Kabata, Hiroki

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Pulmonary Medicine) (Shinanomachi)

Position

Instructor

Other Affiliation 【 Display / hide

  • RIKEN center for Integrative Medical Sciences, Laboratory for Innate Immune Systems, Visiting researcher

Career 【 Display / hide

  • 2006.04
    -
    2008.03

    独立行政法人国立病院機構東京医療センター, 初期研修医

  • 2008.04
    -
    2009.03

    慶應義塾大学医学部, 専修医

  • 2009.04
    -
    2010.03

    川崎市立川崎病院, 総合診療科, 専修医

  • 2011.05
    -
    2014.03

    慶應義塾大学医学部, 内科学, 助教(臨床実習)

  • 2014.04
    -
    2016.04

    川崎市立川崎病院, 呼吸器内科, 副医長

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Academic Background 【 Display / hide

  • 2000.04
    -
    2006.03

    Keio University, 医学部

    University, Graduated

  • 2010.04
    -
    2014.03

    Keio University, 大学院, 医学研究科

    Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Dissertation, 2014.03

    Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

Licenses and Qualifications 【 Display / hide

  • 日本内科学会, 認定医, 2009.09

  • 日本呼吸器学会, 専門医, 2013.12

  • 日本アレルギー学会, 専門医, 2016

 

Research Areas 【 Display / hide

  • Immunology (ILC2)

  • Respiratory organ internal medicine (Asthma)

Research Keywords 【 Display / hide

  • Group 2 innate lymphoid cell, ILC2

  • IL-33

  • TSLP

  • Severe asthma

 

Papers 【 Display / hide

  • The effect of statins for asthma. A systematic review and meta-analysis.

    Sunata K, Kabata H, Kuno T, Takagi H, So M, Masaki K, Fukunaga K

    The Journal of asthma : official journal of the Association for the Care of Asthma    1 - 10 2021.02

    ISSN  0277-0903

  • The real-time reverse transcription-polymerase chain reaction threshold cycle values for severe acute respiratory syndrome coronavirus 2 predict the prognosis of coronavirus disease 2019 pneumonia.

    Fukushima T, Kabata H, Yamamoto R, Suhara T, Uwamino Y, Kondo Y, Masaki K, Kamata H, Nagata H, Homma K, Kaneko Y, Ishii M, Sasaki J, Morisaki H, Hasegawa N, Fukunaga K, Keio Donner Project Team.

    Respiratory investigation  2021.01

    ISSN  2212-5345

  • Left Ventricular Thrombus With COVID-19 Complication in a Patient With Dilated Cardiomyopathy.

    Imaeda S, Kabata H, Shiraishi Y, Kamata H, Tsuruta H, Yuasa S, Ishii M, Fukuda K, Fukunaga K

    CJC open (CJC Open)  3 ( 1 ) 124 - 126 2021.01

     View Summary

    © 2020 Canadian Cardiovascular Society Thrombosis, especially venous thromboembolism, is a complication often associated with coronavirus disease 2019 (COVID-19). However, there have been relatively few reports of arterial thrombosis. Here, we describe a case of non-severe COVID-19 in a patient with dilated cardiomyopathy. After admission, symptoms, laboratory data, and imaging findings improved, but D-dimer levels gradually increased. Contrast computed tomography and echocardiography revealed a left ventricular thrombus. Anticoagulant treatment diminished the thrombus, and the patient recovered and was discharged. Although a left ventricular thrombus is a rare COVID-19 complication, performing appropriate diagnostic tests could improve COVID-19 mortality in patients with dilated cardiomyopathy.

  • Clinical characteristics of patients with not well-controlled severe asthma in Japan: Analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry.

    Tanosaki T, Kabata H, Matsusaka M, Miyata J, Masaki K, Mochimaru T, Okuzumi S, Kuwae M, Watanabe R, Suzuki Y, Sayama K, Izuhara K, Asano K, Fukunaga K

    Allergology international : official journal of the Japanese Society of Allergology (Allergology International)  70 ( 1 ) 61 - 67 2021.01

    ISSN  1323-8930

     View Summary

    © 2020 Japanese Society of Allergology Background: Multiple phenotypes exist within the classification of severe asthma. However, characteristics of patients with not well-controlled severe asthma have not been well identified. Methods: Japanese patients with asthma (age ≥ 20 years) were enrolled at the Keio University Hospital and its affiliated hospitals in this observational study (Keio Severe Asthma Research Program). Among them, patients with severe asthma (those undergoing Global Initiative for Asthma [GINA] 2018 step 4 or 5 treatment) were included in this analysis and investigated clinical characteristics based on asthma control status. Results: Of the 154 patients (men, 46.8%; age, 60.1 ± 14.9 years), 87 (56.5%) had not well-controlled (partly controlled and uncontrolled) asthma (GINA step 4, 42 patients; step 5, 45 patients). Overall, there were no significant differences in clinical characteristics between patients with well-controlled and not well-controlled asthma. However, cluster analysis revealed that distinct 5 clusters (cluster 1, well-controlled; cluster 2, eosinophilic; cluster 3, non–type 2 inflammation; cluster 4, high periostin; and cluster 5, late-onset type 2 inflammation), and clusters 2–5 were not well-controlled. Among them, cluster 3 was characterized by low eosinophil counts, low periostin levels, and less frequent olfactory disturbance, and this cluster had the worst asthma control. Conclusions: Japanese patients with severe asthma were divided into well-controlled and not-well controlled asthma, and we confirmed heterogeneity of not well-controlled severe asthma. These patients, especially non-type 2 phenotype, require a further therapeutic approach. (University Hospital Medical Information Network Clinical Trials Registry, UMIN000002980)

  • Accuracy and stability of saliva as a sample for reverse transcription PCR detection of SARS-CoV-2.

    Uwamino Y, Nagata M, Aoki W, Fujimori Y, Nakagawa T, Yokota H, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Shiraki T, Uchida S, Uno S, Kabata H, Ikemura S, Kamata H, Ishii M, Fukunaga K, Kawaoka Y, Hasegawa N, Murata M

    Journal of clinical pathology (Journal of Clinical Pathology)  74 ( 1 ) 67 - 68 2021.01

    ISSN  0021-9746

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Reviews, Commentaries, etc. 【 Display / hide

  • アレルギー性呼吸器疾患のトランスレーショナルリサーチ Single cell解析によるILC2活性化制御遺伝子の検討

    桑江 美聡, 加畑 宏樹, 松坂 雅子, 馬塲 里英, 鎌谷 高志, 渡辺 理沙, 正木 克宜, 田野崎 貴絵, 奥隅 真一, 白崎 善隆, 上村 想太郎, 茂呂 和世, 福永 興壱

    日本呼吸器学会誌 ((一社)日本呼吸器学会)  9 ( 増刊 ) 132 - 132 2020.08

    ISSN  2186-5876

  • マウスにおける食餌によるアレルギー性気道炎症への影響に関する検討

    奥隅 真一, 宮田 純, 加畑 宏樹, 正木 克宜, 加川 志津子, 田野崎 貴絵, 渡辺 理沙, 桑江 美聡, 秋山 勇人, 西江 美幸, 砂田 啓英也, 福永 興壱

    日本呼吸器学会誌 ((一社)日本呼吸器学会)  9 ( 増刊 ) 228 - 228 2020.08

    ISSN  2186-5876

  • ヨード造影剤により重篤な非心原性肺水腫を発症し救命しえた1例

    長尾 元太, 正木 克宜, 砂田 啓英也, 西江 美幸, 秋山 勇人, 加畑 宏樹, 川田 一郎, 副島 研造, 福永 興壱

    アレルギー ((一社)日本アレルギー学会)  69 ( 4 ) 274 - 274 2020.06

    ISSN  0021-4884

  • 【喘息に対する分子標的治療の新展開】IL-33、TSLP、CRTH2をターゲットとした治療

    加畑 宏樹, 福永 興壱

    炎症と免疫 ((株)先端医学社)  27 ( 6 ) 482 - 487 2019.10

    ISSN  0918-8371

     View Summary

    現在、喘息に対する分子標的薬は、おもにリンパ球から産生される下流のサイトカインをターゲットとしている。一方、リンパ球を活性化する上流のサイトカインや脂質メディエーターをターゲットとした次世代の分子標的治療薬の開発が進んでいる。リンパ球の活性化を抑制することは、リンパ球から産生されるサイトカインを一種類ずつ抑制するよりも、より広範囲かつ根本的な炎症抑制につながると期待されている。本稿では、現在開発が進められているIL-33、TSLP、CRTH2を標的とする薬剤について概説する。(著者抄録)

  • 内科から 重症喘息におけるステロイド抵抗性

    加畑 宏樹, 福永 興壱

    日本小児アレルギー学会誌 ((一社)日本小児アレルギー学会)  33 ( 4 ) 656 - 656 2019.10

    ISSN  0914-2649

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • ILC2をターゲットとした新規抑制化合物・天然物の同定

    2020.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 加畑 宏樹, Grant-in-Aid for Early-Career Scientists , Principal Investigator

     View Summary

    近年、既に臨床で用いられている薬剤の中から本来の薬効とは異なる作用を見つけ、別の疾患の治療薬としての適応を探索する既存薬スクリーニング(Drug repositioning, DR)研究が注目を集めている。本研究では、気管支喘息やアレルギー性疾患に関与する2型自然リンパ球を抑制する新しい物質を調査し、気管支喘息やアレルギー性疾患に対する治療候補物質の検討を行う。

  • GSK Japan Research Grant

    2019.04
    -
    2021.09

    Research grant, Principal Investigator

 

Courses Taught 【 Display / hide

  • LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY)

    2021

  • LECTURE SERIES, INTERNAL MEDICINE (PULMONOLOGY)

    2020