Kitago, Minoru

写真a

Affiliation

School of Medicine, Department of Surgery (General and Gastroenterological Surgery) (Shinanomachi)

Position

Associate Professor

Related Websites

External Links
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Career 【 Display / hide 】

  • 1995.05
    -
    1997.04

    慶應義塾大学医学部研修医

  • 1995.05
    -
    1997.04

    慶應義塾大学医学部研修医

  • 1996.05
    -
    1997.05

    宇都宮済生会病院

  • 1996.05
    -
    1997.05

    宇都宮済生会病院

  • 1997.05
    -
    1999.04

    慶應義塾大学医学部（専修医）

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Academic Degrees 【 Display / hide 】

  • K-ras点突然変異分布からみた膵管内乳頭腫瘍及び通常型膵管癌の特徴, Keio University, Dissertation, 2002.09

    Comparison of K-ras point mutation distributions in intraductal papillary-mucinous tumors and ductal adenocarcinoma of the pancreas

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Papers 【 Display / hide 】

  • ASO Author Reflections: Indication Criteria for Neoadjuvant Therapy for Resectable Pancreatic Ductal Adenocarcinoma.

    Shimane G, Kitago M, Kitagawa Y

    Annals of surgical oncology 32 ( 4 ) 2866 - 2867 2025.04

    ISSN  1068-9265

  • Clinical Impact of Neoadjuvant Therapy for Resectable Pancreatic Ductal Adenocarcinoma: A Single-Center Retrospective Study.

    Shimane G, Kitago M, Yagi H, Abe Y, Hasegawa Y, Hori S, Tanaka M, Tsuzaki J, Yokoyama Y, Masugi Y, Takemura R, Kitagawa Y

    Annals of surgical oncology 32 ( 4 ) 2830 - 2840 2025.04

    ISSN  1068-9265

    　View Summary

    Background: Neoadjuvant therapy is recommended for treating resectable pancreatic ductal adenocarcinoma (PDAC); however, its appropriate use in patients with resectable PDAC remains debatable. Objective: This study aimed to identify independent poor prognostic factors and evaluate the clinical significance of neoadjuvant therapy in patients with resectable PDAC. Methods: We retrospectively reviewed consecutive patients diagnosed with resectable PDAC at our institute between January 2003 and December 2022. We analyzed poor prognostic factors at the time of diagnosis in patients who underwent upfront surgery using the Cox proportional hazards model for overall survival (OS). The prognostic score was calculated by adding the individual prognostic factor scores. Results: Overall, 359 patients were included in this study, with 308 patients undergoing upfront surgery and the remaining 51 patients receiving neoadjuvant therapy. The R0 resection rate was significantly higher in the neoadjuvant therapy group (70.6%) than in the upfront surgery group (64.0%). Multivariate analysis in the upfront surgery group revealed the following independent poor prognostic factors: tumor size ≥ 35 mm, serum albumin level ≤.5 g/dL, neutrophil-to-lymphocyte ratio ≥ 3.5, carbohydrate antigen 19-9 level ≥ 250 U/mL, and Duke pancreatic monoclonal antigen type 2 level ≥ 750 U/mL. Among patients with prognostic scores of 0–1 (n = 263), the intention-to-treat OS did not significantly differ between the neoadjuvant therapy and upfront surgery groups. Among those patients with a prognostic score of ≥ 2 (n = 96), the neoadjuvant therapy group had significantly longer intention-to-treat OS than the upfront surgery group. Conclusions: Prognostic score-based stratification can help identify patients who could benefit from neoadjuvant therapy.

  • Potential New Tumors Associated with Hereditary Breast and Ovarian Cancer (HBOC).

    Nakamura K, Masuda K, Seki T, Kitago M, Kosaka T, Goto Y, Yamada M, Misu K, Ono I, Kobayashi Y, Yamagami W

    The Keio journal of medicine  2025.03

    ISSN  0022-9717

  • ASO Visual Abstract: The Composite Endpoint of Liver Surgery CELS-Development and Validation of a Clinically Relevant Endpoint Requiring Lower Sample Size.

    Kawashima J, Akabane M, Endo Y, Woldesenbet S, Khalil M, Sahara K, Ruzzenente A, Aldrighetti L, Bauer TW, Marques HP, Lopes R, Oliveira S, Martel G, Popescu I, Weiss MJ, Kitago M, Poultsides G, Sasaki K, Maithel SK, Hugh T, Gleisner A, Aucejo F, Pulitano C, Shen F, Cauchy F, Koerkamp BG, Endo I, Pawlik TM

    Annals of surgical oncology  2025.03

    ISSN  1068-9265

  • ASO Visual Abstract: The Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma.

    Kawashima J, Endo Y, Woldesenbet S, Khalil M, Akabane M, Cauchy F, Shen F, Maithel S, Popescu I, Kitago M, Weiss MJ, Martel G, Pulitano C, Aldrighetti L, Poultsides G, Ruzzente A, Bauer TW, Gleisner A, Marques H, Koerkamp BG, Endo I, Pawlik TM

    Annals of surgical oncology  2025.03

    ISSN  1068-9265

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 外部講師による中学校がん教育支援の有効性

    堀 周太郎, 上村 翔, 北郷 実, 平田 賢郎, 大家 基継, 北川 雄光

    日本癌治療学会学術集会抄録集, 

    2024.10
    , 

    (一社)日本癌治療学会

  • 肝胆膵手術における感染性合併症対策　予防と治療　膵頭部癌術後における臓器/体腔手術部位感染(organ SSI)と腹腔内脂肪量の関連性の検討

    上村 翔, 北郷 実, 尾原 秀明, 八木 洋, 阿部 雄太, 長谷川 康, 堀 周太郎, 田中 真之, 清島 亮, 中野 容, 竹内 優志, 北川 雄光

    日本外科感染症学会雑誌, 

    2024.10
    , 

    (一社)日本外科感染症学会

  • 造影CT検査では同定困難であったインスリノーマの1例

    大曽根 史織, 木内 謙一郎, 浅井 愛未, 水谷 洋佑, 中村 俊文, 田村 全, 中塚 誠之, 北郷 実, 林 香

    日本内分泌学会雑誌, 

    2024.10
    , 

    (一社)日本内分泌学会

  • ACLF、High MELDなど重症症例に対する肝移植の適応限界　慢性肝疾患患者が肝移植により長期生存を得るために

    長谷川 康, 尾原 秀明, 篠田 昌宏, 高岡 千恵, 阿部 雄太, 山田 洋平, 北郷 実, 八木 洋, 堀 周太郎, 田中 真之, 中野 容, 尾城 啓輔, 中本 伸宏, 藤野 明浩, 北川 雄光

    移植, 

    2024.09
    , 

    (一社)日本移植学会

  • 肝移植後長期経過症例(10年以上)における問題点と課題　肝移植後長期生存例における悪性腫瘍発生についての検討

    山口 諒, 長谷川 康, 尾原 秀明, 北郷 実, 八木 洋, 阿部 雄太, 山田 洋平, 堀 周太郎, 田中 真之, 中野 容, 藤野 明浩, 北川 雄光

    移植, 

    2024.09
    , 

    (一社)日本移植学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Early diagnosis and optimal treatment of pancreatic cancer through an integrated comprehensive approach

    2024.04
    -
    2027.03

    北郷 実, 基盤研究(C), Principal investigator

  • Experimental study for the clinical application of cryosurgery for pancreatic tumors

    2015.04
    -
    2018.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 北郷 実, Grant-in-Aid for Scientific Research (C), Principal investigator

    　View Summary

    The treatment of pancreatic tumor is mainly surgery. However, pancreatic resection involves a high perioperative complication rate. Cryoablation is a potentially less invasive locoregional ablation modality that has been used to treat malignancy in various organs. We conducted experiments to evaluate the efficacy and safety of this method.
    The experiments included assessment of acute-phase response, procedural availability, and evaluation of postprocedural course. Cryoablation of porcine pancreas was technically practicable by both open and laparoscopic approaches. Histological findings proved that the pancreatic tissue was effectively necrotized by cryoablation and that the degree of necrosis was more severe in proportion to the distance from the freeze center. Serum amylase and lipase levels showed transient elevations shortly after the procedure, followed by rapid decrease to normal level, indicating that the cyroablation of the pancreas did not cause severe pancreatitis.

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Courses Taught 【 Display / hide 】

  • PATHOPHYSIOLOGY FOR ACUTE CARE

    2024

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2024

  • LECTURE SERIES, SURGERY

    2024

  • CLINICAL CLERKSHIP IN GENERAL AND GASTROINTESTINAL SURGERY

    2024

  • PATHOPHYSIOLOGY FOR ACUTE CARE

    2023

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Courses Previously Taught 【 Display / hide 】

  • PATHOPHYSIOLOGY FOR ACUTE CARE

    Keio University

    2024.04
    -
    2025.03

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    Keio University

    2024.04
    -
    2025.03

  • LECTURE SERIES, SURGERY

    Keio University

    2024.04
    -
    2025.03

  • CLINICAL CLERKSHIP IN GENERAL AND GASTROINTESTINAL SURGERY

    Keio University

    2024.04
    -
    2025.03

  • PATHOPHYSIOLOGY FOR ACUTE CARE

    Keio University

    2023.04
    -
    2024.03

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Memberships in Academic Societies 【 Display / hide 】

  • 日本癌治療学会

    　

  • 日本癌学会

    　

  • 日本内視鏡外科学会

    　

  • 日本膵臓学会

    　

  • 日本胆道学会

    　

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