Details of a Researcher - Iwasaki, Eisuke

Iwasaki, Eisuke

写真a

Affiliation: School of Medicine, Department of Internal Medicine (Gastroenterology and Hepatology) (Shinanomachi)

Position: Assistant Professor/Senior Assistant Professor

Related Websites

http://www.keio-med.jp/gastro/index.html

External Links

Pure

Profile 【 Display / hide 】

Eisuke Iwasaki M.D., Ph.D. is a specialist in the diagnosis and treatment of pancreat-biliary disease. He focus especially on endoscopic treatment using EUS and ERCP. His research themes are clinical practice of severe acute pancreatitis, IgG4 related diseases, interventional EUS and endoscopic ampullectomy.

Message from the Faculty Member 【 Display / hide 】

I have been responsible for the education of medical students since 2015 up to the present.　I continue to work together with Dr. Sugimoto to ensure that medical students have an accomplished clinical training.

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Career 【 Display / hide 】

2015.04

慶應義塾大学医学部内科学教室, 消化器内科, 助教
2015.05

-

2017.02

Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor
2017.03

-

Present

Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

Licenses and Qualifications 【 Display / hide 】

ICLS（Immediate Cardiac Life Support) Instructor, 2018.08
A certified occupational physician, 2019年11月30日更新, 2010.11

Research Areas 【 Display / hide 】

Life Science / Gastroenterology

Research Themes 【 Display / hide 】

Multicenter retrospective study in endoscopic papillectomy for duodenal ampullary tumor,

2020.03

-

2024.03

　View Summary

To evaluate the efficacy, prognosis, and treatment of endoscopic papillectomy (EP).
UMIN000040288
Examination of the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease.,

2017.01

-

2021.03

　View Summary

To clarify the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease.
Evaluation of exhaled carbon dioxide monitoring during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography,

2016.08

-

2018.12

　View Summary

to determine whether capnographic monitoring reduces the incidence of hypoxemia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography
Comparison of the electricity method for endoscopic papillectomy.,

2016.03

-

2018.03

　View Summary

To compare of frequency of complications for endoscopic papillectomy.
Examination of the flow of pancreatic juice with pancreatic disease using cine dynamic MRCP with spatially selective inversion recovery pulse.,

2015.10

-

2020.03

　View Summary

To evaluate the flow of pancreatic juice with Chronic pancreatitis,Pancreatic cancer,IPMN,Autoimmune pancreatitis

Proposed Theme of Joint Research 【 Display / hide 】

Clinical study about ERCP or EUS
胆膵悪性腫瘍の内視鏡的治療採取された検体を用いた基礎研究など

Papers 【 Display / hide 】

Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study

Horibe M., Kayashima A., Ohbe H., Bazerbachi F., Mizukami Y., Iwasaki E., Matsui H., Yasunaga H., Kanai T.

Journal of Intensive Care (Journal of Intensive Care) 12 ( 1 ) 27 2024.12

Joint Work, ISSN 2052-0492

　View Summary

Background: Fluid resuscitation is fundamental in acute pancreatitis (AP) treatment. However, the optimal choice between normal saline (NS) and Ringer's solution (RS), and its impact on mortality in critically ill patients, remains controversial. This retrospective cohort study, utilizing a national Japanese inpatient database, investigates this question. Methods: Using the Japanese Diagnosis Procedure Combination database between July 2010 and March 2021, we identified adult patients hospitalized in intensive care units (ICU) or high-dependency care units (HDU) for AP who survived at least three days and received sufficient fluid resuscitation (≥ [10 ml/kg/hr*1 h + 1 ml/kg/hr*71 h] ml) within three days of admission including emergency room infusions. Patients were classified into groups based on the predominant fluid type received: the NS group (> 80% normal saline) and the RS group (> 80% Ringer's solution). Propensity score matching was employed to reduce potential confounding factors and facilitate a balanced comparison of in-hospital mortality between the two groups. Results: Our analysis included 8710 patients with AP. Of these, 657 (7.5%) received predominantly NS, and 8053 (92.5%) received predominantly RS. Propensity score matching yielded 578 well-balanced pairs for comparison. The NS group demonstrated significantly higher in-hospital mortality than the RS group (12.8% [474/578] vs. 8.5% [49/578]; risk difference, 4.3%; 95% confidence interval, 0.3% to 8.3%). Conclusions: In patients admitted to ICU or HDU with AP receiving adequate fluid resuscitation, RS can be a preferred infusion treatment compared to NS.
- Access to Document (DOI)
Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma.

Tamagawa H, Fujii M, Togasaki K, Seino T, Kawasaki S, Takano A, Toshimitsu K, Takahashi S, Ohta Y, Matano M, Kawasaki K, Machida Y, Sekine S, Machinaga A, Sasai K, Kodama Y, Kakiuchi N, Ogawa S, Hirano T, Seno H, Kitago M, Kitagawa Y, Iwasaki E, Kanai T, Sato T

Nature cell biology 2024.09

Joint Work, ISSN 1465-7392
- Access to Document (DOI)
Unique bile acid profiles in the bile ducts of patients with primary sclerosing cholangitis.

Kayashima A, Sujino T, Fukuhara S, Miyamoto K, Kubosawa Y, Ichikawa M, Kawasaki S, Takabayashi K, Iwasaki E, Kato M, Honda A, Kanai T, Nakamoto N

Hepatology communications 8 ( 6 ) 2024.06

Joint Work
- Access to Document (DOI)
Postprocedure serum amylase or lipase levels predict postendoscopic retrograde cholangiopancreatography pancreatitis: Meta-analysis of diagnostic test accuracy studies and utility assessment

Hirota M., Itoi T., Morizane T., Koiwai A., Yasuda I., Ryozawa S., Mukai S., Ikeura T., Irisawa A., Iwasaki E., Katanuma A., Kitamura K., Takenaka M., Ito T., Masamune A., Mayumi T., Takeyama Y.

Digestive Endoscopy (Digestive Endoscopy) 36 ( 6 ) 670 - 687 2024.06

Joint Work, ISSN 09155635

　View Summary

Objectives: We aimed to clarify the clinical utility of measuring serum pancreatic enzymes after endoscopic retrograde cholangiopancreatography (ERCP) for the purpose of predicting post-ERCP pancreatitis (PEP) by a meta-analysis of diagnostic test accuracy studies. Methods: Studies on the prediction accuracy of PEP by serum amylase or lipase measured at 2, 3, and 4 h after ERCP were collected. A literature search was performed in PubMed and the Cochrane Library database for studies published between January 1980 and March 2023. The quality of individual studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2. Data were analyzed using Meta-DiSc 2.0 software. Results: We searched the databases and identified 20 observational studies (12,313 participants). PEPs were defined according to criteria by Cotton or modified Cotton, revised Atlanta criteria, or the Japanese criteria. Meta-analysis of eight studies (4389 participants) showed a pooled sensitivity of 71.1% (95% confidence interval [CI] 56.1–82.5) and pooled specificity of 91.2% (95% CI 85.9–94.6) for the serum amylase cut-off value at 3 times the upper limit of normal (ULN). Another meta-analysis of five studies (1970 participants) showed a pooled sensitivity of 85.8% (95% CI 61.9–95.7) and pooled specificity of 85.3% (95% CI 81.9–88.1) for the serum lipase cut-off value at 3 times ULN. Conclusion: Despite a high risk of bias due to various reference standards, this updated meta-analysis and the utility assessment by a decision tree showed the utility of serum amylase or lipase levels more than 3 times ULN measured 2–4 h after ERCP for predicting PEP.
- Access to Document (DOI)
Unique bile acid profiles in the bile ducts of patients with primary sclerosing cholangitis

Kayashima, A; Sujino, T; Fukuhara, S; Miyamoto, K; Kubosawa, Y; Ichikawa, M; Kawasaki, S; Takabayashi, K; Iwasaki, E; Kato, M; Honda, A; Kanai, T; Nakamoto, N

HEPATOLOGY COMMUNICATIONS 8 ( 6 ) 2024.06

Joint Work
- Access to Document (DOI)

Papers, etc., Registered in KOARA 【 Display / hide 】

Establishment of cancer organoid drug screening test for pancreatic ductal adenocarcinoma

Iwasaki, Eisuke

科学研究費補助金研究成果報告書 2018
Enhanced ghrelin production and secretion and reduced expression of ghrelin receptor in rat stomach with delayed gastric emptying

Iwasaki, Eisuke

科学研究費補助金研究成果報告書 2009

Reviews, Commentaries, etc. 【 Display / hide 】

【肝門部胆管癌～診断と治療の標準化へ向けて～】術前診断と内科的治療(緩和的治療も含めて)　両葉ドレナージvs.片葉ドレナージ

早川宇宙, 岩崎栄典

胆と膵 (医学図書出版(株)) 45 ( 6 ) 575 - 579 2024.06

Joint Work, ISSN 0388-9408

　View Summary

肝門部悪性胆管狭窄(HMBO)に対する内視鏡的ドレナージは近年,技術的な進歩とデバイスの進歩により経皮的ドレナージを代替する形で,黄疸や胆管炎の改善に重要な役割を担うようになった。HMBOのドレナージ戦略は切除可能例(術前症例)と切除不能例では異なる。肝門部胆管の解剖は総胆管から胆管枝が複雑に分かれ,さらに破格も多いうえに,腫瘍の範囲にあわせて適切なドレナージ方法を選択する必要がある。その中でもHMBOに対するドレナージ範囲として片葉,両葉のどちらかを選択するか議論の余地がある。ドレナージ領域を広く取ったほうが感染予防や肝予備能が保たれることは直感的に理解できるものの,細い総胆管から複数の枝にドレナージを留置するとなると技術的問題やデバイス径により制限が生じうる。本稿では両葉・片葉ドレナージについて,最近のエビデンスを概説したい。(著者抄録)
【患者さんからよく尋ねられる内科診療のQuestion】(第8章)肝・胆・膵　[25歳男性,急性膵炎]急性膵炎で入院しました.再発しないか心配です

岩崎栄典

内科 ((株)南江堂) 133 ( 4 ) 875 - 878 2024.04

Joint Work, ISSN 0022-1961
ERCP後膵炎ガイドライン2023

糸井隆夫, 池浦司, 入澤篤志, 岩崎栄典, 潟沼朗生, 北村勝哉, 竹中完, 竹山宜典, 廣田衛久, 正宗淳, 真弓俊彦, 向井俊太郎, 森實敏夫, 安田一朗, 良沢昭銘, 吉田雅博, 伊藤鉄英, 安田健治朗, 伊藤嵩志, 岩野光佑, 圓谷俊貴, 鎌田研, 茅島敦人, 小岩井明信, 谷坂優樹, 豊永啓翔, 中丸洸, 永島一憲, 林伸彦, 堀部昌靖, 本間俊裕, 水出雅文, 三長孝輔, 山宮知, 日本膵臓学会急性膵炎調査研究委員会急性膵炎分科会, 改訂ERCP後膵炎ガイドライン作成委員会

膵臓 ((一社)日本膵臓学会) 39 ( 2 ) 79 - 158 2024.04

Joint Work, ISSN 0913-0071
Interventional EUS　エキスパートセミナー2024

糸井隆夫, 藤森尚, 向井強, 岩崎栄典

胆と膵 (医学図書出版(株)) 45 ( 3 ) 343 - 354 2024.03

Joint Work, ISSN 0388-9408
十二指腸乳頭部腫瘍の内視鏡的マネジメント

岩崎栄典, 川崎慎太郎, 金井隆典

Gastroenterological Endoscopy ((一社)日本消化器内視鏡学会) 66 ( 3 ) 243 - 258 2024.03

Joint Work, ISSN 0387-1207

　View Summary

十二指腸乳頭部腫瘍は内視鏡スクリーニングが広く行われるようになったことから無症状で発見されることが増えている.以前は黄疸をきたした進行癌の状態で発見されることが多く開腹手術による膵頭十二指腸切除が第一選択であった.最近は十二指腸乳頭部腫瘍に対して内視鏡的乳頭切除術が積極的に行われるようになった.また,十二指腸乳頭部腫瘍の診断には十二指腸乳頭部近傍の微細な腫瘍浸潤を評価するために超音波内視鏡の有用性が報告されている.日本消化器内視鏡学会および欧州内視鏡学会から内視鏡的乳頭切除のガイドラインが出版され,現在のエビデンスをもとにした診断と治療方法について標準的方針が提示された.本稿ではさらに最近の新たなエビデンスと論文をレビューしたい.(著者抄録)

Presentations 【 Display / hide 】

Capnographic monitoring using a novel mainstream system during endoscopic ultrasound and endoscopic retrograde cholangiopancreatography: a prospective randomized controlled trial

Iwasaki, Eisuke; Takimoto, Yoichi; Horibe, Masayasu; Kayashima, Atsuto; Kawasaki, Shintaro; Machida, Yujiro; Masaoka, Tatsuhiro; Ogata, Haruhiko; Bazerbachi, Fateh; Kanai, Takanori

(Chicago) ,

2023.05
,
Poster presentation
Clinical outcomes of endoscopic papillectomy; a large multicenter retrospective study

E. Iwasaki, H. Kawashima, A. Katanuma, K. Yamamoto, S. Ryozawa, S. Hashimoto, T. Yamao, K. Kubota, T. Iwai, K. Hara, H. Shiomi, K. Ikezawa, J. Ushio, H. Kato, N. Fujimori, K. Nakahara, E. Ozawa, Y. Nakai, H. Isayama, Y. Igarashi, N. Fujita, T. Ueki, K. Inui . A. Kayashima, T. Itoi

UEGW2022,

2022.10
,
Poster presentation
Ampullary Neoplasia: Is ESD Possible? Or is Endoscopic Ampullectomy and Wide-field EMR the Way?

Eisuke Iwasaki

DDW 2022 (SanDiego) ,

2022.05
,
Oral presentation (invited, special), ASGE
Predicting outcomes using an early hospitalization pancreatitis activity scoring system: a large prospective multicenter study

Masayasu Horibe, Eisuke Iwasaki et al.

DDW 2022 (SanDiego) ,

2022.05
,
Oral presentation (general)
内視鏡的乳頭部腫瘍切除術の断端病理診断とフォロー計画

川崎慎太郎、岩崎栄典、緒方晴彦、金井隆典

日本消化器内視鏡学会総会　2022 (京都) ,

2022.05
,
Oral presentation (general), 日本消化器内視鏡学会

Research Projects of Competitive Funds, etc. 【 Display / hide 】

Exploratory research on the development of new treatments for biliary tract cancer: establishment of patient-derived organoid bank and analysis of bile microbiome

2022.04

-

2025.03

Japan Society for the Promotion of Science (JSPS), The Ministry of Education,Culuture,Sports,Science and Technology (MEXT), Grant-in-Aid for Scientific Research, Eisuke Iwasaki, Grant-in-Aid for Scientific Research（Ｃ）, Research grant, Principal investigator

　View Summary

悪性腫瘍に対する世界的な基礎研究、臨床研究の進歩にも関わらず、胆道癌は難治かつ生命予後不良であり、発生メカニズム、危険因子を解明し、革新的な治療の開発が必要である。標準的な抗がん剤に高度の耐性があり、個別化医療、がんゲノム診療を始めとした新しい治療戦略を構築する必要がある。本研究では胆汁を用いた胆道癌オルガイドバンクを樹立し、胆道癌の生物学的な特性を明らかにし、今後の個別化医療、創薬への基盤となる研究を行う。また、発がん危険因子の探索のために、環境要因である胆道細菌叢、胆汁酸を解析することにより生体内環境リスクに準じた早期発見、予防的な介入の開発への基盤的研究を行いたい。
胆膵がんオルガノイドをもちいた薬剤感受性試験確立と薬剤応答性メカニズムの解明

2019.04

-

2022.03

Japan Society for the Promotion of Science (JSPS), The Ministry of Education,Culuture,Sports,Science and Technology (MEXT), Grant-in-Aid for Scientific Research, Eisuke Iwasaki, Grant-in-Aid for Scientific Research（Ｃ）, Research grant, Principal investigator

　View Summary

難治かつ生命予後不良な胆膵がん疾患における治療成績改善のため、個別化治療の導入が望まれている。研究分担者である佐藤俊朗が世界で初めて確立した三次元組織構造体（オルガノイド）培養をHigh-throughput screening薬剤感受性試験に応用することで、比較的短時間かつ高い精度で効率の良い薬剤感受性試験が実現可能である。手術検体や超音波内視鏡下生検より現在得られたごく微量の腫瘍組織よりオルガノイドを樹立し、バンク化を進めている。胆膵がんオルガノイドバンクより薬剤感受性試験技術を確立させ、臨床データとの相関性を検討する。また薬剤感受性データと全エキソン同定、遺伝子発現アレイ解析などのin vitroデータとの相関解析の他、 CRISPR-Cas9システムを用いたゲノム編集技術を応用し、薬剤応答性の評価方法を確立することで個別化医療への応用、創薬分野への応用を目指す。
Establishment of drug screening test using patient-derived cancer organoid for refractory pancreato-biliary malignancies

2016.04

-

2019.03

Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Scientific Research, Eisuke Iwasaki, Grant-in-Aid for Scientific Research（Ｃ）, Research grant, Principal investigator

　View Summary

難治かつ生命予後不良な胆膵悪性腫瘍における診断治療の革新のため，オーダーメイド治療の導入が望まれている．研究分担者である佐藤らが世界で初めて確立した三次元組織構造体（オルガノイド）培養とHigh-throughput screening（HTS）を応用することで，比較的短時間かつ高い精度で効率の良い薬剤感受性試験が実現可能である．超音波内視鏡下生検より得たごく微量の腫瘍組織よりのオルガノイド培養方法の確立，全エキソン同定，HTS による薬剤感受性試験の確立，
in vivo でゼノグラフトを用いた評価をおこなう．世界初のオルガノイド培養を用いたオーダーメイド治療選択の実現に向けた基礎的な研究・技術開発を目的とする．
難治性疾患等政策研究事業（難治性疾患政策研究事業）オールジャパン体制によるIgG4関連疾患の診断基準並びに診療指針の確率を目指す研究

2023.04

-

2026.03

厚生労働科学研究費, Research grant, Coinvestigator(s)
難治性疾患等政策研究事業（難治性疾患政策研究事業）「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究」

2017.04

-

2019.03

厚生労働省, Health and Labour Sciences Research Grants, Research grant, Coinvestigator(s)

Awards 【 Display / hide 】

Journal of Hepato-Biliary-Pancreatic Sciences Best Reviewer Award 2022

2023.07, JSHBPS

Type of Award： Honored in official journal of a scientific society, scientific journal
Journal of Hepato-Biliary-Pancreatic Sciences Best Reviewer Award 2021

2022.07, JSHBPS

Type of Award： Honored in official journal of a scientific society, scientific journal

Courses Taught 【 Display / hide 】

LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

2024
PATHOPHYSIOLOGICAL ISSUES IN CHRONIC CARE

2023
LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

2023
LECTURE SERIES, INTERNAL MEDICINE

2023
INTRODUCTION TO CLINICAL CLERKSHIPS

2023

Courses Previously Taught 【 Display / hide 】

lecture of gastroenterology

Keio University School of Medicine

2021.04

-

2022.03
,
Autumn Semester, Lecture, Within own ｆaculty, 3h, 120people
lecture of chronic diseases

Keio University Faculty of Nursing And Medical Care

2021.04

-

2022.03
,
Spring Semester, Lecture, Within own ｆaculty, 1h
lecture of gastroenterology

Keio University School of Medicine

2020.04

-

2021.03
,
Autumn Semester, Lecture, Within own ｆaculty, 3h, 120people
内科診断学実習（OSCE講義）

慶應義塾大学医学部

2019.04

-

2020.03
,
Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty, 20people
消化器内科学　講義

慶應義塾大学医学部

2019.04

-

2020.03
,
Spring Semester, Lecture, Within own ｆaculty, 120people

Educational Activities and Special Notes 【 Display / hide 】

PostCC OSCE委員

2019.04

-

Present
OSCE委員

2016.02

-

Present

, Special Affairs

　View Details

OSCE試験腹部担当としてステーションリーダーとなり、評価者の基準を統一にすべく指導を行った。
カリキュラム委員会

2015.04

-

Present

, Device of Educational Contents

　View Details

カリキュラム委員として活動

Social Activities 【 Display / hide 】

第114回日本消化器内視鏡学会関東支部例会　ハンスオンセミナー講師

日本消化器内視鏡学会, (シェーンバッハ・サボー)
,
2022.06
第１回JDDWハンズオントレーニングセミナー　2021

日本消化器内視鏡学会, (神戸国際会議場)
,
2021.11
第108回日本消化器内視鏡学会関東支部例会　ハンスオンセミナー講師

日本消化器内視鏡学会, (シェーンバッハ・サボー)
,
2019.05
JDDWハンズオントレーニングセミナー　2017

日本消化器内視鏡学会, (福岡国際センター)
,
2017.11

Memberships in Academic Societies 【 Display / hide 】

日本消化器病学会,

2003.07

-

Present
Japan Gastroenterological Endoscopy Society,

2003.07

-

Present
日本内科学会,

2001.04

-

Present

Committee Experiences 【 Display / hide 】

2022.02

-

Present

改訂ERCP後膵炎診療ガイドライン作成委員, 日本膵臓学会
2021.07

-

Present

EUS-FNAガイドライン作成委員, 日本消化器内視鏡学会

　View Remarks

https://www.jges.net/medical/about/list/committee#esufna
2021.05

-

Present

IgG4関連消化管病変に関する調査研究 Woriking Gruop, 厚生労働省難治疾患研究班

　View Remarks

https://www.nanbyou.or.jp/entry/4505
2020.10

-

Present

第113回日本消化器内視鏡学会関東支部例会　プログラム委員, 日本消化器内視鏡学会

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http://www.jges-k.umin.jp/113shibureikai/outline.html
2020.08

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Present

日本肝胆膵外科学会　編集委員会　委員, 日本肝胆膵外科学会