

  • lymphangiomatosis, generalized lymphatic anomaly

  • Müllerrian duct

  • Gorham's disease, Gorham-Stout Syndrome

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Proposed Theme of Joint Research 【 Display / hide

  • Regeneration of lymphatic vessel

    Interested in joint research with industry (including private organizations, etc.),  Desired form: Technical Consultation, Cooperative Research

     View Summary

    The purpose of the research is to overcome lymphatic malformations.

     View Message

    For lymphatic diseases caused by developmental abnormalities, removal of the lesion and induction of normal lymphatic vessel is required.

 

Papers 【 Display / hide

  • [Lymphangiomatosis and Gorham-Stout disease]

    Ozeki, M., Fujino, A., Matsuoka, K., Nosaka, S. and Fukao, T.

    Nihon Rinsho 73 ( 10 ) 1777 - 88 2015.10

    ISSN  0047-1852

     View Summary

    Lymphangiomatosis (recently renamed "generalized lymphatic anomaly") is a rare disease of unknown etiology that features an increase in the number of lymphatic vessels in many different tissues. Gorham-Stout disease(GSD) is a related disease characterized by lymphatic vessels involving the bones and resulting in progressive bone destruction. Respective definitions remain unclear because these conditions largely overlap in the clinical setting and are both associated with pleural effusion and other visceral lesions. These two conditions have recently been differentiated based on imaging findings. GSD is characterized by progressive osteolysis with loss of cortical bone. These diseases present considerable diagnostic and therapeutic challenges. Implementation of basic and clinical research is mandatory to improve understanding of these conditions and optimize management.

  • Catheter-related blood stream infection caused by Dermacoccus barathri, representing the first case of Dermacoccus infection in humans

    Takahashi Nobuhiro, Shinjoh Masayoshi, Tomita Hirofumi, Fujino Akihiro, Sugita Kayoko, Katohno Yasuhiro, Kuroda Tatsuo, Kikuchi Ken

    Journal of Infection and Chemotherapy 21 ( 8 ) 613 - 616 2015.08

    ISSN  1341-321X

     View Summary

    <p>A 7-year-old boy undergoing home parenteral nutrition with totally implantable central venous access device for chronic intestinal pseudo-obstruction experienced repeated episodes of fever with a temperature above 39.0°C despite the antibiotic treatment. The fever was considered to be catheter-related blood stream infections, as no other etiology could be justified. Repeated blood culture tests revealed negative after 1-week incubation, whereas some samples of blood collected from the central venous catheter yielded positive and gram-positive rods were detected. These bacteria were detected repeatedly, then the central venous access device was removed with consideration for the possibility of this bacteria being a pathogen. Thereafter, the fever did not recur and the blood culture tests were negative. The causative agent was identified as Dermacoccus barathri based on the 16S rRNA gene sequence and phylogenetic analysis of 6118-bp concatenated sequences of 4 housekeeping genes. Genus Dermacoccus are one form of Actinomycetes isolated from human skin and water, but human infection with Dermacoccus spp. has not been previously reported and the pathogenicity of the bacteria remains unclear. To our knowledge, this is the first reported case of Dermacoccus infection in humans.</p>

  • 過小グラフト症候群様の経過をたどり近位脾動脈塞栓術が有効であった小児生体部分肝移植後の1例

    高橋, 信博, 星野, 健, 石濱, 秀雄, 藤村, 匠, 富田, 紘史, 藤野, 明浩, 篠田, 昌宏, 北川, 雄光 and 黒田, 達夫

    日本小児外科学会雑誌 51 ( 5 ) 905 - 909 2015.08

    ISSN  0288-609X

     View Summary

    17歳男性。原因不明の肝硬変に対し生体部分肝移植術を行った(左葉グラフト、GRWR 1.05)。術後早期より胆汁うっ滞、凝固異常、多量の胸腹水、汎血球減少を認め、連日輸血を必要とした。移植後7日の肝生検で胆汁うっ滞と小葉中心性肝壊死を認めた。超音波検査にて肝動脈の流速低下、拍動係数上昇を認め、過小グラフト症候群に類似した病態を呈していると考え、移植後37日に近位脾動脈塞栓術を行ったところ肝動脈血流は著明に改善した。肝機能は徐々に改善し、移植後93日に軽快退院となった。過小グラフト症候群はグラフトのサイズが機能的な需要に対し不十分な状態で、門脈過還流が本態とされる。リスクが高い場合には予防的に脾摘や脾動脈結紮による門脈血流調節が行われる。本症例ではグラフト重量は充分で発症を予測できなかったが、診断的治療として血管造影、近位脾動脈塞栓術を施行し、低侵襲に状態を改善させることが可能であった。(著者抄録)

  • Pancreatic desmoid tumor in a 4-year-old male with hemihypertrophy

    Saida Ken, Miyazaki Osamu, Matsuoka Kentaro, Watanabe Toshihiko, Fujino Akihiro, Nosaka Shunsuke

    Journal of Pediatric Surgery Case Reports 3 ( 8 ) 344 - 347 2015.07

     View Summary

    <p>We report the first case of a pancreatic desmoid tumor detected during follow-up for hemihypertrophy in a 4-year-old boy. Hemihypertrophy is a rare disorder in which one side of the body grows more than the other, causing asymmetry, and well-known complications include embryonal tumors. However, there has been no report of desmoid tumors in patients with hemihypertrophy, and these tumors are rare and poorly characterized in the literature, especially the cystic variant. For this patient, the lesion was diagnosed as a desmoid tumor based on immunostaining positive for beta-catenin and mutation of the beta-catenin gene (CTNNB1). This case suggests that desmoid tumors should be considered a possible etiology of pancreatic cystic lesions in patients with hemihypertrophy.</p>

  • 【トランジション】 鎖肛術後の直腸尿道瘻

    清水, 隆弘, 藤野, 明浩, 阿部, 陽友, 高橋, 信博, 石濱, 秀雄, 狩野, 元宏, 藤村, 匠, 加藤, 源俊, 山田, 洋平, 星野, 健 and 黒田, 達夫

    小児外科 47 ( 7 ) 700 - 703 2015.07

    ISSN  0385-6313

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 肝巨大血管腫 全国調査から標準化治療へ

    Fujino Akihiro

    第31回日本小児外科学会秋季シンポジウム, 

    2015.10

    Oral presentation (invited, special)

  • リンパ管腫(嚢胞性リンパ管奇形)の治療標準化について

    Fujino Akihiro

    第31回日本小児外科学会秋季シンポジウム (熊本) , 

    2015.10

    Symposium, workshop panel (nominated), 日本小児外科学会

  • リンパ管腫(リンパ管奇形)とリンパ管腫症に対する新しい薬物療法の選択肢

    Fujino Akihiro

    第31回日本小児外科学会秋季シンポジウム, 

    2015.10

    Oral presentation (invited, special)

  • 難治性胸腹水を呈するリンパ管関連疾患の外科的治療

    Fujino Akihiro

    第31回日本小児外科学会秋季シンポジウム, 

    2015.10

    Oral presentation (general)

  • 日本のリンパ管腫患者に対する硬化療法の検討-平成21-23年度厚生労働省難治性疾患克服研究事業結果報告-

    Fujino Akihiro

    第31回日本小児外科学会秋季シンポジウム (熊本) , 

    2015.10

    Oral presentation (general), 日本小児外科学会

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Biological analysis for elucidation of pathogenesis of lymphangioma using human and mouse lymphangioma model

    2015.04
    -
    2019.03

    Grant-in-Aid for Scientific Research, Research grant, Principal investigator

  • Research for establishing clinical guidelines, and for the clinical application of pathological and cell biological findings of congenital lymphatic diseases

    2014.06
    -
    Present

    日本医療研究開発機構, Health and Labour Sciences Research Grants, Research grant, Principal investigator

Awards 【 Display / hide

  • Best Poster Award at the 4th World Congress of the WOFAPS 2013

    2013.10, The World Federation of Associations of Pediatric Surgeons, The clinical criteria for 'intractable' lymphangioma led by Japanese pediatric surgeons

    Type of Award: International academic award (Japan or overseas)

  • 平成23年度刀林賞

    2012.06, 慶應義塾大学医学部外科同窓会, リンパ管腫内リンパ液動態の検討

    Type of Award: Keio commendation etc.

     View Description

    リンパ管腫内リンパ液動態の検討

  • 第45回日本小児外科学会学術集会 ベストポスター会長賞

    2008.05, The Japanese Society of Pediatric Surgeons, ヒトリンパ管腫モデル動物の作成

    Type of Award: Award from Japanese society, conference, symposium, etc.

 

Courses Taught 【 Display / hide

  • SURGERY: SEMINAR

    2023

  • SURGERY: PRACTICE

    2023

  • SURGERY

    2023

  • ADVANCED SURGERY

    2023

Courses Previously Taught 【 Display / hide

  • 外科学(小児)

    Keio University

    2015.04
    -
    2016.03

    Spring Semester

  • Pediatric Surgery

    Keio University

    2015.04
    -
    2016.03

    Spring Semester, Lecture, Within own faculty, 1h, 100people

    pediatric surgery

  • Pediatric Surgery

    Keio University

    2013.04
    -
    2014.03

    Spring Semester, Lecture, Within own faculty, 1h, 100people

    pediatric surgery

 

Memberships in Academic Societies 【 Display / hide

  • The Japanese Society of Pediatric Surgeons, 

    1999
    -
    Present
  • Japan Surgical Society, 

    1996
    -
    Present
  • Japanese Society of Pediatric Hematology/ Oncology, 

    2002
    -
    Present
  • The Japanese Society of Lymphology, 

    2008
    -
    Present
  • Japanese Society of Emergency Pediatrics, 

    2014
    -
    Present

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Committee Experiences 【 Display / hide

  • 2015.08
    -
    Present

    規約委員会, 特定非営利活動法人 日本小外科学会

  • 2015.08
    -
    Present

    庶務委員会, 特定非営利活動法人 日本小児外科学会

  • 2015.04
    -
    Present

    自動車乗車中の子どもの安全推進合同委員会, 特例社団法人 日本小児保健協会

  • 2014.11
    -
    Present

    邦文誌編集委員会, 一般社団法人 日本外科学会

  • 2013
    -
    Present

    データベース委員会, 特定非営利活動法人 日本小児外科学会

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