Iwasaki, Eisuke

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Gastroenterology and Hepatology) （Shinanomachi）

Position

Assistant Professor/Senior Assistant Professor

Related Websites

External Links
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Profile 【 Display / hide 】

  • Eisuke Iwasaki M.D., Ph.D. is a specialist in the diagnosis and treatment of pancreat-biliary disease. He focus especially on endoscopic treatment using EUS and ERCP. His research themes are clinical practice of severe acute pancreatitis, IgG4 related diseases, interventional EUS and endoscopic ampullectomy.

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Message from the Faculty Member 【 Display / hide 】

  • I have been responsible for the education of medical students since 2015 up to the present.　I continue to work together with Dr. Sugimoto to ensure that medical students have an accomplished clinical training.

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Other Disclosed Information 【 Display / hide 】

  • 　

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Profile Summary 【 Display / hide 】

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Career 【 Display / hide 】

  • 2015.04

    慶應義塾大学医学部内科学教室, 消化器内科, 助教

  • 2015.05
    -
    2017.02

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

  • 2017.03
    -
    Present

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

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Licenses and Qualifications 【 Display / hide 】

  • ICLS（Immediate Cardiac Life Support) Instructor, 2018.08

  • A certified occupational physician, 2019年11月30日更新, 2010.11

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Research Areas 【 Display / hide 】

  • Life Science / Gastroenterology

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Research Themes 【 Display / hide 】

  • Multicenter retrospective study in endoscopic papillectomy for duodenal ampullary tumor, 

    2020.03
    -
    2024.03

    　View Summary

    To evaluate the efficacy, prognosis, and treatment of endoscopic papillectomy (EP).
    UMIN000040288

  • Examination of the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease., 

    2017.01
    -
    2021.03

    　View Summary

    To clarify the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease.

  • Evaluation of exhaled carbon dioxide monitoring during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography, 

    2016.08
    -
    2018.12

    　View Summary

    to determine whether capnographic monitoring reduces the incidence of hypoxemia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography

  • Comparison of the electricity method for endoscopic papillectomy., 

    2016.03
    -
    2018.03

    　View Summary

    To compare of frequency of complications for endoscopic papillectomy.

  • Examination of the flow of pancreatic juice with pancreatic disease using cine dynamic MRCP with spatially selective inversion recovery pulse., 

    2015.10
    -
    2020.03

    　View Summary

    To evaluate the flow of pancreatic juice with Chronic pancreatitis,Pancreatic cancer,IPMN,Autoimmune pancreatitis

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Proposed Theme of Joint Research 【 Display / hide 】

  • Clinical study about ERCP or EUS

  • 胆膵悪性腫瘍の内視鏡的治療 採取された検体を用いた基礎研究など

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Papers 【 Display / hide 】

  • Gastroduodenal Stenting with a Flexible Stent Demonstrates Favorable Clinical Effectiveness despite Gradual Expansion: A Multicenter Prospective Study

    Shigoka H., Toki M., Takahashi S., Takahara N., Kitamura K., Iwasaki E., Nakahara K., Isayama H., Nakai Y., Maetani I.

    Journal of Clinical Medicine （Journal of Clinical Medicine)  12 （ 3 ）  2023.02

    Joint Work,  ISSN  2077-0383

    　View Summary

    Aims: This study aimed to evaluate the effectiveness and safety of stenting with a flexible braided self-expandable metal stent (SEMS) for unresectable malignant gastric outlet obstruction (GOO). Methods: Palliative stenting was prospectively carried out at seven university hospitals between October 2017 and August 2020. All procedures were performed using a flexible branded SEMS of the same brand. The primary endpoint was clinical success rate at 7 days after stenting. Secondary endpoints were procedural success rate, adverse events, recurrent gastric outlet obstruction (RGOO), and patient survival time. Results: Sixty patients were enrolled. The procedural and clinical success rates were 100% and 90%, respectively. RGOO occurred in 15 cases (25%). Adverse events other than RGOO were found in seven cases (12%). The 50% survival time was 75.5 days (range: 52–97 days). Median expansion rates at 1, 3, and 7 days after stenting were 55%, 65%, and 75%, respectively. Conclusions: A flexible braided stent woven with relatively thin wires was used for malignant GOO. Despite a gradual expansion with slightly lower expansile force, the stent functioned sufficiently well and showed favorable results. Clinical Trials Registry ID: UMIN000029496.

  • Successful radiotherapy for recurrent obstructive pancreatitis secondary to pancreatic metastasis from cervical squamous-cell carcinoma

    Nakajima Y., Iwasaki E., Kayashima A., Machida Y., Kawasaki S., Horibe M., Kawaida M., Masugi Y., Iwata T., Kanai T.

    Clinical Journal of Gastroenterology （Clinical Journal of Gastroenterology)   2023

    Joint Work,  ISSN  18657257

    　View Summary

    Metastatic pancreatic cancer is a rare condition and cases of pancreatic metastasis from cervical cancer are infrequently reported. Furthermore, the incidence rates of pancreatic tumors as the cause of pancreatitis and of pancreatitis in patients with pancreatic tumors are similarly low. Pancreatitis may occur when a tumor obstructs the pancreatic duct. This condition may be difficult to manage and significantly reduces the quality of life because of severe abdominal pain. Here, we present a rare case of obstructive pancreatitis caused by pancreatic metastasis from cervical squamous-cell carcinoma, pathologically confirmed using endoscopic ultrasonography-guided fine-needle biopsy and treated with palliative irradiation to achieve rapid therapeutic relief. It is important to obtain appropriate tissue samples, confirm the pathological diagnosis, and compare the pathological findings with those of the primary tumor to select the appropriate treatment for obstructive pancreatitis caused by a metastatic pancreatic tumor.

  • Reconsideration of operative indications in pancreatic neuroendocrine neoplasms

    Abe K., Kitago M., Iwasaki E., Yagi H., Abe Y., Hasegawa Y., Hori S., Tanaka M., Nakano Y., Kitagawa Y.

    World Journal of Surgical Oncology （World Journal of Surgical Oncology)  20 （ 1 ） 366 2022.12

    Joint Work

    　View Summary

    Background: The incidence of pancreatic neuroendocrine neoplasm (PNEN) has been increasing. Resection is typically indicated for PNEN, regardless of its size; however, the indications for its resection are controversial. This study aimed to evaluate the treatment results of surgical resection of PNEN at our institute. Methods: In this single-center, retrospective, case-control study, 87 patients who underwent PNEN resection and 17 patients with PNEN who did not undergo surgical resection between 1993 and 2020 were included in this study. Clinical characteristics and outcomes were reviewed and statistically compared. Survival was also estimated for the patients in each cohort. Results: Seventeen patients who underwent resection (20%) had lymph node metastasis. Tumors measuring ≥ 2.0 cm and multiple lesions were identified as independent predictors for lymph node metastasis (odds ratio [OR] 17.3, 95% confidence interval [CI] 3.0–100.0, p = 0.001 and OR 8.7, 95% CI 1.5–52.0, p = 0.018, respectively). There was a significant difference in the survival curves depending on the presence or absence of lymph node metastasis (5-year overall survival 74.7% vs. 94.3%, p < 0.001; 5-year recurrence-free survival: 66.3% vs. 93.6%, p < 0.001). All 17 PNEN cases under observation with a median 8 mm (range 5–23) tumor size for a median of 34 (range 2.4–114) months showed slight morphological change with a median tumor growth rate of 0.15 mm (range 0–3.33) per year. Conclusion: Patients with tumors measuring ≥ 2.0 cm have a high probability of lymph node metastasis or recurrence, thereby requiring resection. PNEN measuring < 1.0 cm may be acceptable for observation.

  • 内視鏡的乳頭切除術を施行した十二指腸乳頭部Gangliocytic paragangliomaの1例

    岡田 はるか, 岩崎 栄典, 中島 悠貴, 茅島 敦人, 町田 雄二郎, 原 健佑, 眞杉 洋平

    胆道 （(一社)日本胆道学会)  36 （ 5 ） 610 - 617 2022.12

    Joint Work,  ISSN  0914-0077

    　View Summary

    症例は54歳男性.上部消化管内視鏡で十二指腸乳頭部腫大を指摘され,精査目的に当院を紹介受診した.十二指腸鏡観察では主乳頭肛門側に10mm大の粘膜下腫瘤があり,EUS検査では乳頭部に連続する粘膜下層に類円形で輪郭整の低エコー腫瘤を認めた.内視鏡下生検で神経内分泌系腫瘍が疑われた.無症状で血圧も正常範囲であり,安静時血清カテコールアミン3分画は正常範囲であった.造影CT検査では十二指腸の病変は判然とせず,有意なリンパ節腫大や遠隔転移を認めなかった.非機能性神経内分泌腫瘍の術前診断で,十分な説明の上で内視鏡的乳頭切除術を施行した.術後出血を認めたが,止血処置追加後は経過良好で術後5日目に退院した.病理組織学的診断は神経節細胞様細胞,神経内分泌細胞様細胞,紡錘形細胞が混在しており,免疫染色と合わせてGangliocytic paragangliomaの診断となった.(著者抄録)

  • Association Between Clinical Backgrounds and Malignant Progression of Suspected Intraductal Papillary Mucinous Neoplasm.

    Fukushima G, Abe K, Kitago M, Iwasaki E, Hirata A, Takemura R, Ishii R, Yagi H, Abe Y, Hasegawa Y, Fukuhara S, Hori S, Tanaka M, Nakano Y, Yokose T, Shimane G, Kitagawa Y

    Pancreas （Pancreas)  51 （ 6 ） 617 - 623 2022.09

    Joint Work,  ISSN  0885-3177

    　View Summary

    Objectives Some intraductal papillary mucinous neoplasms (IPMNs) have malignant potential and can become pancreatic cancer. The mechanism behind the malignant progression of IPMN remains unknown. We aimed to identify the risk factors and interactions between backgrounds for IPMN. Methods We retrospectively enrolled 980 patients of pancreatic cancer or suspected IPMN (sIPMN) who underwent endoscopic ultrasound or retrograde cholangiopancreatography. We classified them into pancreatic cancer, high-risk sIPMN, and low-risk sIPMN, and investigated the risk factors for high-risk sIPMN. Results Smoking habits (odds ratio [OR], 3.74; 95% confidence interval [CI], 2.04-6.85; P < 0.001), serum carbohydrate antigen 19-9 ≥37 U/mL (OR, 6.30; 95% CI, 2.88-13.80; P < 0.001), and family history of cancers (OR, 2.38; 95% CI, 1.30-4.37; P = 0.005) were independent risk factors for high-risk suspected IPMN. Odds ratios of diabetes and neutrophil-to-lymphocyte ratio of 2.45 or greater were significantly higher in patients with a family history of cancer than those without a family history of cancer (OR, 3.28; 95% CI, 0.52-20.80 vs 1.85; 95% CI, 0.78-4.41; OR, 2.44; 95% CI, 0.81-7.34 vs 1.24; 95% CI, 0.67-2.30, respectively). Conclusions Understanding the interactions between background factors can effectively prevent IPMNs' malignant transformation.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 【プライマリケア医に必要な情報をまるっと整理　くすりの使い方便利帳】(第5章)消化器系に作用する薬剤　胆膵疾患治療薬　膵疾患治療薬

    岩崎 栄典

    内科 ((株)南江堂)  131 ( 4 ) 796 - 799 2023.04

    Joint Work,  ISSN  0022-1961

    　View Summary

    ＜文献概要＞・プライマリケアにおける膵疾患に使用される薬剤の代表はcamostat mesilate,pancrelipaseである.・camostat mesilateは慢性膵炎の疼痛に対して効果がある.・pancrelipaseを含んだ膵酵素補充療法は慢性膵炎患者のQOLを改善する.

  • 十二指腸乳頭部腫瘍のガイドラインに基づいた内視鏡的診断と治療

    岩崎 栄典

    Gastroenterological Endoscopy ((一社)日本消化器内視鏡学会)  65 ( Suppl.1 ) 692 - 692 2023.04

    Joint Work,  ISSN  0387-1207

  • 【胆膵疾患と腸内細菌の現状と展望】胆道　胆道細菌叢からみた胆道疾患

    茅島 敦人, 岩崎 栄典

    胆と膵 (医学図書出版(株))  44 ( 3 ) 219 - 222 2023.03

    Joint Work,  ISSN  0388-9408

    　View Summary

    従来,健常人の胆道系は無菌であると考えられてきた。しかしながら次世代シーケンサーの登場に伴い,健常人であっても胆道系には複雑で豊富なマイクロバイオームが存在することが明らかとなった。腸内細菌叢研究の隆盛とともに徐々に胆道細菌叢の報告が認められるようになってきている。本稿では胆石症,胆道癌,原発性硬化性胆管炎における胆道細菌叢についてのこれまでの研究結果についてまとめた。また今後の展望や現在の研究における限界について述べる。(著者抄録)

  • 【上部消化管内視鏡のトラブルシューティング】十二指腸EMR・ESD　EMR・ESD後に縫縮ができない　縫縮困難例に対するトラブルシューティング

    宮崎 蔵人, 加藤 元彦, 岩崎 栄典, 金井 隆典, 矢作 直久

    消化器内視鏡 ((株)東京医学社)  35 ( 2 ) 250 - 251 2023.02

    Joint Work,  ISSN  0915-3217

  • 【胆嚢疾患診療の最前線】治療　急性胆嚢炎に対する経皮経肝的ドレナージ

    岩崎 栄典, 谷木 信仁, 堀 周太郎, 曽我 茂樹

    肝胆膵 ((株)アークメディア)  85 ( 4 ) 543 - 550 2022.10

    Joint Work,  ISSN  0389-4991

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Presentations 【 Display / hide 】

  • Capnographic monitoring using a novel mainstream system during endoscopic ultrasound and endoscopic retrograde cholangiopancreatography: a prospective randomized controlled trial

    Iwasaki, Eisuke; Takimoto, Yoichi; Horibe, Masayasu; Kayashima, Atsuto; Kawasaki, Shintaro; Machida, Yujiro; Masaoka, Tatsuhiro; Ogata, Haruhiko; Bazerbachi, Fateh; Kanai, Takanori

    (Chicago) , 

    2023.05
    , 

    Poster presentation

  • Clinical outcomes of endoscopic papillectomy; a large multicenter retrospective study

    E. Iwasaki, H. Kawashima, A. Katanuma, K. Yamamoto, S. Ryozawa, S. Hashimoto, T. Yamao, K. Kubota, T. Iwai, K. Hara, H. Shiomi, K. Ikezawa, J. Ushio, H. Kato, N. Fujimori, K. Nakahara, E. Ozawa, Y. Nakai, H. Isayama, Y. Igarashi, N. Fujita, T. Ueki, K. Inui . A. Kayashima, T. Itoi

    UEGW2022, 

    2022.10
    , 

    Poster presentation

  • Ampullary Neoplasia: Is ESD Possible? Or is Endoscopic Ampullectomy and Wide-field EMR the Way?

    Eisuke Iwasaki

    DDW 2022 (SanDiego) , 

    2022.05
    , 

    Oral presentation (invited, special), ASGE

  • Predicting outcomes using an early hospitalization pancreatitis activity scoring system: a large prospective multicenter study

    Masayasu Horibe, Eisuke Iwasaki et al.

    DDW 2022 (SanDiego) , 

    2022.05
    , 

    Oral presentation (general)

  • 内視鏡的乳頭部腫瘍切除術の断端病理診断とフォロー計画

    川崎慎太郎、岩崎栄典、緒方晴彦、金井隆典

    日本消化器内視鏡学会総会　2022 (京都) , 

    2022.05
    , 

    Oral presentation (general), 日本消化器内視鏡学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Exploratory research on the development of new treatments for biliary tract cancer: establishment of patient-derived organoid bank and analysis of bile microbiome

    2022.04
    -
    2025.03

    Japan Society for the Promotion of Science (JSPS), The Ministry of Education,Culuture,Sports,Science and Technology (MEXT), Grant-in-Aid for Scientific Research, Eisuke Iwasaki, Grant-in-Aid for Scientific Research（Ｃ）, Research grant, Principal investigator

    　View Summary

    悪性腫瘍に対する世界的な基礎研究、臨床研究の進歩にも関わらず、胆道癌は難治かつ生命予後不良であり、発生メカニズム、危険因子を解明し、革新的な治療の開発が必要である。標準的な抗がん剤に高度の耐性があり、個別化医療、がんゲノム診療を始めとした新しい治療戦略を構築する必要がある。本研究では胆汁を用いた胆道癌オルガイドバンクを樹立し、胆道癌の生物学的な特性を明らかにし、今後の個別化医療、創薬への基盤となる研究を行う。また、発がん危険因子の探索のために、環境要因である胆道細菌叢、胆汁酸を解析することにより生体内環境リスクに準じた早期発見、予防的な介入の開発への基盤的研究を行いたい。

  • 胆膵がんオルガノイドをもちいた薬剤感受性試験確立と薬剤応答性メカニズムの解明

    2019.04
    -
    2022.03

    Japan Society for the Promotion of Science (JSPS), The Ministry of Education,Culuture,Sports,Science and Technology (MEXT), Grant-in-Aid for Scientific Research, Eisuke Iwasaki, Grant-in-Aid for Scientific Research（Ｃ）, Research grant, Principal investigator

    　View Summary

    難治かつ生命予後不良な胆膵がん疾患における治療成績改善のため、個別化治療の導入が望まれている。研究分担者である佐藤俊朗が世界で初めて確立した三次元組織構造体（オルガノイド）培養をHigh-throughput screening薬剤感受性試験に応用することで、比較的短時間かつ高い精度で効率の良い薬剤感受性試験が実現可能である。手術検体や超音波内視鏡下生検より現在得られたごく微量の腫瘍組織よりオルガノイドを樹立し、バンク化を進めている。胆膵がんオルガノイドバンクより薬剤感受性試験技術を確立させ、臨床データとの相関性を検討する。また薬剤感受性データと全エキソン同定、遺伝子発現アレイ解析などのin vitroデータとの相関解析の他、 CRISPR-Cas9システムを用いたゲノム編集技術を応用し、薬剤応答性の評価方法を確立することで個別化医療への応用、 創薬分野への応用を目指す。

  • Establishment of drug screening test using patient-derived cancer organoid for refractory pancreato-biliary malignancies

    2016.04
    -
    2019.03

    Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Scientific Research, Eisuke Iwasaki, Grant-in-Aid for Scientific Research（Ｃ）, Research grant, Principal investigator

    　View Summary

    難治かつ生命予後不良な胆膵悪性腫瘍における診断治療の革新のため，オーダーメイド治療の導入が望まれている．研究分担者である佐藤らが世界で初めて確立した三次元組織構造体（オルガノイド）培養とHigh-throughput screening（HTS）を応用することで，比較的短時間かつ高い精度で効率の良い薬剤感受性試験が実現可能である．超音波内視鏡下生検より得たごく微量の腫瘍組織よりのオルガノイド培養方法の確立，全エキソン同定，HTS による薬剤感受性試験の確立，
    in vivo でゼノグラフトを用いた評価をおこなう．世界初のオルガノイド培養を用いたオーダーメイド治療選択の実現に向けた基礎的な研究・技術開発を目的とする．

  • 難治性疾患等政策研究事業（難治性疾患政策研究事業）オールジャパン体制によるIgG4関連疾患の診断基準並びに診療指針の確率を目指す研究

    2023.04
    -
    2026.03

    厚生労働科学研究費, Research grant, Coinvestigator(s)

  • 難治性疾患等政策研究事業（難治性疾患政策研究事業）「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究」

    2017.04
    -
    2019.03

    厚生労働省, Health and Labour Sciences Research Grants, Research grant, Coinvestigator(s)

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Awards 【 Display / hide 】

  • Journal of Hepato-Biliary-Pancreatic Sciences Best Reviewer Award 2022

    2023.07, JSHBPS

    Type of Award： Honored in official journal of a scientific society, scientific journal

  • Journal of Hepato-Biliary-Pancreatic Sciences Best Reviewer Award 2021

    2022.07, JSHBPS

    Type of Award： Honored in official journal of a scientific society, scientific journal

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Courses Taught 【 Display / hide 】

  • PATHOPHYSIOLOGICAL ISSUES IN CHRONIC CARE

    2023

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2023

  • LECTURE SERIES, INTERNAL MEDICINE

    2023

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2023

  • CLINICAL TRAINING IN DIAGNOSIS

    2023

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Courses Previously Taught 【 Display / hide 】

  • lecture of gastroenterology

    Keio University School of Medicine

    2021.04
    -
    2022.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 3h, 120people

  • lecture of chronic diseases

    Keio University Faculty of Nursing And Medical Care

    2021.04
    -
    2022.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 1h

  • lecture of gastroenterology

    Keio University School of Medicine

    2020.04
    -
    2021.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 3h, 120people

  • 消化器内科学　講義

    慶應義塾大学医学部

    2019.04
    -
    2020.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 120people

  • 内科診断学実習（OSCE講義）

    慶應義塾大学医学部

    2019.04
    -
    2020.03
    , 

    Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty, 20people

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Educational Activities and Special Notes 【 Display / hide 】

  • PostCC OSCE委員

    2019.04
    -
    Present

  • OSCE委員

    2016.02
    -
    Present

    , Special Affairs

    　View Details

    OSCE試験腹部担当としてステーションリーダーとなり、評価者の基準を統一にすべく指導を行った。

  • カリキュラム委員会

    2015.04
    -
    Present

    , Device of Educational Contents

    　View Details

    カリキュラム委員として活動

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Social Activities 【 Display / hide 】

  • 第114回日本消化器内視鏡学会関東支部例会　ハンスオンセミナー講師

    日本消化器内視鏡学会,  （シェーンバッハ・サボー)

    , 
    2022.06

  • 第１回JDDWハンズオントレーニングセミナー　2021

    日本消化器内視鏡学会,  （神戸国際会議場)

    , 
    2021.11

  • 第108回日本消化器内視鏡学会関東支部例会　ハンスオンセミナー講師

    日本消化器内視鏡学会,  （シェーンバッハ・サボー)

    , 
    2019.05

  • JDDWハンズオントレーニングセミナー　2017

    日本消化器内視鏡学会,  （福岡国際センター)

    , 
    2017.11
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Memberships in Academic Societies 【 Display / hide 】

  • 日本消化器病学会, 

    2003.07
    -
    Present

  • Japan Gastroenterological Endoscopy Society, 

    2003.07
    -
    Present

  • 日本内科学会, 

    2001.04
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2022.02
    -
    Present

    改訂ERCP後膵炎診療ガイドライン作成委員, 日本膵臓学会

  • 2021.07
    -
    Present

    EUS-FNAガイドライン作成委員, 日本消化器内視鏡学会

    　View Remarks

    https://www.jges.net/medical/about/list/committee#esufna

  • 2021.05
    -
    Present

    IgG4関連消化管病変に関する調査研究 Woriking Gruop, 厚生労働省難治疾患研究班

    　View Remarks

    https://www.nanbyou.or.jp/entry/4505

  • 2020.10
    -
    Present

    第113回日本消化器内視鏡学会関東支部例会　プログラム委員, 日本消化器内視鏡学会

    　View Remarks

    http://www.jges-k.umin.jp/113shibureikai/outline.html

  • 2020.08
    -
    Present

    日本肝胆膵外科学会　編集委員会　委員, 日本肝胆膵外科学会

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