論文 - 伊藤　裕

TRANSARTERIAL EMBOLIZATION, THORACIC SPINE DECOMPRESSION AND FUSION OF METASTATIC PHEOCHROMOCYTOMA: A CASE REPORT.

Kinouchi, K; Mizutani, Y; Nakamura, T; Yamaguchi, S; Homma, K; Kobayashi, S; Miyashita, K; Kurihara, I; Shibata, H; Itoh, H

JOURNAL OF HYPERTENSION 41   E437 - E438 2023年01月

ISSN  0263-6352

THE IMPACT OF ANTIHYPERTENSIVE DRUG USE ON INTRADIALYTIC BLOOD PRESSURE DECLINE CONSIDERING SEASONAL VARIATION: A RETROSPECTIVE COHORT STUDY

Uchiyama, K; Washida, N; Shibagaki, K; Yanai, A; Nakayama, T; Morimoto, K; Itoh, H

JOURNAL OF HYPERTENSION 41   E386 - E386 2023年01月

ISSN  0263-6352

SLEEP SCORE AMONG HEALTH-RELATED QUALITY OF LIFE SUBSCALES PREDICTS TECHNIQUE SURVIVAL IN PATIENTS WITH PERITONEAL DIALYSIS

Nagasaka, T; Uchiyama, K; Hama, EY; Kusahana, E; Nakayama, T; Yasuda, I; Morimoto, K; Washida, N; Itoh, H

JOURNAL OF HYPERTENSION 41   E385 - E385 2023年01月

ISSN  0263-6352

SIGNIFICANCE OF PODOCYTE DNA DAMAGE AND GLOMERULAR DNA METHYLATION IN CKD WITH PROTEINURIA

Yoshimoto, N; Hayashi, K; Hishikawa, A; Nakamichi, R; Sugita, E; Yoshida, E; Hashiguchi, A; Itoh, H

JOURNAL OF HYPERTENSION 41   E417 - E417 2023年01月

ISSN  0263-6352

SEASONAL VARIATION IN PREDIALYSIS SYSTOLIC BLOOD PRESSURE AND CARDIOVASCULAR EVENTS IN JAPANESE MAINTENANCE HEMODIALYSIS PATIENTS

Uchiyama, K; Washida, N; Shibagaki, K; Yanai, A; Nakayama, T; Takahashi, R; Morimoto, K; Itoh, H

JOURNAL OF HYPERTENSION 41   E386 - E386 2023年01月

ISSN  0263-6352

RENAL FUNCTION AND URINARY PROTEIN 1 YEAR AFTER INITIATION OF ESAXERENONE

Aoyama, K; Nakajima, Y; Meguro, S; Itoh, H

JOURNAL OF HYPERTENSION 41   E403 - E403 2023年01月

ISSN  0263-6352

RECURRENCE OF RENAL ARTERY STENOSIS BY PONATINIB, A MULTI-TARGETED TYROSINEKINASE INHIBITOR

Kusahana, E; Wakino, S; Kanda, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E351 - E351 2023年01月

ISSN  0263-6352

PERFORMANCE OF PREDICTION ALGORITHM FOR THE SUBTYPE DIAGNOSIS OF PRIMARY ALDOSTERONISM WHICH WAS ADVOCATED IN THE JAPAN PRIMARY ALDOSTERONISM STUDY

Kobayashi, S; Kurihara, I; Yokota, K; Kinouchi, K; Nakamura, T; Miyashita, K; Itoh, H

JOURNAL OF HYPERTENSION 41   E402 - E402 2023年01月

ISSN  0263-6352

PEDIATRIC BLOOD PRESSURE CATEGORY PREDICTS LONGITUDINAL VARIABILITY IN BLOOD PRESSURE IN YOUTH

Azegami, T; Uchida, K; Sato, Y; Takeda, A; Inokuchi, M; Itoh, H; Mori, M

JOURNAL OF HYPERTENSION 41   E321 - E321 2023年01月

ISSN  0263-6352

PARTIAL ADRENALECTOMY IN A PATIENT WITH ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA: A CASE REPORT.

Takebayashi, S; Irie, J; Kurihara, I; Kobayashi, S; Miyashita, K; Kinouchi, K; Nakamura, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E438 - E438 2023年01月

ISSN  0263-6352

ONE-YEAR TIME-SERIES OBSERVATIONS OF VARIABLE COMPONENTS OF URINE PROTEIN AND EGFR PREDICT WORSENING RENAL FUNCTION IN TYPE 2 DIABETES

Watanabe, M; Meguro, S; Kimura, K; Furukoshi, M; Masuda, T; Enomoto, M; Itoh, H

JOURNAL OF HYPERTENSION 41   E381 - E381 2023年01月

ISSN  0263-6352

Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification

Jo R., Shibata H., Kurihara I., Yokota K., Kobayashi S., Murai-Takeda A., Mitsuishi Y., Hayashi T., Nakamura T., Itoh H.

Hypertension Research 46 （ 1 ） 19 - 31 2023年01月

ISSN  09169636

　概要を見る

This study investigated the mechanism underlying the beneficial effects of mineralocorticoid receptor (MR) antagonists in patients with resistant hypertension and diabetic nephropathy by examining post-translational modification of the MR by O-linked-N-acetylglucosamine (O-GlcNAc), which is strongly associated with type 2 diabetes. Coimmunoprecipitation assays in HEK293T cells showed that MR is a target of O-GlcNAc modification (O-GlcNAcylation). The expression levels and transcriptional activities of the receptor increased in parallel with its O-GlcNAcylation under high-glucose conditions. Liquid chromatography–tandem mass spectrometry revealed O-GlcNAcylation of the MR at amino acids 295–307. Point mutations in those residues decreased O-GlcNAcylation, and both the protein levels and transcriptional activities of MR. In db/db mouse kidneys, MR protein levels increased in parallel with overall O-GlcNAc levels of the tissue, accompanied by increased SGK1 mRNA levels. The administration of 6-diazo-5-oxo-L-norleucin, an inhibitor of O-GlcNAcylation, reduced tissue O-GlcNAc levels and MR protein levels in db/db mice. Thus, our study showed that O-GlcNAcylation of the MR directly increases protein levels and transcriptional activities of the receptor under high-glucose conditions in vitro and in vivo. These findings provide a novel mechanism of MR as a target for prevention of complications associated with diabetes mellitus.

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MECHANISMS OF MINERALOCORTICOID RECEPTOR-ASSOCIATED HYPERTENSION IN DIABETES MELLITUS: ROLE OF O-GLCNAC MODIFICATION

Jo, R; Shibata, H; Kurihara, I; Yokota, K; Kobayashi, S; Murai-Takeda, A; Mitsuishi, Y; Hayashi, T; Nakamura, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E285 - E286 2023年01月

ISSN  0263-6352

ISH2022KYOTO Hypertension Zero Declaration

Tomaszewski, M; Itoh, H

HYPERTENSION RESEARCH 46 （ 1 ） 1 - 2 2023年01月

ISSN  0916-9636

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RENIN-ANGIOTENSIN SYSTEM INHIBITORS IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE ASSOCIATED WITH A LOWER RISK OF UNPLANNED DIALYSIS INITIATION

Nakayama, T; Morimoto, K; Uchiyama, K; Kusahana, E; Washida, N; Azegami, T; Kanda, T; Yoshida, T; Itoh, H

JOURNAL OF HYPERTENSION 41   E385 - E385 2023年01月

ISSN  0263-6352

RENOVASCULAR HYPERTENSION FROM FIBROMUSCULAR DYSPLASIA WITHOUT ABNORMALITIES IN RENAL DOPPLER ULTRASOUND: A CASE REPORT.

Kato, K; Mizutani, Y; Nakamura, T; Kinouchi, K; Kobayashi, S; Miyashita, K; Itoh, H

JOURNAL OF HYPERTENSION 41   E350 - E350 2023年01月

ISSN  0263-6352

THE ASSOCIATION BETWEEN INSULIN RESISTANCE AND DECLINE IN ORGAN FUNCTION IN NON-OBESE JAPANESE INDIVIDUALS

Kaneko, K; Hirota, RS; Makino, K; Nagasaka, T; Kojima, D; Takaishi, H; Yoshino, J; Itoh, H

JOURNAL OF HYPERTENSION 41   E465 - E465 2023年01月

ISSN  0263-6352

STUDY OF THE ANTIHYPERTENSIVE EFFECTS OF ORAL SEMAGLUTIDE, GLP 1 RECEPTOR AGONIST

Meguro, S; Itoh, H

JOURNAL OF HYPERTENSION 41   E381 - E381 2023年01月

ISSN  0263-6352

Compared effectiveness of sodium zirconium cyclosilicate and calcium polystyrene sulfonate on hyperkalemia in patients with chronic kidney disease

Nakayama T., Yamaguchi S., Hayashi K., Uchiyama K., Tajima T., Azegami T., Morimoto K., Yoshida T., Yoshino J., Monkawa T., Kanda T., Itoh H.

Frontiers in Medicine 10   1137981 - 1137981 2023年

ISSN  2296-858X

　概要を見る

Hyperkalemia is a well-recognized electrolyte abnormality in patients with chronic kidney disease (CKD). Potassium binders are often used to prevent and treat hyperkalemia. However, few studies have evaluated the difference in serum potassium (K+) level-lowering effect during the post-acute phase between the novel potassium binder, sodium zirconium cyclosilicate (ZSC), and conventional agents. This retrospective study included patients who received potassium binders (either ZSC or calcium polystyrene sulfonate [CPS]) in our hospital between May 2020 and July 2022. The patients were divided into the ZSC and CPS groups. After propensity score matching, we compared changes from baseline to the first follow-up point, at least 4 weeks after initiating potassium binders, in electrolytes including K+ level between the two groups. Of the 132 patients, ZSC and CPS were administered in 48 and 84 patients, respectively. After matching, 38 patients were allocated to each group. The ZSC group showed greater reduction in K+ levels than did the CPS group (P < 0.05). Moreover, a significant increase in serum sodium minus chloride levels, a surrogate marker for metabolic acidosis, was observed in the ZSC group (P < 0.05). Our results demonstrated that ZSC could potentially improve hyperkalemia and metabolic acidosis in patients with CKD.

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Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides

Miyamoto J., Shimizu H., Hisa K., Matsuzaki C., Inuki S., Ando Y., Nishida A., Izumi A., Yamano M., Ushiroda C., Irie J., Katayama T., Ohno H., Itoh H., Yamamoto K., Kimura I.

Gut Microbes （Taylor & Francis）  15 （ 1 ） 2161271 - 2161271 2023年

ISSN  19490976

　概要を見る

Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuconostoc mesenteroides; however, the exact mechanism of action of these foods remains unclear. Here, we observed that prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) demonstrate substantial host metabolic benefits. L. mesenteroides-produced EPS is an indigestible α-glucan, and intake of the purified form of EPS improved glucose metabolism and energy homeostasis through EPS-derived gut microbial short-chain fatty acids, and changed gut microbial composition. Our findings reveal an important mechanism that accounts for the effects of diet, prebiotics, and probiotics on energy homeostasis and suggests an approach for preventing lifestyle-related diseases by targeting bacterial EPS.

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