Takatsuki, Seiji



School of Medicine, Endowed Research Laboratory for Arrhythmia Advanced Therapeutics (Shinanomachi)


Project Professor (Non-tenured)

Academic Background 【 Display / hide

  • 1984.04

    Keio University, School of Medicine, 医学科

    University, Graduated

Academic Degrees 【 Display / hide

  • 上室性頻拍症患者の逆行伝導路診断における傍His束刺激と純His束刺激の意義について, Keio University, Dissertation


Papers 【 Display / hide

  • Predictive factors of lead failure in patients implanted with cardiac devices

    Aizawa Yoshiyasu, Negishi Masachika, Kashimura Shin, Nakajima Kazuaki, Kunitomi Akira, Katsumata Yoshinori, Nishiyama Takahiko, Kimura Takehiro, Nishiyama Nobuhiro, Fukumoto Kotaro, Tanimoto Yoko, Kohsaka Shun, Takatsuki Seiji, Fukuda Keiichi

    International Journal of Cardiology 199   277 - 281 2015.09

    ISSN  0167-5273

     View Summary

    <p>Introduction Lead failures (LFs) are one of the most common complications in patients implanted with cardiovascular implantable electronic devices. LFs often cause serious secondary complications such as inappropriate ICD shocks or asystole. This study aimed to identify the clinical factors associated with the occurrence of LFs. Methods A total of 735 consecutive device implantations (mean age 67 ± 15 years, males 64%) performed at a single university hospital setting from 1997 to 2014 were included. The implanted devices consisted of 421 pacemakers, 250 implantable cardioverter defibrillators (ICD), 9 cardiac resynchronization therapy pacemakers (CRT-P), and 55 CRT defibrillators (CRT-D). The primary endpoint was the development of an LF. Results During a mean duration of 5.8 ± 4.3 years, 38 LFs developed in 31 patients (mean age 56 ± 14 years). LFs included 32 ICD (7 Sprint Fidelis, 2 Riata), and 6 pacing leads. Nine patients received inappropriate ICD shocks and 1 had syncope due to an LF. All patients underwent lead reinsertions with device replacements. Eight patients required opposite site implantations due to venous occlusions. The predictive factors of LFs were the age, male sex, taller body length, ICD vs. pacemaker, lesser lead number, extra-thoracic puncture of the axillary vein vs. a cut-down of the cephalic vein, use of recalled leads and patients with idiopathic ventricular fibrillation (IVF) and Brugada syndrome (BrS). Conclusion LFs occurred mainly with ICD leads. A lesser age, the puncture method, lead model, and diagnosis of IVF/BrS were associated with the development of LFs.</p>

  • Left atrial thrombus formation and resolution during dabigatran therapy

    Mitamura Hideo, Nagai Takayuki, Watanabe Atsuyuki, Takatsuki Seiji, Okumura Ken

    Journal of Arrhythmia 31 ( 4 ) 226 - 231 2015.08

    ISSN  1880-4276

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    <p>Background: Protocols on the use of novel oral anticoagulants for stroke prevention in patients with atrial fibrillation (AF) undergoing electrical cardioversion (ECV) are lacking. Aim: The study was aimed at evaluating the efficacy of dabigatran (Dabi) treatment in preventing peri-ECV stroke. Methods: A retrospective survey of the incidence and fate of left atrial (LA) thrombus during Dabi therapy in patients with AF was conducted between December 2012 and January 2013 by the Japanese Heart Rhythm Society. Results: A total of 198 patients from 299 institutions underwent transesophageal echocardiography (TEE) to rule out LA thrombus before ECV. Of these, LA thrombus was found in eight patients (4%), who tended to be older (67.3 vs. 61.3 years, p=0.175), had higher CHADS&lt;inf&gt;2&lt;/inf&gt; scores (1.88 vs. 0.95, p=0.058), and a higher prevalence of prior stroke or transient ischemic attack (22.2% vs. 2.6%, p=0.034) than those without LA thrombus. Of the eight patients with LA thrombus, one had LA thrombus during a Dabi 150 mg b.i.d treatment, whereas the remaining seven were receiving 110 mg b.i.d for 3 weeks or longer. In 6 of the 8 patients with LA thrombus, a second TEE was performed, revealing complete resolution of LA thrombus in five; among these five patients, one received Dabi dosage of 150 mg b.i.d unchanged, two received an increased dosage from 110 mg to 150 mg b.i.d, and two were switched to warfarin. Two patients had a stroke 3 and 15 days after ECV, and one had a major large intestine bleeding episode during Dabi therapy. Conclusions: LA thrombus developed in 4% of patients with AF receiving Dabi. Older patients with a higher CHADS&lt;inf&gt;2&lt;/inf&gt; score receiving a lower Dabi dosage were more likely to develop LA thrombus, which was resolved with a prolonged or increased dosage. A higher Dabi dosage may be more beneficial before ECV but prospective randomized studies would be needed to confirm these results.</p>

  • Optimal conditions for cardiac catheter ablation using photodynamic therapy

    Kimura Takehiro, Takatsuki Seiji, Miyoshi Shunichiro, Takahashi Mei, Ogawa Emiyu, Katsumata Yoshinori, Nishiyama Takahiko, Nishiyama Nobuhiro, Tanimoto Yoko, Aizawa Yoshiyasu, Arai Tsunenori, Fukuda Keiichi

    Europace 17 ( 8 ) 1309 - 1315 2015.06

    ISSN  1099-5129

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    <p>Aims Photodynamic therapy (PDT) is based on non-thermal injury mediated by singlet oxygen species and is used clinically in cancer therapy. In our continuing efforts to apply this technology to cardiac catheter ablation, we clarified the optimal condition for creating PDT-mediated lesions using a laser catheter. Methods and results In a total of 35 canines, we applied a laser directly to the epicardium of the beating heart during open-chest surgery at 15 min after administration of a photosensitizer, talaporfin sodium. We evaluated the lesion size (depth and width) using hematoxylin-eosin staining under varying conditions as follows: laser output (5, 10, 20 W/cm&lt;sup&gt;2&lt;/sup&gt;), irradiation time (0-60 s), photosensitizer concentration (0, 2.5, 5 mg/kg), blood oxygen concentration (103.5 ± 2.1 vs. 548.0 ± 18.4 torr), and contact force applied during irradiations (low: &lt;20 g, high: &gt;20 g). A laser irradiation at 20 W/cm&lt;sup&gt;2&lt;/sup&gt; for 60 s under 5 mg/kg (29 μg/mL) of photosensitizer induced a lesion 8.7 ± 0.8 mm deep and 5.2 ± 0.2 mm wide. The lesion size was thus positively correlated to the laser power, irradiation time, and photosensitizer concentration, and was independent of the applied contact force and oxygen concentration. In addition, the concentration of the photosensitizer strongly correlated with the changes in the pulse oximetry data and fluorescence of the backscattering laser, suggesting that a clinically appropriate condition could be estimated in real time. Conclusion Photodynamic therapy-mediated cardiac lesions might be controllable by regulating the photosensitizer concentration, laser output, and irradiation time.</p>

  • Aiming for zero deaths

    Mitamura Hideo, Iwami Taku, Mitani Yoshihide, Takeda Satoshi, Takatsuki Seiji

    Circulation Journal 79 ( 7 ) 1398 - 1401 2015.06

    ISSN  1346-9843

  • Detection, risk factors and management of the patient with lead failure

    Nishiyama Nobuhiro, Takatsuki Seiji

    Respiration and Circulation 63 ( 5 ) 447 - 457 2015.05

    ISSN  0452-3458

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 単形性心室頻拍発症後,数年の経過で心機能低下と多種類の心室頻拍に進行した症例

    Fukudayukiko, Takatsukiseiji, Mitamurahideo, Tanimotokoujirou, Oohashinarutaka, Iedamasaki, Kuritayasuo, Miyoshishunichirou, Ogawasatoshi



    Oral presentation (general)

  • 大動脈弁置換術後に出現した脚枝間リエントリーの1例

    Fukudayukiko, Takatsukiseiji, Mitamurahideo, Oohashinarutaka, Iedamasaki, Haramotoki, Ogawasatoshi



    Oral presentation (general)

  • T型Caチャネル遮断薬はL型Caチャネル遮断薬よりも長期に心房電気的リモデリングを抑制する

    Oohashi Narutaka



    Oral presentation (general)

  • 洞調律下,遅伝導路の伝導時に胸部不快感を伴った房室二重伝導路の一例

    Katou Yuki, Fukuda Yukiko, Takatsuki Seiji, Mitamura Hideo, Tanimoto Koushirou, Anzai Toshihisa, Satou Tooru, Yoshikawa Tsutomu, Ogawa Satoshi



    Oral presentation (general)

  • T型Caチャネル遮断薬Efonidipineによる電気的リモデリングの長期抑制

    Oohashi Narutaka



    Oral presentation (general)

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Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • Arrhythmia

    Keio University


    Autumn Semester, Lecture, Within own faculty, 2h, 100people