Iwasaki, Eisuke

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Gastroenterology and Hepatology) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

Related Websites

External Links

Profile 【 Display / hide

  • Iwasaki Eisuke M.D., Ph.D. is a specialist in the diagnosis and treatment of pancreat-biliary disease. He focus especially on endoscopic treatment using EUS and ERCP. His research themes are clinical practice of severe acute pancreatitis, IgG4 related diseases, interventional EUS and endoscopic ampullectomy.

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Career 【 Display / hide

  • 2015.04

    慶應義塾大学医学部内科学教室, 消化器内科, 助教

  • 2015.05
    -
    2017.02

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

  • 2017.03
    -
    Present

    Department of Internal Medicine, Keio University School of Medicine, Division of Gastroenterology, Assistant Professor

 

Research Areas 【 Display / hide

  • Gastroenterology

Research Themes 【 Display / hide

  • Multicenter retrospective study in endoscopic papillectomy for duodenal ampullary tumor, 

    2020.03
    -
    2024.03

     View Summary

    To evaluate the efficacy, prognosis, and treatment of endoscopic papillectomy (EP).
    UMIN000040288

  • Examination of the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease., 

    2017.01
    -
    2021.03

     View Summary

    To clarify the usefulness of probe type confocal laser endomicroscopy for duodenum, biliary tract system and pancreas disease.

  • Evaluation of exhaled carbon dioxide monitoring during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography, 

    2016.08
    -
    2018.12

     View Summary

    to determine whether capnographic monitoring reduces the incidence of hypoxemia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography

  • Comparison of the electricity method for endoscopic papillectomy., 

    2016.03
    -
    2018.03

     View Summary

    To compare of frequency of complications for endoscopic papillectomy.

  • Examination of the flow of pancreatic juice with pancreatic disease using cine dynamic MRCP with spatially selective inversion recovery pulse., 

    2015.10
    -
    2020.03

     View Summary

    To evaluate the flow of pancreatic juice with Chronic pancreatitis,Pancreatic cancer,IPMN,Autoimmune pancreatitis

Proposed Theme of Joint Research 【 Display / hide

  • Clinical study about ERCP or EUS

  • 胆膵悪性腫瘍の内視鏡的治療 採取された検体を用いた基礎研究など

 

Papers 【 Display / hide

  • Clinical Practice Guidelines for Endoscopic Papillectomy.

    Itoi T, Ryozawa S, Katanuma A, Kawashima H, Iwasaki E, Hashimoto S, Yamamoto K, Ueki T, Igarashi Y, Inui K, Fujita N, Fujimoto K

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society  2022.01

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0915-5635

  • Endoscopic Diagnosis of Biliary Stricture Combined with Digital Cholangioscope: A Case Series

    Fukuhara S., Iwasaki E., Kayashima A., Machida Y., Tamagawa H., Kawasaki S., Horibe M., Hori S., Abe Y., Kitago M., Ogata H., Kanai T.

    Healthcare (Switzerland) (Healthcare (Switzerland))  10 ( 1 )  2022.01

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    The endoscopic diagnosis of biliary tract lesions is applied as a non-invasive method; however, its diagnostic accuracy is not yet high. Moreover, digital cholangioscopy is used for directly visualizing the inside of the bile duct, resulting in a more precise biopsy. We present the case series of the outcomes of diagnosis using digital cholangioscopy in patients who underwent cholangioscopy for the evaluation of biliary stenosis in our department between January 2014 and March 2021. The controls were those who underwent a biopsy for biliary stenosis with conventional endoscopic retrograde cholangiopancreatography (ERCP). Background data for each case were collected, and the clinical outcomes by biopsy were evaluated, focusing on the accuracy of the diagnosis. Cholangioscopy was performed in 15 cases, while a conventional biopsy by ERCP was performed in 172 cases. Nine of 15 cases (60.0%) were diagnosed with cholangiocarcinoma. The number of specimens obtained through conventional ERCP and cholangioscopy was 2.5 ± 1.3 and 3.3 ± 1.5, respectively (p = 0.043). The diagnostic accuracy of conventional ERCP and cholangioscopy were 65.7% (113 of 172 cases) and 100%, respectively, which was significantly higher in the group with cholangioscopy. Digital cholangioscopy is useful when the diagnosis of the biliary stricture using the conventional ERCP method is difficult.

  • Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata.

    Horibe M, Iwasaki E, Matsuzaki J, Bazerbachi F, Kaneko T, Minami K, Fukuhara S, Masaoka T, Hosoe N, Ogura Y, Namiki S, Hosoda Y, Ogata H, Kanai T

    Gastroenterology report 9 ( 6 ) 543 - 551 2021.12

    Research paper (scientific journal), Joint Work, Accepted

  • Endoscopic papillectomy for tumors of the minor duodenal papilla: a case series of 6 patients and literature review.

    Yamamoto K, Itoi T, Iwasaki E, Tsuchiya T, Ishii K, Tonozuka R, Mukai S, Nagai K, Kitagawa Y

    Journal of hepato-biliary-pancreatic sciences (Journal of Hepato-Biliary-Pancreatic Sciences)   2021.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1868-6974

     View Summary

    Background/Purpose: Various tumors of the minor duodenal papilla have been reported, most of which are treated by laparotomy. Although early-stage tumors of the major papilla are increasingly being treated by endoscopic resection with relative ease and low invasiveness, there are only a few reports on endoscopic resection of tumors in the minor papilla. Methods: Six patients with tumors in the minor papilla were treated by endoscopic papillectomy (EP), and their clinical and histopathological data were analyzed retrospectively. Results: The final pathological diagnoses were carcinoma in adenoma in two patients and adenoma, neuroendocrine neoplasm (G1), hyperplastic lesion, and no neoplastic lesion (disappearance of adenoma after biopsy) in one patient each. En bloc resection was performed in five patients and piecemeal resection in one patient. There were no procedure-related adverse events, such as bleeding, pancreatitis, or perforation. There was one case with a residual lesion, which was treated by ablation therapy, and no recurrences during a mean follow-up of 12 ± 10.33 months (maximum, 28 months) from the date of EP. Conclusions: Endoscopic papillectomy appears to be an effective minimally invasive treatment for ampullary tumors of the minor duodenal papilla.

  • Concordance of the histological diagnosis of type 1 autoimmune pancreatitis and its distinction from pancreatic ductal adenocarcinoma with endoscopic ultrasound-guided fine needle biopsy specimens: an interobserver agreement study

    Notohara Kenji, Kamisawa Terumi, Furukawa Toru, Fukushima Noriyoshi, Uehara Takeshi, Kasashima Satomi, Iwasaki Eisuke, Kanno Atsushi, Kawashima Atsuhiro, Kubota Kensuke, Kuraishi Yasuhiro, Motoya Masayo, Naitoh Itaru, Nishino Takayoshi, Sakagami Junichi, Shimizu Kyoko, Tomono Teruko, Aishima Shinichi, Fukumura Yuki, Hirabayashi Kenichi, Kojima Motohiro, Mitsuhashi Tomoko, Naito Yoshiki, Ohike Nobuyuki, Tajiri Takuma, Yamaguchi Hiroshi, Fujiwara Hideyo, Ibuki Emi, Kobayashi Shota, Miyaoka Masashi, Nagase Mamiko, Nakashima Junko, Nakayama Masamichi, Oda Shinsuke, Taniyama Daiki, Tsuyama Sho, Watanabe Syunsuke, Ikeura Tsukasa, Kawa Shigeyuki, Okazaki Kazuichi

    VIRCHOWS ARCHIV (Virchows Archiv)   2021.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0945-6317

     View Summary

    The histological diagnosis of type 1 autoimmune pancreatitis (AIP) based on the findings obtained by an endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) is feasible, but the diagnostic consistency of this method has not been confirmed. We determined the interobserver agreement among 20 pathologists regarding the diagnosis of type 1 AIP, including the distinction from pancreatic ductal adenocarcinoma (PDAC) using large tissue samples obtained by EUS-FNB. After guidance for diagnosing AIP with biopsy tissues was provided, a round 2 was performed. The median sensitivity and specificity for diagnosing PDAC vs. non-neoplastic diseases were 95.2% and 100%, respectively. In groups of specialists (n = 7) and the generalists (n = 13), Fleiss’ к-values increased from 0.886 to 0.958 and from 0.750 to 0.816 in round 2. The concordance was fair or moderate for obliterative phlebitis and storiform fibrosis but slight for ductal lesion of type 1 AIP. Discordant results were due to ambiguous findings and biopsy tissue limitations. Among the specialists, the ratio of cases with perfect agreement regarding the presence of storiform fibrosis increased in round 2, but agreement regarding obliterative phlebitis or ductal lesions was not improved. Although the histological definite diagnosis of type 1 AIP was achieved by most observers in > 60% of the cases, the confidence levels varied. Because some ambiguities exist, the histological diagnostic levels based on the diagnostic criteria of type 1 AIP should not be taken for granted. Guidance is effective for improving accurate PDAC diagnoses (notably by recognizing acinar-ductal metaplasia) and for evaluating storiform fibrosis.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Inoperable duodenal ampullary carcinoma: Can endoscopic radiofrequency ablation therapy be a promising palliative treatment in the future?

    Iwasaki E.

    Digestive Endoscopy (Digestive Endoscopy)   2022

    Research paper, Joint Work,  ISSN  09155635

  • 【膵疾患に対する内視鏡診療のすべて】膵疾患に対する内視鏡診断 慢性膵炎・早期慢性膵炎・自己免疫性膵炎のEUS診断

    瀧本 洋一, 入澤 篤志, 星 恒輝, 山部 茜子, 井澤 直哉, 山宮 知, 永島 一憲, 水口 貴仁, 岩崎 栄典

    消化器内視鏡 ((株)東京医学社)  33 ( 9 ) 1403 - 1410 2021.09

    Research paper, Joint Work,  ISSN  0915-3217

     View Summary

    EUSはきわめて至近距離から高解像度で膵を観察できるため、慢性膵炎(早期慢性膵炎を含む)や自己免疫性膵炎(AIP)の診断には必須のモダリティである。特に、早期慢性膵炎診断においてはEUS画像診断の意義は大きく、2019年に改訂された「慢性膵炎臨床診断基準2019」では、診断特異性を向上させるために2009年の診断基準の7項目のうち近似した所見をひとまとめとし、4項目が制定されている。EUSは、特に限局型AIP診断において膵癌との鑑別に有用とされ、画像診断のみならずEUS-FNB(EUS-guided fine-needle biospy)が大きな役割を果たす。また、造影EUSやEUSエラストグラフィーなどによる膵炎診断の新知見も報告されてきており、この領域におけるさらなる発展が期待される。(著者抄録)

  • 乳頭部腺腫に対するEP症例の術後成績の検討

    町田 雄二郎, 岩崎 栄典, 福原 誠一郎

    胆道 (日本胆道学会)  35 ( 3 ) 415 - 415 2021.08

    Research paper, Joint Work,  ISSN  0914-0077

  • 胆膵領域の内視鏡診断の最前線 胆道狭窄に対するデジタル胆道鏡による直視下生検と透視下生検・擦過細胞診の成績

    岩崎 栄典, 福原 誠一郎, 茅島 敦人, 緒方 晴彦, 金井 隆典

    Progress of Digestive Endoscopy ((一社)日本消化器内視鏡学会-関東支部)  99 ( Suppl. ) s76 - s76 2021.06

    Research paper, Joint Work,  ISSN  1348-9844

  • 【内科疾患の診断基準・病型分類・重症度】(第2章)消化器 急性膵炎

    岩崎 栄典

    内科 ((株)南江堂)  127 ( 4 ) 590 - 592 2021.04

    Research paper, Joint Work,  ISSN  0022-1961

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Presentations 【 Display / hide

  • 膵切除術後膵液瘻に対する内視鏡処置の工夫

    岡田はるか, 岩崎栄典, 川崎慎太郎, 緒方晴彦, 金井隆典

    第113回日本消化器内視鏡学会関東支部例会 (東京) , 2021.12, Symposium, Workshop, Panelist (public offering), 日本内視鏡学会関東支部

  • 迷入防止のために新しく開発された「セミピッグテイル」プラスチック胆管ステント使用に関するパイロット前向き研究

    中島悠貴、茅島敦人、堀部昌靖、岩崎栄典、金井隆典

    第113回日本消化器内視鏡学会関東支部例会 (東京) , 2021.12, Symposium, Workshop, Panelist (public offering), 日本内視鏡学会関東支部

  • 胆膵疾患におけるInterventional EUSの選択と安全性についての検討

    水上耀介, 岩崎栄典, 川崎慎太郎, 堀部昌靖, 金井隆典

    第113回日本消化器内視鏡学会関東支部例会 (東京) , 2021.12, Symposium, Workshop, Panelist (public offering), 日本内視鏡学会関東支部

  • 内視鏡的乳頭切除術を施行した十二指腸乳頭部gangliocytic paragangliomaの一例

    岡田 はるか, 岩崎 栄典, 茅島 敦人, 町田 雄二郎, 川崎 慎太郎, 原 健佑, 眞杉 洋平, 金井 隆典

    第57回日本胆道学会学術集会 (東京) , 2021.10, Oral Presentation(general), 日本胆道学会

     View Summary

    【症例】54歳男性【現病歴】定期検査の上部消化管内視鏡で十二指腸乳頭部腫大を認め,星槎目的に当院を紹介受診した.内視鏡検査では主乳頭の肛門側に10mm大の粘膜下腫瘤があり,同部の超音波内視鏡検査では乳頭部に連続する粘膜下層に類円形で辺縁整の低エコー腫瘤を認めた.内視鏡下生検で神経内分泌系の腫瘍が疑われた.無症
    状かつ高血圧もなく,安静時血液検査でカテコールアミン3分画は正常範囲であった.造影CT検査では十二指腸の病変は判然とせず,有意なリンパ節腫大や遠隔転移を認めなかった.非機能性神経内分泌腫瘍の術前診断で,十分な説明の上で,内視鏡的乳頭切除術を施行した.乳頭部近傍であったため,乳頭部も含めて十分なマージンを取ってスネアで一括切除をおこなった.胆管孔に乳頭切開術をおこない膵管ステントを留置した上で,ステント直下から肛門側の潰瘍底をクリップで縫縮した.合併症なく経過し,術後5日目に退院した.病理組織学的診断は神経節細胞様細胞,神経内分泌細胞様細胞,紡錘形細胞が混在しており,免疫染色と合わせて,gangliocytic paraganglioma(GP)の診断となった.【考察】十二指腸乳頭部および近傍に好発するGPは比較的まれな腫瘍であり,内視鏡的乳頭切除の適応は定められていない.近年では画像上リンパ節転移を認めない症例で内視鏡的乳頭切除例が増加しており,その有用性が報告されている.一般的に良性腫瘍と考えられているが,リンパ節転移を含めた悪性症例が含まれることも指摘されており,慎重な術前評価と詳細な病理評価,適切な術後観察が望ましいと考えられた.

  • 乳頭部腺腫に対するEP症例の術後成績の検討

    町田 雄二郎, 岩崎 栄典, 福原 誠一郎

    第57回日本胆道学会学術集会 (東京) , 2021.10, Oral Presentation(general), 日本胆道学会

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 胆膵がんオルガノイドをもちいた薬剤感受性試験確立と薬剤応答性メカニズムの解明

    2019.04
    -
    2022.03

    日本学術振興会, 文部省科学研究費, 岩崎栄典, 基盤研究(C), Research grant, Principal Investigator

     View Summary

    難治かつ生命予後不良な胆膵がん疾患における治療成績改善のため、個別化治療の導入が望まれている。研究分担者である佐藤俊朗が世界で初めて確立した三次元組織構造体(オルガノイド)培養をHigh-throughput screening薬剤感受性試験に応用することで、比較的短時間かつ高い精度で効率の良い薬剤感受性試験が実現可能である。手術検体や超音波内視鏡下生検より現在得られたごく微量の腫瘍組織よりオルガノイドを樹立し、バンク化を進めている。胆膵がんオルガノイドバンクより薬剤感受性試験技術を確立させ、臨床データとの相関性を検討する。また薬剤感受性データと全エキソン同定、遺伝子発現アレイ解析などのin vitroデータとの相関解析の他、 CRISPR-Cas9システムを用いたゲノム編集技術を応用し、薬剤応答性の評価方法を確立することで個別化医療への応用、 創薬分野への応用を目指す。

  • 難治性疾患等政策研究事業(難治性疾患政策研究事業)「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究」

    2017.04
    -
    2019.03

    厚生労働省, Health and Labour Sciences Research Grants, 関西医科大学 岡崎和一教授, Research grant, Co-investigator

  • 難治性胆膵悪性腫瘍に対するがんオルガノイド培養を用いた薬剤感受性検査の確立

    2016.04
    -
    2019.03

    文部科学省, Grant-in-Aid for Scientific Research, 岩崎栄典, Research grant, Principal Investigator

     View Summary

    難治かつ生命予後不良な胆膵悪性腫瘍における診断治療の革新のため,オーダーメイド治療の
    導入が望まれている.研究分担者である佐藤らが世界で初めて確立した三次元組織構造体(オル
    ガノイド)培養とHigh-throughput screening(HTS)を応用することで,比較的短時間かつ高い精
    度で効率の良い薬剤感受性試験が実現可能である.超音波内視鏡下生検より得たごく微量の腫瘍
    組織よりのオルガノイド培養方法の確立,全エキソン同定,HTS による薬剤感受性試験の確立,
    in vivo でゼノグラフトを用いた評価をおこなう.世界初のオルガノイド培養を用いたオーダーメイド治療選択の実現に向けた基礎的な研究・技術開発を目的とする.

 

Courses Taught 【 Display / hide

  • PATHOPHYSIOLOGICAL ISSUES IN CHRONIC CARE

    2021

  • LECTURE SERIES, INTERNAL MEDICINE (GASTROENTEROLOGY)

    2021

  • LECTURE SERIES, INTERNAL MEDICINE

    2021

  • INTRODUCTION TO CLINICAL CLERKSHIPS

    2021

  • CLINICAL TRAINING IN DIAGNOSIS

    2021

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Courses Previously Taught 【 Display / hide

  • lecture of gastroenterology

    Keio University School of Medicine, 2021, Autumn Semester, Major subject, Lecture, Within own faculty, 3h, 120people

  • lecture of chronic diseases

    Keio University Faculty of Nursing And Medical Care, 2021, Spring Semester, Major subject, Lecture, Within own faculty, 1h

  • lecture of gastroenterology

    Keio University School of Medicine, 2020, Autumn Semester, Major subject, Lecture, Within own faculty, 3h, 120people

  • 内科診断学実習(OSCE講義)

    慶應義塾大学医学部, 2019, Autumn Semester, Major subject, Laboratory work/practical work/exercise, Within own faculty, 20people

  • 消化器内科学 講義

    慶應義塾大学医学部, 2019, Spring Semester, Major subject, Lecture, Within own faculty, 120people

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Educational Activities and Special Notes 【 Display / hide

  • PostCC OSCE委員

    2019.04
    -
    Present

  • OSCE委員

    2016.02
    -
    Present

    , Special Affairs

     View Details

    OSCE試験腹部担当としてステーションリーダーとなり、評価者の基準を統一にすべく指導を行った。

  • カリキュラム委員会

    2015.04
    -
    Present

    , Device of Educational Contents

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    カリキュラム委員として活動

 

Memberships in Academic Societies 【 Display / hide

  • 日本膵臓学会, 

    2013.10
    -
    Present
  • 日本胆道学会, 

    2013.10
    -
    Present
  • 日本消化器病学会, 

    2003.07
    -
    Present
  • Japan Gastroenterological Endoscopy Society, 

    2003.07
    -
    Present
  • 日本内科学会, 

    2001.04
    -
    Present

Committee Experiences 【 Display / hide

  • 2021.07
    -
    Present

    EUS-FNAガイドライン作成委員, 日本消化器内視鏡学会

     View Remarks

    https://www.jges.net/medical/about/list/committee#esufna

  • 2021.05
    -
    Present

    IgG4関連消化管病変に関する調査研究 Woriking Gruop, 厚生労働省難治疾患研究班

     View Remarks

    https://www.nanbyou.or.jp/entry/4505

  • 2020.10
    -
    Present

    第113回日本消化器内視鏡学会関東支部例会 プログラム委員, 日本消化器内視鏡学会

     View Remarks

    http://www.jges-k.umin.jp/113shibureikai/outline.html

  • 2020.08
    -
    Present

    日本肝胆膵外科学会 編集委員会 委員, 日本肝胆膵外科学会

  • 2020.07
    -
    Present

    an official member in Education Committee, under EUS & ERCP Workgroup, The Asian Pacific Society for Digestive Endoscopy.

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