Chubachi, Shotaro

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Pulmonary Medicine) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor
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Career 【 Display / hide 】

  • 2015.04
    -
    Present

    内科学教室、呼吸器内科, 助教

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Academic Background 【 Display / hide 】

  • 2005.03

    昭和大学, 医学部

    University

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Academic Degrees 【 Display / hide 】

  • 博士（医学）, 慶應義塾大学, Dissertation

    Polymorphism of LRP5 gene and emphysema severity are associated with osteoporosis　in Japanese patients with or at risk for COPD.

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Research Areas 【 Display / hide 】

  • Life Science / Respiratory medicine

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Research Themes 【 Display / hide 】

  • COPD, 

    2009.04
    -
    Present

  • 肺癌, 

    2009.04
    -
    Present

  • COPD, 

    2009.04
    -
    Present

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Books 【 Display / hide 】

  • 呼吸器内科

    Chubachi Shotaro, 科学評論社, 2013.06

    Scope: 【COPDの併存症とその治療】 COPDと骨粗鬆症

  • Medical Practice

    Chubachi Shotaro, 文光堂, 2012.04

    Scope: 【気管支喘息・実地診療の最前線】 セミナー/病態に基づく実地診療のポイント　喘息とCOPDの関連性と鑑別　診療上の相違点

  • 呼吸器内科

    Chubachi Shotaro, 科学評論社, 2011.09

    Scope: COPDのバイオマーカー(解説)

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Papers 【 Display / hide 】

  • Prognostic significance of chronic kidney disease and impaired renal function in Japanese patients with COVID-19

    Tanaka H., Chubachi S., Asakura T., Namkoong H., Azekawa S., Otake S., Nakagawara K., Fukushima T., Lee H., Watase M., Sakurai K., Kusumoto T., Masaki K., Kamata H., Ishii M., Hasegawa N., Okada Y., Koike R., Kitagawa Y., Kimura A., Imoto S., Miyano S., Ogawa S., Kanai T., Fukunaga K.

    BMC Infectious Diseases 24 ( 1 )  2024.12

    　View Summary

    Background: Renal impairment is a predictor of coronavirus disease (COVID-19) severity. No studies have compared COVID-19 outcomes in patients with chronic kidney disease (CKD) and patients with impaired renal function without a prior diagnosis of CKD. This study aimed to identify the impact of pre-existing impaired renal function without CKD on COVID-19 outcomes. Methods: This retrospective study included 3,637 patients with COVID-19 classified into three groups by CKD history and estimated glomerular filtration rate (eGFR) on referral: Group 1 (n = 2,460), normal renal function without a CKD history; Group 2 (n = 905), impaired renal function without a CKD history; and Group 3 (n = 272), history of CKD. We compared the clinical characteristics of these groups and assessed the effect of CKD and impaired renal function on critical outcomes (requirement for respiratory support with high-flow oxygen devices, invasive mechanical ventilation, or extracorporeal membrane oxygen, and death during hospitalization) using multivariable logistic regression. Results: The prevalence of comorbidities (hypertension, diabetes, and cardiovascular disease) and incidence of inflammatory responses (white blood counts, and C-reactive protein, procalcitonin, and D-dimer levels) and complications (bacterial infection and heart failure) were higher in Groups 2 and 3 than that in Group 1. The incidence of critical outcomes was 10.8%, 17.7%, and 26.8% in Groups 1, 2, and 3, respectively. The mortality rate and the rate of requiring IMV support was lowest in Group 1 and highest in Group 3. Compared with Group 1, the risk of critical outcomes was higher in Group 2 (adjusted odds ratio [aOR]: 1.32, 95% confidence interval [CI]: 1.03–1.70, P = 0.030) and Group 3 (aOR: 1.94, 95% CI: 1.36–2.78, P < 0.001). Additionally, the eGFR was significantly associated with critical outcomes in Groups 2 (odds ratio [OR]: 2.89, 95% CI: 1.64–4.98, P < 0.001) and 3 (OR: 1.87, 95% CI: 1.08–3.23, P = 0.025) only. Conclusions: Clinicians should consider pre-existing CKD and impaired renal function at the time of COVID-19 diagnosis for the management of COVID-19.

  • Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis

    Shimizu K., Kimura H., Tanabe N., Tanimura K., Chubachi S., Iijima H., Sato S., Wakazono N., Nakamaru Y., Okada K., Makita H., Goudarzi H., Suzuki M., Nishimura M., Konno S.

    Journal of Allergy and Clinical Immunology: Global 3 ( 3 )  2024.08

    　View Summary

    Background: Deteriorated sinusitis and increased adiposity relative to muscle mass may affect quality of life in patients with asthma. However, whether these effects are observed regardless of intrapulmonary pathology is unknown. Objectives: We evaluated the correlation of the cross-sectional ratio of abdominal visceral fat (VF) to erector spinae muscle (ESM) and sinus findings based on Lund-Mackey scoring system (LMS) on computed tomography (CT) with the impaired score of the Asthma Quality of Life Questionnaire (AQLQ), regardless of airway and parenchymal disease, in patients with asthma. Methods: We recruited participants from the Hokkaido-based severe asthma cohort who had completed AQLQ and CT examination at the entry. The participants were divided into high (highest) and low (other quartiles) groups on the bases of the extrapulmonary indices. Multivariate analysis examined the association of VF/ESM for the adiposity-to-muscle ratio and LMS with AQLQ after adjusting for the airway fractal dimension for airway index and percentage of low attenuation volume to lung volume for parenchymal index. Results: No significant differences were observed in VF/ESM and LMS in terms of sex. The AQLQ score in the high VF/ESM group and high LMS group was lower than those in low VF/ESM group and low LMS group (63 male and 100 female subjects). High VF/ESM (estimate [95% confidence interval] (−0.43 [−0.61, −0.25]) and high LMS scores (−0.22 [−0.41, −0.03]) were associated with low AQLQ scores when adjusted for age, body mass index, smoking status, blood eosinophil count, and intrapulmonary CT indices. Conclusions: Increased VF relative to ESM mass and high LMS may deteriorate asthma-related quality of life, regardless of presence of intrapulmonary disease.

  • CT-derived vertebral bone mineral density is a useful biomarker to predict COVID-19 outcome

    Azekawa S., Maetani T., Chubachi S., Asakura T., Tanabe N., Shiraishi Y., Namkoong H., Tanaka H., Shimada T., Fukushima T., Otake S., Nakagawara K., Watase M., Terai H., Sasaki M., Ueda S., Kato Y., Harada N., Suzuki S., Yoshida S., Tateno H., Yamada Y., Jinzaki M., Hirai T., Okada Y., Koike R., Ishii M., Kimura A., Imoto S., Miyano S., Ogawa S., Kanai T., Fukunaga K.

    Bone 184 2024.07

    ISSN  87563282

    　View Summary

    The low vertebral bone computed tomography (CT) Hounsfield unit values measured on CT scans reflect low bone mineral density (BMD) and are known as diagnostic indicators for osteoporosis. The potential prognostic significance of low BMD defined by vertebral bone CT values for the coronavirus disease 2019 (COVID-19) remains unclear. This study aimed to assess the impact of BMD on the clinical outcome in Japanese patients with COVID-19 and evaluate the association between BMD and critical outcomes, such as high-flow nasal cannula, non-invasive and invasive positive pressure ventilation, extracorporeal membrane oxygenation, or death. We examined the effects of COVID-19 severity on the change of BMD over time. This multicenter retrospective cohort study enrolled 1132 inpatients with COVID-19 from the Japan COVID-19 Task Force database between February 2020 and September 2022. The bone CT values of the 4th, 7th, and 10th thoracic vertebrae were measured from chest CT images. The average of these values was defined as BMD. Furthermore, a comparative analysis was conducted between the BMD on admission and its value 3 months later. The low BMD group had a higher proportion of critical outcomes than did the high BMD group. In a subanalysis stratifying patients by epidemic wave according to onset time, critical outcomes were higher in the low BMD group in the 1st–4th waves. Multivariable logistic analysis of previously reported factors associated with COVID-19 severity revealed that low BMD, chronic kidney disease, and diabetes were independently associated with critical outcomes. At 3 months post-infection, patients with oxygen demand during hospitalization showed markedly decreased BMD than did those on admission. Low BMD in patients with COVID-19 may help predict severe disease after the disease onset. BMD may decrease over time in patients with severe COVID-19, and the impact on sequelae symptoms should be investigated in the future.

  • Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society

    Kamata H., Takamatsu K., Fukunaga K., Chubachi S., Nakagawara K., Namkoong H., Terai H., Tanaka K., Sato S., Hagiwara E., Takei R., Kondoh Y., Takazono T., Hashimoto M., Tasaka S., Ohrui T., Tanino Y., Mineshita M., Komase Y., Miyazaki K., Nishikawa M., Ando A., Kita H., Ichihara E., Ohshimo S., Murata Y., Ishida M., Kobayashi S., Uchida T., Tateno H., Ikari J., Terashima T., Kozu Y., Tateishi T., Shinkai M., Sagara H., To Y., Ito Y., Yamamoto M., Yamamoto Y., Kita T., Ito Y., Tomii K., Fujita Y., Funaki Y., Yatera K., Yamasue M., Komiya K., Kozawa S., Manabe H., Hozumi H., Horiguchi T., Kitajima T., Nakano Y., Nagaoka T., Hojo M., Ebihara A., Kobayashi M., Takayama K., Jinta T., Sawai T., Fukuda Y., Kaneko T., Chin K., Ogura T., Mukae H., Ishii M., Yokoyama A.

    Respiratory Investigation 62 ( 4 ) 572 - 579 2024.07

    ISSN  22125345

    　View Summary

    Background: No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT. Methods: For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021. Disease severity was classified as moderateⅠ, moderate II, and severe, defined primarily according to the degree of respiratory failure. The data on post-COVID-19 conditions over 12 months, pulmonary function, and chest CT findings at 3 months were evaluated in this study. Additionally, the impact of COVID-19 severity on pulmonary sequelae, such as impaired diffusion capacity, restrictive pattern, and CT abnormalities, was also evaluated. Results: The most frequently reported post-COVID-19 conditions at 3 months after COVID-19 were muscle weakness, dyspnea, and fatigue (48.4%, 29.0%, and 24.7%, respectively). The frequency of symptoms gradually decreased over subsequent months. In pulmonary function tests at 3 months, the incidence of impaired diffusion capacity and restrictive pattern increased depending on disease severity. There also were differences in the presence of chest CT abnormalities at the 3 months, which was markedly correlated with the severity. Conclusion: We reported a comprehensive analysis of post-COVID-19 condition, pulmonary function, and chest CT abnormalities in Japanese patients with COVID-19. The findings of this study will serve as valuable reference data for future post-COVID-19 condition research in Japan.

  • Lung volume measurement using chest CT in COVID-19 patients: a cohort study in Japan

    Otake S., Shiraishi Y., Chubachi S., Tanabe N., Maetani T., Asakura T., Namkoong H., Shimada T., Azekawa S., Nakagawara K., Tanaka H., Fukushima T., Watase M., Terai H., Sasaki M., Ueda S., Kato Y., Harada N., Suzuki S., Yoshida S., Tateno H., Yamada Y., Jinzaki M., Hirai T., Okada Y., Koike R., Ishii M., Hasegawa N., Kimura A., Imoto S., Miyano S., Ogawa S., Kanai T., Fukunaga K.

    BMJ Open Respiratory Research 11 ( 1 )  2024.04

    　View Summary

    Objective This study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients. Methods This retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLCct (n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months. Results The incidence of critical outcomes was higher in the low TLCct (%pred) group than in the high TLCct (%pred) group (14.2% vs 3.3%, p<0.0001). Multivariable analysis of previously reported factors (age, sex, body mass index and comorbidities) demonstrated that CT-derived lung volume was significantly associated with critical outcomes. The low TLCct (%pred) group exhibited a higher incidence of bacterial infection, heart failure, thromboembolism, liver dysfunction and renal dysfunction than the high TLCct (%pred) group. TLCct (%pred) at 3 months was similarly divided into two groups at the median (71.8%). Among patients with follow-up CT scans, lung volumes showed a recovery trend from the time of admission to 3 months but remained lower in critical cases at 3 months. Conclusion Lower CT lung volume was associated with critical outcomes, posthospitalisation complications and slower improvement of clinical conditions in COVID-19 patients.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • A second update on mapping the human genetic architecture of COVID-19

    Kanai M., Andrews S.J., Cordioli M., Stevens C., Neale B.M., Daly M., Ganna A., Pathak G.A., Iwasaki A., Karjalainen J., Mehtonen J., Pirinen M., Chwialkowska K., Trankiem A., Balaconis M.K., Veerapen K., Wolford B.N., Ahmad H.F., von Hohenstaufen Puoti K.A., Boer C., Boua P.R., Butler-Laporte G., Cadilla C.L., Colombo F., Douillard V., Dueker N., Dutta A.K., El-Sherbiny Y.M., Eltoukhy M.M., Esmaeeli S., Faucon A., Fave M.J., Cadenas I.F., Francescatto M., Francioli L., Franke L., Fuentes M., Durán R.G., Cabrero D.G., Harry E.N., Jansen P., Szentpéteri J.L., Kaja E., Kirk C., Kousathanas A., Krieger J.E., Patel S.K., Lemaçon A., Limou S., Lió P., Marouli E., Marttila M.M., Medina-Gómez C., Michaeli Y., Migeotte I., Mondal S., Moreno-Estrada A., Moya L., Nakanishi T., Nasir J., Pasko D., Pearson N.M., Pereira A.C., Priest J., Prijatelj V., Prokic I., Teumer A., Várnai R., Romero-Gómez M., Roos C., Rosenfeld J., Ruolin L., Schulte E.C., Schurmann C., Sedaghati-khayat B., Shaheen D., Shivanathan I., Sipeky C., Sirui Z., Striano P., Tanigawa Y., Remesal A.U., Vadgama N., Vallerga C.L., van der Laan S., Verdugo R.A., Wang Q.S., Wei Z., Zainulabid U.A., Zárate R.N., Auton A., Shelton J.F., Shastri A.J., Weldon C.H., Filshtein-Sonmez T., Coker D., Symons A.

    Nature 621 ( 7977 ) E7 - E26 2023.09

    ISSN  00280836

  • A rare case of COVID-19 infection with laryngeal involvement

    Asaoka M., Chubachi S., Yamada Y., Fukunaga K.

    BMJ Case Reports 14 ( 6 )  2021.06

  • Blood eosinophil and neutrophil counts differentially identify frequent exacerbation in patients with COPD with physician-diagnosed asthma and COPD

    Mochimaru T., Chubachi S., Irie H., Sakurai K., Okuzumi S., Sunata K., Masaki K., Miyata J., Nakamura H., Asano K., Fukunaga K.

    Allergology International 70 ( 2 ) 255 - 257 2021.04

    ISSN  13238930

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Presentations 【 Display / hide 】

  • COPDと間質性肺炎に合併する肺癌の臨床

    Chubachi Shotaro

    第37回日本画像医学会, 

    2018.02
    , 

    Symposium, workshop panel (public)

  • Radiological features of structural basis where cancer develops in COPD lungs

    Chubachi Shotaro

    American Thoracic Society 2017 International Conference, 

    2017.05
    , 

    Oral presentation (general)

  • COPDコホート研究追跡期間に新規に発症した肺癌の発症前CTの画像的特徴

    Chubachi Shotaro

    第57回日本呼吸器学会学術講演会, 

    2017.04
    , 

    Symposium, workshop panel (public)

  • Cluster Analysis Based on Comorbidities for Japanese COPD Patients

    Chubachi Shotaro

    American Thoracic Society 2016 International Conference, 

    2016.05
    , 

    Oral presentation (general)

  • 全身併存症クラスター解析を用いた日本人COPD患者のフェノタイプ分類

    Chubachi Shotaro

    第56回日本呼吸器学会学術講演会, 

    2016.04
    , 

    Symposium, workshop panel (public)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 喫煙誘導肺癌及び肺気腫における脂質メディエーターの役割

    2022.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

  • 肺気腫及び肺気腫合併肺癌の新規予防薬の探索

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 喫煙誘導マウスモデルにおける肺がん発生機序

    2017.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Principal investigator

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Awards 【 Display / hide 】

  • Pneumo Forum最優秀賞

    2022.10

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本呼吸器学会学術部会賞　優秀賞　

    2017.04, 日本呼吸器学会

  • 昭和大学　上條旗が丘賞

    2005.03, 昭和大学

    　View Description

    課外活動で本学の名を宣揚せしめ、かつ人物、学業ともに優秀と認められた学生を卒業時に表彰。

  • 昭和大学　上條賞

    2005.03, 昭和大学

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    最終学年において、人物が優秀で学業成績が抜群の学生を卒業時に表彰。

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Courses Taught 【 Display / hide 】

  • LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY)

    2024

  • CASE STUDIES OF INTERNAL MEDICINE

    2023

  • CLINICAL TRAINING IN DIAGNOSIS

    2023

  • LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY)

    2023

  • LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY)

    2022

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Courses Previously Taught 【 Display / hide 】

  • 診断学実習　ケーススタディー

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty

  • 診断学実習　血液ガス分析

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty

  • 内科学呼吸器　急性呼吸窮迫症候群と急性呼吸不全の管理

    Keio University

    2018.04
    -
    2019.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

  • 日本呼吸器学会

    　

  • 日本内科学会

    　

  • American thoracic society

    　
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