Iwasaki, Eisuke

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Gastroenterology and Hepatology) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

Related Websites

External Links

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  • Iwasaki Eisuke M.D., Ph.D. is a specialist in the diagnosis and treatment of pancreat-biliary disease. He focus especially on endoscopic treatment using EUS and ERCP. His research themes are clinical practice of severe acute pancreatitis, IgG4 related diseases, interventional EUS and endoscopic ampullectomy.

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Career 【 Display / hide

  • 2015.04

    慶應義塾大学医学部内科学教室, 消化器内科, 助教

  • 2015.05
    -
    2017.02

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

  • 2017.03
    -
    Present

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

 

Research Areas 【 Display / hide

  • Gastroenterology

Research Themes 【 Display / hide

  • Multicenter retrospective study in endoscopic papillectomy for duodenal ampullary tumor, 

    2020.03
    -
    2024.03

     View Summary

    To evaluate the efficacy, prognosis, and treatment of endoscopic papillectomy (EP).
    UMIN000040288

  • Examination of the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease., 

    2017.01
    -
    2021.03

     View Summary

    To clarify the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease.

  • Evaluation of exhaled carbon dioxide monitoring during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography, 

    2016.08
    -
    2018.12

     View Summary

    to determine whether capnographic monitoring reduces the incidence of hypoxemia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography

  • Comparison of the electricity method for endoscopic papillectomy., 

    2016.03
    -
    2018.03

     View Summary

    To compare of frequency of complications for endoscopic papillectomy.

  • Examination of the flow of pancreatic juice with pancreatic disease using cine dynamic MRCP with spatially selective inversion recovery pulse., 

    2015.10
    -
    2020.03

     View Summary

    To evaluate the flow of pancreatic juice with Chronic pancreatitis,Pancreatic cancer,IPMN,Autoimmune pancreatitis

Proposed Theme of Joint Research 【 Display / hide

  • Clinical study about ERCP or EUS

  • 胆膵悪性腫瘍の内視鏡的治療 採取された検体を用いた基礎研究など

 

Papers 【 Display / hide

  • New strategy for evaluating pancreatic tissue specimens from endoscopic ultrasound-guided fine needle aspiration and surgery

    Fukuhara S., Iwasaki E., Iwano T., Machida Y., Tamagawa H., Kawasaki S., Seino T., Yokose T., Endo Y., Yoshimura K., Kashiwagi K., Kitago M., Ogata H., Takeda S., Kanai T.

    JGH Open (JGH Open)  5 ( 8 ) 953 - 958 2021.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  2397-9070

     View Summary

    Background and Aim: Preoperative histological evaluation of pancreatic neoplasms is important for guiding the resection strategy and preventing postoperative adverse events. However, conventional endoscopic methods have technical limitations that reduce the accuracy of the histopathological examination. Probe electrospray ionization mass spectrometry (PESI-MS) may be a useful technique for rapidly evaluating small specimens. Methods: This single-center prospective study included patients with pancreatic neoplasms between October 2018 and December 2019. Pancreatic ductal adenocarcinoma (PDAC) specimens were obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and non-neoplastic tissue was obtained via surgery. Specimens were subjected to PESI-MS and the mass spectra were analyzed using partial least squares regression-discriminant analysis. Results: The study included 40 patients with 20 nonneoplastic specimens and 19 PDAC specimens (1 case of neuroendocrine carcinoma was omitted). All nonneoplastic specimens were sufficient for PESI-MS analysis, although only 7 of 19 PDAC specimens were sufficient for PESI-MS analysis because of poor sample quality or insufficient quantity (<1 mg). Among the 27 analyzed cases, the mass spectra clearly differentiated between the PDAC and nonneoplastic specimens. Conclusions: This study revealed that PESI-MS could differentiate between PDAC and nonneoplastic specimens, even in cases where EUS-FNA produced very small specimens.

  • Expert consensus on endoscopic papillectomy using a Delphi process.

    Fritzsche JA, Fockens P, Barthet M, Bruno MJ, Carr-Locke DL, Costamagna G, Coté GA, Deprez PH, Giovannini M, Haber GB, Hawes RH, Hyun JJ, Itoi T, Iwasaki E, Kylänpaä L, Neuhaus H, Park JY, Reddy DN, Sakai A, Bourke MJ, Voermans RP

    Gastrointestinal endoscopy  2021.04

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0016-5107

  • Impact of Enteral Nutrition Within 24 Hours Versus Between 24 and 48 Hours in Patients With Severe Acute Pancreatitis: A Multicenter Retrospective Study

    Nakashima I., Horibe M., Sanui M., Sasaki M., Sawano H., Goto T., Ikeura T., Takeda T., Oda T., Yasuda H., Ogura Y., Miyazaki D., Kitamura K., Chiba N., Ozaki T., Yamashita T., Koinuma T., Oshima T., Yamamoto T., Hirota M., Moriya T., Shirai K., Izai J., Takeda K., Sekino M., Iwasaki E., Kanai T., Mayumi T.

    Pancreas (Pancreas)  50 ( 3 ) 371 - 377 2021.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0885-3177

     View Summary

    OBJECTIVES: In patients with severe acute pancreatitis (SAP), early enteral nutrition (EN) is recommended by major clinical practice guidelines, but the exact timing for the initiation of EN is unknown. METHODS: We conducted a post hoc analysis of the database for a multicenter (44 institutions) retrospective study of patients with SAP in Japan. The patients were classified into 3 groups according to the timing of EN initiation after the diagnosis of SAP: within 24 hours, between 24 and 48 hours, and more than 48 hours. The primary outcome was in-hospital mortality. RESULTS: Of the 1094 study patients, 176, 120, and 798 patients started EN within 24 hours, between 24 and 48 hours, and more than 48 hours after SAP diagnosis, respectively. On multivariable analysis, hospital mortality was significantly better with EN within 48 hours than with more than 48 hours (adjusted odds ratio, 0.49; 95% confidence interval, 0.29-0.83; P < 0.001) but did not significantly differ between the groups with EN starting within 24 hours and between 24 and 48 hours (P = 0.29). CONCLUSIONS: Enteral nutrition within 24 hours may not confer any additional benefit on clinical outcomes compared with EN between 24 and 48 hours.

  • Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment

    Iwasaki Eisuke, Fukuhara Seiichiro, Horibe Masayasu, Kawasaki Shintaro, Seino Takashi, Takimoto Yoichi, Tamagawa Hiroki, Machida Yujiro, Kayashima Atsuto, Noda Marin, Hayashi Hideyuki, Kanai Takanori

    DIAGNOSTICS 11 ( 3 )  2021.03

    Research paper (scientific journal), Joint Work, Accepted

  • Peritoneal dissemination of pancreatic cancer caused by endoscopic ultrasound-guided fine needle aspiration: A case report and literature review

    Kojima H., Kitago M., Iwasaki E., Masugi Y., Matsusaka Y., Yagi H., Abe Y., Hasegawa Y., Hori S., Tanaka M., Nakano Y., Takemura Y., Fukuhara S., Ohara Y., Sakamoto M., Okuda S., Kitagawa Y.

    World Journal of Gastroenterology (World Journal of Gastroenterology)  27 ( 3 ) 294 - 304 2021.01

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  10079327

     View Summary

    BACKGROUND Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a biopsy technique widely used to diagnose pancreatic tumors because of its high sensitivity and specificity. Although needle-tract seeding caused by EUS-FNA has been recently reported, dissemination of pancreatic cancer cells is generally considered to be a rare complication that does not affect patient prognosis. However, the frequency of dissemination and needle-tract seeding appears to have been underestimated. We present a case of peritoneal dissemination of pancreatic cancer due to preoperative EUS-FNA. CASE SUMMARY An 81-year-old man was referred to the Department of Surgery of our hospital in Japan owing to the detection of a pancreatic mass on computed tomography during medical screening. Trans-gastric EUS-FNA revealed that the mass was an adenocarcinoma; hence laparoscopic distal pancreatectomy with lymphadenectomy was performed. No intraoperative peritoneal dissemination and liver metastasis were visually detected, and pelvic lavage cytology was negative for carcinoma cells. The postoperative surgical specimen was negative for carcinoma cells at the dissected margin and the cut end margin; however, pathological findings revealed adenocarcinoma cells on the peritoneal surface proximal to the needle puncture site, and the cells were suspected to be disseminated via EUS-FNA. Hence, the patient received adjuvant therapy with S-1 (tegafur, gimeracil, and oteracil potassium); however, computed tomography performed 5 mo after surgery revealed liver metastasis and cancerous peritonitis. The patient received palliative therapy and died 8 mo after the operation. CONCLUSION The indications of EUS-FNA should be carefully considered to avoid iatrogenic dissemination, especially for cancers in the pancreatic body or tail.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 【内科疾患の診断基準・病型分類・重症度】(第2章)消化器 急性膵炎

    岩崎 栄典

    内科 ((株)南江堂)  127 ( 4 ) 590 - 592 2021.04

    Research paper, Joint Work,  ISSN  0022-1961

  • 【EUS-BDのすべて】EUS-HGS・HJSの手技とコツ

    岩崎 栄典, 福原 誠一郎, 茅島 敦人, 町田 雄二郎, 玉川 空樹, 瀧本 洋一, 片山 正, 南 一洋, 川崎 慎太郎, 金井 隆典

    胆と膵 (医学図書出版(株))  42 ( 4 ) 293 - 304 2021.04

    Research paper, Joint Work,  ISSN  0388-9408

     View Summary

    超音波内視鏡下胆道ドレナージ術(EUS-BD)のうち、EUS-hepaticogastrostomy(EUS-HGS)、EUS-hepaticojejunostomy(HJS)は、胃あるいは挙上空腸から肝外側区胆管にステントを留置する方法である。本邦でも近年「超音波内視鏡下瘻孔形成術」として保険収載され、ハイボリュームセンターを中心に行われるようになってきた。世界的にも症例集積が進んだことで、多くの臨床研究や経験が報告され、各処置の段階における技術、用いるデバイスの選択などが共有されるようになってきた。本治療法の有用性が広まると同時に、施行医のニーズを取り込んださまざまな専門処置具が開発され、国内でも実際に臨床応用されはじめている。EUS-HJSは狭い空腸管腔内へ胆汁逆流による嘔吐をきたすこともあり、同時にアンテグレードで狭窄部にメタリックステントを挿入してドレナージ経路を確保することが多い。本稿ではEUS処置の導入を考えている胆膵内視鏡専門医を対象にEUS-HGSを中心とした具体的な処置方法とコツについて概説したい。(著者抄録)

  • 内視鏡的乳頭切除術(endoscopic papillectomy:EP)診療ガイドライン

    糸井 隆夫, 良沢 昭銘, 潟沼 朗生, 川嶋 啓揮, 岩崎 栄典, 橋元 慎一, 山本 健治郎, 植木 敏晴, 五十嵐 良典, 乾 和郎, 藤田 直孝, 藤本 一眞, 日本消化器内視鏡学会, 日本胆道学会, 日本消化器内視鏡学会ガイドライン委員会, 内視鏡的乳頭切除術診療ガイドラインワーキング委員会

    Gastroenterological Endoscopy ((一社)日本消化器内視鏡学会)  63 ( 4 ) 451 - 480 2021.04

    Research paper, Joint Work,  ISSN  0387-1207

  • 【胆道ドレナージを極める】経皮的胆道ドレナージは内視鏡医には不要か?

    岩崎 栄典, 福原 誠一郎, 川崎 慎太郎, 玉川 空樹, 町田 雄二郎, 茅島 敦人, 金井 隆典

    消化器内視鏡 ((株)東京医学社)  33 ( 3 ) 617 - 619 2021.03

    Research paper, Joint Work,  ISSN  0915-3217

  • 【急性膵炎診療up-to-date】今日の急性膵炎診療

    正宗 淳, 多田 稔, 北村 勝哉, 岩崎 栄典

    肝胆膵 ((株)アークメディア)  82 ( 1 ) 13 - 24 2021.01

    Research paper, Joint Work,  ISSN  0389-4991

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Presentations 【 Display / hide

  • 胆道狭窄に対するデジタル胆道鏡による直視下生検と透視下生検・擦過細胞診の成績

    岩崎栄典 「他」

    第112回 日本消化器内視鏡学会 関東支部例会 (東京) , 2021.06, Oral Presentation(general), 日本消化器内視鏡学会

  • 内視鏡的乳頭切開術に伴う穿孔に対する胆管膵管ドレナージの有用性

    福原誠一郎、岩崎栄典、南一洋、緒方晴彦、金井隆典

    内視鏡学会関東地方会 (東京) , 2019.12, Symposium, Workshop, Panelist (public offering)

  • 自己免疫性膵炎におけるEUS所見の検討

    南一洋、福原誠一郎、岩崎栄典

    内視鏡学会関東地方会 (神戸) , 2019.12, Oral Presentation(general)

  • Prevention of adverse events after endoscopic ampullectomy: a retrospective study

    Eisuke Iwasaki

    APDW2019 (Biswa Bangla Convention Centre, Kolkata) , 2019.12, Oral Presentation(general), APDWF

  • 治療内視鏡(胆膵)における穿孔とその対処

    岩崎栄典

    JDDW2019, 2019.11, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 胆膵がんオルガノイドをもちいた薬剤感受性試験確立と薬剤応答性メカニズムの解明

    2019.04
    -
    2022.03

    日本学術振興会, 文部省科学研究費, 岩崎栄典, 基盤研究(C), Research grant, Principal Investigator

     View Summary

    難治かつ生命予後不良な胆膵がん疾患における治療成績改善のため、個別化治療の導入が望まれている。研究分担者である佐藤俊朗が世界で初めて確立した三次元組織構造体(オルガノイド)培養をHigh-throughput screening薬剤感受性試験に応用することで、比較的短時間かつ高い精度で効率の良い薬剤感受性試験が実現可能である。手術検体や超音波内視鏡下生検より現在得られたごく微量の腫瘍組織よりオルガノイドを樹立し、バンク化を進めている。胆膵がんオルガノイドバンクより薬剤感受性試験技術を確立させ、臨床データとの相関性を検討する。また薬剤感受性データと全エキソン同定、遺伝子発現アレイ解析などのin vitroデータとの相関解析の他、 CRISPR-Cas9システムを用いたゲノム編集技術を応用し、薬剤応答性の評価方法を確立することで個別化医療への応用、 創薬分野への応用を目指す。

  • 難治性疾患等政策研究事業(難治性疾患政策研究事業)「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究」

    2017.04
    -
    2019.03

    厚生労働省, Health and Labour Sciences Research Grants, 関西医科大学 岡崎和一教授, Research grant, Co-investigator

  • 難治性胆膵悪性腫瘍に対するがんオルガノイド培養を用いた薬剤感受性検査の確立

    2016.04
    -
    2019.03

    文部科学省, Grant-in-Aid for Scientific Research, 岩崎栄典, Research grant, Principal Investigator

     View Summary

    難治かつ生命予後不良な胆膵悪性腫瘍における診断治療の革新のため,オーダーメイド治療の
    導入が望まれている.研究分担者である佐藤らが世界で初めて確立した三次元組織構造体(オル
    ガノイド)培養とHigh-throughput screening(HTS)を応用することで,比較的短時間かつ高い精
    度で効率の良い薬剤感受性試験が実現可能である.超音波内視鏡下生検より得たごく微量の腫瘍
    組織よりのオルガノイド培養方法の確立,全エキソン同定,HTS による薬剤感受性試験の確立,
    in vivo でゼノグラフトを用いた評価をおこなう.世界初のオルガノイド培養を用いたオーダーメイド治療選択の実現に向けた基礎的な研究・技術開発を目的とする.

 

Courses Taught 【 Display / hide

  • PATHOPHYSIOLOGICAL ISSUES IN CHRONIC CARE

    2021

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2021

  • LECTURE SERIES, INTERNAL MEDICINE

    2021

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2021

  • CLINICAL TRAINING IN DIAGNOSIS

    2021

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Courses Previously Taught 【 Display / hide

  • lecture of gastroenterology

    Keio University School of Medicine, 2021, Autumn Semester, Major subject, Lecture, Within own faculty, 3h, 120people

  • lecture of chronic diseases

    Keio University Faculty of Nursing And Medical Care, 2021, Spring Semester, Major subject, Lecture, Within own faculty, 1h

  • lecture of gastroenterology

    Keio University School of Medicine, 2020, Autumn Semester, Major subject, Lecture, Within own faculty, 3h, 120people

  • 内科診断学実習(OSCE講義)

    慶應義塾大学医学部, 2019, Autumn Semester, Major subject, Laboratory work/practical work/exercise, Within own faculty, 20people

  • 消化器内科学 講義

    慶應義塾大学医学部, 2019, Spring Semester, Major subject, Lecture, Within own faculty, 120people

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Educational Activities and Special Notes 【 Display / hide

  • PostCC OSCE委員

    2019.04
    -
    Present

  • OSCE委員

    2016.02
    -
    Present

    , Special Affairs

     View Details

    OSCE試験腹部担当としてステーションリーダーとなり、評価者の基準を統一にすべく指導を行った。

  • カリキュラム委員会

    2015.04
    -
    Present

    , Device of Educational Contents

     View Details

    カリキュラム委員として活動

 

Memberships in Academic Societies 【 Display / hide

  • 日本膵臓学会, 

    2013.10
    -
    Present
  • 日本胆道学会, 

    2013.10
    -
    Present
  • 日本消化器病学会, 

    2003.07
    -
    Present
  • Japan Gastroenterological Endoscopy Society, 

    2003.07
    -
    Present
  • 日本内科学会, 

    2001.04
    -
    Present

Committee Experiences 【 Display / hide

  • 2021.07
    -
    Present

    EUS-FNAガイドライン作成委員, 日本消化器内視鏡学会

     View Remarks

    https://www.jges.net/medical/about/list/committee#esufna

  • 2021.05
    -
    Present

    IgG4関連消化管病変に関する調査研究 Woriking Gruop, 厚生労働省難治疾患研究班

     View Remarks

    https://www.nanbyou.or.jp/entry/4505

  • 2020.10
    -
    Present

    第113回日本消化器内視鏡学会関東支部例会 プログラム委員, 日本消化器内視鏡学会

     View Remarks

    http://www.jges-k.umin.jp/113shibureikai/outline.html

  • 2020.08
    -
    Present

    日本肝胆膵外科学会 編集委員会 委員, 日本肝胆膵外科学会

  • 2020.07
    -
    Present

    an official member in Education Committee, under EUS & ERCP Workgroup, The Asian Pacific Society for Digestive Endoscopy.

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