YAMANOI Kazuhiro

写真a

Affiliation

School of Medicine, Division of Diagnostic Pathology （Shinanomachi）

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)
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Other Affiliation 【 Display / hide 】

  • Shinshu Univ., School of Medicine, Molecular Pathology, Project recturer

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Career 【 Display / hide 】

  • 2010.03
    -
    2012.03

    National Cancer Center Institute, Dep. of Pathology, Trainee

  • 2012.04
    -
    2014.12

    Aizawa Hospital, Dep. of Pathology, Medical Doctor

  • 2015.01
    -
    2016.05

    Asama General Hospital, Dep. of Clinical Laboratory, Chief Doctor

  • 2016.05
    -
    2019.03

    Shinshu Univ., ICCER, Inst. of Biomedical Sciences, Assistant Professor

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Academic Background 【 Display / hide 】

  • 1999.04
    -
    2005.03

    Keio University, School of medicine

    University, Graduated

  • 2008
    -
    2012

    Keio University, Graduate School of medicine, Department of pathology

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Doctor of Medicine, Keio University, Coursework, 2013.09

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Licenses and Qualifications 【 Display / hide 】

  • 医師免許, 2005.04

  • 臨床研修指導医, 2012.10

  • 病理専門医研修指導医, 2018.04

  • 細胞診教育研修指導医, 2019.04

  • 臨床検査管理医, 2014.12

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Research Areas 【 Display / hide 】

  • Life Science / Human pathology

  • Life Science / Tumor diagnostics and therapeutics

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Research Keywords 【 Display / hide 】

  • Pathology

  • Oncology

  • multi-step carcinogenesis

  • glycobiology

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Research Themes 【 Display / hide 】

  • Significance of glycosilation in carcinogenesis, 

    2014.01
    -
    Present

  • Clinico-pathological feature of familial tumor, 

    2012.04
    -
    Present

  • Molecular mechanisms of gastric carcinogenesis, 

    2008.04
    -
    Present

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Papers 【 Display / hide 】

  • MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung

    K Yamanoi, C Fujii, H Yuzuriha, M Kumazawa, M Shimoda, K Emoto, H Asamura, J Nakayama

    Histochemistry and Cell Biology  2022

    Research paper (scientific journal), Lead author, Corresponding author, Accepted

  • Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy

    A Yuki, C Fujii, K Yamanoi, H Matoba, S Harumiya, M Kawakubo, J Nakayama

    Cancer Science 113 （ 2 ） 576 - 586 2022.02

    Research paper (scientific journal), Joint Work, Accepted

  • Decreased αGlcNAc glycosylation in biliary tract cancer progression from BilIN to invasive adenocarcinoma

    Motohiro Okumura, Kazuhiro Yamanoi, Takeshi Uehara, Jun Nakayama

    CANCER SCIENCE 113 （ 2 ） 4629 - 4635 2020.10

    Research paper (scientific journal), Joint Work, Corresponding author, Accepted

  • Diffuse MIST1 expression and decreased αGlcNAc glycosylation on MUC6 are distinct hallmark for gastric neoplasms exhibiting oxyntic gland differentiation

    Shigenori Yamada, Kazuhiro Yamanoi, Yoshiko Sato, Jun Nakayama

    HISTOPATHOLOGY 77 （ 3 ） 413 2020.09

    Research paper (scientific journal), Joint Work, Corresponding author, Accepted

  • αGlcNAc and its catalyst α4GnT are diagnostic and prognostic markers in uterine cervical tumor, gastric type.

    Ida K, Yamanoi K, Asaka S, Takeuchi H, Miyamoto T, Shiozawa T, Nakayama J.

    Scientific Reports （Nature publishing)  9 （ 1 ） 13043 2019.09

    Research paper (scientific journal), Joint Work, Corresponding author, Accepted,  ISSN  2045-2322

    　View Summary

    © 2019, The Author(s). Cervical adenocarcinoma, gastric type (GAS) is not associated with human papilloma virus (HPV) infection. GAS patients prognoses are significantly worse compared with cervical adenocarcinoma associated with HPV infection, as their tumors exhibit resistance to conventional chemotherapy and radiotherapy. GAS is often associated with lobular endocervical glandular hyperplasia (LEGH), which is regarded as a precursor to GAS in the latest WHO classification. Recently, we reported that a decrease in expression of terminal α1,4-linked N-acetylglucosamine (αGlcNAc) relative to that of MUC6 was already apparent in atypical LEGH in the LEGH-GAS sequence. Here, we analyzed expression of α1,4-N-acetylglucosaminyltransferase (α4GnT), the sole enzyme catalyzing αGlcNAc biosynthesis, and that of αGlcNAc and MUC6 in cases representing non-neoplastic endocervical gland (NNEG) (11 cases), LEGH (26 cases) and GAS (12 cases). α4GnT protein was detected in a “dot-like” pattern, indicating localization in the Golgi apparatus in all 26 LEGH cases and 5 of 12 GAS cases. α4GnT- and αGlcNAc-positive cells largely overlapped, suggesting that α4GnT gene expression regulates αGlcNAc biosynthesis. Interestingly, all NNEG cases were negative for α4GnT and αGlcNAc expression, but 7 of 11 NNEG and all LEGH cases were MUC6-positive. In GAS cases, patients whose tumors were α4GnT- and αGlcNAc-positive had more favorable prognosis than others. Multivariate analysis revealed that positive expressions of α4GnT and αGlcNAc were independent prognostic indicators. These results indicate that α4GnT and αGlcNAc could serve as useful markers not only to distinguish LEGH from NNEG but to evaluate prognoses of GAS patients.

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Reduced alpha GlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer

    Yamanoi, Kazuhiro; Nakayama, Jun;

    HISTOCHEMISTRY AND CELL BIOLOGY 149 ( 6 ) 569 - 575 2018.06

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • 最新のトピックス　リンチ症候群のスクリーニング

    Yamanoi Kazuhiro

    信州医学雑誌 (信州医学会)  66 ( 3 ) 221 - 223 2018.06

    Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  0037-3826

  • 早期分化型胃癌における癌抑制分子、TFF1とαGlcNAcの関与

    福島 万奈, 川久保 雅友, 山田 重徳, 山ノ井 一裕, 中山 淳

    日本病理学会会誌 ((一社)日本病理学会)  107 ( 1 ) 289 - 289 2018.04

    ISSN  0300-9181

  • 第５回信州Neuro CPC 軽度の前頭側頭葉変性症(FTLD)を随伴したパーキンソン病の一剖検例

    山ノ井一裕、須藤素弘、樋口佳代子、小柳清光

    信州医学雑誌 60 ( 2 ) 101 - 105 2012.04

    Lecture material (seminar, tutorial, course, lecture, etc.)

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Presentations 【 Display / hide 】

  • Significance of aGlcNAc expression in biliary ductal cancer progression

    山ノ井　一裕, 奥村　征大, 上原　剛, 尾島　英知, 中山　淳

    第109回日本病理学会総会, 

    2020.07
    , 

    Oral presentation (general)

  • 子宮頸部細胞診で胃型粘液性癌が疑われた通常型内頸部腺癌の一例

    服部 守恭, 藤井 真一, 山ノ井 一裕, 中山 淳, 福島 万奈, 的場 久典

    第58回日本臨床細胞学会秋期大会, 

    2019.11
    , 

    Poster presentation

  • Significance of aGlcNAc expression during progression of cholangiocarcinoma

    Okumura M. Yamanoi K, Nakayama J

    78th Japanese cancer association annual meeting, 

    2019.09
    , 

    Poster presentation

  • 免疫組織学的にPSA染色陽性であった原発性膀胱癌の1例

    野口 渉, 井上 善博, 山ノ井 一裕, 中山 淳

    第83回日本泌尿器科学会東部総会, 

    2018.10
    , 

    Poster presentation

  • ALPHA-GLCNAC AND Α4GNT CAN BE FAVORABLE PROGNOSTIC MARKERS FOR CERVICAL MUCINOUS CARCINOMA, GASTRIC TYPE

    K. Ida, K. Yamanoi, H. Takeuchi, Y. Yamada, H. Kobara, H. Kashima, T. Miyamoto, J. Nakayama, T. Shiozawa

    17th Biennial Meeting of the International Gynecologic Cancer Society (Kyoto) , 

    2018.09
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 幽門腺粘液の糖鎖αGlcNAcの発現低下とがんの悪性度の分子機構の解明

    2019.04
    -
    2022.03

    Keio University, 日本学術振興会科学研究費, Grant-in-Aid for Early-Career Scientists, Research grant, Principal investigator

    　View Summary

    本研究では、胃、膵臓、子宮頸部のがん病変、前がん病変におけるαGlcNAcの発現低下について、予後を含めた悪性度の関係まで調べ、対象臓器も肺、胆道などに広げて検討することを１つの目的とする。がん由来の培養細胞株を用いて、αGlcNAcの発現に呼応する細胞機能の変化と、関連する遺伝子発現やリン酸化の変化を調べ、αGlcNAcががんの悪性化を抑制する分子生物学的な機序を明らかにし、αGlcNAcの発現変化を基盤とした、新たな治療標的の知見を得ることが２つ目の目的である。
    本研究で、がんの悪性化に関わる糖鎖修飾の変化が臓器横断的に理解されれば、糖鎖修飾を鍵にした新たながんの治療標的の研究の基盤になる。

  • Significance of alphaGlcNAc expression status in human tumors

    2017.04
    -
    2019.03

    Shinshu University, 科学研究費, Yamanoi Kazuhiro, Nakayama Jun, Fujii Chifumi, Ohya Ayumu, Ida Koichi, Ishii Keiko, Asaka Shiho, Shimojo Hisashi, Miyamoto Tsutomu, Shiozawa Tanri, Grant-in-Aid for Young Scientists (B), Research grant, Principal investigator

    　View Summary

    Gastric pyloric glands characteristically contain O-glycans having α1,4-linked　N-acetylglucosamine residue (αGlcNAc) largely attached to MUC6 scaffold. In normal human gastric mucosa, αGlcNAc and MUC6 are co-expressed in pyloric gland cells. We examined αGlcNAc and MUC6 expression in human gastric, pancreas and uterine cervical tumors. We showed that reduced αGlcNAc expression relative to MUC6 was observed not only in invasive carcinoma lesions but also in their pre-malignant lesions, such as high-grade pyloric gland adenoma, high-grade intraepithelial neoplasia, high-grade intraductal papillary-mucinous neoplasm and atypical lobular endocervical gland hyperplasia. These results indicate that reduced αGlcNAc expression has already started in pre-malignant status in these organs. Thus, αGlcNAc could serve as a critical biomarker for malignant potential in early stage of gastric, pancreas and uterine cervical neoplasms.

  • 特殊型胃癌における幹細胞マーカーの発現とその意義

    2018.04
    -
    2019.03

    信州医学振興会, 平成３０年度研究助成, Research grant, Principal investigator

  • 粘液産生性肺腺癌において、幽門腺型粘液のコア蛋白であるＭＵＣ６が、がんの悪性化を抑制するメカニズムの解析

    2017.04
    -
    2018.03

    ノバルティスファーマ株式会社, Research grant, Principal investigator

  • 幽門腺型粘液の糖鎖に注目したがん抑制機構の解明と、早期がん診断への応用

    2023.04
    -
    2027.03

    基盤研究(C), Principal investigator

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Awards 【 Display / hide 】

  • 日本病理学会学術奨励賞

    2020.07

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Other 【 Display / hide 】

  • 　View Details

    信州大学医学部附属病院　がんのクリニカルシークエンス　コアメンバー

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Courses Taught 【 Display / hide 】

  • GENERAL PATHOLOGY

    2024

  • DISEASES OF ORGAN SYSTEMS

    2024

  • GENERAL PATHOLOGY

    2023

  • DISEASES OF ORGAN SYSTEMS

    2023

  • 医学概論

    2022, Full academic year

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Courses Previously Taught 【 Display / hide 】

  • 病理学総論・各論

    信州大学医学部

    2017.04
    -
    2022.12
    , 

    Full academic year, Undergraduate (specialized), Lecture

  • 自主研究演習

    信州大学医学部

    2017.04
    -
    2019.03

  • 形態学研究方法特論

    信州大学大学院医理工学研究科

    2017.04
    -
    2019.03
    , 

    Postgraduate

  • 腫瘍病理学

    信州大学大学院医理工学研究科

    2018.04
    -
    2019.03
    , 

    Postgraduate

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Educational Activities and Special Notes 【 Display / hide 】

  • 2021年度医学教育実践者コース　修了

    2021
    -
    2022

    , Special Affairs

  • 学生指導者を対象とした医学教育FD　修了(信州大学医学部)

    2016
    -
    2018

    , Device of Educational Contents

  • CBT試験　学内ブラッシュアップ委員 (信州大学医学部)

    2018

    , Special Affairs

  • CBT試験・追試験　試験監督（信州大学医学部）

    2018

    , Special Affairs

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Memberships in Academic Societies 【 Display / hide 】

  • 日本臨床細胞学会

    　

  • 日本臨床検査医学会

    　

  • 日本癌学会

    　

  • 日本病理学会

    　
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Committee Experiences 【 Display / hide 】

  • 2017.05
    -
    Present

    学術評議員, 日本病理学会

  • 2021.06
    -
    Present

    評議員, 日本臨床細胞学会

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