Iwasaki, Eisuke

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Gastroenterology and Hepatology) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

Related Websites

External Links

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  • Iwasaki Eisuke M.D., Ph.D. is a specialist in the diagnosis and treatment of pancreat-biliary disease. He focus especially on endoscopic treatment using EUS and ERCP. His research themes are clinical practice of severe acute pancreatitis, IgG4 related diseases, interventional EUS and endoscopic ampullectomy.

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Career 【 Display / hide

  • 2015.04

    慶應義塾大学医学部内科学教室, 消化器内科, 助教

  • 2015.05
    -
    2017.02

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

  • 2017.03
    -
    Present

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

 

Research Areas 【 Display / hide

  • Gastroenterology

Research Themes 【 Display / hide

  • Multicenter retrospective study in endoscopic papillectomy for duodenal ampullary tumor, 

    2020.03
    -
    2024.03

     View Summary

    To evaluate the efficacy, prognosis, and treatment of endoscopic papillectomy (EP).
    UMIN000040288

  • Examination of the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease., 

    2017.01
    -
    2021.03

     View Summary

    To clarify the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease.

  • Evaluation of exhaled carbon dioxide monitoring during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography, 

    2016.08
    -
    2018.12

     View Summary

    to determine whether capnographic monitoring reduces the incidence of hypoxemia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography

  • Comparison of the electricity method for endoscopic papillectomy., 

    2016.03
    -
    2018.03

     View Summary

    To compare of frequency of complications for endoscopic papillectomy.

  • Examination of the flow of pancreatic juice with pancreatic disease using cine dynamic MRCP with spatially selective inversion recovery pulse., 

    2015.10
    -
    2020.03

     View Summary

    To evaluate the flow of pancreatic juice with Chronic pancreatitis,Pancreatic cancer,IPMN,Autoimmune pancreatitis

Proposed Theme of Joint Research 【 Display / hide

  • Clinical study about ERCP or EUS

  • 胆膵悪性腫瘍の内視鏡的治療 採取された検体を用いた基礎研究など

 

Papers 【 Display / hide

  • External drainage of bile and pancreatic juice after endoscopic submucosal dissection for duodenal neoplasm: A feasibility study (with video).

    Fukuhara S, Kato M, Iwasaki E, Machida Y, Tamagawa H, Kawasaki S, Sasaki M, Kiguchi Y, Takatori Y, Matsuura N, Nakayama A, Ogata H, Kanai T, Yahagi N

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society  2020.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0915-5635

  • Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019

    Masamune A., Kikuta K., Kume K., Hamada S., Tsuji I., Takeyama Y., Shimosegawa T., Okazaki K., Miura S., Takikawa T., Hongo S., Nakano E., Nabeshima T., Matsumoto R., Tanaka Y., Ueno M., Mukai T., Matsumoto M., Kudo Y., Azuma S., Okuwaki K., Yamamoto S., Inui K., Kobashigawa K., Unno J., Fujimori N., Kitamura K., Miyakawa H.i., Takahashi K., Ikeura T., Takenaka M., Fukasawa M., Funayama H., Mitoro A., Takagi T., Sekine M., Suwa K., Sakagami J., Ishida M., Ohtsuka M., Kagawa S.h., Muraki T., Watanabe T., Watanabe T., Yamamoto K., Masaka T.o., Nagahama M., Sato A., Aruga Y., Nakai Y., Iwasaki E., Itoi T.a., Kawaji Y., Kitano M., Mizukami K., Iwasaki S., Mori M., Kaneko N., Kodama Y., Sato H., Yoshida N., Hatayama K., Kobayashi T., Hirano A., Kaino M., Fujisawa T., Ushijima T., Chiba M., Shimizu K.y., Ota H., Toki M., Nishikawa T., Yoshida Y., Tanaka K., Uetsuki K., Motoya D., Muro S., Watanabe H., Imamura Y., Ishizawa T., Kamisawa T., Tsuruoka M.i., Hayashi K., Terai S., Iwatsuka K.u., Iwata K., Yoshida M., Takagi T.o., Goto M., Oza N., Takeda Y.a., Hagiwara H., Tadano T., Sakai T., Sumimoto K., Nishimura N., Irisawa A., Kuwatani M., Shirahata N., Satoh M.

    Journal of Gastroenterology (Journal of Gastroenterology)  55 ( 11 ) 1062 - 1071 2020.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  09441174

     View Summary

    © 2020, Japanese Society of Gastroenterology. Objectives: To provide updated clinico-epidemiological information on chronic pancreatitis (CP) in Japan. Methods: We conducted a two-stage nationwide epidemiological survey; the number of CP patients was estimated in the first-stage survey, and their clinical features were examined in the second-stage survey. We surveyed patients with CP who had visited hospitals in 2016 and were diagnosed according to the Japanese diagnostic criteria 2009 (DC2009). Furthermore, we validated the new Japanese diagnostic criteria (DC2019) in patients with early CP diagnosed according to DC2009. Results: The number of patients with definite/probable CP in 2016 was 56,520 (prevalence, 44.5 per 100,000 persons), and that of early CP was 4470 (prevalence, 3.5 per 100,000 persons). We obtained detailed clinical information of 2150 patients with definite/probable CP and 249 patients with early CP. Compared with the early CP cases, the definite/probable CP cases had higher proportions of male (4.8 vs. 1.3), alcohol-related etiology (72.0% vs. 45.8%), smoking history (69.6% vs. 41.0%), diabetes mellitus (42.3% vs. 19.3%), and past history of acute pancreatitis (AP) (50.4% vs. 22.1%). Among the patients with early CP diagnosed according to DC2009, 93 (37.3%) were diagnosed with early CP according to DC2019, but the diagnosis of the remaining 156 (62.7%) patients was downgraded. Alcohol-related etiology, smoking history, early disease onset, and past history of AP were associated with the maintenance of early CP diagnosis in DC2019. Conclusion: We clarified the current status of CP in Japan. Further validation studies are warranted to clarify the diagnostic utility of DC2019.

  • Efficacy and safety of immediate oral intake in patients with mild acute pancreatitis: A randomized controlled trial

    Horibe M., Iwasaki E., Nakagawa A., Matsuzaki J., Minami K., Machida Y., Tamagawa H., Takimoto Y., Ueda M., Katayama T., Kawasaki S., Matsushita M., Seino T., Fukuhara S., Kanai T.

    Nutrition (Nutrition)  74   110724 2020.06

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  08999007

     View Summary

    © 2020 Objectives: Early enteral nutrition is recommended for patients with severe acute pancreatitis (AP); however, nutritional management strategies for patients with mild AP have not been established. The aim of this study was to evaluate the benefits and safety of immediate oral intake of low-fat solid food in patients with mild AP who were allowed to take opioid analgesics. Methods: In this single-center randomized study, the immediate feeding (IMF) group was permitted immediate oral intake of low-fat (15 g/d) solid food. In the standard food (STF) group, patients received gradually increasing amounts of dietary fat. Twenty-six patients were randomized, with 13 allocated to each group. The primary outcome was the period between diagnosis and recovery from AP. The cost and rate of progression to severe disease were evaluated as secondary outcomes. Results: The IMF group (mean recovery days: 2 ± 1) recovered significantly earlier (mean difference in recovery days: 6.3; 95% confidence interval [CI], 4.8–7.9; P < 0.001) than the STF group (mean recovery days: 8.3 ± 2.3), with a lower overall treatment cost (mean difference in costs: −$460; 95% CI, −$880 to –$40; P = 0.034). The IMF group showed a lower rate of progression to severe AP (IMF, 0%; STF, 15.3%; P = 0.48). Conclusion: The initial treatment strategy for mild AP should be altered from the gradual introduction of oral feeding upon the absence of pain to immediate oral nutrition with opioid analgesics, to improve treatment efficacy and reduce treatment cost.

  • Insights and updates on endoscopic papillectomy.

    Yamamoto K, Iwasaki E, Itoi T

    Expert review of gastroenterology & hepatology (Expert Review of Gastroenterology and Hepatology)  14 ( 6 ) 1 - 10 2020.05

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1747-4124

     View Summary

    © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Endoscopic papillectomy (EP) has been established as a useful endoscopic therapy by the efforts of many pancreatobiliary endoscopists and is presently accepted as a reliable alternative therapy to surgery in patients with ampullary adenoma. Moreover, there have been numerous advancements in EP techniques in recent years. Various approaches and attempts toward expanding the indications of endoscopic resection have been reported. Furthermore, the management and prevention of adverse events (AEs) and endoscopic treatment for remnant or recurrent lesions have also been reported. In the present review, we focus on recent advancements in the EP technique, as well as speculate on the future issues of EP. Area covered: This review of EP encompasses the indications, preoperative assessments, endoscopic techniques, outcomes, and AEs of EP, post-EP surveillance techniques, and treatments for remnant or recurrence lesions. Expert opinion: The ultimate goal of EP is the complete resection of ampullary tumors, regardless of whether they are adenomatous or carcinomatous lesions, without causing any AEs. Therefore, the most important issue is preoperative evaluation, that is, the accurate diagnosis of lesions contraindicated for EP. In addition, further research on the prevention of AEs is also necessary towards establishing EP as a safe endoscopic procedure.

  • The Horibe GI bleeding prediction score: a simple score for triage decision-making in patients with suspected upper GI bleeding.

    Horibe M, Iwasaki E, Bazerbachi F, Kaneko T, Matsuzaki J, Minami K, Masaoka T, Hosoe N, Ogura Y, Namiki S, Hosoda Y, Ogata H, Chan AT, Kanai T

    Gastrointestinal endoscopy (Gastrointestinal Endoscopy)  92 ( 3 ) 578 - 588.e4 2020.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0016-5107

     View Summary

    © 2020 American Society for Gastrointestinal Endoscopy Background and Aims: Although upper GI bleeding (UGIB) is a significant cause of inpatient admissions, no scoring method has proven to be accurate and simple as a standard for triage purposes. Therefore, we compared a previously described 3-variable score (1 point each for absence of daily proton pump inhibitor use in the week before the index presentation, shock index [heart rate/systolic blood pressure] ≥1, and blood urea nitrogen/creatinine ≥30 [urea/creatinine≥140]), the Horibe gAstRointestinal BleedING scoRe (HARBINGER), with the 8-variable Glasgow-Blatchford Score (GBS) and 5-variable AIMS65 to evaluate and validate the accuracy in predicting high-risk features that warrant admission and urgent endoscopy. Methods: Consecutive patients presenting with suspected UGIB between 2012 and 2015 were prospectively enrolled in 3 acute care Japanese hospitals. On presentation to the emergency setting, an endoscopy was performed in a timely fashion. The primary outcome was the prediction of high-risk endoscopic stigmata. Results: Of 1486 enrolled patients, 637 (43%) harbored high-risk endoscopic stigmata according to international consensus statements. The area under the receiver operating characteristic curve (AUC) for the HARBINGER was.76 (95% confidence interval [CI],.72-.79), which was significantly superior to both the GBS (AUC,.68; 95% CI,.64-.71; P <.001) and the AIMS65 (AUC,.54; 95% CI,.50-.58; P <.001). When the HARBINGER cutoff value was set at 1 to rule out patients who needed admission and urgent endoscopy, its sensitivity and specificity was 98.8% (95% CI, 97.9-99.6) and 15.5% (95% CI, 13.1-18.0), respectively. Conclusions: The HARBINGER, a simple 3-variable score, provides a more accurate method for triage of patients with suspected UGIB than both the GBS and AIMS65.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 【肝胆膵における結石診療のベストプラクティス】胆嚢結石症 胆道消化管瘻Bilioenteric fistulaの病態と治療 Bouveret症候群と合わせて

    岩崎 栄典, 鳥海 史樹, 大平 正典, 前田 祐助, 上田 真裕, 金井 隆典

    肝・胆・膵 ((株)アークメディア)  81 ( 2 ) 313 - 318 2020.08

    Research paper, Joint Work,  ISSN  0389-4991

  • 【肝胆膵における結石診療のベストプラクティス】肝胆膵結石に対する集学的治療 Beyond the EBM

    糸井 隆夫, 岩崎 栄典, 渡邉 学, 樋口 亮太

    肝・胆・膵 ((株)アークメディア)  81 ( 2 ) 395 - 406 2020.08

    Research paper, Joint Work,  ISSN  0389-4991

  • 【肝膵内視鏡治療におけるトラブルシューティング】ERCP関連治療における偶発症予防とトラブルシューティング 内視鏡的胆管ステント留置術(プラスチックステント) こんなときどうする?

    岩崎 栄典, 金井 隆典

    消化器内視鏡 ((株)東京医学社)  32 ( 3 ) 369 - 375 2020.03

    Research paper, Joint Work,  ISSN  0915-3217

  • 【消化器外科手術の論点2020 誌上ディベートと手術手技】肝胆膵外科 早期十二指腸乳頭部粘膜癌に対する術式 縮小手術の立場から

    北郷 実, 林 航輝, 篠田 昌宏, 岩崎 栄典, 相浦 浩一, 北川 雄光

    手術 (金原出版(株))  74 ( 4 ) 640 - 649 2020.03

    Research paper, Joint Work,  ISSN  0037-4423

  • 【胆膵疾患における緊急内視鏡-リスクマネージメントも含めて-】胆膵内視鏡呼吸循環器系偶発症におけるリスクマネージメント 適切なモニタリングと急変時シミュレーション

    岩崎 栄典, 瀧本 洋一, 福原 誠一郎, 南 一洋, 茅島 敦人, 野田 まりん, 町田 雄二郎, 玉川 空樹, 片山 正, 川崎 慎太郎, 細江 直樹, 緒方 晴彦, 金井 隆典

    胆と膵 (医学図書出版(株))  41 ( 2 ) 129 - 136 2020.02

    Research paper, Joint Work,  ISSN  0388-9408

     View Summary

    胆膵内視鏡処置における鎮静は2013年の日本消化器内視鏡学会による鎮静に関するガイドラインに基づいて行われている。胆膵処置の高度化、被験者の高齢化や多種の鎮静薬が導入されるようになったこともあり、胆膵内視鏡中の呼吸循環器偶発症のリスクは高まっている。また、急性胆管炎には休日時間外でも早期の胆道ドレナージが必要となる。意識下鎮静で施行する胆膵内視鏡において、全身モニタリングは重要であり、最近注目されている呼気二酸化炭素モニター(カプノモニター)の有用性を報告する。また、予防策に加えて偶発症発生時の万全な体制を整えるという点で当院で運用している急変時シミュレーション、タイムアウトなどについて各施設での今後の安全な胆膵内視鏡システム構築に資するものと考えて共有したい。(著者抄録)

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Presentations 【 Display / hide

  • 内視鏡的乳頭切開術に伴う穿孔に対する胆管膵管ドレナージの有用性

    福原誠一郎、岩崎栄典、南一洋、緒方晴彦、金井隆典

    内視鏡学会関東地方会 (東京) , 2019.12, Symposium, Workshop, Panelist (public offering)

  • 自己免疫性膵炎におけるEUS所見の検討

    南一洋、福原誠一郎、岩崎栄典

    内視鏡学会関東地方会 (神戸) , 2019.12, Oral Presentation(general)

  • Prevention of adverse events after endoscopic ampullectomy: a retrospective study

    Eisuke Iwasaki

    APDW2019 (Biswa Bangla Convention Centre, Kolkata) , 2019.12, Oral Presentation(general), APDWF

  • 治療内視鏡(胆膵)における穿孔とその対処

    岩崎栄典

    JDDW2019, 2019.11, Poster (general)

  • 内視鏡的十二指腸乳頭腫瘍切除術における、術後出血の検討

    南一洋、岩崎栄典

    JDDW2019, 2019.11, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 胆膵がんオルガノイドをもちいた薬剤感受性試験確立と薬剤応答性メカニズムの解明

    2019.04
    -
    2022.03

    日本学術振興会, 文部省科学研究費, 岩崎栄典, 基盤研究(C), Research grant, Principal Investigator

     View Summary

    難治かつ生命予後不良な胆膵がん疾患における治療成績改善のため、個別化治療の導入が望まれている。研究分担者である佐藤俊朗が世界で初めて確立した三次元組織構造体(オルガノイド)培養をHigh-throughput screening薬剤感受性試験に応用することで、比較的短時間かつ高い精度で効率の良い薬剤感受性試験が実現可能である。手術検体や超音波内視鏡下生検より現在得られたごく微量の腫瘍組織よりオルガノイドを樹立し、バンク化を進めている。胆膵がんオルガノイドバンクより薬剤感受性試験技術を確立させ、臨床データとの相関性を検討する。また薬剤感受性データと全エキソン同定、遺伝子発現アレイ解析などのin vitroデータとの相関解析の他、 CRISPR-Cas9システムを用いたゲノム編集技術を応用し、薬剤応答性の評価方法を確立することで個別化医療への応用、 創薬分野への応用を目指す。

  • 難治性疾患等政策研究事業(難治性疾患政策研究事業)「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究」

    2017.04
    -
    2019.03

    厚生労働省, Health and Labour Sciences Research Grants, 関西医科大学 岡崎和一教授, Research grant, Co-investigator

  • 難治性胆膵悪性腫瘍に対するがんオルガノイド培養を用いた薬剤感受性検査の確立

    2016.04
    -
    2019.03

    文部科学省, Grant-in-Aid for Scientific Research, 岩崎栄典, Research grant, Principal Investigator

     View Summary

    難治かつ生命予後不良な胆膵悪性腫瘍における診断治療の革新のため,オーダーメイド治療の
    導入が望まれている.研究分担者である佐藤らが世界で初めて確立した三次元組織構造体(オル
    ガノイド)培養とHigh-throughput screening(HTS)を応用することで,比較的短時間かつ高い精
    度で効率の良い薬剤感受性試験が実現可能である.超音波内視鏡下生検より得たごく微量の腫瘍
    組織よりのオルガノイド培養方法の確立,全エキソン同定,HTS による薬剤感受性試験の確立,
    in vivo でゼノグラフトを用いた評価をおこなう.世界初のオルガノイド培養を用いたオーダーメイド治療選択の実現に向けた基礎的な研究・技術開発を目的とする.

 

Courses Taught 【 Display / hide

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2020

  • LECTURE SERIES, INTERNAL MEDICINE

    2020

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2020

  • CLINICAL TRAINING IN DIAGNOSIS

    2020

  • CASE STUDIES OF INTERNAL MEDICINE

    2020

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Courses Previously Taught 【 Display / hide

  • 内科診断学実習(OSCE講義)

    慶應義塾大学医学部, 2019, Autumn Semester, Major subject, Laboratory work/practical work/exercise, Within own faculty, 20people

  • 消化器内科学 講義

    慶應義塾大学医学部, 2019, Spring Semester, Major subject, Lecture, Within own faculty, 120people

  • 内科学(消化器)

    Keio University, 2018, Full academic year, Major subject, Lecture, Within own faculty, 1h, 120people

  • 内科学講義

    慶應義塾大学医学部, 2018

  • 内科診断学実習(OSCE講義)

    慶應義塾大学医学部, 2018

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Educational Activities and Special Notes 【 Display / hide

  • PostCC OSCE委員

    2019.04
    -
    Present

  • OSCE委員

    2016.02
    -
    Present

    , Special Affairs

     View Details

    OSCE試験腹部担当としてステーションリーダーとなり、評価者の基準を統一にすべく指導を行った。

  • カリキュラム委員会

    2015.04
    -
    Present

    , Device of Educational Contents

     View Details

    カリキュラム委員として活動

 

Memberships in Academic Societies 【 Display / hide

  • 日本膵臓学会, 

    2013.10
    -
    Present
  • 日本胆道学会, 

    2013.10
    -
    Present
  • 日本消化器病学会, 

    2003.07
    -
    Present
  • Japan Gastroenterological Endoscopy Society, 

    2003.07
    -
    Present
  • 日本内科学会, 

    2001.04
    -
    Present

Committee Experiences 【 Display / hide

  • 2020.08
    -
    Present

    日本肝胆膵外科学会 編集委員会 委員, 日本肝胆膵外科学会

  • 2019.04
    -
    Present

    Assistant editor of Digestive Endoscopy, 日本消化器内視鏡学会

  • 2019.04
    -
    Present

    日本消化器病学会総会 学会評議員, 日本消化器病学会

  • 2018.05
    -
    Present

    Councilor, Japan Gastroenterological Endoscopy Society

  • 2017.04
    -
    Present

    日本膵臓学会 急性膵炎分科会, 日本膵臓学会

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