Meguro, Shu



School of Medicine, Department of Internal Medicine (Nephrology, Endocrinology and Metabolism) (Shinanomachi)


Assistant Professor/Senior Assistant Professor

E-mail Address

E-mail address

Career 【 Display / hide

  • 1993.04

    慶應義塾大学病院 内科研修医

  • 1995.04

    慶應義塾大学医学部内科学教室 助手

  • 1997.04

    慶應義塾大学医学部 腎臓内分泌代謝内科 助手

  • 2001.07


  • 2010.07

    慶應義塾大学医学部 腎臓内分泌代謝内科 助教

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Academic Background 【 Display / hide

  • 1993.03

    Hokkaido University, Faculty of Medicine

    University, Graduated

Academic Degrees 【 Display / hide

  • 医学博士, Keio University, Dissertation, 2003

Licenses and Qualifications 【 Display / hide

  • fellow of the Japanese Society of Internal Medicine, 2006.12

  • 日本糖尿病学会 専門医, 2009.04


Research Areas 【 Display / hide

  • Metabolomics (Metabolism Studies)

  • Endocrinology


Papers 【 Display / hide

  • Efficacy and safety of switching to insulin glargine 300 U/mL from 100 U/mL in Japanese patients with type 2 diabetes: A 12-month retrospective analysis

    Sugiyama K., Meguro S., Saisho Y., Irie J., Tanaka M., Itoh H.

    Heliyon (Heliyon)  5 ( 2 )  2019.02

    ISSN  24058440

     View Summary

    © 2019 The Authors Aims: To evaluate the efficacy and safety of switching to insulin glargine 300 U/mL (Gla-300) from insulin glargine 100 U/mL (Gla-100) in Japanese patients with type 2 diabetes (T2DM). Methods: This was a 12-month retrospective study comprising 109 patients. Primary endpoint was glycated hemoglobin (HbA1c) level at month 12. Secondary endpoints were hypoglycemia for the overall study period as well as body weight and insulin dose at month 12. Results: Similar glycemic control was achieved with mean (standard deviation) HbA1c level of 7.7 (1.1)% (61 [12] mmol/mol) at baseline and 7.7 (1.3)% (61 [14] mmol/mol) at month 12. Fewer confirmed (<3.0 mmol/L [< 54 mg/dL]) or severe hypoglycemic events were observed (0.52 vs. 0.85 events per patient-year; rate ratio 0.61; 95% confidence interval 0.38–0.97; p = 0.037), but the percent of patients experiencing ≥1 hypoglycemic event did not differ. There was no difference in confirmed (≤3.9 mmol/L [≤ 70 mg/dL]) or severe hypoglycemia and nocturnal hypoglycemia. Conclusions: In Japanese patients with T2DM who switched to Gla-300 from Gla-100, similar glycemic control was achieved with fewer confirmed (<3.0 mmol/L [< 54 mg/dL]) or severe hypoglycemic events over a 12-month period, although the absolute benefit was marginal.

  • Difference of seasonal variation between glycated albumin and glycated haemoglobin

    Tanaka K., Meguro S., Tanaka M., Irie J., Saisho Y., Itoh H.

    Annals of Clinical Biochemistry (Annals of Clinical Biochemistry)  55 ( 5 ) 583 - 587 2018.09

    ISSN  00045632

     View Summary

    © The Author(s) 2018. Background: Glycated albumin reflects 2–3-week glycaemic controls, and in addition to glycated haemoglobin, it has been used as a glycaemic control indicator. We presumed that glycated albumin also has seasonal variations and is related to temperature, similar to glycated haemoglobin. Methods: The subjects were diabetic outpatients from April 2007 to March 2013. This resulted in the enrolment of 2246 subjects and the collection of a total of 53,968 measurements. Mean glycated haemoglobin, glycated albumin, and plasma glucose were calculated for each month over six years. The associations of the measures with each other and the average temperature for each month in Tokyo were assessed using Spearman rank correlation coefficients. Results: Plasma glucose was highest in January and lowest in May. Glycated haemoglobin was highest in March and lowest in September. Glycated albumin was highest in May and lowest in December. Glycated albumin tended to have a disjunction with plasma glucose in winter. Glycated haemoglobin had seasonal variation, but glycated albumin did not. Plasma glucose and glycated haemoglobin showed significant negative correlations with temperature (rs = −0.359, P < 0.001, rs = −0.449, P < 0.001, respectively), but glycated albumin did not. However, glycated albumin was inter-correlated with plasma glucose (rs = 0.396, P < 0.001) and glycated haemoglobin (rs = 0.685, P < 0.001), and glycated haemoglobin was inter-correlated with plasma glucose (rs = 0.465, P < 0.001). Conclusion: Glycated albumin and glycated haemoglobin showed different seasonal variations from each other over the six-year study period. Thus, further studies to identify factors that contribute to glycated albumin are needed.

  • Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

    Fujii, Chikako, Kawai, Toshihide, Azuma, Koichiro, Oguma, Yuko, Katsukawa, Fuminori, Hirose, Hiroshi, Tanaka, Kumiko, Meguro, Shu, Matsumoto, Hideo, Itoh, Hiroshi

    JOURNAL OF DIABETES RESEARCH    2512 - 2514 2017

    Research paper (scientific journal),  ISSN  2314-6745

  • Increased grip strength with sodium-glucose cotransporter 2

    Sano, Motoaki, Meguro, Shu, Kawai, Toshihide, Suzuki, Yoshihiko

    JOURNAL OF DIABETES 8 ( 5 ) 736 - 737 2016.09

    Research paper (scientific journal),  ISSN  1753-0393

  • A case of autoimmune polyendocrine syndrome type I with strong positive GAD antibody titer, followed up with glucose tolerance measured by oral glucose tolerance test

    Murakami, Rie, Kawai, Toshihide, Meguro, Shu, Hayashi, Matsuhiko, Itoh, Hiroshi

    NEUROENDOCRINOLOGY LETTERS 37 ( 8 ) 540 - 542 2016

    Research paper (scientific journal),  ISSN  0172-780X

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide


Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • Internal medicine

    Keio University, 2017, Full academic year, Major subject, Lecture

  • 内科学臨床実習アドバンスト 腎臓内分泌代謝

    Keio University, 2015, Spring Semester, Major subject, Laboratory work/practical work/exercise

  • 内科学「腎臓・内分泌・代謝」 糖尿病(薬物療法(インクレチン、インスリン含む)

    Keio University, 2015, Spring Semester, Major subject, Lecture, Within own faculty


Memberships in Academic Societies 【 Display / hide

  • Japan Diabetes Society

  • Japan Endocrine Society

  • Japanese Society of Internal Medicine