目黒 周 (メグロ シュウ)

Meguro, Shu

写真a

所属(所属キャンパス)

医学部 内科学教室(腎臓・内分泌・代謝) (信濃町)

職名

専任講師

メールアドレス

メールアドレス

経歴 【 表示 / 非表示

  • 1993年04月
    -
    1995年03月

    慶應義塾大学病院 内科研修医

  • 1995年04月
    -
    1997年03月

    慶應義塾大学医学部内科学教室 助手

  • 1997年04月
    -
    2001年06月

    慶應義塾大学医学部 腎臓内分泌代謝内科 助手

  • 2001年07月
    -
    2010年06月

    東京都済生会中央病院

  • 2010年07月
    -
    2012年03月

    慶應義塾大学医学部 腎臓内分泌代謝内科 助教

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学歴 【 表示 / 非表示

  • 1993年03月

    北海道大学, 医学部

    大学, 卒業

学位 【 表示 / 非表示

  • 医学博士, 慶應義塾, 論文, 2003年

免許・資格 【 表示 / 非表示

  • 日本内科学会 総合内科専門医, 2006年12月

  • 日本糖尿病学会 専門医, 2009年04月

 

研究分野 【 表示 / 非表示

  • 代謝学 (Metabolism Studies)

  • 内分泌学

 

論文 【 表示 / 非表示

  • Efficacy and safety of switching to insulin glargine 300 U/mL from 100 U/mL in Japanese patients with type 2 diabetes: A 12-month retrospective analysis

    Sugiyama K., Meguro S., Saisho Y., Irie J., Tanaka M., Itoh H.

    Heliyon (Heliyon)  5 ( 2 )  2019年02月

    ISSN  24058440

     概要を見る

    © 2019 The Authors Aims: To evaluate the efficacy and safety of switching to insulin glargine 300 U/mL (Gla-300) from insulin glargine 100 U/mL (Gla-100) in Japanese patients with type 2 diabetes (T2DM). Methods: This was a 12-month retrospective study comprising 109 patients. Primary endpoint was glycated hemoglobin (HbA1c) level at month 12. Secondary endpoints were hypoglycemia for the overall study period as well as body weight and insulin dose at month 12. Results: Similar glycemic control was achieved with mean (standard deviation) HbA1c level of 7.7 (1.1)% (61 [12] mmol/mol) at baseline and 7.7 (1.3)% (61 [14] mmol/mol) at month 12. Fewer confirmed (<3.0 mmol/L [< 54 mg/dL]) or severe hypoglycemic events were observed (0.52 vs. 0.85 events per patient-year; rate ratio 0.61; 95% confidence interval 0.38–0.97; p = 0.037), but the percent of patients experiencing ≥1 hypoglycemic event did not differ. There was no difference in confirmed (≤3.9 mmol/L [≤ 70 mg/dL]) or severe hypoglycemia and nocturnal hypoglycemia. Conclusions: In Japanese patients with T2DM who switched to Gla-300 from Gla-100, similar glycemic control was achieved with fewer confirmed (<3.0 mmol/L [< 54 mg/dL]) or severe hypoglycemic events over a 12-month period, although the absolute benefit was marginal.

  • Difference of seasonal variation between glycated albumin and glycated haemoglobin

    Tanaka K., Meguro S., Tanaka M., Irie J., Saisho Y., Itoh H.

    Annals of Clinical Biochemistry (Annals of Clinical Biochemistry)  55 ( 5 ) 583 - 587 2018年09月

    ISSN  00045632

     概要を見る

    © The Author(s) 2018. Background: Glycated albumin reflects 2–3-week glycaemic controls, and in addition to glycated haemoglobin, it has been used as a glycaemic control indicator. We presumed that glycated albumin also has seasonal variations and is related to temperature, similar to glycated haemoglobin. Methods: The subjects were diabetic outpatients from April 2007 to March 2013. This resulted in the enrolment of 2246 subjects and the collection of a total of 53,968 measurements. Mean glycated haemoglobin, glycated albumin, and plasma glucose were calculated for each month over six years. The associations of the measures with each other and the average temperature for each month in Tokyo were assessed using Spearman rank correlation coefficients. Results: Plasma glucose was highest in January and lowest in May. Glycated haemoglobin was highest in March and lowest in September. Glycated albumin was highest in May and lowest in December. Glycated albumin tended to have a disjunction with plasma glucose in winter. Glycated haemoglobin had seasonal variation, but glycated albumin did not. Plasma glucose and glycated haemoglobin showed significant negative correlations with temperature (rs = −0.359, P < 0.001, rs = −0.449, P < 0.001, respectively), but glycated albumin did not. However, glycated albumin was inter-correlated with plasma glucose (rs = 0.396, P < 0.001) and glycated haemoglobin (rs = 0.685, P < 0.001), and glycated haemoglobin was inter-correlated with plasma glucose (rs = 0.465, P < 0.001). Conclusion: Glycated albumin and glycated haemoglobin showed different seasonal variations from each other over the six-year study period. Thus, further studies to identify factors that contribute to glycated albumin are needed.

  • Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

    目黒 周

    JOURNAL OF DIABETES RESEARCH    2512 - 2514 2017年

    研究論文(学術雑誌),  ISSN  2314-6745

  • Increased grip strength with sodium-glucose cotransporter 2

    目黒 周

    JOURNAL OF DIABETES 8 ( 5 ) 736 - 737 2016年09月

    研究論文(学術雑誌),  ISSN  1753-0393

  • A case of autoimmune polyendocrine syndrome type I with strong positive GAD antibody titer, followed up with glucose tolerance measured by oral glucose tolerance test

    目黒 周

    NEUROENDOCRINOLOGY LETTERS 37 ( 8 ) 540 - 542 2016年

    研究論文(学術雑誌),  ISSN  0172-780X

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

総説・解説等 【 表示 / 非表示

 

担当授業科目 【 表示 / 非表示

  • 慢性期病態学各論

    2019年度

  • 内科学(腎臓・内分泌・代謝)講義

    2019年度

  • 内科学講義

    2019年度

  • 内科ケーススタディー

    2019年度

担当経験のある授業科目 【 表示 / 非表示

  • 内科学(腎臓内分泌代謝)

    慶應義塾, 2017年度, 通年, 専門科目, 講義

  • 内科学臨床実習アドバンスト 腎臓内分泌代謝

    慶應義塾, 2015年度, 春学期, 専門科目, 実習・実験

  • 内科学「腎臓・内分泌・代謝」 糖尿病(薬物療法(インクレチン、インスリン含む)

    慶應義塾, 2015年度, 春学期, 専門科目, 講義, 専任